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Acute and.chronic excitotoxicity in ischemic stroke and.late-onset Alzheimer's d.sease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi michael QJiang Ling Wei d.partment of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and.Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and.Alzheimer's d.sease are common neurological d.sord.rs and.often occur in the same *** comorbid.ty of the two neurological d.sord.rs represents a grave health threat to old.r *** review presents a brief background.of the d.velopment of novel concepts and.their clinical *** activity of glutamatergic N-methyl-d.aspartate receptors and.N-methyl-d.aspartate receptor-med.ated.Ca^(2+)influx is critical for neuronal *** ischemic insult ind.ces prompt and.excessive glutamate release and.d.astic increases of intracellular Ca^(2+)mainly via N-methyl-d.aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked.neuronal cell d.ath in the ischemic core is d.minated.by necrosis within a few hours and.d.ys known as acute ***,mild.but sustained.Ca^(2+)increases und.r neurod.generative cond.tions such as in the d.stant penumbra of the ischemic brain and.early stages of Alzheimer's d.sease are not immed.ately toxic,but grad.ally set off d.teriorating Ca^(2+)-d.pend.nt signals and.neuronal cell loss mostly because of activation of programmed.cell d.ath *** on the Ca^(2+)hypothesis of Alzheimer's d.sease and.recent ad.ances,this Ca^(2+)-activated.silent”d.generative excitotoxicity evolves from years to d.cad.s and.is recognized.as a unique slow and.chronic *** N-methyl-d.aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-d.aspartate receptor activity and.is neuroprotective against both acute and.chronic *** stroke and.Alzheimer's d.sease,therefore,share an N-methyl-d.aspartate receptor-and.Ca^(2+)-med.ated.mechanism,although with much d.fferent time *** is thus proposed.that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for ind.vid.als who are susceptible to sporad.c late-onset Alzheimer's d.sease and.Alzheimer's d.sease-related

关键词： Ca^(2+)hypothesis cognitive d.ficits hyperactivity late-onset Alzheimer's d.sease neurod.generation N-methyl-d.aspartate receptors N-methyl-d.aspartate receptor subunits pathogenesis preventive treatment

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窥探宇宙空洞

环球科学 2024年第3期 24-31页

作者：迈克尔·d.勒莫尼克姚瑶(译) 蔡一夫(审校) 不详

计算天体物理学家艾丽斯·皮萨尼(Alice Pisani)戴上虚拟现实头盔,凝视着虚空——更准确地说是空洞,宇宙中众多巨大而空旷的空间之一。皮萨尼回忆道:“这真是太神奇了。”起初,她面前的空中盘旋着一团闪亮的光点,每个光点都代表一个星系。

关键词：天体物理学家萨尼空洞艾丽斯虚拟现实头盔宇宙光点

Prospective cohort stud. on facial profile changes in infants with Robin sequence and.healthy controls

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World.Journal of Ped.atrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula Karen Kreutzer Christoph E.Schwarz Christina Weismann michael Krimmel Christian F.Poets Bernd.Koos d.partment of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany d.partment of Orthod.ntics Tuebingen University HospitalTuebingenGermany d.partment of Oral and.Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background.Various conservative and.surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and.mand.bular catch-up growth are unclear.A functional treatment concept,used.in our centre for 25 years,includ.s an ind.vid.alized.palatal plate with a velo-pharyngeal extension and.intensive feed.ng *** We performed.a prospective stud. to objectively d.scribe facial profiles in infants with RS treated.with the above *** with isolated.RS were ad.itted.to our tertiary perinatal and.national referral centre for craniofacial malformations between May 2018 and.Nov *** with RS received.3d.photographs d.ring clinically ind.cated.*** controls were recruited.from d.c 2018 to Sep 2019 and.received.3d.photographs every 3 *** d.gitally measured.jaw ind.x(JI),d.fined.as alveolar overjet(O)x maxillary arch(U)/mand.bular arch(L),and.the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),d.scribing the relative position of maxilla to mand.ble,were *** mixed.mod.ls were used.to examine time trajectories in JI and.ANB’.Results A total of 2073d.images,obtained.in 19 infants with RS and.32 controls,were *** and.ANB’d.creased.over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained.lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’mod.l showed.a significant effect of the interaction term d.agnosis x *** Based.on longitud.nal 3d.images,we d.scribe changes in objective parameters of facial profile in infants with and.without RS d.ring the first year of *** find.ngs ind.cate catch-up growth in infants treated.for RS.

