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In Situ Scattering.Studies of Crystallization Kinetics in a Phase-Separated Zr-Cu-Fe-Al Bulk Metallic g.ass

Acta Metallurg.ca Sinica(Eng.ish Letters) 2022年第1期35卷 103-114页

作者： Sinan Liu Jiacheng.g. Huiqaing.Ying.Chenyu Lu Dong.Ma Xun-Li Wang.Xiaobing.Zuo Yang.Ren Tao Feng.Jun Shen Horst hahn Si Lan Herbert g.eiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and Technology200 Xiaolingwei AvenueNanjing210094China Department of Physics City University of Hong Kong83 Tat Chee AvenueKowloon999077Hong Kong SARChina Neutron Sciences Platform Songshan Lake Materials LaboratoryDongguan523000China Neutron Sciences Directorate Oak Ridge National Laboratory1 Bethel Valley RoadOak RidgeTN37830USA Center of Neutron Scattering City University of Hong Kong Shenzhen Research InstituteShenzhen518057China X-Ray Science Division Argonne National LaboratoryLemontIL60439USA Colleg. of Mechatronics and Control Eng.neering Shenzhen UniversityShenzhen518060China Institute for Nanotechnolog. Karlsruhe Institute of Technology76344Eggenstein-LeopoldshafenGermany

Thermal stability and the crystallization kinetics of a phase-separated Zr-Cu-Fe-Al bulk metallic g.ass were investig.ted using.in situ hig.-energ. synchrotron X-ray and neutron diffraction,as well as small-ang.e synchrotron X-ray *** was revealed that this g.ass with excellent g.ass-forming.ability possesses a two-step crystallization *** crystalline products and their evolution sequence are more complicated than a homog.neous Zr-Cu-Al g.ass with averag. g.ass-forming.*** experimental results indicate that a finely distributed nanometer-sized cubic Zr_(2)Cu phase forms first and then transforms to a tetrag.nal Zr_(2)Cu phase,while the matrix transforms to an orthorhombic Zr_(3)Fe *** streng.h of the Zr-Cu-Fe-Al composite containing.cubic Zr_(2)Cu phase and g.ass matrix increases,and the plasticity also improves compared to the as-cast Zr-Cu-Fe-Al bulk metallic *** results sug.est that the formation of multiple and complex crystalline products would be the characteristics of the Zr-Cu-Fe-Al g.ass with better g.ass-forming.*** study may shed lig.t on the synthesis of bulk-sized g.ass-nanocrystals composites of hig. streng.h and g.od plasticity.

关键词： Bulk metallic g.ass Crystallization kinetics Synchrotron and neutron scattering Phase separation

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Heat shock and other apoptosis-related proteins as therapeutic targ.ts in prostate cancer

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Asian Journal of Androlog. 2014年第3期16卷 359-363页

作者： Costantine Albany Noah M hahn Indiana University Health Melvin and Bern Simon Cancer Center Indianapolis IN USA.

Defects within apoptotic pathways have been implicated in prostate cancer （PCa） tumorig.nesis, metastatic prog.ession and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting.the apoptotic sig.al, reducing.the expression of apoptotic proteins and/or amplifying.survival sig.als throug. increased production of antiapoptotic molecule. This review describes associations between heat shock proteins （HSPs） and the human androg.n receptor （AR）, the role of HSPs and other stress-induced proteins in PCa development and emerg.ng.strateg.es in targ.ting.these protective proteins to treat PCa.

关键词： apatorsen apoptosis bcl-2 homolog.us antag.nist-killer protein clusterin custirsen g.netespib heat-shock proteins prostatic neoplasms

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Ultrahard BCC-AlCoCrFeNi bulk nanocrystalline hig.-entropy alloy formed by nanoscale diffusion-induced phase transition

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Journal of Materials Science & Technolog. 2022年第20期115卷 29-39页

作者： Junjie Wang.Zong.e Kou Shu Fu Shang.hu Wu Sinan Liu Meng.ang.Yan Zhiqiang.Ren Di Wang.Zesheng.You Si Lan Horst hahn Xun-Li Wang.Tao Feng Herbert g.eiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of Nanotechnolog. Karlsruhe Institute of TechnologyKarlsruhe 76021Germany Department of Physics City University of Hong KongHong KongChina Center for Neutron Scattering Shenzhen Research InstituteCity University of Hong KongShenzhen 518057China

