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Journal of Environmental Science and Engineering(A) 2016年第6期5卷 286-293页

作者： Bishambar Dayal Apexa Mehta Sagar Patel Dhaval Shah Priyanka Chitkul michael anthony lea 2 Department of Medicine Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA Department of Microbiology Biochemistry and Molecular Genetics Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA

Recently microwave-induced chemical synthesis of curcumin-metformin adduct to enhance the efficacy of metformin in preventing the formation of Advanced Glycation End Products （AGEs） has been reported from authors＇ laboratory. The present studies describe microwave-induced chemical synthesis and mass spectral characterization of curcumin-phenformin adducts using LC-MS/MS. The mechanism of formation and its analytical data via Thin-Layer Chromatography （TLC） combined with MS/MS fragmentation revealed a major six membered ring adduct and a minor eight membered ring isomer. A facile chemical synthesis and identification of major and minor isomers presented in this study may offer novel therapeutic strategies for inhibiting AGEs as well as anti-cancer treatments.

关键词： Diabetes mellitus advanced glycation end- products glycated human serum albumin curcumin phenformin metformin anti-cancer agents.

Facile Synthetic Design and Characterization of Curcumin-Metformin Adduct： Potential Insights into the Role of This Conjugate in Diseases of Aging

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Journal of Environmental Science and Engineering(B) 2016年第3期5卷 123-130页

作者： Bishambar Dayal Apexa Mehta Abhimanyu Teja Yarramaneni Biren Patel Sagar Patel James Patrick O'Connor michael anthony lea Jesse Chou Department of Medicine Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA Department of Microbiology Biochemistry and Molecular Genetics Rutgers University-New Jersey Medical School Newark NewJersey 07103 USA Department of Chemistry Princeton University Princeton New Jersey 08544 USA

Recently, the anti-glycation and anticancer properties of curcumin longa and okra seed extract were studied alone and also in combination with the well-established drug metformin. The combined effect of curcumin with metformin and metformin with okra seed extract was found to be highly efficacious in inhibiting Advanced Glycation End-products （AGEs）. In order to understand the mechanistic implications of curcumin combined with metformin and its enhanced anti-glycation activity, a Curcumin-Metformin Adduct was chemically synthesized. This adduct was fully characterized by thin-layer chromatography, Nano Drop spectrophotometry and electrospray-ionization mass spectrometry. The adduct may be helpful not only in elucidating the mechanism of anti-glycation and anti-cancer activities but also in studying the role of curcumin in binding of AI3-oligomers and disaggregating fibrillar formation in Alzheimer＇s disease.

关键词： Curcumin metformin diabetes anticarcinogenic.

On Perron’s Formula and the Prime Numbers

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Advances in Pure Mathematics 2024年第6期14卷 487-494页

作者： michael M. anthony Department of Engineering Enertron Inc. Hohenwald Tennessee USA

The Riemann hypothesis is intimately connected to the counting functions for the primes. In particular, Perron’s explicit formula relates the prime counting function to fixed points of iterations of the explicit formula with particular relations involving the trivial and non-trivial roots of the Riemann Zeta function and the Primes. The aim of the paper is to demonstrate this relation at the fixed points of iterations of explicit formula, defined by functions of the form limT∈Ν→∞fT(zw)=zw,where, zwis a real number.

关键词： Perron Fixed Points Iterations Number Theory Riemann Hypothesis Iterations Invariance Primes

Two-stage corrective operation for the treatment of pes cavovarus in patients with spina bifida

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World Journal of Orthopedics 2024年第7期15卷 618-626页

作者： anthony Mack Padgett Ezan Kothari michael J Conklin Department of Orthopedics Indiana UniversityIndianapolisIN 46202United States Department of Orthopaedic Surgery University of Alabama at BirminghamBirminghamAL 35233United States Department of Orthopedic Surgery Children’s of AlabamaBirminghamAL 35233United States

