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Neural Regeneration Research 2022年第9期17卷 1955-1956页

作者： Jianli Hu Li-Qing Jin michael e.Selzer Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation) Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA Department of Neurology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Background:Failure of axon regeneration after spinal cord injury(SCI)underlies the paralysis that so profoundly affects patients’quality of *** factors are involved in the regeneration *** sulfate proteoglycans(CSPGs),normal constituents of the perineuronal nets in central nervous system(CNS),are secreted at the injury site and initially were thought to act as a purely physical *** the past decade,the receptor-like protein tyrosine phosphatases,protein tyrosine phosphatase sigma(PTPσ),and leukocyte common antigen-related phosphatase(LAR),have been identified as transmembrane receptors for *** two receptors for myelin-associated growth inhibitors,Nogo receptors 1 and 3(NgR1 and NgR3)also have been found to bind with CSPGs(Sharma et al.,2012).These findings suggest that CSPGs inhibit regeneration by interacting with these receptors,initiating downstream inhibitory signaling(Figure 1).

关键词： paralysis injury leukocyte

College Algebra with Trigonometry Raymond A. Barnett, michael R. Ziegler, Karl e. Byleen 7th ed.

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Ultrasound diagnosis of diverticulitis

丛书名： Barnett, Ziegler & Byleen's precalculus series

2001年

作者： Raymond A. Barnett michael R. Ziegler Karl e. Byleen

Includes indexes.

ISBN: (纸本)0072368691

Includes indexes.

关键词： Algebra.

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World Journal of emergency Medicine 2016年第1期7卷 74-76页

作者： michael e. Abboud Sarah e. Frasure michael B. Stone emergency Department Harvard University 45 Francis St Neville House - 236A Boston Massachusetts 02115 USA

Diverticular disease accounts for approximately 312 000 hospital admissions in the United States annually, and costs nearly 2.6 billion dollars. Approximately 20% of Americans with diverticular disease will experience at least one episode of acute diverticulitis, necessitating a visit to their physician＇s office or the emergency department （eD） for *** As the risk of developing diverticulitis rises with age （nearly 50% of people aged over 60 years have colonic diverticula）, the incidence is rising as the elderly population grows.

关键词： will oral

Geography education for Sustainable Development

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Geography and Sustainability 2020年第1期1卷 88-92页

作者： michael e.Meadows Department of environmental&Geographical Science University of Cape TownRondebosch 7701South Africa School of Geographical Sciences East China Normal UniversityShanghai 200241China College of Geography and environmental Sciences Zhejiang Normal UniversityJinhua 321004China

Increased pressure on the earth’s resources has led to what is increasingly referred to as the climate *** a whole range of environmental parameters have been transformed through such pressures,the effect of human activities on the climate is symbolic of the nature of the human footprint upon our planet and makes the lack of any coherent political leadership in most countries even more *** discipline of Geography has a distinct advantage in developing a more holistic understanding of global environmental challenges in that it reaches across all the sciences(including social sciences and humanities).Geographical education therefore represents an important vehicle for citizens of all ages to help them understand the complexity of the sustainability goal and what can(and should)be done to achieve a more sustainable *** this essay,I reflect on three approaches that are available to individuals and communities towards taking the steps to *** philosophy embodied by the International Year of Global Understanding(IYGU)is suggested as a particularly valuable tool for geography *** activities of the International Geographical Union(IGU)offer important opportunities for geographers to learn from each other and promote best practice in geographical ***‘the science for sustainability’,Geography has an increasingly important role to play in developing the knowledge and the skills to equip future generations with the tools to adapt to and mitigate potentially catastrophic global environmental change.

关键词： Geographical education SDGs Anthropocene Global environmental change IYGU International Charter on Geographical education

east African topography and volcanism explained by a single,migrating plume

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Geoscience Frontiers 2020年第5期11卷 1669-1680页

作者： Rakib Hassan Simon e.Williams michael Gurnis Dietmar Muller School of Geosciences Room 412Madsen Building F09 Eastern AvenueThe University of SydneyNSW2006Australia Seismological Laboratory California Institute of TechnologyPasadenaCA91125USA Now at Geoscience Australia GPO Box 378CanberraACT2601Australia State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China

Anomalous topographic swells and Cenozoic volcanism in east Africa have been associated with mantle *** models involving one or more fixed plumes beneath the northeastward migrating African plate have been suggested to explain the space-time distribution of magmatism in east *** devise paleogeographically constrained global models of mantle convection and,based on the evolution of flow in the deepest lower mantle,show that the Afar plume migrated southward throughout its *** models suggest that the mobile Afar plume provides a dynamically consistent explanation for the spatial extent of the southward propagation of the east African rift system(eARS),which is difficult to explain by the northeastward migration of Africa over one or more fixed plumes alone,over the last≈45 *** further show that the age-progression of volcanism associated with the southward propagation of eARS is consistent with the apparent surface hotspot motion that results from southward motion of the modelled Afar plume beneath the northeastward migrating African *** models suggest that the Afar plume became weaker as it migrated southwards,consistent with trends observed in the geochemical record.

关键词： Numerical mantle flow models Deep mantle flow LLSVP morphology Plume dynamics Plume motion Dynamic topography

exploring and integrating cellulolytic systems of insects to advance biofuel technology

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Insect Science 2010年第3期17卷 163-165页

作者： Jian-Zhong Sun michael e. Scharf Biofuels Institute School of the Environment Jiangsu University Zhenjiang 212013Jiangsu China entomology and Nematology Department PO Box 110620 Bldg 970 Natural Area Dr. University of FloridaGainesville FL 32611-0620 USA

In line with the requirements for sustainable economies and clean environments, cellulose-based biofuels have recently received tremendous attention both in industry and academic communities worldwide. Alternative and renewable fuels derived from lignocellulosic biomass offer the potential to reduce our dependence on fossil fuels and mitigate global climate change.