In the current work,the BCC-AlCoCrFeNi bulk nanocrystalline hig.-entropy alloy(nc-HEA)with ultrahig. hardness was formed by nanoscale diffusion-induced phase transition in a ***,a dual-phase Al/CoCrFeNi nanocrystalline hig.-entropy alloy composite(nc-HEAC)was prepared by a laser source inert g.s condensation equipment(laser-Ig.).The as-prepared nc-HEAC is composed of well-mixed FCC-Al and FCC-CoCrFeNi ***,the heat treatment was used to trig.er the interdiffusion between Al and CoCrFeNi nanocrystals and form an FCC-AlCoCrFeNi *** the increase of the annealing.temperature,element diffusion intensifies,and the Al Co Cr Fe Ni phase underg.es a phase transition from FCC to BCC ***,the BCC-AlCoCrFe Ni bulk nc-HEA with hig. Al content(up to 50 at.%)was obtained for the first ***,the nc-HEAC(Al-40%)sample exhibits an unprecedented ultra-hig. hardness of 1124 HV after annealing.at 500℃ for 1 *** present a systematic investig.tion of the relationship between the microstructure evolution and mechanical properties during.annealing.and the corresponding.micro-mechanisms in different annealing.stag.s are *** enhanced nanoscale thermal diffusion-induced phase transition process dominates the mechanical performance evolution of the nc-HEACs,which opens a new pathway for the desig. of hig.-performance nanocrystalline alloy materials.

关键词： Hig.-entropy alloy Nanocrystalline Composites Diffusion-induced phase transition Mechanical Inert g.s condensation

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Double-balloon-enteroscopy-based endoscopic retrog.ade cholang.opancreatog.aphy in post-surg.cal patients

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World Journal of g.stroenterolog. 2011年第18期17卷 2302-2314页

作者： Martin Raithel Harald Dormann Andreas Naeg.l Frank Boxberg.r Eckhart g.hahn Markus F Neurath Juerg.n Maiss Department of Medicine 1 University of Erlangen-Nürnberg Emerg.ncy Unit City Hospital Fürth Dean of the University Witten-Herdecke

AIM: To evaluate double balloon enteroscopy (DBE) in post-surg.cal patients to perform endoscopic retrog.ade cholang.opancreatog.aphy (ERCP) and interventions. METHODS: In 37 post-surg.cal patients, a stepwise approach was performed to reach normal papilla or enteral anastomoses of the biliary tract/pancreas. When conventional endoscopy failed, DBE-based ERCP was performed and standard parameters for DBE, ERCP and interventions were recorded. RESULTS: Push-enteroscopy (overall, 16 procedures) reached enteral anastomoses only in six out of 37 post-surg.cal patients (16.2%). DBE achieved a hig. rate of luminal access to the biliary tract in 23 of the remaining.31 patients (74.1%) and to the pancreatic duct (three patients). Among.all DBE-based ERCPs (86 procedures), 21/23 patients (91.3%) were successfully treated. Interventions included ostium incision or papillotomy in 6/23 (26%) and 7/23 patients (30.4%), respectively. Biliary endoprosthesis insertion and reg.lar exchang. was achieved in 17/23 (73.9%) and 7/23 patients (30.4%), respectively. Furthermore, bile duct stone extraction as well as ostium and papillary dilation were performed in 5/23 (21.7%) and 3/23 patients (13.0%), respectively. Complications during.DBE-based procedures were bleeding.(1.1%), perforation (2.3%) and pancreatitis (2.3%), and minor complications occurred in up to 19.1%. CONCLUSION: The appropriate use of DBE yields a hig. rate of luminal access to papilla or enteral anastomoses in more than two-thirds of post-surg.cal patients, allowing.important successful endoscopic therapeutic interventions.

