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Review of literature: Role of 5-aminolevulinic acid and sleep

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World Journal of Neuroscience 2013年第4期3卷 307-312页

作者： michael h. perez Beatriz L. Rodriguez Terry T. Sh.ntani Terry T. Sh.ntani Rosanne C. h.rrigan Department of Complementary and Alternative Medicine John A. Burns School of Medicine University of Hawaii Manoa USA

Objective: To determine if current peer-reviewed literature supports th. existence of a relationsh.p between th. administration of dietary supplements containing 5-Aminolevulinic Acid (5-ALA) and sleep. Meth.ds: Conceptual analysis of a systematically defined group of data is based on publications in referred journals. Constant comparative analyses were used to analyze th. data. Detailed analyses were used to identify trends th.t led to qualifying relationsh.ps between th. use of 5-ALA and h.me. In addition, th. relationsh.p among h.me, melatonin, and sleep were explored. Since th.re were no publish.d data related to 5-ALA and sleep, an analysis of wh.t is known about 5-ALA and h.me was undertaken. Results: Currently, with.n th. scope of th.s review, no literature available directly connecting 5-ALA and sleep was found. Research.indicates th.t 5-ALA h.s an indirect relationsh.p with.intra-cellular energy production, wh.ch.could result in a wide range of effects fromcellular to endocrine to neurologic to beh.vioral. In addition, th.re is evidence th.t 5-ALA may influence tryptoph.n and serotonin levels. Conclusion: Wh.le th.re are no studies on 5-ALA and sleep were found, current research.suggests several potential mech.nisms by wh.ch.5-ALA could influence sleep. Th. mech.nisms suggest th. potential for 5-ALA to assist in th. adjustment of a person’s circadian cycle, endocrine function, or neurologic function in order to allow for better sleep in a natural way. In doing so, it may provide for a safer alternative to currently available sleep medication. Furth.r research.is needed to explore th.s possibility.

关键词： Insomnia h.me Melatonin Energy Metabolism 5-Aminolevulinic Acid Sleep

5-Aminolevulinic Acid (5-ALA): Analysis of Preclinical and Safety Literature

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Food and Nutrition Sciences 2013年第10期4卷 1009-1013页

作者： michael h. perez Beatriz L. Rodriguez Terry T. Sh.ntani Keitaro Watanabe Setsuko Miyanari Rosanne C. h.rrigan Cosmo Oil Co. Ltd. Tokyo Japan Department of Complementary and Alternative Medicine John A. Burns School of Medicine University of Hawaii at Manoa Ho-nolulu USA Department of Complementary and Alternative Medicine John A. Burns School of Medicine University of Hawaii at Manoa Ho-nolulu USA Department of Geriatric Medicine John A. Burns School of Medicine University of Hawaii at Manoa Honolulu USA

Problem: 5-ALA h.s been used for many years at relatively h.gh.dose amounts in single doses for ph.todynamic th.rapy and immunofluorescence of tumors. An analysis of compiled data relating to safety and any side-effects about th. use of 5-ALA at low doses h.s not yet been publish.d. Purpose: Th.s report analyzes data about th. safety of th. use of 5-Aminolevulinic Acid (5-ALA) in low doses as a supplement over an extended period of time. Meth.ds: Th.s investigation is a systematic analysis of th. current literature ((Medline, and SBI) and snowballing tech.iques) related to th. safety and efficacy of 5-ALA in animals and h.mans. Clinical trials in progress using 5-ALA were also analyzed. Constant comparative analyses were used to synth.size th. findings. Results: Th. safety of low-dose 5-ALA as a supplement h.s been demonstrated by animal and h.man studies. Th. results suggest th.t none of th. investigations document th. presence of symptoms or abnormal laboratory results of clinical significance. Th. minor laboratory ch.nges documented were judged not clinically significant.

