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Treatable causes of fever among children under five years in a seasonal malaria transmission area in Burkina Faso

Infectious Diseases of Poverty 2018年第1期7卷 583-592页

作者： Francois Kiemde Marc Christian Tahita Palpouguini Lompo Toussaint Rouamba Athanase M.Some Halidou Tinto Petra F.Mens Henk D.F.H.Schallig michael boele van hensbroek Institut de Recherche en Science de la Sante-Unite de Recherche Clinique de Nanoro NanoroBurkina Faso Academic Medical Centre Department of Medical MicrobiologyParasitology UnitAmsterdamThe Netherlands Global Child Health Group Academic Medical CentreUniversity of AmsterdamAmsterdamThe Netherlands

Background:Fever remains a major public health *** Burkina Faso,more than half of febrile children are considered not to be infected by *** study prospectively assessed probable(treatable)causes of fever in Burkinabe ***:A prospective study was conducted among febrile children(≥37.5°C)under 5 years of age presenting at four health facilities and one referral hospital in rural Burkina *** each participant,blood was collected for malaria microscopy and culture,urine for dipstick testing and culturing if tested positive for leucocytes and nitrite,stool for rotavirus/adenovirus testing,culture and parasitology,and a nasopharyngeal swab for ***:In total 684 febrile children were included in the *** falciparum malaria was found in 49.7%(340/684)of the participants and non-malaria infections in 49.1%(336/684)of *** non-nalaria infections included gastro-intestinal infections(37.0%),common bacterial pathogens of nasopharynx(24.3%),bacterial bloodstream infections(6.0%)and urinary tract infections(1.8%).Nearly 45%(154/340)of the malaria infected children were co-infected with non-nalaria infections,but only 3.2%(11/340)of these co-infections could be considered as a possible alternative cause of *** contrast,in the malaria microscopy negative children 18.0%(62/344)of the infections could be the probable cause of the *** were not isolated from 23.7%(162/684)of the febrile ***:Malaria remains the most common pathogen found in febrile children in Burkina ***,a relative high number of febrile children had non-malaria *** correct diagnosis of these non-malaria fevers is a major concern,and there is an urgent need to develop more point-of-care diagnostic tests and capacities to identify and treat the causes of these fevers.

关键词： Fever Children Infectious diseases Malaria

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The Global Energy and Water Exchanges(GEWEX)Project in Central Asia:The Case for a Regional Hydroclimate Project

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Advances in Atmospheric Sciences 2024年第5期41卷 777-783页

作者： michael BRODY Maksim KULIKOV Sagynbek ORUNBAEV Peter J.van OEVELEN International Agricultural University Tashkent 111200Uzbekistan George Mason University FairfaxVirginia 22030USA University of Central Asia Bishkek 720001Kyrgyz Republic American University of Central Asia Bishkek 720060Kyrgyz Republic International GEWEX project George Mason UniversityFairfaxVirginia 22030USA

Central Asia consists of the former Soviet Republics,Kazakhstan,Kyrgyz Republic,Tajikistan,Turkmenistan,and *** region’s climate is continental,mostly semi-arid to *** is a significant part of the region’s *** its nature of intensive water use,agriculture is extremely vulnerable to climate *** growth and irrigation development have significantly increased the demand for water in the *** climate change issues include melting glaciers and a shrinking snowpack,which are the foundation of the region’s water resources,and a changing precipitation *** glaciers are located in Kyrgyzstan and Tajikistan,leading to transboundary water resource *** already has extremely high *** indicate that Central Asia has been warming and precipitation might be *** warming is expected to increase,but its spatial and temporal distribution depends upon specific global *** of future precipitation show significant uncertainties in type,amount,and *** Hydroclimate Projects(RHPs)are an approach to studying these *** steps to develop an RHP began in 2021 with a widely distributed online survey about these climate *** was followed up with an online workshop and then,in 2023,an in-person workshop,held in Tashkent,*** for the Global Energy and Water Exchanges(GEWEX)project for the region include both observations and modeling,as well as development of better and additional precipitation observations,all of which are topics for the next workshop.A well-designed RHP should lead to reductions in critical climate uncertainties in policy-relevant timeframes that can influence decisions on necessary investments in climate adaptation.

