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App-based assessment of memory functions in patients after transfemoral aortic valve replacement

老年心脏病学杂志:英文版 2023年第9期20卷 664-672页

作者： Jonathan Nübel michael hauptmann Julika Schön Georg Fritz Christian Butter Anja Haase-Fielitz Department of Cardiology University Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Biostatistics and Registry Research Brandenburg Medical School Theodor FontaneNeuruppinGermany Faculty of Health Sciences(FGW) Joint Faculty of the University of Potsdamthe Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-SenftenbergCottbusGermany Anesthesia and Intensive Care University Hospital Ruppin Brandenburg(ukrb)Brandenburg Medical School(MHB)Theodor FontaneNeuruppinGermany Department of Anesthesiology Intensive Care and Pain TherapyUniversity Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Social Medicine and Health System Research Otto von Guericke University MagdeburgGermany

BACKGROUND Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve stenosis.Although safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and dementia.In clinical practice,comprehensive cognitive testing is difficult to perform.AI-assisted digital applications may help to optimize diagnosis and monitoring.METHODS Neurocognitive function was assessed by validated psychometric tests using“Δelta-App”,which uses artificial intelligence and computational linguistic methods for extraction and analysis.Memory function was assessed using the‘Consortium to Establish a Registry for Alzheimer’s Disease’(CERAD)word list and digit span task(DST)before TAVR and before hospital discharge.The study is registered in the German Register of Clinical Trials(https://drks.de/search/de/trial/DRKS00020813).RESULTS From October 2020 until March 2022,141 patients were enrolled at University Hospital Heart Centre Brandenburg.Mean age was 81±6 years,42.6%were women.Time between the pre-and post-interventional test was on average 6±3 days.Memory function before TAVR was found to be below average in relation to age and educational level.The pre-post TAVR comparison showed significant improvements in the wordlist repeat,P<0.001 and wordlist recall test of CERAD,P<0.001.There were no changes in the digital span test.CONCLUSIONS Despite impaired preoperative memory function before TAVR,no global negative effect on memory function after TVAR was detected.The improvements shown in the word list test should be interpreted as usual learning effects in this task.

关键词： patients impaired valve

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可视化认证系统保障可追溯性

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现代制造 2010年第40期 34-35页

作者： Uwe Drücker michael hauptmann

可追溯性是FDA认证的核心。因此,打印控制系统使用的都是标准的部件和配置。这也就有可能实现在各个不同企业网络中的数据传输以及信息传递的无缝连接。医药产品生产属于具有高度责任意识和高度质量意识的行业领域。产品和产品质量从开... 详细信息

可追溯性是FDA认证的核心。因此,打印控制系统使用的都是标准的部件和配置。这也就有可能实现在各个不同企业网络中的数据传输以及信息传递的无缝连接。医药产品生产属于具有高度责任意识和高度质量意识的行业领域。产品和产品质量从开始生产到包装出厂,乃至出厂使用若干年后都应该具有很好的可追溯性。作为这方面的相关技术规范,首先是各国颁布的相关法律法规,即包含了GMP(药品生产质量管理规范)和GAMP(优秀自动化制造规范)等内容的法律法规。作为执行机构,FDA(美国食品药品管理局)

关键词：可追溯性可视化系统企业网络药品生产质量管理规范操作者法律法规服务器数据库灌装线数据传输

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Endocarditis after transcatheter aortic valve implantation： a current assessment

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Journal of Geriatric Cardiology 2018年第1期15卷 61-65页

作者： Emmanouil Chourdakis Ioanna Koniari George Hahalis Nicholas G Kounis Karl Eugen hauptmann Krankenhaus der Barmherzigen Briider Trier Germany Patras University Hospital: Rio Patras Greece

Transcatheter aortic valve implantation (TAVI) constitutes an established treatment in inoperable or high perioperative risk patients with severe aortic stenosis, demonstrating similar mortality rates (at 30 days and 1 year) with surgical aortic valve replacement (SAVR). Various complications have been reported during TAVI, weeks or months post procedure. The most frequent causes of transcatheter heart valve (THV) failure are paravalvular regurgitation, infective endocarditis (IE), thrombosis and late valve Migration. Post TAVI endocarditis diagnosis can be established according to the valve academic research consortium-2 criteria which include (1) Duke endocarditis criteria; or (2) evidence of abscess, paravalvular leak, pus, or vegetation confirmed by histological or bacteriological studies during a reoperation; or (3) abscess, pus, or vegetation confirmed by an autopsy.

