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流程工业 2009年第24期 49-49,51页

作者： michael baer 德国Langewiesen市Silicaglas Ilmenau有限公司

当对流程工艺技术提出很高的绝缘性和纯净度要求时，则必须使用石英法兰。一种新的生产制造工艺——“石英浇铸”工艺利用合成石英制造出高精度的石英法兰，从而使费时费力的热加工和冷加工石英法兰制造工艺成为“过去时”。

关键词：石英法兰制造工艺光洁纯净度绝缘性高精度冷加工

Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook James Gee Lauren Elman Colin Quinn Defne A.Amado michael baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan Penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden Penn Image Computing and Science Lab(PICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDP-43 or TDP-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDP-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TBK1 and TARDBP genes,and a higher proportion of TDP-43 types B,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDP-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

Endogenous bioelectric fields: a putative regulator of wound repair and regeneration in the central nervous system

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Neural Regeneration Research 2016年第6期11卷 861-864页

作者： Matthew L.baer Raymond J.Colello Department of Anatomy & Neurobiology Virginia Commonwealth University

Studies on a variety of highly regenerative tissues, including the central nervous system（CNS） in non-mammalian vertebrates, have consistently demonstrated that tissue damage induces the formation of an ionic current at the site of injury. These injury currents generate electric fields（EF） that are 100-fold increased in intensity over that measured for uninjured tissue. In vitro and in vivo experiments have convincingly demonstrated that these electric fields（by their orientation, intensity and duration） can drive the migration, proliferation and differentiation of a host of cell types. These cellular behaviors are all necessary to facilitate regeneration as blocking these EFs at the site of injury inhibits tissue repair while enhancing their intensity promotes repair. Consequently, injury-induced currents, and the EFs they produce, represent a potent and crucial signal to drive tissue regeneration and repair. In this review, we will discuss how injury currents are generated, how cells detect these currents and what cellular responses they can induce. Additionally, we will describe the growing evidence suggesting that EFs play a key role in regulating the cellular response to injury and may be a therapeutic target for inducing regeneration in the mammalian CNS.

关键词： repair regeneration currents inducing consistently regulating migration potent wound facilitate

Mowing and fertilizer effects on seedling establishment in a successional old field

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Journal of Plant Ecology 2011年第3期4卷 157-168页

作者： David J.Gibson Jared Urban Sara G.baer Department of Plant Biology and Center for Ecology Southern Illinois University CarbondaleCarbondaleIL 62901USA

Aims We used a 10-year field experiment that consisted of mowing and fertilizer treatments to evaluate the role of niche limitation in seedling establishment of species from different functional groups and of varying local abundance in an old field undergoing *** Seedlings of nine different species were planted into a successional field subjected to mowing and fertilizer treatments for 10 years that resulted in different plant communities and resource *** representative of the factorial combination of three functional groups(C4 grasses,C3 grasses and legumes)and three abundance categories(abundant,present,or absent in the old field)were planted in four treatments resulting from the factorial combination of annual spring mowing(mowed and unmowed)and fertilizer application(annually fertilized and unfertilized).Survivorship,relative growth rate(RGR)and biomass were measured to determine the role of niche limitation on recruitment and *** Findings Mowing increased the establishment success of *** had little influence on seedling performance and survivorship.C3 grasses had the highest survivorship,while C4 grasses and legumes had equivalent RGRs,but higher than C3 *** contrast,survivorship of legumes was unrelated to mowing or fertilizer,suggesting that establishment of this functional group was dependent on other,unmeasured conditions or *** already present,but at low abundance,performed better than locally abundant or absent *** limitation may restrict the arrival of a ***,recruitment and establishment was subject to niche limitation,which varied among species,functional groups and whether a species is already resident at the site and its ***,species interactions restrict establishment during old-field succession,supporting the niche limitation hypothesis.

关键词： disturbance niche limitation plant functional group seedlings succession

Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression

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Engineered Regeneration

Engineered Regeneration 2024年第3期5卷 421-431页

作者： Siufui Hendrawan Olivia Marcelina Sukmawati Tansil Tan Hans Ulrich baer Tarumanagara Human Cell Technology Laboratory Faculty of MedicineTarumanagara UniversityJakarta 11440Indonesia Department of Biochemistry and Molecular Biology Faculty of MedicineTarumanagara UniversityJakarta 11440Indonesia Department of Dermato-venereology Faculty of MedicineTarumanagara UniversityJakarta 11440Indonesia baermed Centre of Abdominal SurgeryHirslanden Clinic 8032 ZürichSwitzerland Department of Visceral and Transplantation Surgery University of BernSwitzerland

Conditioned medium(CM)derived from human umbilical cord-mesenchymal stem cells(hUC-MSCs)which con-tains numerous amounts of growth factors,has demonstrated potential in treatment of diabetic ***,for practical application,a biodegradable supporting material is needed to hold the CM and fill in the injury site,where deep cavity wounds are often present in diabetic ***-l-lactic acid matrix coated with collagen(PLLA/CC)is a suitable carrier due to its biodegradability and ***,we present a method to immobilize the hUC-MSCs CM on PLLA/CC through freeze-drying process(PLLA/CC CM FD).When seeded on PLLA/CC CM FD,fibroblasts had an increased cellular function in producing collagen;although no enhancement in cell viability was ***,implantation of PLLA/CC CM FD on the wound of diabetic rats showed improvement in wound closure and collagen deposition in the wound ***,this study exhibits the potential of PLLA/CC CM FD as a therapy for diabetic deep cavity wound.

