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Satiety testing: Ready for the clinic?

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World Journal of Gastroenterology 2008年第35期14卷 5371-5376页

作者： michael P Jones Division of Gastroenterology Northwestern UniversityChicagoIL 60611United States

Drink tests are advocated as an inexpensive, nonivasive technique to assess gastric function in patients with a variety of upper digestive symptoms. Many patients with dyspeptic complaints will achieve satiation or develop symptoms at ingested volumes below those typically required to achieve these endpoints in controls. Substantial variation in test performance exists and a greater degree of standardization is required. Additionally, it remains unclear exactly what drink tests measure as correlations with measures of gastric sensation, accomodation and emptying are modest at best. Finally, results of drink tests do not guide therpay. At present, these tests are best reserved for research studies and are not advocated for use in clinical practice.

关键词： Drink test Dyspepsia Gastroparesis

Frailty and cardiovascular disease： potential role of gait speed in surgical risk stratification in older adults

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Journal of Geriatric Cardiology 2015年第1期12卷 44-56页

作者： michael A. Chen Harborview Medical Center University of Washington School of Medicine 325 9th Avenue Box 359748 Seattle WA 98104 USA

Frailty is a state of late life decline and vulnerability, typified by physical weakness and decreased physiologic reserve. The epidemiology and pathophysiology of frailty share features with those of cardiovascular disease. Gait speed can be used as a measure of frailty and is a powerful predictor of mortality. Advancing age is a potent risk factor for cardiovascular disease and has been associated with an increased risk of adverse outcomes. Older adults comprise approximately half of cardiac surgery patients, and account for nearly 80% of the major complications and deaths following surgery. The ability of traditional risk models to predict mortality and major morbidity in older patients being considered for cardiac surgery may improve if frailty, as measured by gait speed, is included in their assessment. It is possible that in the future frailty assessment may assist in choosing among therapies （e.g., surgical vs. percutaneous aortic valve replacement for patients with aortic stenosis）.

关键词： Cardiac surgery Frailty Gait speed Risk scores Risk stratification

The Short Local Algebras of Dimension 6 with Non-projective Reflexive Modules

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Communications in Mathematics and Statistics 2023年第2期11卷 195-227页

作者： Claus michael Ringel Fakultät für Mathematik Universität BielefeldPO Box 10013133501 BielefeldGermany

Let A be a finite-dimensional local algebra over an algebraically closed field,let J be the radical of *** modules we are interested in are the finitely generated left *** are always reflexive,and an algebra is self-injective iff allmodules are *** discuss the existence of non-projective reflexive modules in case A is not *** assume that A is short(this means that J^(3)=0).In a joint paper with Zhang Pu,it has been shown that 6 is the smallest possible dimension of A that can occur and that in this case the following conditions have to be satisfied:J^(2)is both the left socle and the right socle of A and there is no uniform ideal of length *** present paper is devoted to showing the converse.

关键词： Short local algebra Reflexive module Gorenstein-projective module Bristle Atom Bar Bristle-bar layout

A class of singular integrals on the n-complex unit sphere

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Science China Mathematics 1999年第12期42卷 1233-1245页

作者： michael Cowling 钱涛 Department of Pure Mathematics University of New South Walse

The operaton on the n-complex unit sphere under study have three forms: the singular integrals with holomorphic kernels, the bounded and holomorphic Fourier multipliers, and the Cauchy-Dunford bounded and holomorphic functional calculus of the radial Dirac operator $D = \sum\nolimits_{k = 1}^n {z_k \frac{\partial }{{\partial _{z_k } }}} $ . The equivalence between the three fom and the strong-type (p,p), 1

关键词： singular integral Fourier multiplier the unit sphere in C n lunetional calculus

On Multi-Level Thinking and Scientific Understanding

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Advances in Atmospheric Sciences 2017年第10期34卷 1150-1158页

作者： michael Edgeworth McINTYRE Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB3 0WAUnited Kingdom.

Professor Duzheng YE＇s name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960 s. I had the enormous pleasure of meeting Professor YE personally in 1992 in Beijing. His concern to promote the very best science and to use it well, and his thinking on multi-level orderly human activities, reminds me not only of the communication skills we need as scientists but also of the multi-level nature of science itself. Here I want to say something（a） about what science is;（b） about why multi-level thinking—and taking more than one viewpoint—is so important for scientific as well as for other forms of understanding; and（c） about what is meant, at a deep level, by ＂scientific understanding＂ and trying to communicate it, not only with lay persons but also across professional disciplines. I hope that Professor YE would approve.