关键词：心内膜炎大动脉阀门培植评价死亡率并发症子过程

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Transcatheter Valve-in-Valve implantation after late migration of balloon expandable Sapien- XT prosthesis in a severe pure aortic regurgitation case

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Journal of Geriatric Cardiology 2017年第12期14卷 763-765页

作者： Emmanouil Chourdakis Ioanna Koniari George Hahalis Nicholas Kounis Karl Eugen hauptmann Krankenhaus der Barmherzigen Briider Trier Germany Department of InterventionalElectriphysiology Royal Brompton Hospital London United Kingdom Cardiology Department Patras University Hospital Rio Patras Greece

A 76-year old female, was admitted in our cardiac surgery clinic to perform surgical aortic valve replacement due to a severe aortic regurgitation with symptoms of congestive heart failure. Her past medical history in... 详细信息

关键词：大动脉修复术移植智慧培植盒子外科充血

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Restrictive perimembranous ventricular septal defect with left to right Shunt post urgent aortic balloon valvuloplasty and transcatheter aortic valve replacement

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Journal of Geriatric Cardiology 2018年第1期15卷 113-116页

作者： Emmanouil Chourdakis Ioanna Konlari Nicholas G Kounis Dimitrios Velissaris George Hahalis Karl Eugen hauptmann Cardiology Department Hospital of the Brothers of Mercy Trier Germany Cardiology Department Queen Elizabeth University Hospital Birmingham UK Cardiology Department Patras University Hospital Rio Patras Greece

An 86-year-old male patient was admitted in our cardiology ward with signs of congestive biventricular heart failure. The patient presented with deteriorating dyspnea on mild exertion and at rest the last days, compatible with class NYHA III-IV heart failure, bilateral peripheral oedema, increased NT-proBNP (9198 pg/mL), mildly elevated Troponin (TnT 64 pg/mL), interstitial pulmonary oedema and bilateral pleural effusions in chest X ray. Permanent atrial fibrillation, known left branch bundle block (QRS = 170 ms), hypertension, and chronic renal failure were referred as co-morbidities. The transthoracic echocardiogram (TTE) revealed severely impaired left ventricle (LV) function [ejection fraction (EF) = 25%-30%] with diffuse wall hypokinesia, a high-grade aortic stenosis with mean trans valvular pressure gradient of 44 mmHg, despite the low ejection fraction, accompanied with mild-moderate aortic regurgitation in the context of a severe degenerative tricuspid aortic valve disease, an ascending aorta aneurysm with 5.4 cm diameter, as well as severe pulmonary hypertension (85 mmHg). The patient demonstrated mild clinical improvement with intravenous diuretic therapy and given the very high surgical risk (estimated logistic Euroscore II = 41%) for aortic valve replacement, retrograde aortic balloon valvuloplasty as a bridge to transcatheter aortic valve replacement (TAVR) was decided.

关键词：大动脉柱子分流阀门呼吸困难 TnT 水肿双边

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Guild composition and habitat use of voles in 2 forest landscapes in south-eastern Norway

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Integrative Zoology 2011年第4期6卷 299-310页

作者： Lucrezia GORINI John D.C.LINNELL Luigi BOITANI Ulrike hauptmann Morten ODDEN Per WEGGE Erlend B.NILSEN Department of Animal and Human Biology Sapienza University of RomeRomeItaly Faculty of Applied Ecology and Agricultural Sciences Hedmark University CollegeCampus EvenstadKoppangNorway Norwegian Institute for Nature Research TrondheimNorway Department of Ecology and Natural Resource Management Norwegian University of Life SciencesÅsNorway

It is widely believed that intensive forestry has influenced small mammal population dynamics,and thereby the entire mammalian community in Fennoscandian boreal forests.The nature of these impacts on the different species is subject to debate.We live-trapped voles between 2006 and 2009 in 2 commercially harvested forests in south-eastern Norway.We investigated the variation in vole abundance among habitat types(e.***.mature forest and clear-cut)and the hypothesis that graminivorous species such as field voles(Microtus agrestis L.)benefit from clear-cuts at the expense of forest dwellers(i.***.the bank vole,Myodes glareolus Schreb.),using fine-scale descriptors of the ground vegetation.We could not find support for the hypothesis that field voles show a preference for clear-cuts,and their overall abundance was low,while bank voles were the dominant species in all habitat types,including clear-cuts in the peak and pre-peak years.We found a positive association between bank vole abundance and bilberry(Vaccinium myrtillus L.)availability rather than a specific habitat type.Low field vole density in clear-cuts might be due to variation in local productivity and ground vegetation as well as to large variation in the species temporal dynamics.The latter is particularly associated with the widespread decline of field voles in Scandinavia.Logging has the potential to negatively affect bank vole population dynamics because of the negative effect on bilberry development.

