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Phagocytosed Polyhedrin-Cytokine Cocrystal Nanoparticles Provide Sustained Secretion of Bioactive Cytokines from Macrophages

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BioDesign Research 2021年第1期2021卷 47-58页

作者： Astrid Wendler Nicholas James michael h.jones Christian Pernstich Cell Guidance Systems Ltd. Maia BuildingBabraham Research CampusCambridge CB223ATUK

Many cells possess the ability to engulf and incorporate particles by *** active process is characteristic of microorganisms as well as higher order *** mammals,monocytes,macrophages,and microglia are among the so-called professional *** addition,cells such as fibroblast and chondrocytes are classified as nonprofessional *** phagocytes play important roles in both the innate and adaptive immune responses,wound healing,and tissue ***,these cells are increasingly studied as targets and vectors of therapeutic intervention to treat a range of *** phagocytes are notoriously difficult to transfect limiting their study and ***,efforts have shifted towards the development of nanoparticles to deliver a cargo to phagocytic cells via ***,this approach carries significant technical challenges,particularly for protein *** have focused on the development of nanoscale cocrystalline protein depots,known as PODS®,that contain protein cargos,including ***,we show that PODS are readily phagocytosed by nonprofessional as well as professional phagocytic cells and have attributes,such as highly sustained release of cargo,that suggest potential utility for the study and exploitation of phagocytic cells for drug *** and macrophages that ingest PODS retain normal characteristics including a robust chemotactic ***,the PODS-cytokine cargo is secreted by the loaded cell at a level sufficient to modulate the behavior of surrounding nonphagocytic *** results presented here demonstrate the potential of PODS nanoparticles as a novel molecular tool for the study and manipulation of phagocytic cells and for the development of Trojan horse immunotherapy strategies to treat cancer and other diseases.

关键词： sustained healing professional

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使用离子选择性电极的氧化铜矿石试验室硫化过程的最佳化与控制

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国外金属矿选矿 1979年第9期 31-39页

作者： michael h.jones James T.Woodcock 王淑秋

因为硫化物离子选择性电极（ISE）对S2-浓度变化的反应敏捷,在不同ph值条件下能指示低的S2-浓度,几乎不受干扰,并且在矿浆中使用是足够结实的,所以在硫化过程中硫化物离子选择性电极用于控制硫化钠的添加是适宜的。应用ISE电极测量和控... 详细信息

因为硫化物离子选择性电极（ISE）对S2-浓度变化的反应敏捷,在不同ph值条件下能指示低的S2-浓度,几乎不受干扰,并且在矿浆中使用是足够结实的,所以在硫化过程中硫化物离子选择性电极用于控制硫化钠的添加是适宜的。应用ISE电极测量和控制S2-浓度研究了三种硫化工艺。根据精矿品位和铜回收率评价其选别效果。用分批添加硫化钠的方法不能精确表明硫化条件,而且重复性差。尽管多次添加硫化钠能达到满意的指标,但硫化钠的消耗量太高。控制电位的硫化方法容易得到好的浮选结果。对于硫化过程中ISE的最佳电位约为-500毫伏[对于饱和甘汞电极（SCE）],但也与硫化及浮选时间有关。对于三至五段的硫化时间分别为3分钟和5分钟。本方法用于以前未试验过的矿样上,在第一次试验中,尽管该矿石的硫化钠需要量变化了三倍、也得到了良好的选别指标。当ISE电位为-450毫伏（对于SCE）进行试验时,最好是硫化和浮选同时进行。黄铜矿—氧化铜混合矿样的试验结果是令人满意的。除了选择最佳的硫化条件外,也必需选择最佳的黄药用量（例如通过测定残余黄药量）。

关键词：硫化钠精矿品位毫伏 SCE 硫化物氧化铜矿石铜回收率离子选择性电极硫化过程

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Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

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Nano Research 2024年第10期17卷 9031-9043页

作者： Narsimha Mamidi michael Poellmann Kaila Javius-jones KiChang Nam Seungpyo hong Wisconsin Center for NanoBioSystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

