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Using Cgi (Special Edition Using) Special ed.

1996年

作者： Jeffry Dwight michael Erwin Tobin anthony Danny Brands Ron Clark Mike Ellsworth David Geller Galen A. Grimes Matthew D. Healy Greg Knauss Robert Niles Bill Schongar Crispen A. Scott K. Mitchell Thompson Matt Wright

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A new prognostic histopathologic classification of nasopharyngeal carcinoma

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Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

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A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New michael J.Norman Ted Paine anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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“纳”样的生活

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现代装饰（家居） 2015年第9期 54-61页

作者： Andrea Rekalidis Alan Wisniewski anthony Keeler ferm LIVING Flamant j-me Jan Hoekstra Jordan Murphy michael Bang Maria Berntsen Mika Tolvanen Paul Rowan Sarah Bttger StokkeAustad Sung Wook ParkUmbra Theresa Arns 伏平范嘉苑 Nir Meiri Design Studio

日常生活中，家居收纳是不得不面临的一大难题，要想做到好的收纳，同时还能起到装饰美化居室的效果还真得花点心思。“断含离”是由日本杂物管理咨询师山下英子提出的生活理念，所谓“断舍离”就是断绝不需要的东西，舍弃多余的废物，... 详细信息

日常生活中，家居收纳是不得不面临的一大难题，要想做到好的收纳，同时还能起到装饰美化居室的效果还真得花点心思。“断含离”是由日本杂物管理咨询师山下英子提出的生活理念，所谓“断舍离”就是断绝不需要的东西，舍弃多余的废物，脱离对物品的执着，透过整理物品了解自己，整理心中的混沌，让人生轻松而愉快。

关键词：生活理念管理咨询装饰美物品整理人生

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植入型心律转复除颤器放电后患者的诊治

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美国医学会杂志（中文版） 2007年第6期26卷 348-355页

作者： Anil K. Gehi Davendra Mehta J. anthony Gomes 樊颖婕（译）陈新（校） Division of Cardology Emory University School of Medicine Atlanta Ga The Zena and michael A. Wiener Cardiovascular Institute Mount Sinai School of MedicineNew YorkNY 不详

背景：多项大规模临床试验表明，植入型心律转复除颤器（implantable cardioverter-defibrillator，ICD）能够有效降低部分心脏病患者的死亡率。此后，ICD的植入量大幅增加，非电生理专科医生也因此经常会遇到实施ICD电转复除颤的患者... 详细信息

背景：多项大规模临床试验表明，植入型心律转复除颤器（implantable cardioverter-defibrillator，ICD）能够有效降低部分心脏病患者的死亡率。此后，ICD的植入量大幅增加，非电生理专科医生也因此经常会遇到实施ICD电转复除颤的患者。目的：在接受ICD电转复除颤的患者中评估诊疗策略。证据获取：采用下列医学主题词在PubMed和MEDLINE数据库中检索1990年1月至2006年9月发表的文献：defibrillators，implantable（除颤器，植入型）；defibrillmors，implantable／adverse effects（除颤器，植入型／不良反应）；抗心律失常药物（anti-arrhythmic agents）；电除颤（electric countershock）；生活质量（quality of life）；心动过速治疗（tachycardia therapy）；运算法则（algorithm）；室性心动过速／诊断（ventricular tachycardia／diagnosis）；室上性心动过速／诊断（supraventricular tachycardia／diagnosis）。排除病例报告，仅纳入英文文献。参考美国心脏病学会（American College of Cardiology）、美国心脏协会（American Heart Association）、心脏节律学会（Heart Rhythm Society）发布的建议、指南及所附参考文献，获得其他相关文献。证据综合：ICD恰当放电和误放电均有诸多原因。误放电可严重影响患者的生活质量。目前有多种ICD程控技术可有效控制ICD恰当放电和误放电的发生。采用抗心律失常药也能有效减少放电频率。结论：采用有效的ICD程控和抗心律失常药物可在保障ICD急救功能的同时减少ICD放电。对现有各种治疗手段有一个基本的了解是诊治接受ICD放电者的基础。

关键词：植入型心律转复除颤器误放电诊治抗心律失常药物 MEDLINE数据库美国心脏病学会室性心动过速大规模临床试验

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Advanced Microwave Laminate Materials for the Improvement of Efficiency and Reliability in Antennas and Feed Networks

Advanced Microwave Laminate Materials for the Improvement of...

