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Neural differentiation protocols:how to choose the correct approach

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Neural Regeneration Research 2023年第6期18卷 1273-1274页

作者： michael Telias Flaum Eye Institute University of RochesterRochesterNYUSA

Pluripotent stem cells in neural differentiation:characterization and potential:The establishment and use of pluripotent stem cells(PSCs),including embryonic(ESCs)and induced(iPSCs),constitutes a major scientific breakthrough of the last decades.Human PSCs hold the potential to deliver regenerative therapies in many diseases,including neurological ones.The general approach is to produce functioning human neurons and glial cells in vitro,to be later implanted in the diseased nervous system,replacing dysfunctional or dead cells.In addition,human and other animal-sourced PSCs make useful and dynamic in vitro models for neurodevelopmental,neurodegenerative and psychiatric disorders,enabling researchers to continuously produce normal and diseased neurons to investigate basic mechanistic questions,which can eventually lead to new therapeutics.Therefore,the development of efficient protocols to induce neural differentiation in ESCs and iPSCs is currently a major effort in the field(Mertens et al.,2016).

关键词： eventually breakthrough approach

Inequalities for Sums and Products of Complex Zeros of Solutions to ODE with Polynomial Right Parts

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1524-1533页

作者： michael Gil’ The Department of Mathematics Ben-Gurion University of the NegevBeer-Sheva84105Israel

The paper is devoted to non-homogeneous second-order differential equations with polynomial right parts and polynomial coefficients.We derive estimates for the partial sums and products of the zeros of solutions to the considered equations.These estimates give us bounds for the function counting the zeros of solutions and information about the zero-free domains.

关键词： Ordinary differential equations Linear equations Zeros of solutions

How to make the "jump" on understanding the importance of the intrinsic foot muscles for propulsion

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Journal of Sport and Health Science 2023年第5期12卷 648-650页

作者： michael J.Asmussen Department of Biology Faculty of Science&TechnologyMount Royal UniversityCalgaryAB T3E 6K6Canada

In this issue of the Journal of Sport and Health Science,Smith and colleagues1addressed a unique aspect of human locomotion;they evaluated the effects of the intrinsic foot musculature on the mechanical properties and energetic function of the human foot.By performing a controlled jumping experiment to mimic components of human locomotion.

关键词： intrinsic muscles propulsion

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5565-5567页

作者： Manqiang Lin michael Sigal Department of Hepatology and Gastroenterology CharitéUniversitätsmedizin Berlin13353 BerlinGermany Berlin Institute for Medical Systems Biology(BIMSB) Max Delbrück Center for Molecular Medicine10115 BerlinGermany

In three recent articles published in Nature and Cell,Weatherbee et al.1,Pedroza et al.2 and Liu et al.3 have demonstrated how human pluripotent stem cells can be coaxed to self-organize into compartmentalized structures that mirror post-implantation embryos.Building on the successful establishment of stem cell-derived mouse embryo models ex utero,these models now shed light on human embryo development during the period between implantation and gastrulation,which has so far been challenging to investigate.

关键词： implantation Human mirror

Geriatric issues in patients with or being considered for implanted cardiac rhythm devices: a case-based review

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Journal of Geriatric Cardiology 2020年第11期17卷 710-722页

作者： michael A Chen Harborview Medical Center University of Washington School of Medicine3259th AvenueBox 359748SeattleWA 98104USA

1 Introduction Virtually all cardiovascular diseases including arrhythmias,valve disease,coronary artery disease and heart failure(HF)are increasingly common with advancing age.^([1])Age and disease-related changes in the heart including fibrosis in the atrial and ventricular myocardium and conduction system,scar tissue from myocardial infarction or other cardiomyopathic processes,increased inflammatory cytokines and changes to ion channels are just some of the factors that predispose older adults to arrhythmias.^([2]).

关键词： Arrhythmias Cardiac implanted electronic devices Older adults Palliative care Syncope

Exosome treatment for stroke with diabetic comorbidity

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Neural Regeneration Research 2022年第2期17卷 315-317页

作者： Poornima Venkat michael Chopp Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA

Ischemic stroke is a cerebrovasculardisease with a high risk of mortality andlong-lasting neurological disabilities.Medical advances have resulted in adeclining trend in stroke incidence anddeaths in the United States... 详细信息

关键词： mortality morbidity Exosome

Commentary on"Speed and surface steepness affect internal tibial loading during running"

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Journal of Sport and Health Science 2024年第1期13卷 125-126页

作者： michael Baggaley Arash Khassetarash Faculty of Kinesiology University of CalgaryCalgaryAB T2N 1N4Canada McCaig Institute for Bone and Joint Health University of CalgaryCalgaryAB T2N 4Z6Canada

It is a pleasure to write a commentary on the work of Dr.Hannah Rice and colleagues,l who have advanced our understanding of how the mechanical loading environment of the tibia changes as a function of running grade and speed.It is important that we understand how the tibia is loaded during conditions that an individual is likely to encounter when running as it is these internal loads which we believe are responsible for the development of bone-stress injuries.

关键词： loading injuries likely

A simple human cell model for TAU trafficking and tauopathy-related TAU pathology

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Neural Regeneration Research 2022年第4期17卷 770-772页

作者： michael Bell Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCenter for Molecular Medicine Cologne(CMMC)University of CologneCologneGermany

The microtubule(MT)-associated protein TAU is highly abundant in the axon of human brain neurons,where it binds to and stabilizes MT filaments.Thereby,TAU regulates the dynamic(dis)assembly of MT strands and is involved in a wide range of neuronal functions.In Alzheimer's disease(AD)and other tauopathies,TAU is missorted into the somatodendritic compartment.TAU missorting is accompanied by(or leads to)abnormal TAU phosphorylation,MT destabilization,and loss of dendritic spines and mitochondria,eventually resulting in TAU aggregation,neuronal dysfunction and cell death(Arendt et al.,2016).Strikingly,the mechanisms of TAU sorting,and the detrimental cascade upon its failure,are still not fully understood.

关键词： tau sorting eventually

利用深地加速器核反应研究恒星等离子环境近阈量子效应

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Science Bulletin 2023年第7期68卷 666-669页

作者： michael Wiescher 柳卫平 Department of Physics and Astronomy University of Notre DameNotre Dame IN 46556USA School of Physics and Astronomy University of EdinburghEdinburgh EH93FDUK College of Science Southern University of Science and TechnologyShenzhen 518055China China Institute of Atomic Energy Beijing 102413China

Low energy particle accelerators,located at deep underground locations,have been developed over the last three decades,to perform nuclear reaction measurements at nearly cosmic ray free background conditions.They are a unique tool in our desire to study and interpret the origin of the elements in our universe,from the Big Bang to present times[1].

关键词： conditions. 量子效应 elements