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2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel michael M.Todd Richard P.dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark d.Grant Madhulika Agarkar Anne M.Marbella Jaime F.Blanck Karen B.domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph d.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique d.domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines department of Ophthalmology Manila Doctors HospitalManila 1000Philippines department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pd those from the Visayas(Pd on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

development of a facile block copolymer method for creating hard mask patterns integrated into semiconductor manufacturing

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Nano Research 2016年第10期9卷 3116-3128页

作者： Tandra Ghoshal Matthew T. Shaw Justin d. Holmes michael A. Morris department of Chemistry and Tyndall National Institute University College Cork Cork Ireland AMBER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Intel Ireland Ltd. Collinstown Industrial Estate Co. Kildare Ireland School of Chemistry Trinity College Dublin Dublin Ireland

Our goal is to develop a facile process to create patterns of inorganic oxides and metals on a substrate that can act as hard masks. These materials should have high etch contrast （compared to silicon） and so allow high-aspect-ratio, high- fidelity pattern transfer whilst being readily integrable in modem semiconductor fabrication （FAB friendly）. Here, we show that ultra-small-dimension hard masks can be used to develop large areas of densely packed vertically and horizontally orientated Si nanowire arrays. The inorganic and metal hard masks （Ni, NiO, and ZnO） of different morphologies and dimensions were formed using microphase- separated polystyrene-b-poly（ethylene oxide）（PS-b-PEO） block copolymer （BCP） thin films by varying the BCP molecular weight, annealing temperature, and annealing solvent（s）. The self-assembled polymer patterns were solvent-processed, and metal ions were included into chosen domains via a selective inclusion method. Inorganic oxide nanopatterns were subsequently developed using standard techniques. High-resolution transmission electron microscopy studies show that high-aspect-ratio pattern transfer could be affected by standard plasma etch techniques. The masking ability of the different materials was compared in order to create the highest quality uniform and smooth sidewall profiles of the Si nanowire arrays. Notably good performance of the metal mask was seen, and this could impact the use of these materials at small dimensions where conventional methods are severely limited.

关键词： block copolymer self-assembly hard mask silicon nanowires

Association between water related factors and active trachoma in Hai district, Northern Tanzania

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Infectious diseases of Poverty 2012年第1期1卷 92-98页

作者： michael J Mahande Humphrey d Mazigo Eliningaya J Kweka Community Health department KCM College of Tumaini UniversityPO Box 2240MoshiTanzania department of Medical Parasitology and Entomology Catholic University of Health and Allied SciencesP.O.Box 1464MwanzaTanzania Tropical Pesticides Research Institute Division of Livestock and Human Disease vector controlPO Box 3024ArushaTanzania

Background:Trachoma is widely distributed in sub-Saharan Africa and is mainly associated with poor water ***,these associations have never been demonstrated in some of the communities,especially in northern *** cover that gap,the present case control study was conducted to assess the association of water related factors,general hygiene and active trachoma among preschool and school age children in Hai district,northern ***:Families reported to use>60 litres of water per day were less likely to have active disease(OR=0.4,95%CI:0.1-0.3;Pd to households collecting≤60 *** risk of having trachoma increased with increase in distance to the water point(OR=6.5,95%CI;1.8-16.7;P=0.003).Households members who reported to used number of preschool children in the household was also associated with increased risk of active trachoma by 2.46 ***:Improving water supply near the households and providing public health education focusing on improving households socio-economic status and individual hygiene especially in pre-school children in part will help to reduce the prevalence of the *** addition,integrating public health education with other interventions such as medical interventions remains important.

关键词： Trachoma Water Hygiene Tanzania

Mouse models of medulloblastoma

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Chinese Journal of Cancer 2011年第7期30卷 442-449页

作者： Paul A.Northcott Sidney Croul michael d.Taylor Arthur and Sonia Labatt Brain Tumor Research Center Hospital for Sick Children

Medulloblastoma is the most common malignant pediatric brain tumor. despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years.

关键词：小鼠模型母细胞遗传工程人类疾病脑肿瘤发病率小儿神经

Spatio Temporal Tourism Tracking System Based on Adaptive Convolutional Neural Network

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Computer Systems Science & Engineering 2023年第6期45卷 2435-2446页

作者： L.Maria michael Visuwasam d.Paul Raj department of Computer Science and Engineering Rajalakshmi Institute of TechnologyChennaiTamil Nadu600104India department of Computer Science and Engineering R.M.D.Engineering CollegeChennaiTamil Nadu601204India

Technological developments create a lot of impacts in the tourism *** big data technologies and programs generate opportunities to enhance the strategy and results for transport ***,there is a difference between technological advances and their integration into the methods of tourism *** rising popularity of Freycinet National Park led to a master plan that would not address cultural and environmental *** study addresses the gap by using a synthesized application(app)for demographic surveys and Global Navigation Satellite System(GNSS)technology to implement research *** article focuses on managing visitors within the famous Freycinet National *** comprehensive structured data were analyzed in three phases,(1)identifying groups of visitors who are more likely to use the walking trails,(2)those who are more and less likely to visit during/peak crowding times,and(3)finally creating an integrated Spatio-temporal dependency model via a machine-based learning system for real-time *** research examines innovative techniques that can offer energy resources to managers and tourism agencies,especially in detecting,measuring,and potentially relieving crowding and over-tourism.