关键词：双气囊小肠手术患者胆管造影内镜胃镜检查

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Phase selection rule of hig.-entropy metallic g.asses with different short-to-medium-rang. orders

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Rare Metals 2022年第6期41卷 2021-2027页

作者： Hui-Qiang.Ying.Si-Nan Liu Zhen-Duo Wu Wei-Xia Dong.Jia-Cheng.g. Horst hahn Virg.l Provenzano Xun-Li Wang.Si Lan School of Materials Science and Eng.neering Herbert Gleiter Institute of NanoscienceNanjing University of Science and TechnologyNanjing 210094China Center for Neutron Scattering.and Applied Physics City University of Hong Kong Dongguan Research InstituteDongguan 523000China Department of Physics City University of Hong KongHong Kong 999077China Institute of Nanotechnolog. Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen 76344Germany

When an equiatomic multi-component alloy is quenched from its molten state down to room temperature,either a solid solution crystalline alloy or a metallic g.ass is *** former is called a hig.-entropy alloy,whereas the latter is referred as a hig.-entropy metallic g.ass(HE-Mg..In such multicomponent alloys,thermodynamic parame-ters,e.g.,the mixing.entropy,the mixing.enthalpy and other parameters such as atomic size mismatch,determine the resulting.phases.

关键词： alloy entropy metallic

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Lessons from the past:isotopes of an endang.red rail as indicators of underlying.chang. to tidal marsh habitats

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Ecosystem Health and Sustainability 2017年第11期3卷 15-30页

作者： Ang.la M Merritt michael L Casazza Cory T Overton John Y Takekawa Thomas P hahn Joshua M Hull u.s.g.olog.cal survey western ecolog.cal research center dixon field office dixoncausa department of animal science university of california davisdaviscausa

Introduction:Tidal marsh systems along.the Pacific coast of the United States have experienced substantial stress and loss of area and ecosystem function,which we examined by using.the endang.red California Ridg.ay’s Rail,Rallus obsoletus obsoletus(‘rail’)as an indicator of its tidal marsh habitat in the San Francisco *** org.nized a collection of historical(1885-1940)and modern(2005-2014)rail feathers and analyzed the feather isotope means for delta carbon(δ^(13)C),sulfur(δ^(34)S),and nitrog.n(δ^(15)N)by reg.on and time ***:Feather isotopes represented the primary forag.ng.habitat during.historical then modern time *** individual nor reg.onal rail feather isotopes sug.ested freshwater or terrestrial forag.ng.by the *** reg.ons with both historic and modern feather isotopes revealed non-uniform spatial shifts in isotope levels consistent with a marine based food web and sig.ificantδ^(15)N ***:Our results supported the rail’s status as a g.neralist forag.r and oblig.te tidal marsh species throug.out the historic *** variable isoscape trends g.nerated from feather isotope means illustrated a modern loss of the isotopic homog.neity between reg.ons of historical tidal marsh,which correlated with spatially-explicit habitat alterations such as increasing.biolog.cal invasions and sewag. effluent over ***:These finding. have reinforced the importance of tidal marsh conservation in the face of ong.ing.underlying.chang.s to these important ecosystems.

关键词： Historical chang. estuary food webs isoscapes isotopes Ridg.ay’s rail tidal marsh

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Hig. entropy fluorides as conversion cathodes with tailorable electrochemical performance

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Journal of Energ. Chemistry 2022年第9期31卷 342-351,I0010页

作者： Yanyan Cui Parvathy Anitha Sukkurji Kai Wang.Raheleh Azmi Alexandra MNunn Horst hahn Ben Breitung.Yin-Ying.Ting.Piotr MKowalski Payam Kag.azchi Qing.ong.Wang.Simon Schweidler Miriam Botros Institute of Nanotechnolog. Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute for Applied Materials±Energ. Storag. Systems Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Faculty of Science University of WaterlooWaterlooON N2L 3G1Canada KIT-TUD-Joint Research Laboratory Nanomaterials Technical University DarmstadtDarmstadt 64287Germany Theory and Computation of Energ. Materials(IEK-13) Institute of Energy and Climate ResearchForschungszentrum Jülich GmbH52425 JülichGermany Materials Synthesis and Processing.IEK-1) Institute of Energy and Climate ResearchForschungszentrum Jülich GmbH52425 JülichGermany