关键词： communication skills cross-disciplinary communication scientific understanding unconscious assumptions multiple viewpoints brain hemispheres biological evolution

Regulation of antitumor immunity by inflammation-induced epigenetic alterations

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Cellular & Molecular Immunology 2022年第1期19卷 59-66页

作者： michael Karin Shabnam Shalapour Department of Pharmacology School of MedicineUniversity of California San DiegoLa JollaCAUSA Laboratory of Gene Regulation and Signal Transduction Department of PharmacologySchool of MedicineUniversity of California San DiegoLa JollaCAUSA Department of Cancer Biology University of Texas MD Anderson Cancer CenterHoustonTXUSA

Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment *** accumulation of genetic alterations and loss of normal cellular regulatory processes are not only associated with cancer growth and progression but also result in the expression of tumor-specific and tumor-associated antigens that may activate antitumor *** antagonism between inflammation and immunity and the ability of cancer cells to avoid immune detection affect the course of cancer development and treatment *** inflammation,particularly acute inflammation,supports T-cell priming,activation,and infiltration into infected tissues,chronic inflammation is mostly ***,the main mechanisms that dictate the outcome of the inflammation-immunity interplay are not well *** data suggest that inflammation triggers epigenetic alterations in cancer cells and components of the tumor *** alterations can affect and modulate numerous aspects of cancer development,including tumor growth,the metabolic state,metastatic spread,immune escape,and immunosuppressive or immunosupportive leukocyte *** this review,we discuss the role of inflammation in initiating epigenetic alterations in immune cells,cancer-associated fibroblasts,and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.

关键词： Inflammation Epigenetics Antitumor immunity Immunotherapy

The Neglected Role of Risk Mitigation Perception in the Risk Governance of Underground Technologies——The Example of Induced Seismicity

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International Journal of Disaster Risk Science 2020年第5期11卷 630-639页

作者： Lisa Haemmerli michael Stauffacher D-USYS Transdisciplinarity Lab Department of Environmental Systems Science(D-USYS)ETH Zurich(Swiss Federal Institute of Technology/Eidgenossische Technische Hochschule)8092 ZurichSwitzerland

Subsurface technologies,such as geothermal energy and carbon capture and storage,are options to help limit global *** tech no logies involve the risk of induced *** successful implementation of these technologies depends on the public perception of these *** governance frameworks propose assessing the level of public concern and designing adapted risk mitigation *** propose that concerns should not only be investigated with respect to the perceived risks but also with respect to the potential mitigation *** explore this by analyzing the perception of risk mitigation measures for different subsurface *** an online survey(N=808)in Switzerland we analyzed four technologies(in-between subject design)and four mitigation measures(within subject design).We found that risk mitigation measures are perceived differently,within and across ***,public concerns about risk mitigation really *** suggest that future research should focus on how risk mitigation measures can be applied and communicated to realize the full potential of risk governance frameworks.

关键词： Carbon capture and storage Enhanced geothermal systems Induced seismicity Risk mitigation perception Shale gas Switzerland

Spectral Methods for Resolving Spike Dynamics in the Geirer-Meinhardt Model

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Communications in Computational Physics 2008年第3期3卷 659-678页

作者： michael McCourt Nicholas Dovidio michael Gilbert Department of Applied Mathematics Illinois Institute of TechnologyChicagoIL 60616USA Department of Mathematics Davidson CollegeNorth CarolinaUSA Department of Mathematics and Physics Colorado State University-PuebloColoradoUSA.

The Gierer-Meinhardt reaction-diffusion model is analyzed using a spectralcollocation method. This reaction-diffusion system is governed by activator and inhibitorconcentrations. Initially, the system is considered in one dimension and thenin two dimensions;numerical results are presented for both cases. The algorithmiccomplexity and accuracy are compared to those of a moving finite element ***, observations are made concerning when to use the proposed spectral methodas opposed to the established moving mesh method.

关键词： Spike dynamics Gierer-Meinhardt model spectral collocation.

EndoN treatment allows neuroblasts to leave the rostral migratory stream and migrate towards a lesion within the prefrontal cortex of rats

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Neural Regeneration Research 2020年第9期15卷 1740-1747页

作者： Jannis Gundelach michael Koch Department of Neuropharmacology Center for Cognitive Sciences University of Bremen

The binding properties of neural cell adhesion molecule are modulated by a polysialic acid moiety. This plays an important role in the migration of adult born neuroblasts from their area of origin, the subventricular zone, towards the olfactory bulb. Polysialisation increases the migration speed of the cells and helps to prevent the neuroblasts from leaving their migration route, the rostral migratory stream. Here, we evaluated the potential of intraventricular application of endoneuraminidase-N, an enzyme that specifically cleaves polysialic acid from neural cell adhesion molecule, in a rat model for structural prefrontal cortex damage. As expected, endoneuraminidase-N caused the rostral migratory stream to become wider, with a less uniform cellular orientation. Furthermore, endoneuraminidase-N treatment caused the neuroblasts to leave the rostral migratory stream and migrate towards the lesioned tissue. Despite the neuroblasts not being differentiated into neurons after a survival time of three weeks, this technique provides a solid animal model for future work on the migration and differentiation of relocated neuroblasts and might provide a basis for a future endogenous stem cell-based therapy for structural brain damage. The experiments were approved by the local animal care committee(522-27-11/02-00, 115;Senatorin für Wissenschaft, Gesundheit und Verbraucherschutz, Bremen, Germany) on February 10, 2016.

关键词： endogenous stem cells endoneuraminidase neural cell adhesion molecule neuroblast migration olfactory bulb polisialic acid structural brain damage subventricular zone