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Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review

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Acta Pharmaceutica Sinica B 2020年第1期10卷 113-122页

作者： Albert Braeuning michael Schwarz German Federal Institute for Risk Assessment Dept.Food SafetyBerlin 10589Germany Eberhard Karls University of Tu¨bingen Inst.of Pharmacology and ToxicologyDept.of ToxicologyTu¨bingen 72074Germany

Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell *** regulation of genes related to cell growth,survival,and death has been extensively studied,much less is known on the regulation of drug-metabolizing enzymes(DMEs)by oncogenic ***,a comprehensive review of the available literature is presented summarizing the impact of the most relevant genetic alterations in human and rodent liver tumors on the expression of DMEs with a focus on phasesⅠandⅡof xenobiotic *** few data are available with respect to DME regulation by p53-dependent signaling,telomerase expression or altered chromatin *** contrast,DME regulation by constitutive activation of oncogenic signaling via the RAS/RAF/mitogen-activated protein kinase(MAPK)cascade or via the canonical WNT/β-catenin signaling pathway has been analyzed in greater depth,demonstrating mostly positive-regulatory effects of WNT/β-catenin signaling and negativeregulatory effects of MAPK *** studies have revealed molecular interactions between oncogenic signaling and nuclear xeno-sensing receptors which underlie the observed alterations in DME expression in liver *** of altered DME expression and inducibility in liver tumors with a specific gene expression profile may impact pharmacological treatment options.

关键词： Xenobiotic metabolism Hepatocytes WNT/b-catenin signaling RAS/MAPK signaling Gene mutation Cytochrome P450

Book review of Land Use Transitions and Rural Restructuring in China by Hualou Long

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Journal of Geographical Sciences 2020年第8期30卷 1382-1384页

作者： WOODS michael Department of Geography and Earth Sciences Aberystwyth UniversityAberystwyth SY233DBUK

The restructuring of rural China is one of the most important elements of global social and economic change in the early twenty-first *** a traditionally rural country,with deep cultural roots in the‘soil’,China has been transformed into a highly advanced and largely urbanized society within the course of a few *** scale and significance of the transformation is equivalent to the industrialization and urbanization of Europe in the nineteenth and early twentieth centuries,and like the European experience a century earlier,its impacts reverberate around the ***,contemporary China is not Victorian-era Europe and whilst there are parallels,we cannot assume that the trajectories,consequences and responses are the same.

关键词： Rural Transition consequences

A method for automatic tuning of flight simulator motion platforms

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第4期8卷 43-63页

作者： michael Jones German Aerospace Center Braunschweig NiedersachsenGermany

When tuning motion platforms,subjective opinion is usually regarded as sufficient for most applications,as it should provide verification that no false cueing ***,often systems are not configured to fully utilize the available motion for the desired *** paper presents a new method to objectively tune simulation motion *** usage of the available platform motion space is shown through an example of its application to a specific mission *** difference in motion filter settings for two simulator platform geometries is *** displays the suitability of the platforms for completion of the two-axis lateral reposition task.

关键词： Simulation flight motion optimization

Representation theory of Dynkin quivers. Three contributions

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Frontiers of Mathematics in China 2016年第4期11卷 765-814页

作者： Claus michael RINGEL Fakultat fiir Mathematik Universitat Bielefeld P. O. Box 100 131 D-33501 Bielefeld Germany Department of Mathematics Shanghai Jiao Tong University Shanghai 200240 China

The representations of the Dynkin quivers and the corresponding Euclidean quivers are treated in many books. These notes provide three building blocks for dealing with representations of Dynkin （and Euclidean） quivers. They should be helpful as part of a direct approach to study representations of quivers, and they shed some new light on properties of Dynkin and Euclidean quivers.

关键词： Quiver Dynkin quiver Euclidean quiver the exceptional vertices of a Dynkin quiver representations of quivers thin representations filtrations of vector spaces conical representations of star quivers Auslander- Reiten quiver thick subcategories perpendicular subcategories one-point extension antichains of a poset antichains of an additive category simplifi- cation hammocks the 2-4-8 property the magic Freudenthal-Tits square

Using Gaussian Eigenfunctions to Solve Boundary Value Problems

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Advances in Applied Mathematics and Mechanics 2013年第4期5卷 569-594页

作者： michael McCourt Center for Applied Mathematics Cornell UniversityIthacaNY 14853USA

Kernel-basedmethods are popular in computer graphics,machine learning,and statistics,among other fields;because they do not require meshing of the domain under consideration,higher dimensions and complicated domains can be managed with reasonable ***,the high order of accuracy associated with these methods has been tempered by ill-conditioning,which ariseswhen highly smooth kernels are used to conduct the *** advances in representing Gaussians using eigenfunctions have proven successful at avoiding this destabilization in scattered data approximation *** paper will extend these techniques to the solution of boundary value problems using *** method of particular solutions will also be considered for elliptic problems,using Gaussian eigenfunctions to stably produce an approximate particular solution.