关键词： GEWEX Central Asia climate change agriculture

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Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa Wang Yifan Yang Shizhi He George G.Chen Jason YK.Chan michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

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Ethernet based time synchronization for Raspberry Pi network improving network model verification for distributed active turbulent flow control

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Control Theory and Technology 2015年第2期13卷 204-210页

作者： Marcel DUECK Mario SCHLOESSER Stefan van WAASEN michael SCHIEK Central Institute of Engineering Electronics and Analytics ZEA-2: Electronic SystemsForschungszentrum Juelich Gmb H ZEA-2 Wilhelm-Johnen-Straβe University of Duisburg-Essen Faculty of Engineering

Friction drag primarily determines the total drag of transport systems. A promising approach to reduce drag at high Reynolds numbers(> 104) are active transversal surface waves in combination with passive methods like a riblet surface. For the application in transportation systems with large surfaces such as airplanes, ships or trains, a large scale distributed real-time actuator and sensor network is required. This network is responsible for providing connections between a global flow control and distributed actuators and sensors. For the development of this network we established at first a small scale network model based on Simulink and True Time. To determine timescales for network events on different package sizes we set up a Raspberry Pi based testbed as a physical representation of our first model. These timescales are reduced to time differences between the deterministic network events to verify the behavior of our model. Experimental results were improved by synchronizing the testbed with sufficient precision. With this approach we assure a link between the large scale model and the later constructed microcontroller based real-time actuator and sensor network for distributed active turbulent flow control.

关键词： Raspberry Pi True Time distributed actuator and sensor network network model

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Immunomodulatory approaches to CNS injury:extracellular matrix and exosomes from extracellular matrix conditioned macrophages

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Neural Regeneration Research 2016年第4期11卷 554-556页

作者： Yolandi van der Merwe michael B.Steketee Department of Bioengineering Swanson School of EngineeringUniversity of Pittsburgh Department of Ophthalmology School of MedicineUniversity of Pittsburgh Mc Gowan Institute for Regenerative Medicine University of Pittsburgh Center for Neuroscience University of Pittsburgh University of Pittsburgh

After central nervous system（CNS）injury,a pro-inflammatory,innate immune response contributes to permanently lost neuronal function by promoting changes in the micro-environment and extracellular matrix（ECM）that l... 详细信息

关键词： cell CNS ECM Immunomodulatory approaches to CNS injury

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Comparison of three regionalization techniques for predicting streamflow in ungaged watersheds in Nebraska,USA using SWAT model

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International Journal of Agricultural and Biological Engineering 2018年第3期11卷 110-119页

作者： michael W.van Liew Aaron R.Mittelstet Department of Biological Systems Engineering University of NebraskaLincolnNE 68583USA

This study compared three approaches,regional averaging,nearest neighbor,and donor techniques,to regionalize parameters in the Soil and Water Assessment Tool(SWAT)on eleven watersheds located in the Dissected Plains,Plains,and Rolling Hills Landforms in the eastern portion of the State of Nebraska,*** the Rolling Hills Landform,three watersheds were randomly selected as calibration watersheds while two were randomly selected as validation *** watersheds were randomly selected as calibration watersheds while one was randomly selected as a validation watershed within each of the Dissected Plains and Plains *** seven calibration watersheds were used to provide the necessary calibrated parameter sets to execute each of the regional approaches,while the four validation watersheds were used to assess the impact of applying each of these approaches to an uncalibrated *** Bias(PBIAS)and the Nash Sutcliffe Coefficient of Efficiency(NSE)were used to assess model *** results of this study show that all three methods performed poorly,since the majority of watersheds among each method tested exhibited PBIAS values greater than ±25% and/or NSE values less than 0.50,which were considered to be unsatisfactory in terms of model *** average regionalization,nearest neighbor and donor methods resulted in only four(two calibration and two validation),zero and one satisfactory set of simulated watershed results,*** findings from this study indicate that although each watershed was successfully calibrated with NSE values ranging from 0.51 to 0.84,none of the three regionalization methods provided suitable calibration data sets to define parameter values for performing satisfactory simulations on ungaged watersheds across the eastern Nebraska landscape.