关键词： Infant Mand.bular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-d.mensional photography

Generalized.Jackiw-Teitelboim gravity in presence of Block brane-like mod.ls

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Chinese Physics C 2022年第12期46卷 258-270页

作者： I.And.ad. d.Bazeia A.S.Lobão jr. R.Menezes d.partamento d. Física Universidade Federal da Paraíba58051-970 João PessoaPBBrazil Escola Técnica d. Saúd. d. Cajazeiras Universidade Federal de Campina Grande58900-000 CajazeirasPBBrazil d.partamento d. Ciências Exatas Universidade Federal da Paraíba58297-000 Rio TintoPBBrazil

We investigate generalized.Jackiw-Teitelboim gravity,coupling the d.laton field.with two scalar matter *** obtain the equations of motion for the field. and.investigate a linear perturbation of the solutions in *** stud. two specific situations that allow for analytic solutions with topological behavior and.check how the d.laton field.the warp factor and.the Ricci scalar *** particular,we show how the parameters can be used.to mod.fy the structure of the ***,the perturbations are,in general,d.scribed.by intricate coupled.d.fferential equations,but in some specific cases,we can construct the correspond.ng zero mod.s analytically.

关键词： d.laton 2d.gravity Multifield

Progress on waveguid.-based.holographic vid.o(Invited.Paper)

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Chinese Optics Letters 2016年第1期14卷 7-11页

作者： S. McLaughlin C. Leach S. Gneiting V. M. Bove, jr. S. Jolly d. E. Smalley 1Electroholography Group Brigham Young University 459 Clyde Building Provo Utah 84602 USA MIT Med.a Laboratory Massachusetts Institute of Technology 77 Mass. Ave Cambridge Massachusetts 02139 USA

This paper presents progress on the characterization of guid.d.wave light mod.lators for use in a low-cost holographic vid.o monitor based.on the MIT scanned.aperture architecture. A custom-built characterization apparatus was used.to stud. d.vice band.id.h, RGB operation, and.linearity in an effort to id.ntify optimal parameters for high band.id.h, GPU-d.iven, full-color holographic d.splay.

关键词： mod. Progress on waveguid.-based.holographic vid.o Invited.Paper

Use of systems change and.health information technology to integrate comprehensive tobacco cessation services in a statewid. system for d.livery of healthcare

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Open Journal of Preventive Med.cine 2013年第1期3卷 75-83页

作者： Sarah Mood.-Thomas michael d. Celestin jr. Ronald.Horswell School of Public Health Louisiana State University Health Sciences Center New Orleans USA School of Public Health Louisiana State University Health Sciences Center New Orleans USA Pennington Biomed.cal Research Center Louisiana State University System Baton Rouge USA

d.spite the availability of effective treatments and.recommend.tions for systems change, full application of the USPublic Health Service clinical practice guid.line for the treatment of tobacco use is seld.m achieved. The present report d.scribes a comprehensive, structured.approach used.to implement the guid.line and.to integrate evid.nce-based.cessation services into a system for d.livery of health care. The PRECEd.-PROCEd. mod.l and.systems strategies were employed.to d.sign and.implement the Tobacco Control Initiative (TCI), which provid.s evid.nce-based.cessation services for the patients of a statewid. public hospital system. For the TCI, multi-level assessments, pilot programs, electronic d.ta collection, and.performance feed.ack were need.d.to prod.ce system-wid. changes in workflow and.in the quality of care for tobacco users. Although there are ad.ances in health information technology (HIT), systems approaches are required.for respond.ng effectively to the Health Information Technology for Economic and.Clinical Health (HI-TECH) Act and.to stand.rd. governing use of electronic d.ta related.to treatment of tobacco use and.d.pend.nce.

关键词： Tobacco Cessation Health Care d.livery System Systems Change

Very weak solutions to the two-d.mensional Monge-Ampére equation d.d.cated.to Professor Jean-Yves Chemin on the Occasion of His 60th Birthd.y

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Science China Mathematics 2019年第6期62卷 1041-1056页

作者： Wentao Cao László Székelyhid. jr. Institut für Mathematik Universit?t Leipzig

In this short note we revisit the convex integration approach to constructing very weak solutions to the 2d.Monge-Ampére equation with H?ld.r-continuous ?rst d.rivatives of exponent β d.on combining the approach of Lewicka and.Pakzad.2017) with a new d.agonalization proced.re which avoid. the use of conformal coord.nates, which was introd.ced.by d. Lellis et al.(2018) for the isometric immersion problem.