关键词： Meshless method method of particular solutions boundary value problem

Using three-dimensional discrete spherical Fourier descriptors based on surface curvature voxels for pollen particle recognition

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Chinese Physics B 2010年第11期19卷 236-242页

作者：谢永华 michael OhEigeartaigh Institute of Computer Science Nanjing University of Information Science and Technology School of Science Waterford Institute of TechnologyWaterfordIreland

This paper presents a new method for extract three-dimensional （3D） discrete spherical Fourier descriptors based on surface curvature voxels for pollen particle recognition. In order to reduce the high amount of pollen information and noise disturbance, the geometric normalized curvature voxels with the principal curvedness are first extracted to represent the intrinsic pollen volumetric data. Then the curvature voxels are decomposed into radial and angular components with spherical harmonic transform in spherical coordinates. Finally the 3D discrete Fourier transform is applied to the decomposed curvature voxels to obtain the 3D spherical Fourier descriptors for pollen recognition. Experimental results show that the presented descriptors are invariant to different pollen particle geometric transformations, such as pose change and spatial rotation, and can obtain high recognition accuracy and speed simultaneously.

关键词： curvature voxels spherical coordinates three-dimensional discrete Fourier descriptors pollen particles recognition

Diagnosing Battery Degradation via Gas Analysis

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Energy & Environmental Materials 2022年第3期5卷 688-692页

作者： michael Metzger Hubert A.Gasteiger Department of Physics and Atmospheric Science Dalhousie UniversityHalifax Nova Scotia B3H 4R2Canada Department of Chemistry Dalhousie UniversityHalifax Nova Scotia B3H 4R2Canada Chair of Technical Electrochemistry Department of Chemistry and Catalysis Research CenterTechnical University of MunichD-85748Garching Germany

Interfacial reactions in lithium-ion batteries often involve gaseous reaction *** investigation of material degradation processes requires a technique to identify and quantify these gases in battery *** electrochemical mass spectrometry(OEMS)is an operando gas analysis method that continuously samples the headspace of a custom battery ***-time gas analysis by quantitative OEMS was used to create mechanistic understanding of battery degradation reactions,some of which will be highlight in this article.

关键词： aging mechanisms batteries energy storage gas analysis in situ and operando characterization

Efficiency breakthrough for all-perovskite tandem solar cells

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Science China Chemistry 2020年第3期63卷 294-295页

作者： Tingming Jiang Yang(michael)Yang State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310027China

The power conversion efficiency(PCE)of single-junction perovskite solar cells(PSCs)has rapidly boosted to 25.2%[1],approaching the Shockley-Queisser limit.A potential strategy to further elevate the PCE of single-junction PSCs is to fabricate all-perovskite tandem solar cells[2,3],which is composed of a wide-bandgap(1.7–1.9 eV)top sub-cell and a low-bandgap(0.9–1.2 eV)bottom sub-cell.

关键词： PCE Efficiency breakthrough for all-perovskite tandem solar cells

Regular nicotine intake increased tooth movement velocity,osteoclastogenesis and orthodontically induced dental root resorptions in a rat model

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International Journal of Oral Science 2017年第3期9卷 174-184页

作者： christian kirschneck michael maurer michael wolf claudia reicheneder peter proff department of orthodontics university medical centre of regensburgRegensburgGermany department of oral and maxillofacial surgery university medical centre of regensburgRegensburgGermany department of orthodontics rheinische friedrich wilhelm university of bonnBonnGermany

Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further （side） effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each （A/B/C） to 3 experimental groups （7 rats, 112/3）. （A） cone-beam-computed tomography （CBCT）; （B） histology/serology; （C） reverse- transcription quantitative real-time polymerase chain reaction （RT-qPCR）/cotinine serology--（1） control; （2） orthodontic tooth movement （OTM） of the first and second upper left molar （NiTi closed coil spring, 0.25 N）; （3） OTM with 1.89 mg-kg- 1 per day s.c. of L（- ）-nicotine. After 14 days of OTM, serum cotinine and IL-6 concentration as well as orthodontically induced inflammatory root resorption （OIIRR）, osteoclast activity （histology）, orthodontic tooth movement velocity （CBCT, within 14 and 28 days of OTM） and relative gene expression of known inflammatory and osteoclast markers were quantified in the dental-periodontal tissue （RT-qPCR）. Animals exposed to nicotine showed significantly heightened serum cotinine and IL-6 levels corresponding to those of regular European smokers. Both the extent of root resorption, osteoclast activity, orthodontic tooth movement and gene expression of inflammatory and osteoclast markers were significantly increased compared to controls with and without OTM under the influence of nicotine. We conclude that apart from increased periodontal bone loss, a progression of dental root resorption and accelerated orthodontic tooth movement are to be anticipated during orthodontic therapy, if nicotine consumption is present. Thus patients should be informed about these risks and the necessity of nicotine abstinence during treatment.

关键词： dental research inbred Fischer344 nicotine orthodontics rats root resorption tooth movement