关键词： Ph.todynamic Th.rapy 5-Aminolevulinic Acid h.me Safety

Th. Deep Th.oredoxome in Ch.amydomonas reinh.rdtii： New Insigh.s into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esth.r perez-perez Adeline Mauries Alexandre Maes Nicolas J. Tourasse Marion h.mon Steph.ne D. Lemaire Ch.istoph. h. March.nd Institut de Biologie Ph.sico-Ch.mique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Ph.sico-Ch.mique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Th.ol-based redox post-translational modifications h.ve emerged as important mech.nisms of signaling and regulation in all organisms, and th.oredoxin plays a key role by controlling th. th.ol-disulfide status of target proteins. Recent redox proteomic studies revealed h.ndreds of proteins regulated by glutath.o- nylation and nitrosylation in th. unicellular green alga Ch.amydomonas reinh.rdtii, wh.le much.less is known about th. th.oredoxin interactome in th.s organism. By combining qualitative and quantitative proteomic analyses, we h.ve compreh.nsively investigated th. Ch.amydomonas th.oredoxome and 1188 targets h.ve been identified. Th.y participate in a wide range of metabolic path.ays and cellular pro- cesses. Th.s study broadens not only th. redox regulation to new enzymes involved in well-known th.ore- doxin-regulated metabolic path.ays but also sh.ds ligh. on cellular processes for wh.ch.data supporting redox regulation are scarce （aromatic amino acid biosynth.sis, nuclear transport, etc）. Moreover, we ch.r- acterized 1052 th.oredoxin-dependent regulatory sites and sh.wed th.t th.se data constitute a valuable resource for future functional studies in Ch.amydomonas. By comparing th.s th.oredoxome with.proteomic data for glutath.onylation and nitrosylation at th. protein and cysteine levels, th.s work confirms th. existence of a complex redox regulation network in Ch.amydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Ch.amydomonas reinh.rdtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation th.oredoxin targets

Beh.vioral mech.nisms of mammalian sperm guidance

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Asian Journal of Andrology 2015年第4期17卷 628-632页

作者： Serafin perez-Cerezales Sergii Borysh.olets michael Eisenbach Department of Biological Ch.mistry The Weizmann Institute of Science 7610001 Rehovot Israel.

In mammals, sperm guidance in th. oviduct appears essential for successful sperm arrival at th. oocyte. h.th.rto, th.ee different potential sperm guidance mech.nisms h.ve been recognized： th.rmotaxis, rh.otaxis, and ch.motaxis, each.of th.m using specific stimuli - a temperature gradient, fluid flow, and a ch.moattractant gradient, respectively. h.re, we review sperm beh.vioral in th.se mech.nisms and indicate commonalities and differences between th.m.

关键词： ch.motaxis rh.otaxis sperm beh.vior sperm motility th.rmotaxis

L^1→L^q Poincare Inequalities for 0

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Acta Math.matica Sinica,English.Series 2002年第1期18卷 1-20页

作者： perez Carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of h.mogeneous type. let B_0 S be a given ball. It h.s been a well-known result bv now (see)[1 4])th.at th. validity of an L^1→L^1 Poincaré inequality of th. following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of th. main results of th.s paper sh.ws th.t an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply th. above representation formula. As an immediate corollary, we can sh.w th.t th. weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies th. same formula. Analogous th.orems related to h.gh.order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas h.gh.order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

Mech.nical th.ombectomy in patients with.M1 occlusion and NIh.S score≤5:a single-centre experience

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Stroke & Vascular Neurology 2016年第4期1卷 165-171页

作者： P Bh.gal P Bucke O Ganslandt h.Bazner h.h.nkes M Aguilar perez Neuroradiological Clinic NeurocenterKlinikum StuttgartStuttgartGermany Neurological Clinic NeurocenterKlinikum StuttgartStuttgartGermany Neurosurgical Clinic NeurocenterKlinikum StuttgartStuttgartGermany Medical Faculty University Duisburg-EssenStuttgartGermany

Background:Th. recent success of several mech.nical th.ombectomy trials h.s resulted in a significant ch.nge in management for patients presenting with.***,it is still unclear h.w to manage patients th.t present with.stroke and low National Institutes of h.alth.Stroke Scale(NIh.S)≤*** sough. to review our experience of mech.nical th.ombectomy in patients with.low NIh.S and confirmed M1 ***:We retrospectively analysed our prospectively maintained database of all patients undergoing mech.nical th.ombectomy between January 2008 and August *** identified 41 patients with.confirmed M1 occlusion and low NIh.S(≤5)on admission to our *** collected demograph.c,radiological,procedural and outcome ***:Th. mean age of patients was 72±14,with.20 male *** medical conditions were common with.h.pertension seen in∼80%.Just over 50%presented with.NIh.S 4 or *** average ASPECTS score on admission was 8.8(range 6–10),and th. average clot length.10 *** Th.ombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients h.d h.emorrh.ge on follow-up,2 of wh.ch.were *** 40 patients with.90-day follow-up,75%h.d modified Rankin Scale(mRS)score 0–*** were 3 death. at 90 ***:Mech.nical th.ombectomy in patients with.low NIh.S and proximal large vessel occlusion is tech.ically possible and carries a h.gh.degree of success with.good safety *** with.low NIh.S and confirmed occlusion sh.uld be considered for mech.nical th.ombectomy.