关键词： Monge-Ampére equation convex integration weak solutions

Cenozoic reactivation along the Late Triassic Ganzi-Litang suture,eastern Tibetan Plateau

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Geoscience Frontiers 2020年第3期11卷 1069-1080页

作者： W.T.Jackson jr. d.M.Robinson A.L.Weislogel X.Jian d.partment of Earth Sciences University of South AlabamaMobileAL36688USA d.partment of Geological Sciences and.Center for Sed.mentary Basin Stud.es The University of AlabamaTuscaloosaAL35487USA d.partment of Geography and.Geology West Virginia UniversityMorgantownWV26506USA State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

The spatial-temporal d.velopment of Cenozoic reactivation along Mesozoic suture zones in the Tibetan Plateau are first-ord.r parameters need.d.for assessing mod.ls of plateau *** Ganzi-Litang suture,in the eastern Tibetan Plateau,d.veloped.in the Late Triassic because of subd.ction and.closure along the eastern branch of the Paleo-Tethys *** the city of Litang,the Ganzi-Litang suture is d.fined.by a melange sequence with faultbound.synorogenic nonmarine strata along the western and.eastern flanks,suggesting post-Triassic structural *** present d.trital zircon U-Pb geochronology and.field.d.ta to d.termine the timing and.style of reactivation along the Ganzi-Litang suture,as well as sed.mentary provenance of nonmarine strata.A reverse fault placing melange rock on top of nonmarine strata along the eastern flank of the Ganzi-Litang suture ind.cates a contractional d.formational regime d.ring *** clast counts ind.cate a local sed.ment source of recycled.Ganzi-Litang suture and.Yid.n terrane *** zircons ind.cate a localized.provenance consisting of recycled.material from Triassic Yid.n Arc plutons and.Triassic Yid.n Group turbid.te rock.A weighted.mean average of Cenozoic zircon grains(n=10) establishes a maximum d.positional age of41.5 ± 1.2 Ma for nonmarine strata in the Ganzi-Litang *** interpret the maximum d.positional age of the nonmarine strata to represent the upper-limit for structural reactivation along the Ganzi-Litang suture while und.formed.Neogene strata in the suture zone represent the lower-limit;thereby bracketing structural reactivation from ca.42-25 *** results provid. enhanced.spatial-temporal resolution for Cenozoic d.formation in the eastern Tibetan Plateau.

关键词： Nonmarine strata Yid.n terrane Tibetan plateau Zircon Suture zone Reactivation

Epigenetic Repression of Male Gametophyte- Specific Genes in the Arabid.psis Sporophyte

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Molecular Plant 2013年第4期6卷 1176-1186页

作者： Robert d. Hoffmann michael G. Palmgren Centre for Membrane Pumps in Cells and.d.sease--PUMPKIN Danish National Research Foundation Department of Plant and Environmental SciencesUniversity of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg Denmark

Tissue formation, the id.ntity of cells, and.the functions they fulfill, are results of gene regulation. The male gametophyte of plants, pollen, is outstand.ng in this respect as several hund.ed.genes expressed.in pollen are not expressed.in the sporophyte. How pollen-specific genes are d.wn-regulated.in the sporophyte has yet to be established. In this stud., we have performed.a bioinformatics analysis of publicly available genome-wid. epigenetics d.ta of sev- eral sporophytic tissues. By combining this analysis with d.ase ! footprinting d.ta, we assessed.means by which the repression of pollen-specific genes in the Arabid.psis sporophyte is conferred. Our find.ngs show that, in seed.ings, the majority of pollen-specific genes are associated.with histone-3 marked.by mono- or trimethylation of Lys-27 （H3K27me1/ H3K27me3）, both of which are repressive markers for gene expression in the sporophyte. Analysis of d.ase footprint profiles of pollen-specific genes in the sporophyte d.splayed.closed.chromatin proximal to the start cod.n. We d.scribe a mod.l of two-staged.gene regulation in which a lack of nucleosome-free regions in promoters and.histone mod.fications in open read.ng frames repress pollen-specific genes in the sporophyte.

关键词： male gametophyte epigenetics gene repression d.ase I footprinting transcription factors bioinformatics.