关键词： exploring integrating cellulolytic systems advance biofuel

Design of a water curtain to reduce accumulations of float coal dust in longwall returns

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International Journal of Mining Science and Technology 2020年第4期30卷 443-447页

作者： Clara e.Seaman michael R.Shahan Timothy W.Beck Steven e.Mischler National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA

Accumulation of float coal dust(FCD)in underground mines is an explosion hazard that affects all underground coal mine *** this hazard is addressed by the application of rock dust,inadequate rock dusting practices can leave miners exposed to an explosion *** at the National Institute for Occupational Safety and Health(NIOSH)have focused on developing a water curtain that removes FCD from the airstream,thereby reducing the buildup of FCD in mine *** this study,the number and spacing of the active sprays in the water curtain were varied to determine the optimal configuration to obtain peak knockdown efficiency(Ke)while minimizing water consumption.

关键词： Float coal dust Longwall Water spray Knockdown efficiency explosion prevention Dust control

Compressibility of a natural kyanite to 17.5 GPa

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Progress in Natural Science:Materials International 2009年第10期19卷 1281-1286页

作者： Sean R. Shieh michael e. Fleet Department of earth Sciences University of Western Ontario

The compressional behaviour of a natural kyanite,(Al1.99Fe0.01)SiO5,has been investigated to about 17.5 GPa at 300 K using a diamond-anvil cell and synchrotron X-ray *** pressure-volume data fitted to the third-order Birch-Murnaghan equation of state(eoS) yield an isothermal bulk modulus(K0T) of 192 ± 6 GPa and pressure derivative(K00T) of 6 ± *** K00T is fixed as 4,the derived K0T is 201 ± 2 *** values are in excellent agreement with most experimental determinations in the ***,it can be concluded that the compressibility of kyanite under high pressures has been accurately constrained.

关键词： Compressibility High-pressure Isothermal bulk modulus Kyanite Synchrotron X-ray diffraction

Identification of a novel population of human cord blood cells with hema-topoietic and chondrocytic potential

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Cell Research 2004年第4期14卷 268-282页

作者： Karen e JAY,Anne ROULeAU,T michael UNDeRHILL,Mickie BHATIA Stem Cell Biology and Regenerative Medicine The John P. Robarts Research Institute 100 Perth Drive London Ontario N6A 5K8 Canada Department of Microbiology and Immunology The University of Western Ontario London Ontario Canada Stem Cell Biology and Regenerative Medicine The John P. Robarts Research Institute 100 Perth Drive London Ontario N6A 5K8 Canada Department of Physiology The University of Western Ontario London Ontario Canada Stem Cell Biology and Regenerative Medicine The John P. Robarts Research Institute 100 Perth Drive London Ontario N6A 5K8 Canada Department of Microbiology and Immunology The University of Western Ontario London Ontario Canada. Department of Physiology The University of Western Ontario London Ontario Canada

With the exception of mature erythrocytes, cells within the human hematopoietic system are characterized by the cell surface expression of the pan-leukocyte receptor CD45. Here, we identify a novel subset among mononuclear cord blood cells depleted of lineage commitment markers (Lin) that are devoid of CD45 expression. Surprisingly, functional examination of Lin"CD45" cells also lacking cell surface CD34 revealed they were capable of multipotential hematopoietic progenitor capacity. Co-culture with mouse embryonic limb bud cells demonstrated that Lin-CD45-CD34- cells were capable of contributing to cartilage nodules and differentiating into human chondrocytes. BMP-4, a mesodermal factor known to promote chondrogenesis, significantly augmented Lin-CD45-CD34- differentiation into chondrocytes. Moreover, unlike CD34+ human hematopoietic stem cells, Lin-CD45-CD34- cells were unable to proliferate or survive in liquid cultures, whereas single Lin-CD45-CD34- cells were able to chimerize the inner cell mass (IC

关键词： hematopoietic chondrocyte CD45 embryonic.

The Japanese ladybirds, Coccinula crotchi and Coccinula sinensis, are infected with very closely related strains of male-killing Flavobacterium

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Insect Science 2014年第6期21卷 699-706页

作者： Sherif elnagdy Susan Messing michael e. N. Majerus Department of Genetics University of Cambridge Downing Street Cambridge CB2 3EH UK Botany Department Faculty of Science Cairo University Giza Egypt University of Rochester Rochester New York USA Department of Biostatistics and Computational Biology University of Rochester Rochester New York USA

Male-killing is 1 of 4 known strategies that inherited parasitic endosymbionts have evolved to manipulate their host＇s reproduction. In early male-killing, infected male offspring are killed early in embryogenesis. Within the Insecta, male-killing bacteria have been found in a wide range of hosts. The Coccinellidae families of beetles, better known as ladybirds, are particularly prone to male-killer invasion. In samples of the coccinellid, Coc- cinula crotchi, from Japan, a new male-killing bacterium was revealed by phenotypic assay. Molecular genetic analysis revealed the identity to be a tetracycline-sensitive Flavobac- terium that causes female-biased offspring sex ratio. Furthermore, that Flavobacterium strain was found to be closely related to the Flavobacterium causing male-killing in the congeneric Japanese coccinellid, Coccinula sinensis, which was collected from the same region. However, we found slightly different Flavobacterium strains infecting C. sinen- sis from regions with different environmental conditions. This may be an indication of horizontal transmission of male-killing Flavobacterium between these 2 ladybird spices. Finally, environmental conditions may affect the spread of male-killing bacteria among their hosts.

关键词： Coccinula crotchi Coccinula sinensis endosymbionts Flavobacterium inherited bacteria male-killing sex ratio distorter