关键词： SWAT model watersheds hydrology model calibration parameter regionalization Nebraska ungaged watersheds

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Co-localization hypothesis:A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis

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World Journal of Gastroenterology 2006年第13期12卷 1985-1990页

作者： Gijs JD van Acker George Perides michael L Steer Department of Surgery and the Boston Pancreas Group Tufts-New England Medical Center 860 Washington StreetBostonMA 02111United States

Acute pancreatitis is generally believed to be a disease in which the pancreas is injured by digestive enzymes that it normally produces. Most of the potentially harmful digestive enzymes produced by pancreatic acinar cells are synthesized and secreted as inactive zymogens which are normally activated only upon entry into the duodenum but, during the early stages of acute pancreatitis, those zymogens become prematurely activated within the pancreas and, presumably, that activation occurs within pancreatic acinar cells. The mechanisms responsible for intracellular activation of digestive enzyme zymogens have not been elucidated with certainty but, according to one widely recognized theory （the ＂co-localization hypothesis＂）, digestive enzyme zymogens are activated by lysosomal hydrolases when the two types of enzymes become co-localized within the same intracellular compartment. This review focuses on the evidence supporting the validity of the m-localization hypothesis as an explanation for digestive enzyme activation during the early stages of pancreatitis. The findings, summarized in this review, support the conclusion that co-localization of lysosomal hydrolases with digestive enzyme zymogens plays a critical role in permitting the intracellular activation of digestive enzymes that leads to acinar cell injury and pancreatitis.

关键词： Acute pancreatitis Digestive enzymes Pancreatic acinar cells

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Impaired Pulmonary Function as a Potential Contributor to Reduced Exercise Capacity Associated with MAFLD

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 181-183页

作者： Derrick michael van Rooyen Oyekoya Taiwo Ayonrinde Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdochWAAustralia Medical School The University of Western AustraliaNedlandsAustralia Faculty of Health Sciences Curtin UniversityBentleyAustralia

For over a century,fatty liver has been associated with inadequate physical activity.1 A sedentary lifestyle has long been considered a major contributor to obesity and fatty *** with fatty liver are consequently often deemed to be unwilling or unable to increase their physical activity as a therapeutic lifestyle *** is ongoing toward identifying obstacles to physical exercise in people with fatty liver,exposing intrinsic and extrinsic factors that may sometimes be bidirectional.

关键词： obesity identifying willing

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Experiment meets biogeography:plants of river corridor distribution are not more stress tolerant but benefit less from more benign conditions elsewhere

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Journal of Plant Ecology 2010年第3期3卷 149-155页

作者： Markus Fischer michael Burkart vanessa Pasqualetto Mark van Kleunen Institute for Biochemistry and Biology University of PotsdamMaulbeerallee 1D-14469 PotsdamGermany Institute of Plant Sciences and Oeschger Centre University of BernAltenbergrain 21CH-3013 BernSwitzerland

Aims Factors limiting distributions of species are fundamental to ecology and evolution but have rarely been addressed experimentally for multiple *** conspicuous linear distribution patterns of plant species confined to river corridors in the Central European lowlands constitute an especially long-standing distribution *** experimentally tested our novel hypothesis that the tolerance of species to river corridor conditions is independent of the degree of confinement to river corridor habitats,but that species not confined to river corridors are better able to take advantage of the more benign non-river corridor *** We grew 42 herbaceous species differing in their confinement to river corridors in a common garden experiment on loamy soil typical for river corridor areas and sandy soil typical for non-river corridor areas,and with and without a flooding *** a subset of species,we grew plants of both river corridor and non-river corridor origin to test for adaptation to river corridor *** findings Species more confined to river corridor areas benefited less from the more benign non-flooded and non-river corridor soil conditions than species of wider distributional range *** subsets of 7 and 12 widespread species,the response to flooding and soil origin,respectively,did not differ between plants from river corridor sites and plants from other sites,suggesting that the habitat tolerance of widespread species is due to phenotypic plasticity rather than to local ***,we found clear support for our novel hypothesis that species not confined to river corridors are more able to take advantage of the more benign non-river corridor *** study provides a general hypothesis on differences between species confined to stressful habitats and widespread species out for test in further multispecies comparative experiments.

关键词： distributional patterns edaphic factors environmental tolerance flooding local adaptation multispecies experiment phenotypic plasticity

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Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [Med Nov Technol Dev, 13, 2022, 100112]

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Medicine in Novel Technology and Devices 2024年第1期21卷 120-120页

作者： michael A.Kokko Ryan M.Chapman Martin W.Roche Douglas W.van Citters Thayer School of Engineering at Dartmouth College 14 Engineering DriveHanoverNH03755USA Department of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and informed consent statement for this *** study did not involve human subjects or animal research,and was therefore not subject to institutional ethics approval and did not require informed *** single cadaveric specimen used in ex vivo evaluation was obtained from Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statement alignment

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