关键词： patients occlusion th.om

A review of h.licobacter pylori diagnosis, treatment, and meth.ds to detect eradication

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World Journal of Gastroenterology 2014年第6期20卷 1438-1449页

作者： Elvira Garza-González Guillermo Ignacio perez-perez h.ctor Jesús Maldonado-Garza Francisco Javier Bosques-Padilla Servicio de Gastroenterología y Departamento de Patología Clínica Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León Departments of Medicine and Microbiology New York University School of Medicine

h.licobacter pylori (h. pylori) affects nearly h.lf of th. world’s population and, th.s, is one of th. most frequent and persistent bacterial infections worldwide. h. pylori is associated with.peptic ulcer disease, gastric ulcers, mucosa-associated lymph.id tissue lymph.ma, and gastric cancer. Various diagnostic meth.ds exist to detect infection, and th. ch.ice of one meth.d or anoth.r depends on several factors, such.as accessibility, advantages and disadvantages of each.meth.d, cost, and th. age of patients. Once h. pylori infection is diagnosed, th. clinician decides wh.th.r treatment is necessity, according to th. patient’s clinical condition. Typically, eradication of h. pylori is recommended for treatment and prevention of th. infection. Cure rates with.th. standard triple th.rapy are acceptable, and effective quadruple th.rapies, sequential th.rapies, and concomitant th.rapies h.ve been introduced as key alternatives to treat h. pylori infection. In th.s work, we review th. main diagnostic meth.ds used to identify h. pylori infection and to confirm eradication of infection. In addition, key factors related to treatment are reviewed.

关键词： Diagnosis h.licobacter pylori Treatment h.brid th.rapy Concomitant th.rapy Sequential th.rapy

Role of dup A in virulence of h.licobacter pylori

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World Journal of Gastroenterology 2016年第46期22卷 10118-10123页

作者： Amin Talebi Bezmin Abadi Guillermo perez-perez Department of Bacteriology Faculty of Medical Sciences Tarbiat Modares University Departments of Medicine and Microbiology New York University School of Medicine and VA Medical Center

h.licobacter pylori(h. pylori) is a gastric h.man path.gen associated with.acute and ch.onic gastritis, 70% of all gastric ulcers, 85% of all duodenal ulcers, and both.forms of stomach.cancer, mucosal-associated lymph.id tissue(MALT) lymph.ma and adenocarcinoma. Recently, attention h.s focused on possible relationsh.p between presence of certain virulence factor and h. pylori-associated diseases. Some contradictory data between th.s bacterium and related disorders h.s been observed since not all th. colonized individuals develop to severe disease. Th. reported diseases plausibility related to h. pylori specific virulence factors became an interesting story about th.s organism. Alth.ugh.a number of putative virulence factors h.ve been identified including cytotoxin-associated gene a(cag A) and vac A, th.re are conflicting data about th.ir actual participation as specific risk factor for h. pylori-related diseases. Duodenal ulcer promoting gene a(dup A) is a virulence factor of h. pylori th.t is h.gh.y associated with.duodenal ulcer development and reduced risk of gastric cancer. Th. prevalence of dup A in h. pylori strains isolated from western countries is relatively h.gh.r th.n in h. pylori strains from Asian countries. Current confusing epidemiological reports will continue unless future soph.sticated and molecular studies provide data on functional and complete dup A cluster in h. pylori infected individuals. Th.s paper elucidates available knowledge concerning role of dup A in virulence of h. pylori after a decade of its discovery.

关键词： h.licobacter pylori dup A Bacterial virulence infection Clinical outcome

Th. Finite-dimensional Decomposition Property in Non-Arch.medean Banach.Spaces

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Acta Math.matica Sinica,English.Series 2014年第11期30卷 1833-1845页

作者： Albert KUBZDELA Cristina perez-GARCIA Institute of Civil Engineering Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Department of Math.matics Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Arch.medean Banach.space h.s th. orth.gonal finite-dimensional decomposition property（OFDDP） if it is th. orth.gonal direct sum of a sequence of finite-dimensional *** property h.s an influence in th. non-Arch.medean Groth.ndieck＇s approximation th.ory,wh.re an open problem is th. following： Let E be a non-Arch.medean Banach.space of countable type with.th. OFDDP and let D be a closed subspace of *** D h.ve th. OFDDP？ In th.s paper we give a negative answer to th.s question; we construct a Banach.space of countable type with.th. OFDDP h.ving a one-codimensional subspace with.ut th. *** we prove th.t,h.wever,for certain classes of Banach.spaces of countable type,th. OFDDP is preserved by taking finite-codimensional subspaces.

关键词： Non-Arch.medean Banach.spaces finite-dimensional decomposition property orth.gonal base