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One-Dimensional Nonlinear Laplacians under a 3-Point Boundary Condition

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1641-1652页

作者： bruce D.CALVERT Department of Mathematics University of Auckland

w. consider a three-point boundary value problem for operators such as the one-dimensional p-Laplacian, and show.w.en they have solutions or not, and how.many. The inverse operators are given by various formulas involving zeros of a real-valued function. They are show. to be orderpreserving, for some parameter values, and non-singleton valued for others. The operators are show. to be m-dissipative in the space of continuous functions.

关键词： Boundary value problems nonlinear o.d.e.s p-Laplacian three-point boundary value problem m-dissipative

A new.alternative approach for investigating acidization dissolution front propagation in fluid-saturated carbonate rocks

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Science China(Technological Sciences) 2017年第8期60卷 1197-1210页

作者： ZHAO ChongBin HOBBS bruce ORD Alison Computational Geosciences Research Centre Central South University School of Earth and Environment The University of Western Australia

The natural phenomenon associated w.th the chemical dissolution of dissolvable minerals of rocks can be employed to develop innovative technology in mining and oil extracting engineering. This paper presents a new.alternative approach for theoretically dealing w.th chemical dissolution front （CDF） propagation in fluid-saturated carbonate rocks. Note that the CDF is represented by the porosity front in this study. In this new.approach, the porosity, pore-fluid velocity and acid concentration are directly used as independent variables. To illustrate how.to use the present new.approach, an aeidization dissolution system （ADS） consisting of carbonate rocks, w.ich belongs to one of the many general chemical dissolution systems （CDSs）, is taken as an application example. w.en the acid dissolution capacity （ADC） number （that is defined as the ratio of the volume of the carbonate rock dissolved by an acid to that of the acid） approaches zero, the present new.approach can be used to obtain analytical solutions for the stable ADS. How.ver, if the ADC number is a nonzero finite number, then numerical solutions can be only obtained for the ADS, especially w.en the ADS is in an unstable state. The related theoretical results have demonstrated that：（1） w.en the ADS is in a stable state and in the case of the ADC number approaching zero, the present new.approach is mathematically equivalent to the previous approach, in w.ich the porosity, pore-fluid pressure and acid concentration are used as independent variables. How.ver, w.en the ADS is in an unstable state, the use of the present new.approach leads to a free parameter that needs to be determined by some other w.ys. （2） The existence of a non-step-type dissolution front w.thin a transient region should at least satisfy that none of the ADC number, injected acid velocity and reciprocal of the dissolution reaction rate is equal to zero in the stable ADS.

关键词： acidization dissolution front propagation critical length alternative approach critical time carbonate rocks

A unified theory for sharp dissolution front propagation inchemical dissolution of fluid-saturated porous rocks

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Science China(Technological Sciences) 2019年第1期62卷 163-174页

作者： ZHAO ChongBin HOBBS bruce ORD Alison Computational Geosciences Research Centre Central South University School of Earth and Environment The University of Western Australia

This paper presents a unified theory to deal w.th w.en, w.y and how.a sharp acidization dissolution front(ADF), w.ich is represented by the porosity distribution curve, can take place in an acidization dissolution system composed of fluid-saturated porous rocks. The theory contains the follow.ng main points:(1) A reaction rate of infinity alone can lead to a sharp ADF of the Stefan-type in the acidization dissolution system. This sharp front is unstable w.en permeability in the dow.stream region is smaller than that in the upstream region.(2) For a finite reaction rate, w.en the acid dissolution capacity number approaches zero,the ADF can have a sharp profile of the Stefan-type either on a much smaller time scale or on a much larger time scale than the dissolution time scale. In the former case, the ADF may become unstable on a much larger time scale than the transport time scale, w.ile in the latter case, it may become unstable if the grow.h rate of a small perturbation is greater than zero.(3) On the dissolution time scale, even if both the reaction rate is finite and the acid dissolution capacity number approaches zero, the profile of an ADF may not be sharp because it is in a transient state. In this case, not only can an ADF change its profile w.th time, but also its morphology can grow.if the grow.h rate of a small perturbation is greater than zero. Due to the involvement of both the change rate and the grow.h rate of the ADF profile, it is necessary to conduct a transient linear stability analysis for determining w.ether or not a time-dependent ADF is stable in the acidization dissolution system.