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The Influence of Variable (Monsoon) Rainfall on Sedimentation in the Roaches Grit and Other Upper Carboniferous Delta Sequences in the UK Pennine Basin

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International Journal of Geosciences 2024年第8期15卷 632-666页

作者： Colin michael jones Retired Cambridge UK

The Roaches Grit in the UK Pennine Basin was a complex deep water deltaic sequence deposited during the Late Carboniferous glacial period. The channels of the upper part of the Roaches Grit, deposited towards the end of the cyclothem after the eustatic minimum, contain evidence for very high seasonal discharges related to strong monsoon rainfall in the catchment areas. In some channels, intense turbulence near the delta front, led to knick point recession and deep incision. These channels were filled with sediments during reduced discharge, including very large sets of cross-bedding up to 16 m thick. Channels were short-lived with frequent avulsions. Over time slightly lower discharges formed laterally migrating channels dominated by bar forms. Different discharge-controlled processes operated on the reactivated delta slope. Incised channels generated turbidity currents during floods which transported sediments directly into the basin far from the delta. Migrating channels built mouth bars;resedimentation during floods formed density currents which then deposited sediment on the lower parts of the slope.

关键词： Carboniferous Delta Climate Monsoon Rainfall ITCZ Precession

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Sanya Beyond the Sea

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China Weekly 2024年第7期 60-61页

作者： michael jones 不详

Sanya,the tropical paradise on the southern tip of the island province of hainan,has long been a destination for those in China seeking rest,relaxation and *** miles of quiet beaches,golden sands,and magnificent palm ... 详细信息

关键词： seeking island relaxation

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Lost horizons

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China Weekly 2024年第4期 60-61页

作者： michael jones 不详

A trip off the beaten track in Xizang Autonomous Region will reward with stunning sights and isolated monasteries in the Tibetan grasslands and mountains.

关键词： mountains Tibetan sights

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Gants of the Past

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China Weekly 2024年第1期 60-61页

作者： michael jones 不详

The ancient statues of southwestern China are an authentic reminder of the pinnacle of Buddhist rock carving.

关键词： authentic southwestern ancient

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Laid-back Lamma

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China Weekly 2024年第9期 60-61页

作者： michael jones 不详

Away from the frenetic pace of hong Kong,no-car Lamma lsland is an oasis of calm with great food options,treks,beaches and a walk on the wild side hong Kong is a dynamic and creative city,centered around a vibrant and bustling *** times,the city can provide a unique rush of *** can be empowering,exciting and ***,the dense city center also has the ability to drain you of all your energy,especially on an oppressively hot summer's day.

关键词： energy. island beach

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Sun Yat-sen Sites:Revolutionary Roads

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China Weekly 2024年第8期 60-61页

作者： michael jones 不详

Dr Sun Yat-sen(1866-1925)is a monumental figure in Chinese *** is held in high esteem by Chinese people across the Chinese mainland and many other regions and countries,as well as among Chinese *** is regarded as a revolutionary,a visionary and a *** might explain why so many cities in China promote tourist attractions connected to Sun's life and *** story of Sun's life is not only historically important,it is also fascinating,especially for those who are interested in the Chinese revolution of 1911 and the foundation of the Republic of China.

关键词： evolutionary mainland attraction

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Arches to the Past

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China Weekly 2024年第2期 60-61页

作者： michael jones 不详

Visiting Zhujiajiao ancient water town,reachable by metro,provides a perfect place to get a taste for Qing-era history,as well as temples,museums and the post office。I't is strange how the most alien of places can sometimes feel the most like *** is exactly how I felt when I first visited Zhujiajiao,and it is what has kept me revisiting year after year ever *** is a classic Chinese water town located in the Qingpu District of *** was founded over 1,700 years ago and developed as a trading center for businesses specializing in rice and ***,the small town has a population of less than 100,000 people,who are often dwarfed by the number of visiting tourists,especially on public holidays.

关键词： trading visiting founded

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