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The Effect of a Food Supplement and a Hair Lotion on the Progression of Androgenetic Alopecia

Journal of Cosmetics, Dermatological Sciences and Applications 2019年第4期9卷 292-304页

作者： michael bayer Manfred Gahrtz Werner Voss Gerrit Schlippe Thomas Whitfield Dermatest GmbH Münster Germany Oxford Biolabs Deutschland GmbH Regensburg Germany Oxford Biolabs Ltd. Oxford UK

Background: Progressing androgenetic alopecia (AGA), in both sexes, can result in severe distress. Treatments with the capacity to slow down the progression of AGA, or even to bring it to a halt, and at the same time don’t come with side effects are consequently highly sought for. Therefore this study investigates the effect of an over-the-counter nutritional supplement and a similarly formulated topical hair lotion on the progression of AGA. Methods: Seventy-nine healthy study participants of both sexes, who were diagnosed with AGA were divided into 4 study groups. The subjects of the first group were treated with the nutritional supplement, the subjects of the second group with the topical hair lotion, the subjects of the third group with both products, and the subjects of the fourth group served as a no-treatment control. At the beginning and at the end of this nine-month study, the participants were evaluated for their hair loss status. They also answered a questionnaire for self-assessment. A part of the subjects from each study group were further analysed by phototrichography, in order to measure the number of anagen and telogen hairs. Results: It turned out that the supplement, the lotion as well as the treatment with both products not only lead to a reduction in hair loss but also to an increased anagen to telogen hair ratio, whereas no such effects could be measured for the control group. Conclusion: The results show that a systemic delivery via a nutritional supplement, as well as a follicular delivery via a topically applied lotion, both resulted in a reduced hair loss rate as well as in an increased anagen to telogen hair ratio. This demonstrates that the tested formulation is effectively slowing down the progression of AGA.

关键词： Androgenetic Alopecia (AGA) Nutritional Supplement Topical Hair Treatment L-Carnitine Zinc

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Revealing true coupling strengths in two-dimensional spectroscopy with sparsity-based signal recovery

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Light(Science & Applications) 2017年第1期6卷 322-327页

作者： Hadas Frostig Tim bayer Yonina C Eldar Yaron Silberberg Department of Physics of Complex Systems Weizmann Institute of ScienceRehovot 76100Israel Institut für Physik Carl von Ossietzky Universität OldenburgOldenburg 26129Germany Department of Electrical Engineering TechnionHaifa 32000Israel

Two-dimensional(2D)spectroscopy is used to study the interactions between energy levels in both the field of optics and nuclear magnetic resonance(NMR).Conventionally,the strength of interaction between two levels is inferred from the value of their common off-diagonal peak in the 2D spectrum,which is termed the cross ***,stronger diagonal peaks often have long tails that extend into the locations of the cross peaks and alter their ***,we introduce a method for retrieving the true interaction strengths by using sparse signal recovery techniques and apply our method in 2D Raman spectroscopy experiments.

关键词： multidimensional spectroscopy nonlinear optics sparsity-based algorithms

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THERMODYNAMIC ANALYSIS OF THE ENANTIOMER RESOLUTION OF TFA-Ala-OMe, TFA-Ala-Ala-OMe, AND TFA-Ala-Ala-Ala-OMe BY GAS CHROMATOGRAPHY ON CHIRASIL-VAL

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Science China Chemistry 1991年第7期34卷 769-776页

作者：林炳承 E.bayer V.MUSCHALEK B.KOPPENHOEFER Dalian Institute of Chemical Physics Academia SinicaDalian 116012 PRC Instisut

TFA-Ala-OMe, TFA-Ala-Ala-OMe, and TFA-Ala-Ala-Ala-OMe can be separated into 1, 2, and 4 enantiomeric pairs, respectively, by GC on the chiral stationary phase Chirasil-Val. The selectivity of the chiral stationary phase for the different stereoisomers is controlled by both interaction enthalpy and interaction entropy. The interaction enthalpy is approximately proportional to the number of Ala units. Although the whole molecule is involved in the interaction, the C-terminus plays an important role. The elution order of DDD- and LLL-TFA-Ala-Ala-Ala-OMe is opposite to the order of the enhalpy values, and the ratio of net retention data t’r(DDD)/t’r(LLL) is increased with increasing temperature. By lowering the temperature, peak crossing of the enantiomeric pair has been observed. Below the isoselective temperature Tiso’ the order of elution is ruled by the enthalpy of interaction, above Tiso by the entropy of interaction.

关键词： gas chromatography enantiomer resolution oligopeptides Chirasil-Val thermodynamic analysis reversal of peak order.