关键词： PLLA matrix Diabetic wound Conditioned medium Human umbilical cord Mesenchymal stem cell

CROSS-SECTION FORMULAE FOR SPECIFIC PROCESSES

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Chinese Physics C 2016年第10期40卷 570-578页

作者： H. baer R.N. Cahn University of Oklahoma LBNL

PART I： STANDARD MODEL PROCESSES Setting aside leptoproduction （for which, see Sec. 16 of this Review）, the cross sections of primary interest are those with light incident particles, e＋e-, γγ qq, gq , gg, etc., where g and q represent gluons and light quarks. The produced particles include both light particles and heavy ones - t, W, Z, and the Higgs boson H. We provide the production cross sections calculated within the Standard Model for several such processes.

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Adipose-derived mesenchymal stromal/stem cells: An update on their phenotype in vivo and in vitro

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World Journal of Stem Cells 2014年第3期6卷 256-265页

作者： Patrick C baer Division of Nephrology Department of Internal Medicine ⅢGoethe-University

Adipose tissue is a rich, ubiquitous and easily acces-sible source for multipotent stromal/stem cells and has, therefore, several advantages compared to other sourc-es of mesenchymal stromal/stem cells. Several studies have tried to identify the origin of the stromal/stem cell population within adipose tissue in situ. This is a complicated attempt because no marker has currently been described which unambiguously identifies native adipose-derived stromal/stem cells(ASCs). Isolated and cultured ASCs are a non-uniform preparation consisting of several subsets of stem and precursor cells. Cultured ASCs are characterized by their expression of a panel of markers(and the absence of others), whereas their in vitro phenotype is dynamic. Some markers were ex-pressed de novo during culture, the expression of some markers is lost. For a long time, CD34 expression was solely used to characterize haematopoietic stem and progenitor cells, but now it has become evident that it is also a potential marker to identify an ASC subpopula-tion in situ and after a short culture time. Nevertheless, long-term cultured ASCs do not express CD34, perhaps due to the artificial environment. This review gives an update of the recently published data on the origin and phenotype of ASCs both in vivo and in vitro. In addition, the composition of ASCs(or their subpopula-tions) seems to vary between different laboratories andpreparations. This heterogeneity of ASC preparationsmay result from different reasons. One of the main problems in comparing results from different laborato-ries is the lack of a standardized isolation and culture protocol for ASCs. Since many aspects of ASCs, suchas the differential potential or the current use in clinical trials, are fully described in other recent reviews, this review further updates the more basic research issues concerning ASCs' subpopulations, heterogeneity andculture standardization.

关键词： Adipose-derived stromal/stem cells Adi-pose tissue Subpopulation Heterogeneity Phenotype CD34 Mesenchymal stem cells

Measuring Whitespace Pattern Sequences as an Indication of Plagiarism

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Journal of Software Engineering and Applications 2012年第4期5卷 249-254页

作者： Nikolaus baer Robert Zeidman Zeidman Consulting Cupertino USA Zeidman Consulting Cupertino USA.

There are several methods and technologies for comparing the statements, comments, strings, identifiers, and other visible elements of source code in order to efficiently identify similarity. In a prior paper we found that comparing the whitespace patterns was not precise enough to identify copying by itself. However, several possible methods for improving the precision of a whitespace pattern comparison were presented, the most promising of which was an examination of the sequences of lines with matching whitespace patterns. This paper demonstrates a method of evaluating the sequences of matching whitespace patterns and a detailed study of the method’s reliability.

关键词： Plagiarism Source Code Source Code Similarity Whitespace Obfuscation Indentation Maintainability Copyright Infringement Intellectual Property Litigation Open Source

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全球气候模式(GCM)对辐射强迫的响应

应用气象学报 1997年第S1期 79-87页

作者：沈元芳Ｆ．Ｂａｅｒ国家气象中心美国马里兰大学气象系

长波辐射加热（ＬＷＲＨ）对气候预报有显著作用．文章比较了６种取自ＧＣＭ的ＬＷＲＨ算法所产生的加热率廓线，表明在有云情况下，ＬＷＲＨ算法对输入变量的敏感性．ＬＷＲＨ算法对ＧＣＭ变化的敏感性测试结果表明，加热率强烈地依赖... 详细信息

长波辐射加热（ＬＷＲＨ）对气候预报有显著作用．文章比较了６种取自ＧＣＭ的ＬＷＲＨ算法所产生的加热率廓线，表明在有云情况下，ＬＷＲＨ算法对输入变量的敏感性．ＬＷＲＨ算法对ＧＣＭ变化的敏感性测试结果表明，加热率强烈地依赖于模式截断、模式变化（包括长波辐射ＬＷＲ算法）和地表强迫（ＳＳＴ）．引入假观测评价各种ＬＷＲ算法所产生加热率的精确性．在ＣＣＭ２模式中应用ＮＣＡＲ原版本和移植的ＥＣＭＷＦ方案计算ＬＷＲ，结果表明ＥＣＭＷＦ方案比ＣＣＭ２方案在南半球热带地区产生更强的加热率．

关键词：全球气候模式长波辐射加热率假观测响应

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全球气候模式(GCM)对辐射强迫的响应

应用气象学报 1997年第A期8卷 78-86页

作者：沈元芳 F.baer 国家气象中心美国马里兰大学气象系

关键词：全球气候模式辐射强迫加热率天气预报