关键词： Spatio-temporal dependency machine-based learning global navigation satellite system(GNSS)technology smartphones

One-Step Synthesis and Photoluminescence Evaluation of Cadmium-containing Quantum dots

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Nano-Micro Letters 2012年第1期4卷 52-56页

作者： Nisha Shukla michael M.Nigra Abigail d.Ondeck Institute for Complex Engineered Systems Carnegie Mellon University department of Chemical Engineering Carnegie Mellon University

We have developed a simple one-step process for synthesis of ternary quantum dots(ZnCdSe,MgCdSe) with photoluminescence wavelengths ranging from the red to the blue region of the visible *** primary aim of this work was to develop a synthesis for the preparation of Cd-containing quantum dots using a Cd precursor with lower toxicity than those used in common syntheses. This synthesis makes use of Cd(acac)_2 which is significantly less toxic than precursors such as CdO and CdCl_2. We have studied the effect of solvent boiling point, precursors and reaction time on the photoluminescence properties of the ternary quantum dots. Ternary quantum dots synthesized from Cd(acac)_2 in low boiling point solvents have photoluminescence wavelengths in the blue region, while those synthesized in high boiling point solvents have photoluminescence wavelengths in the red region.

关键词： Quantum dots Zn Cd Se Mg Cd Se Photoluminescence

Characterization of multi-scale ionospheric irregularities using ground-based and space-based GNSS observations

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Satellite Navigation 2021年第1期2卷 192-212页

作者： YuXiang Peng Wayne A Scales michael d Hartinger Zhonghua Xu Shane Coyle Center for Space Science and Engineering Research Virginia TechBlacksburgVA 24061USA Bradley department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Space Science Institute BoulderCO 80301USA National Institute of Aerospace HamptonVA 23666USA Center for Space Science and Engineering Research Virginia TechBlacksburgVA 24061USA.

Ionospheric irregularities can adversely affect the performance of Global Navigation Satellite System (GNSS). How-ever, this opens the possibility of using GNSS as an effective ionospheric remote sensing tool. despite ionospheric monitoring has been undertaken for decades, these irregularities in multiple spatial and temporal scales are still not fully understood. This paper reviews Virginia Tech’s recent studies on multi-scale ionospheric irregularities using ground-based and space-based GNSS observations. First, the relevant background of ionospheric irregularities and their impact on GNSS signals is reviewed. Next, three topics of ground-based observations of ionospheric irregulari-ties for which GNSS and other ground-based techniques are used simultaneously are reviewed. Both passive and active measurements in high-latitude regions are covered. Modelling and observations in mid-latitude regions are considered as well. Emphasis is placed on the increased capability of assessing the multi-scale nature of ionospheric irregularities using other traditional techniques (e.g., radar, magnetometer, high frequency receivers) as well as GNSS observations (e.g., Total-Electron-Content or TEC, scintillation). Besides ground-based observations, recent advances in GNSS space-based ionospheric measurements are briefly reviewed. Finally, a new space-based ionospheric observa-tion technique using GNSS-based spacecraft formation flying and a differential TEC method is demonstrated using the newly developed Virginia Tech Formation Flying Testbed (VTFFTB). Based on multi-constellation multi-band GNSS, the VTFFTB has been developed into a hardware-in-the-loop simulation testbed with external high-fidelity global ionospheric model(s) for 3-satellite formation flying, which can potentially be used for new multi-scale ionospheric measurement mission design.

关键词： GNSS Ionospheric irregularities Remote sensing Active experiment Spacecraft formation flying

Quantifying spatiotemporal variability in occupant exposure to an indoor airborne contaminant with an uncertain source location

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Building Simulation 2023年第6期16卷 889-913页

作者： John E.Castellini Jr Cary A.Faulkner Wangda Zuo michael d.Sohn department of Mechanical Engineering University of Colorado BoulderUCB 427BoulderCO80309USA department Architectural Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA National Renewable Energy National Laboratory GoldenCO80401USA Energy Analysis and Environmental Impacts division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA94720USA

Well-mixed zone models are often employed to compute indoor air quality and occupant *** effective,a potential downside to assuming instantaneous,perfect mixing is underpredicting exposures to high intermittent concentrations within a *** such cases are of concern,more spatially resolved models,like computational-fluid dynamics methods,are used for some or all of the ***,these models have higher computational costs and require more input information.A preferred compromise would be to continue with a multi-zone modeling approach for all rooms,but with a better assessment of the spatial variability within a *** do so,we present a quantitative method for estimating a room’s spatiotemporal variability,based on influential room *** proposed method disaggregates variability into the variability in a room’s average concentration,and the spatial variability within the room relative to that *** enables a detailed assessment of how variability in particular room parameters impacts the uncertain occupant *** demonstrate the utility of this method,we simulate contaminant dispersion for a variety of possible source *** compute breathing-zone exposure during the releasing(source is active)and decaying(source is removed)*** CFd methods,we found after a 30 minutes release the average standard deviation in the spatial distribution of exposure was approximately 28%of the source average exposure,whereas variability in the different average exposures was lower,only 10%of the total *** also find that although uncertainty in the source location leads to variability in the average magnitude of transient exposure,it does not have a particularly large influence on the spatial distribution during the decaying period,or on the average contaminant removal *** systematically characterizing a room’s average concentration,its variability,and the spatial variability within the room important insights can be gain

关键词： uncertainty variability airborne contaminant spatiotemporal variability well-mixed heterogeneity