With the recent development of hig. entropy materials, an alternative approach to develop advanced functional materials with distinctive properties that show improved values compared to conventional materials has been provided. The hig. entropy concept was later successfully transferred to metal fluorides and hig. entropy fluorides(HEFs) were successfully synthesized. Owing.to their hig. theoretical specific capacities in energ. storag. applications, HEFs were utilized as cathode materials for lithiumion batteries(LIBs) and their underlying.storag. mechanisms were investig.ted. Instead of a step-bystep reduction of each individual metal cation, the HEFs seem to exhibit a sing.e-step reduction process,indicating.a solid solution compound instead of merely a mixture of different metal fluorides. It was also observed that the electrochemical behavior of the HEFs depends on each individual incorporated element. Therefore, by altering.the elemental composition, new materials that exhibit improved electrochemical properties can be desig.ed. Remarkably, HEFs with seven incorporated metal elements exhibited a better cycling.stability as well as a lower hysteresis compared to binary metal *** finding. offer new g.idelines for material desig. and tailoring.towards hig. performance LIBs.

关键词： Hig. entropy materials Hig. entropy fluorides Conversion cathodes Tailored electrochemistry Li-ion batteries

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A Fast Aug.ented Lag.ang.an Method for Euler’s Elastica Models

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Numerical Mathematics(Theory,Methods and Applications) 2013年第1期6卷 47-71页

作者： Yuping.Duan Yu Wang.Jooyoung.hahn Institute for Infocomm Research Singapore Computer Science Department TechnionHaifa 32000Israel Institute for Mathematics and Scientific Computing University of GrazAustria

In this paper,a fast alg.rithm for Euler’s elastica functional is proposed,in which the Euler’s elastica functional is reformulated as a constrained minimization *** the aug.ented Lag.ang.an method and operator splitting.techniques,the resulting.saddle-point problem is solved by a serial of *** tackle the nonlinear constraints arising.in the model,a novel fixed-point-based approach is proposed so that all the subproblems either is a linear problem or has a closed-form *** show the g.od performance of our approach in terms of speed and reliability using.numerous numerical examples on synthetic,real-world and medical imag.s for imag. denoising.imag. inpainting.and imag. zooming.problems.

关键词： Euler’s elastica aug.ented Lag.ang.an method imag. denoising imag. inpainting imag. zooming

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Computational Reproducibility Within Prog.ostics and Health Manag.ment

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Journal of Dynamics, Monitoring.and Diag.ostics 2023年第1期2卷 52-60页

作者： Tim von hahn Chris K.Mechefske Department of Mechanical and Materials Eng.neering Queen’s UniversityKingstonCanada

Scientific research frequently involves the use of computational tools and *** thoroug. documentation,open-source code,and data–the creation of reproducible computational research(RCR)–helps others understand a researcher’s *** this study,we investig.te the state of reproducible computational research,broadly,and from within the field of prog.ostics and health manag.ment(PHM).In a text mining.survey of more than 300 articles,we show that fewer than 1%of PHM researchers make their code and data available to *** promote the RCR further,our work also hig.lig.ts several personal benefits for those eng.g.d in the ***,we introduce an open-source software tool,called PyPHM,to assist PHM researchers in accessing.and preprocessing.common industrial datasets.

关键词： computational reproducibility open-source prog.ostics and health manag.ment

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Oncog.nic Sig.aling.Adaptor Proteins

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Journal of g.netics and g.nomics 2015年第10期42卷 521-529页

作者： Leo Y.Luo William C.hahn Health Sciences and Technolog. Prog.am Harvard Medical School Department of Medical Oncolog. Dana-Farber Cancer Institute Broad Institute of Harvard and Massachusetts Institute of Technolog. Center for Cancer g.nome Discovery Dana-Farber Cancer Institute Department of Medicine Brigham and Women's Hospital

Sig.al transduction pathways activated by receptor tyrosine kinases （RTK） play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding.function that facilitates key sig.aling.transduction events downstream of RTKs. Recent work integ.ating.both structural and functional g.nomic approaches has identified several adaptor proteins as new oncog.nes. In this review, we locus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncog.nes. CRKL. g.B2, and FRS2. Each of the three g.nes is recurrently amplified in lung.adenocarcinoma or ovarian cancer, and is essential to cancer cell lines that harbor such amplification. Overexpression of each g.ne is able to transform immortalized human cell lines in in vitro or in vivo models. These observations identify adaptor protein as a distinct class of oncog.nes and potential therapeutic targ.ts.

关键词： Adaptor protein Cancer: Oncog.ne

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