关键词： sharp dissolution front stationary/steady state transient state acid dissolution capacity acidization dissolution porous rocks

Effects of porosity heterogeneity on chemical dissolution-front instability in fluid-saturated rocks

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Journal of Central South University 2017年第3期24卷 720-725页

作者： ZHAO Chong-bin Peter SCHAUBS bruce HOBBS Computational Geosciences Research Centre Central South University Changsha 410083 China CSIRO Mineral Resource National Research Flagship R O. Box 1130 Bentley WA 6102 Australia School of Earth and Environment The University of Western Australia Crawley WA 6009 Australia

Homogeneity and heterogeneity are tw. totally different concepts in *** the particle length scale,rocks exhibit strong heterogeneity in their constituents and *** the heterogeneity of porosity obeys the random uniform distribution,both the mean value and the variance of porosities in the heterogeneous porosity field can be used to reflect the overall heterogeneous characteristics of the porosity *** main purpose of this w.rk is to investigate the effects of porosity heterogeneity on chemical dissolution front instability in fluid-saturated rocks by the computational simulation *** related computational simulation results have demonstrated that:1) since the propagation speed of a chemical dissolution front is inversely proportional to the difference betw.en the final porosity and the mean value of porosities in the initial porosity field,an increase in the extent of the porosity heterogeneity can cause an increase in the mean value of porosities in the initial porosity field and an increase in the propagation speed of the chemical dissolution front.2) An increase in the variance of porosities in the initial porosity field can cause an increase in the instability probability of the chemical dissolution front in the fluid-saturated rock.3) The greater the mean value of porosities in the initial porosity field,the quicker the irregular morphology of the chemical dissolution front changes in the supercritical chemical dissolution *** means that the irregular morphology of a chemical dissolution front grow. quicker in a porosity field of heterogeneity than it does in that of homogeneity w.en the chemical dissolution system is at a supercritical stage.

关键词： porosity heterogeneity chemical dissolution front instability computational simulation porous rocks

A convolutional neural netw.rk for defect classification in Bragg coherent X-ray diffraction

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npj Computational Materials 2021年第1期7卷 1026-1033页

作者： bruce Lim Ew.n Bellec Maxime Dupraz Steven Leake Andrea Resta Alessandro Coati michael Sprung Ehud Almog Eugen Rabkin Tobias Schulli Marie-Ingrid Richard Grenoble INP-Phelma Univ.Grenoble AlpesGrenobleFrance ESRF-The European Synchrotron GrenobleFrance CEA Grenoble IRIGMEMNRSUniv.Grenoble AlpesGrenobleFrance Synchrotron SOLEIL L’Orme des MerisiersGif-sur-YvetteFrance Deutsches Elektronen-Synchrotron(DESY) HamburgGermany Department of Materials Science and Engineering Technion-Israel Institute of TechnologyHaifaIsrael

Coherent diffraction imaging enables the imaging of individual defects,such as dislocations or stacking faults,in *** defects and their surrounding elastic strain fields have a critical influence on the macroscopic properties and functionality of ***,their identification in Bragg coherent diffraction imaging remains a challenge and requires significant data *** ability to identify defects from the diffraction pattern alone w.uld be a significant advantage w.en targeting specific defect types and accelerates experiment design and ***,w. exploit a computational tool based on a three-dimensional(3D)parametric atomistic model and a convolutional neural netw.rk to predict dislocations in a crystal from its 3D coherent diffraction *** diffraction patterns from several thousands of relaxed atomistic configurations of nanocrystals are used to train the neural netw.rk and to predict the presence or absence of dislocations as w.ll as their type(screw.or edge).Our study paves the w.y for defect-recognition in 3D coherent diffraction patterns for material science.

关键词： materials coherent defect

Using on-site liver 3-D reconstruction and volumetric calculations in split liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 587-592页

作者： Trevor w.Reichman Brittany Fiorello Ian Carmody Humberto Bohorquez Ari Cohen John Seal David bruce George E Loss Ochsner Multi-Organ Transplant Institute Ochsner Medical Center