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计算机电话系统-CTI与呼叫中心 4

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2002年

作者：（美）michael bayer 姜晓铭杨水超等译

本书以清晰的结构、简练的语言和标准的图像示例对CT进行全面的介绍，并且在本书中还提供了大量的实例以便读者深入理解CT和CTI技术。

ISBN: (数字)7505371169

ISBN: (纸本)7505371169

本书以清晰的结构、简练的语言和标准的图像示例对CT进行全面的介绍，并且在本书中还提供了大量的实例以便读者深入理解CT和CTI技术。

关键词：计算机应用电话通信系统

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Dynamics of Complex Intracontinental Basins 2008

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2008年

作者： Ralf Littke Ulf bayer Dirk Gajewski Susanne Nelskamp

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In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines

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World Journal of Gastroenterology 2007年第22期13卷 3063-3070页

作者： Dennis Hoffmann Wibke bayer Oliver Wildner Department of Molecular and Medical Virology Institute of Microbiology and Hygiene Ruhr-University Bochum Bldg. MA Rm. 6/40 D-44801 Bochum Germany

AIM： To evaluate whether intratumoral expression of measles virus fusogenic membrane glycoproteins H and F （MV-FMG）, encoded by an adenovirus vector ***-HI F, alone or in combination with local coexpression of cytokines （IL-2, IL-12, IL-18, IL-21 or GM-CSF）, can serve as a platform for inducing tumor-specific immune responses in colon cancer.METHODS： We used confocal laser scanning microscopy and flow cytometry to analyze cell-cell fusion after expression of MV-FMG by dye colocalization. In a syngeneic bilateral subcutaneous MC38 and Colon26 colon cancer model in C57BL/6 and BALB/c mice, we assessed the effect on both the directly vector-treated tumor as well as the contralateral, not directly vector- treated tumor. We assessed the induction of a tumorspecific cytotoxic T lymphocyte （CTL） response with a lactate dehydrogenase （LDH） release assay.RESULTS： We demonstrated in vitro that transduction of MC38 and Colon26 cells with ***-H/F resulted in dye colocalization, indicative of cell-cell fusion, in addition, in the syngeneic bilateral tumor model we demonstrated a significant regression of the directly vector-inoculated tumor upon intratumoral expression of MV-FMG alone or in combination with the tested cytokines. We observed the highest anti-neoplastic efficacy with MV-FMG and lL-21 coexpression. The degree of tumor regression of the not directly vector-treated tumor correlated with the anti-neoplastic response of the directly vector-treated tumor. This regression was mediated by a tumor-specific CTL response.CONCLUSION： Our data indicate that intratumoral expression of measles virus fusogenic membrane glycoproteins is a promising tool both for direct tumor treatment as well as for tumor vaccination approaches that can be further enhanced by cytokine coexpression.

关键词： Adenovirus vectors Measles virus fusogenic membrane glycoproteins Colorectal cancer Interleukins

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Response of hydrological drought to meteorological drought in the eastern Mediterranean Basin of Turkey

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Journal of Arid Land 2021年第5期13卷 470-486页

作者： Türkan bayer ALTIN Bekir N ALTIN Department of Geography Faculty of Science and LettersNiğdeÖmer Halisdemir UniversityNiğde 51240Turkey

The hydrographic eastern Mediterranean Basin of Turkey is a drought sensitive *** basin is an important agricultural area and it is necessary to determine the extent of extreme regional climatic changes as they occur in this ***’s correlation coefficient was used to show the correlation between standardized precipitation index(SPI)and standardized streamflow index(SSI)values on different time *** from five meteorological stations and seven stream gauging stations in four sub-basins of the eastern Mediterranean Basin were analyzed over the period from 1967 to *** correlation between SSI and SPI indicated that in response to meteorological drought,hydrological drought experiences a one-year delay then occurs in the following *** is more evident at all stations from the mid-1990 *** main factor causing hydrological drought is prolonged low precipitation or the presence of a particularly dry *** showed that over a long period(12 months),hydrological drought is longer and more severe in the upper part than the lower part of the *** to SPI-12 values,an uninterrupted drought period is observed from 2002–2003 to 2008–*** indicated that among the drought events,moderate drought is the most common on all timescales in all sub-basins during the past 51 ***-term dry periods with moderate and severe droughts are observed for up to 10 years or more since the late 1990 s,especially in the upper part of the *** precipitation increases in late autumn and early winter,the stream flow also increases and thus the highest and most positive correlation values(0.26–0.54)are found in *** values(ranging between–0.11 and–0.01)are weaker and negative in summer and autumn due to low *** is more evident at all stations in *** relation between hydrological and meteorological droughts is more evident,with the correlation values above 0.50 on longer timescales(12-and 24-month

关键词： meteorological drought hydrological drought standardized precipitation index(SPI) standardized streamflow index(SSI) eastern Mediterranean Basin

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Higher Plant Proteins of Cyanobacterial Origin:Are They or Are They Not Preferentially Targeted to Chloroplasts?

