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Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice(Mus musculus)

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 114-118页

作者： Lejan Miguel Alabastro Villareal Rachelle Anne Montes Cruz michael bagui ples Rodel Jonathan Santos Vitor Ⅱ Biology Department College of Science De La Salle University

Objective: To identify the effects of the consumption of non-nutritive sweeteners on memory retention and on the histology of the ***: In this study, 20 mice were used to determine if there is an effect of consuming the maximum allowable dose of the non-nutritive sweeteners on the memory retention and on the histology of the hippocampus. The mice were distributed into four groups and the treatments were given via oral gavage: Group 1(water), Group 2(aspartame: 1 000 mg/kg), Group 3(stevia: 1 000 mg/kg) and Group 4(sucralose:16 000 mg/kg). Treatments were administered to the different experimental groups for 32 days, after which memory retention was tested using the two-day water maze *** the tests, the mice were sacrificed and the brain was analyzed histologically for neurotrophic ***: Based on the results of the two-day water maze protocol, there were no differences between the non-nutritive sweeteners and the control group. However, stevia showed high cellular apoptosis followed by aspartame, sucralose and control ***: There was no significant effect on the memory of the mice. It showed histologically however, that stevia had a significant neurotropic effect compared to the other sweeteners.

关键词： Aspartame Hippocampus Learning Memory Mus musculus Stevia Sucralose

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Hematological effects of Ipomoea batatas(camote) and Phyllanthus niruri(sampa-sampalukan) from Philippines in the ICR mice(Mus musculus)

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 29-33页

作者： Jessa Fidel Montejo Juan Arturo Burgos Mondonedo Matthew Genesis Aguila Lee michael bagui ples Rodel Jonathan Santos Vitor Ⅱ Biology Department College of ScienceDe La Salle University

Objective:To analyze the hematological effects of administering Ipomoea batatas(***)and Phyllanthus niruri(***) in the ICR ***:Powdered leaves of /.batatas and *** were fed to mice for 4 weeks.A total of six groups were used to determine the effect of the plants to the complete blood count of the *** A(blank control) mice were feed with pellets only;Group B(negative control) mice were fed with pellets coated with honey;Group C(low dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 10 g/kg body weight of the mouse;Group D(high dosage) mice were fed with honey-coated pellets and powdered leaves of I,batatas at 20 g/kg body weight of the mouse;Group E(low dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 10 g/kg body weight of the mouse:and Group F(high dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 20 g/kg body weight of the *** blood count was performed on Days 0.14 and ***:It was shown that *** can increase the values of hematocrit and hemoglobin on both the low dose and high dose at Day 28 and red blood cells(RBC) on both Days 14 and28 of *** the other *** can increase *** and hemoglobin on Day 28 with only the low *** were no significant differences with white blood cell,absolute granulocyte,lymphocyte and monocyte,and platelet counts observed for both plant ***:*** and *** have effects on the hematocrit,RBC and hemoglobin levels in mice.

关键词： Camote Hematology ICR mice Ipomea batatas Phyllanthus niruri Sampa-sampalukan

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Simple Regulator Provides±12V from 5V Source

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电源世界 2001年第11期 9-9页

作者： michael Shrivathsan

Many systems require a±12V power supply. Typical exam-ples include analog circuits or RS-232 driver power supplies. The ±12V typically needs to be generated from a SV system bus. The solutions normally used involv... 详细信息

关键词：收稿日期

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