关键词： bank vole bilberry clear-cut field vole forestry

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The role of echocardiography and CT angiography in transcatheter aortic valve implantation patients

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Journal of Geriatric Cardiology 2018年第1期15卷 86-94页

作者： Emmanouil Chourdakis Ioanna Koniari Nicholas G Kourlis Dimitrios Velissaris Nikolaos Koutsogiannis Grigorios Tsigkas Karl Eugen hauptmann Bruno Sontag George Hahalis Krankenhaus der Barmherzigen Briider Trier Germany Department of Cardiology University Hospital of Patras Rion Patras Greece Department of Internal Medicine University Hospital of Patras Rion Patras Greece

transcatheter 大动脉的阀门培植(TAVI ) 在于在有严重大动脉的狭窄的病人的其他的治疗。Multimodality 成像使用 transthoracic echocardiography (TTE ) 或 transesophageal echocardiography (脚趾) 和 multislice CT (MSCT ) 为外科手术前的管理组成奠基石技术，仙子程序的指导，列在后面在上面并且可能的 transcatheter 阀门的识别联系了复杂并发症。CT angiography 关于大动脉的体环直径和环绕的区域的全部的定义是更精确的。二维(2D ) echocardiography，与 3D 成像技术(MSCT， MRI 和 3D 脚趾) 相比低估大动脉的阀门体环直径。三维的脚趾成像提供类似于 MSCT 交付的那些的大动脉的阀门体环的大小。pre 程序的 MSCT 组成最小化 paravalvular 的存在的标准答案形式大动脉的流回，最经常的复杂并发症之一。TOE/TTE 和 MSCT 性能能预言心律调整器培植 procedural 以后的可能性。一位新短暂或坚持的先生的存在能被脚趾估计很好。TTE 和脚趾，开始在于为柱子 TAVI 评估的基本考试。在 transcatheter 心阀门失败的情况下， MSCT 能被用作另外的成像技术。

关键词：大动脉阀门 CT 培植成像技术外科手术标准答案子程序

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Early prosthetic valve endocarditis after transcatheter aortic valve implantation with periannular complication

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Journal of Geriatric Cardiology 2017年第11期14卷 711-711页

作者： Enlmanouil Chourdakis Ioanna Koniari George Hahalis Nicholas G Kounis Karl Eugen hauptmann Krankenhaus der Barmherigen Briider Trier Germally Royal Brompton Hospital London UK Patras University Hospital Patras Greece

In the next three weeks, a repeat TOE showed a further extension of endocarditis-lesions with mitral valve involvement, formation of a new abscess cavity and a rupture with fistula between aortic annulus and left atri... 详细信息

关键词：心内膜炎大动脉修复术阀门培植并发症死亡率 PVE

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可变脉冲重复频率的脉冲多普勒雷达

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现代雷达 1990年第5期12卷 33-37页

作者： Harald Siegel Rudolf hauptmann 胡德民 Siemens Aktiengesellschaft

为了防止超视距接收条件下动目标显示性能变坏,可变脉冲重复频率的脉冲多普勒雷达系统备有一个相干积累器,反射脉冲加到这个相干积累器上。该相干积累器利用若干滤波器使这些反射脉冲实现简单的矢量相加。这种改进的相干积累方法的先决... 详细信息

为了防止超视距接收条件下动目标显示性能变坏,可变脉冲重复频率的脉冲多普勒雷达系统备有一个相干积累器,反射脉冲加到这个相干积累器上。该相干积累器利用若干滤波器使这些反射脉冲实现简单的矢量相加。这种改进的相干积累方法的先决条件是脉冲重复周期参差以使其在相继脉冲重复周期内的和值恒定,并得到信号幅度的一个相位基准,以使相位差在每隔一个脉冲重复周期后等于零。

关键词：脉冲多普勒雷达重复频率

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综合制造的秘密

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现代制造 2017年第32期 32-34页

作者： Nicola hauptmann

一家生产医疗器械的制造厂商常常面临着为用户研发和制造用户专用产品的挑战，通过把连续的CAD／CAM工作与NC模拟工作相结合，该企业现在可以节省很多研发和生产时间。

关键词：制造厂商 CAD/CAM 生产时间医疗器械用户研发 NC

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