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Antioxidant, hepatoprotective and nephroprotective activities of Gazania rigens against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats

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Traditional Medicine Research 2022年第5期7卷 29-39页

作者： Alshymaa Abdel-Rhman Gomaa Mamdouh Nabil Samy Eman Zekry Attia Mina Ezzat Attya michael atef fawzy Samar Yehia Desoukey Mohamed Salah Kamel Department of Pharmacognosy Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Pathology Faculty of MedicineMinia UniversityMinia 61519Egypt Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt

Objective:The current study investigated the efficacy of total ethanolic extract and various fractions of Gazania rigens to protect against carbon tetrachloride-induced liver and kidney damage in rats and evaluated their antioxidant ***:The antioxidant activity of the total extract and fractions(petroleum ether,ethyl acetate,and aqueous)of Gazania rigens was examined using 2,2’-diphenyl-1-picrylhydrazyl radical scavenging and phosphomolybdate assays,and their total phenolic and flavonoid contents were *** hepatoprotective and nephroprotective potentials were studied at a dose of 300 mg/kg for six consecutive days followed by induction of hepatorenal injury using carbon tetrachloride single dose(1.5 mL/kg,1:1 v/v in olive oil,intraperitoneal)the next ***:The results revealed the potent hepato and nephroprotective effects of ethyl acetate and aqueous fractions by significantly(P<0.01 or P<0.001)reducing the serum levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,creatinine,urea,triglycerides,cholesterol,and lactate dehydrogenase,along with elevated serum albumin *** improvement of hepatic and renal antioxidant capacities and catalase activities,together with the prominent reduction of hepatic and renal malondialdehyde contents,were confirmed by histopathological ***:The potent hepatoprotective and nephroprotective effects of the total extract and different fractions of Gazania rigens may be attributed to the presence of highly phenolic and flavonoid compounds along with their complementary antioxidant scavenging properties.

关键词： Asteraceae Gazania rigens antioxidant hepatoprotective nephroprotective

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A survey on herbal management of hepatocellular carcinoma

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World Journal of Hepatology 2011年第7期3卷 175-183页

作者： Nabil Mohie Abdel-Hamid Maiiada Hasan Nazmy Ahmed Wahid Mahmoud michael atef fawzy Marco Youssof Bioche mistry Department Unit of Liver cancer researchFaulty of PharmacyMinia University

In this review we outline the different mechanisms mediating hepatocarcinogenesis. We also discuss possible targets of bioactive herbal agents at different stages of hepatocarcinogenesis and highlight their role at each individual stage. We gathered information on the most common herbal prescriptions and extracts thought to be useful in prevention or sensitization for chemotherapy in management of hepatocellular carcinoma (HCC). The value of this topic may seem questionable compared to the promise offered for HCC management by chemotherapy and radiation. However, we would recommend the use of herbal preparations not as alternatives to common chemo /and or radiotherapy, but rather for prevention among atrisk individuals, given that drug/herb interactions are still in need of extensive clarification. The bioactive constituents of various herbs seem to be promising targets for isolation, cancer activity screening and clinical evaluation. Finally, herbal preparations may offer a cost effective protective alternative to individuals known to have a high risk for HCC and possibly other cancers, through maintaining cell integrity, reversingoxidative stress and modulating different molecular pathways in preventing carcinogenesis.

关键词： Active ingredients Chemoprevention Chemo s ensitization Hepatocellular carcinoma Herbs Molecular targets

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