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Molecular Plant 2014年第12期7卷 1797-1800页

作者： Roman G.bayer Tina Kostler, Arpit Jain Simon Stael Ingo Ebersberger Markus Teige Department of Biochemistry and Cell Biology MFPLUniversity of ViennaDr Bohr Gasse 9A-1030 ViennaAustria CIBIV—Center for Integrative Bioinformatics Vienna MFPLDr.Bohr Gasse 9A-1030 ViennaAustria Department for Applied Bioinformatics Institute for Cell Biology and NeuroscienceGoethe UniversityMax-von-Laue Str.13D-60438 FrankfurtGermany VIB Department of Plant Systems Biology Ghent UniversityTechnologiepark 9279052 GentBelgium Department of Ecogenomics and Systems Biology University of ViennaAlthanstr 14A-1090 ViennaAustria Department of Applied Genetics and Cell Biology University of Natural Resources and Life SciencesMuthgasse 18A-1190 ViennaAustria

Dear Editor, What does the evolutionary origin of a plant protein tell about its subcellular localization？ Naively thinking, one would assume that plant proteins that were originally encoded in the endosymbiont genome are targeted to the chloroplast. However, published data seem to support only a loose link between evolutionary origin and subcel- lular localization. About half of the Arabidopsis proteins with a detectable cyanobacterial ortholog are targeted to subcellular compartments other than the chloroplast （Martin et al., 2002）. H

关键词： Plant protein The origin of evolution chloroplast

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bayer　COUNTER　CURRENT　SYSTEMS　IN　COMPARISON　WITH　CONVENTIONAL　CO－CURRENT　SYSTEM　IN　THE　FIELD　OF　WATER　TREATMENT

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Chinese Journal of Reactive Polymers 1994年第1期3卷 117-126页

作者： Mitschker. A. RauchfuB. K.,(bayer AG, D--51368 Leverkusen, Germany)

From an economical point of view, both foe quality of the ion exchange resins and the technology used in the field of industrial water treatment are important for a successful *** general, two different technologies have been established on the market. The main differences between the CO-- and counter current technologies will be discussed and data concerning the requirement of chemicale for regeneration and the quality of the deionized water will be *** addition several different varieties of the modern counter current technologies, developed and patented by bayer AG, will be described and the advantages,depending on the application and the demand on the quality of the deionized water,pointed out. In view of stronger regulations concerning the consumption of regeneration chemicals, and waste water, and also because of the superior quality of the produced water, the market share of counter current technologies will continue to increase world--wide.

关键词：拜耳反向电流系统离子交换理论拜耳逆流系统相互流系统水处理

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Integrating Systemic Risk and Risk Analysis Using Copulas

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International Journal of Disaster Risk Science 2018年第4期9卷 561-567页

作者： Stefan Hochrainer-Stigler Georg Pflug Ulf Dieckmann Elena Rovenskaya Stefan Thurner Sebastian Poledna Gergely Boza Joanne Linnerooth-bayer Ake Brannstrom International Institute for Applied Systems Analysis(IIASA) 2361 LaxenburgAustria Department of Statistics and Operations Research University of Vienna1010 ViennaAustria Complexity Science Hub 1080 ViennaAustria Faculty of Computational Mathematics and Cybernetics Lomonosov Moscow State UniversityMoscowRussia 119234 Medical University of Vienna 1090 ViennaAustria Santa Fe Institute Santa FeNM 87501USA Evolutionary Systems Research Group MTA-oK-BLI Centre for Ecological ResearchHungarian Academy of SciencesTihany 8237Hungary Department of Mathematics and Mathematical Statistics Umea University90187 UmeaSweden

Systemic risk research is gaining traction across diverse disciplinary research communities, but has as yet not been strongly linked to traditional, well-established risk analysis research. This is due in part to the fact that systemic risk research focuses on the connection of elements within a system, while risk analysis research focuses more on individual risk to single elements. We therefore investigate how current systemic risk research can be related to traditional risk analysis approaches from a conceptual as well as an empirical point of view. Based on Sklar's Theorem, which provides a one-to-one relationship between multivariate distributions and copulas, we suggest a reframing of the concept of copulas based on a network perspective. This provides a promising way forward for integrating individual risk(in the form of probability distributions) and systemic risk(in the form of copulasdescribing the dependencies among such distributions)across research domains. Copulas can link continuous node states, characterizing individual risks, with a gradual dependency of the coupling strength between nodes on their states, characterizing systemic risk. When copulas are used for describing such refined coupling between nodes,they can provide a more accurate quantification of a system's network structure. This enables more realistic systemic risk assessments, and is especially useful when extreme events(that occur at low probabilities, but have high impacts) affect a system's nodes. In this way, copulas can be informative in measuring and quantifying changes in systemic risk and therefore be helpful in its management. We discuss the advantages and limitations of copulas for integrative risk analyses from the perspectives of modeling, measurement, and management.

关键词： Copulas Individual risk Risk analysis Systemic risk

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