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2009年全国天线年会

作者： George Q. Kang Helena Li Hai John C. Frankosky michael T. Smith Arlon Inc.Materials for Electronics Division 1100 Governor Lea RoadBearDE19701 USA Arlon Inc.Materials for Electronics Division No.8 Hong Gu RoadShanghai 200336 P.R.CHINA

Demands for higher system efficiency and improved product reliability at higher powers and wider operating temperature ranges in mission-critical antennas and feed networks have placed heightened and unique requirements on board materials. To meet these challenges, advanced laminate materials need to possess high electrical phase stability, dielectric constant control, high thermal conductivity and multilayer capability. This paper discusses the importance of critical material properties and explores new material developments for these applications.

关键词： High frequency laminate phase stability thermal conductivity reliability military and space RF antennas

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Calibration and Confidence in Snowplow Fleet Operations and Fleet Telematics

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Journal of Transportation Technologies（交通科技期刊） 2022年第4期

作者： justin anthony mahlberg jairaj desai howell li rahul suryakant sakhare timothy wells darcy michael bullock

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Nitrogen Dioxide and Ozone Pollution in the Chicago Metropolitan Area

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Journal of Environmental Protection（环境保护） 2020年第8期

作者： Zixian Wang Jennifer L.anthony Larry E.Erickson michael J.Higgins Gregory L.Newmark

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雌激素替代疗法治疗轻到中度Alzheimer病：随机对照试验

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美国医学会杂志（中文版） 2000年第6期19卷 282-290页

作者： Ruth A. Mulnard, RN, DNSc anthony Gamst, PhD michael Grundman, MD,MPH Ronald Thomas, PhD Leon J. Thal, MD Alzheimer病协作组 Carl W. Cotman, PhD Claudia Kawas, MD Christopher H. van Dyck, MD Mary Sano, PhD Rachelle Doody, MD, PhD Elizabeth Koss, PhD Eric Pfeiffer, MD Shelia Jin, MD, MPH

背景：几项小型临床试验提示雌激素替代疗法可能有助于女性Alzheimer病（AD）患者的治疗。　　目的：确定雌激素替代疗法能否改善轻到中度女性AD患者总体功能、认知或日常生活能力。　　设计：Alzheimer病协作组于1995年10月至1999年1... 详细信息

背景：几项小型临床试验提示雌激素替代疗法可能有助于女性Alzheimer病（AD）患者的治疗。　　目的：确定雌激素替代疗法能否改善轻到中度女性AD患者总体功能、认知或日常生活能力。　　设计：Alzheimer病协作组于1995年10月至1999年1月进行的一项随机、双盲、安慰剂对照临床试验。　　参加单位：美国32个研究中心。　　受试对象：总共120例轻到中度女性AD患者。细微精神状态检查评分介于12～28分间，既往已行子宫切除术。　　干预：受试者随机服用雌激素0.625 mg/d（n=42）、1.25 mg/d（n=39）或者剂型相同的安慰剂（n=39）。1例患者于随机后接受药物治疗前退出试验；97例完成试验。　　主要结果评定：主要结果评定指标为临床整体印象的改变（CGIC），分值为7分，采用意向治疗(intent-to-treat)分析。次要指标包括其他总评估以及情绪、特殊认知功能（记忆、注意力和语言）、运动功能和日常生活能力；于随访 2、6、12和15个月时，对雌激素组与安慰剂组进行比较。　　结果：雌激素组与安慰剂组CGIC评分为5.1比5.0 (P=0.43)；雌激素组80%的患者恶化，而安慰剂组74%恶化(P=0.48)。除临床痴呆评分提示雌激素组恶化外(雌激素组与安慰剂组相比治疗后平均变化为0.5比0.2，P=0.01)，两组次要结果指标无显著差异。　　结论：雌激素替代治疗1年不能延缓轻、中度女性AD患者病情的进展，整体功能、认知和功能预后亦无改善。研究结果不支持雌激素对这种疾病有治疗作用的结论。雌激素对AD的潜在预防作用尚需进一步研究。

关键词：早老性痴呆雌激素替代疗法

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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo michael Andreeff Jeffery W.Tyner Aaron Schimmer anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Department of Cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance Dana-Farber Cancer Institute BostonMAUSA Department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer Center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina Department of Lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

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