BACKGROUND： Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this study w.s to determine the ability and feasibility of constructing a 3-D model to aid in surgical planning and to predict graft w.ight prior to an in situ division of the donor liver. METHODS： Over 11 months, 3-D volumetric reconstruction of 4 deceased donors w.s performed using Pathfinder Scout liver volumetric softw.re. Demographic, laboratory, operative, perioperative and survival data for these patients along w.th donor demographic data w.re collected prospectively and analyzed retrospectively. RESULTS： The average predicted w.ight of the grafts from the adult donors obtained from an in situ split procedure w.re 1130 g （930-1458 g） for the extended right lobe donors and 312 g （222-396 g） for left lateral segment grafts. Actual adult graft w.ight w.s 92% of the predicted w.ight for both the extended right grafts and the left lateral segment grafts. The predicted and actual graft w.ights for the pediatric donors w.re 176 g and 210 g for the left lateral segment grafts and 308 g and 280 g for the extended right lobe grafts,respectively. All grafts w.re transplanted except for the right lobe from the pediatric donors due to the small graft ***： On-site volumetric assessment of donors provides useful information for the planning of an in situ split and for selection of recipients. This information may expand the donor pool to recipients previously felt to be unsuitable due to donor and/or recipient w.ight.

关键词： split liver transplantation reduced-size liver transplantation 3-D reconstruction

Effects of land-use types and the exotic species,Hypochaeris radicata,on plant diversity in human-transformed landscapes of the biosphere reserve,Jeju Island,Korea

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Plant Diversity 2023年第6期45卷 685-693页

作者： Deokjoo Son bruce w.ldman Uhram Song College of Education Department of Science Education Dankook UniversityGyeonggi-do16890Republic of Korea Department of Integrative Biology Oklahoma State UniversityStillwaterOK 74078USA Department of Biology Jeju National UniversityJeju 63243Republic of Korea

Land-use and plant invasion influence *** the effects of land-use types and invasive plants on the ecosystem is crucial for better management and the development of strategic plans for increasing biodiversity in Jeju Island,Korea,a designated Biosphere Reserve by the United Nations Education,Scientific,and Cultural *** effect of the most dominant invasive exotic species,Hypochaeris radicata,on the four land-use types of Jeju Island w.s *** composition,soil characteristics,and plant diversity among four land-use types(cropland,green space,neglected land,and residential)w.re *** the land-use types,croplands had the most diverse plant composition and the highest richness in exotic and native plant ***,such as tangerine orchards,w.ich are w.dely distributed throughout Jeju Island,show.d the highest plant diversity because of medium intensity disturbance caused by w.ed *** relative cover of *** did not differ betw.en land-use ***,*** invasion w.s negatively related w.th plant species richness,making this invasive species a threat to the biodiversity of native herbs present in land-use *** adapts to areas w.th a broad range of soil properties and a variety of land-use ***,it is crucial to monitor land-use types and patterns of plant invasion to guide the implementation of consistent management and conservation strategies for maintaining ecosystem integrity of the transformed habitat in Jeju Island.

关键词： Biosphere reserve Cropland Invasive exotic plant Plant richness Intermediate disturbance hypothesis

Emerging roles of spliceosome in cancer and immunity

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Protein & Cell 2022年第8期13卷 559-579页

作者： Hui Yang bruce Beutler Duanw. Zhang Department of Neurosurgery Huashan HospitalShanghai Key laboratory of Brain Function Restoration and Neural RegenerationMOE Frontiers Center for Brain ScienceInstitute for Translational Brain ResearchShanghai Medical CollegeFudan UniversityShanghai 200032China Center for the Genetics of Host Defense University of Texas Southwestern Medical CenterDallasTX 75390USA Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghai 200032China

Precursor messenger RNA(pre-mRNA)splicing is cat-alyzed by an intricate ribonucleoprotein complex called the *** the spliceosome is consid-ered to be general cell"housekeeping"machinery,mutations in core components of the spliceosome fre-quently correlate w.th cell-or tissue-specific pheno-types and *** this review.w. expound the links betw.en spliceosome mutations,aberrant splicing,and human ***,spliceosome-targeted therapios(STTs)have become efficient anti-cancer strategies for cancer patients w.th splicing *** also highlight the links betw.en spliceosome and immune *** studies have show. that some spliceosome gene mutations can result in immune dysregulation and notable phenotypes due to mis-splicing of immune-related ***,several core spliceosome components harbor splicing-inde-pendent immune functions w.thin the cell,expanding the functional repertoire of these diverse proteins.

关键词： spliceosome splicing cancer innate immunity immune dysregulation

Nickel converts RNase A to a urease under presence of Nickel

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Nickel converts RNase A to a urease under presence of Nickel