BACKGROUND Pes cavovarus has an estimated incidence of 8%-17%in patients with spina bifida(SB).The majority of the current literature on surgical treatment of cavovarus feet in children and adolescents includes a variety of *** are currently no case series describing a treatment algorithm for deformity correction in this specific patient *** authors of this study present the results of a retrospective case series performed to assess the radiographic outcomes of two-stage corrective surgery in patients with *** Retrospective chart review was performed on patients with SB with a diagnosis of pes cavovarus at a freestanding children’s hospital who underwent surgical correction of the *** were excluded for lack of two-stage corrective operation,nonambulatory status,lack of at least six months follow-up,and age>18 years at the time of *** resulted in a cohort of 19 *** analysis was performed on 11 feet that had a complete series of preoperative and postoperative weightbearing *** and postoperative radiographic outcome measurements were compared using a two-sample *** Significant changes between the preoperative and postoperative measurements were seen in Meary’s angle,the anteroposterior talo-first metatarsal(AP TMT1)angle,and the talonavicular *** values of Meary’s angle were 17.9±13.1 preoperatively and 4.7±10.3 postoperatively(P=0.016).Mean AP TMT1 angle was 20.6±15.1 preoperatively and 9.3±5.5 postoperatively(P=0.011).Mean talonavicular coverage values were-10.3±9.6 preoperatively and-3.8±10.1 postoperatively(P=0.025).CONCLUSION The two-stage corrective procedure demonstrated efficacy in correcting cavovarus deformity in patients with *** should strongly consider employing the staged surgical algorithm presented in this manuscript for management of these patients.

关键词： Cavovarus Spina bifida Osteotomy Plantar release Radiographs Pediatrics

Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient:A case report and review of literature

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World Journal of Clinical Cases 2024年第18期12卷 3561-3566页

作者： Binyamin Ravina Abramowitz michael Coles Ayse Aytaman Bani Chander-Roland Daniel anthony DiLeo Department of Gastroenterology and Hepatology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States Department of Gastroenterology and Hepatology Brooklyn Campus of the Veterans Affairs New York Harbor Healthcare SystemBrooklynNY 11209United States

BACKGROUND It is well-described that the coronavirus disease 2019(COVID-19)infection is associated with an increased risk of thrombotic *** there have been many cases of pulmonary emboli and deep vein thrombosis in these patients,reports of COVID-19 associated portal vein thrombosis(PVT)have been *** present a unique case of concomitant PVT and splenic artery thrombosis in a COVID-19 *** SUMMARY A 77-year-old-male with no history of liver disease presented with three days of left-sided abdominal *** week earlier,the patient was diagnosed with mildly symptomatic COVID-19 and was treated with nirmatrelvir/*** exam revealed mild right and left lower quadrant tenderness,but was otherwise *** laboratory findings included white blood cell count 12.5 K/μL,total bilirubin 1.6 mg/dL,aminoaspartate transferase 40 U/L,and alanine aminotransferase 61 U/*** tomography of the abdomen and pelvis revealed acute PVT with thrombus extending from the distal portion of the main portal vein into the right and left *** noted was a thrombus within the distal portion of the splenic artery with resulting splenic *** workup including prothrombin gene analysis,factor V Leiden,cardiolipin antibody,and JAK2 mutation were all *** with enoxaparin was initiated,and the patient’s pain *** was discharged on *** It is quite uncommon for PVT to present simultaneously with an arterial thrombotic occlusion,as in the case of our *** thrombotic manifestations are classically linked to hypercoagulable states including malignancy and hereditary and autoimmune *** infections such as Epstein-Barr virus,cytomegalovirus,viral hepatitis,and COVID-19 have all been found to increase the risk of splanchnic venous occlusions,including *** our patient,prompt abdominal imaging led to early detection of thrombus,early treatment,and an exce

关键词： COVID-19 Thromboembolism Portal vein thrombosis Splenic artery thrombosis Anticoagulation Lovenox Thrombotic complication Case report

Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-Yin Chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat michael Wong anthony Chi-Fai Ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： TheFundamentalsof Laparoscopic Surgery The Objective Structured Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

Unilateral mimicking bilateral BPPV- a forgotten entity? Characteristics of a largecohort of patients, comparison with posterior canal BPPV and clinical implications

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Journal of Otology 2021年第4期16卷 252-257页

作者： lea Pollak Ronit Gilad Tal michael Neurology and Dizziness Clinic Kupat Cholim Macabi and the Ben GurionUniversity of the NegevBeer ShevaIsrael Neurology Department Kaplan Medical CenterRechovotAffiliated to the HebrewUniversityJerusalemIsrael The Faculty of Health Public Ben Gurion University of the NegevBeerShevaIsrael

Objective: Unilateral mimicking bilateral benign paroxysmal positional vertigo (umb-BPPV) was attributed to inappropriate head positioning during testing of the posterior canal. Despite its inclusion in theDiagnostic criteria for the classification of vestibular disorders of the Barany Society, the clinical characteristics and treatment responsiveness of this BPPV subtype have not been intensively ***: Records of patients with BPPV seen at a single outpatient dizziness clinic during the years 2000e2020 were reviewed. Eighty seven patients with umb-BPPV and 86 random patients with posteriorcanal BPPV (p-BPPV) were retrieved. Their demographics and BPPV characteristics were ***: Patients' and BPPV characteristics were similar in umb- and p-BPPV except for the prevalence ofmales in the umb-BPPV group. No differences were found between treatment responsiveness and recurrences in both groups. The recurrence rate of umb-BPPV was not influenced by age, gender, BPPV side,duration of symptoms or treatment responsiveness during the first ***: In accordance with our hypothesis about mixed canalo- and cupulolithiasis as the underlying mechanism of umb-BPPV, patients did not differ in characteristics and treatment responsivenessfrom p-BPPV patients. Recognition of umb-BPPV is important since inappropriate treatment can cause anunnecessary delay in therapy success.

关键词： Benign paroxysmal positional vertigo Canalo-and cupulolithiasis

Growth inhibition of colon cancer cells by compounds affecting AMPK activity

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World Journal of Gastrointestinal Oncology 2014年第7期6卷 244-252页

作者： michael A lea Jacob Pourat Rupali Patel Charles desBordes Department of Biochemistry and Molecular Biology New Jersey Medical School Rutgers University Newark NJ 07103 United States Department of Biology Medgar Evers Col-lege-City University of New York Brooklyn NY 11225 United States

AIM:To determine if other molecules reported to modulate AMP-dependent protein kinase(AMPK)activ-ity would have effects resembling those of metformin and phenformin on colon cancer cell proliferation and ***:Studies were performed with four hu-man colon cancer cell lines,Caco-2,HCT116,HT29 and *** compounds that were studied included A-769662,5-aminoimidazole-4-carboxamide-1-ribofu-ranoside,butyrate,(-)-epigallocatechin gallate(EGCG),KU-55933,quercetin,resveratrol and *** parameters that were measured were cell proliferation and viability,glucose uptake,lactate production and acidification of the incubation ***:Investigations with several molecules that have been reported to be associated with AMPK activa-tion(A-769662,5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside,EGCG,KU-55933,quercetin,resve-ratrol and salicylates)or AMPK inhibition(compound C)failed to reveal increased medium acidification and increased glucose uptake in colon cancer cells as previ-ously established with metformin and *** only exception was 5-aminosalicylic acid with which there were apparently lower glucose levels in the me-dium after incubation for 72 *** study in the absence of cells revealed that the effect was an artifact due to inhibition of the enzyme-linked glucose *** compounds were studied at concentrations that inhibited cell ***:It was concluded that treatment with several agents that can affect AMPK activity resulted in the inhibition of the proliferation of colon cancer cells under conditions in which glucose metabolism is not enhanced,in contrast to the effect of biguanides.

关键词： Colon cancer cells Proliferation AMP-dependent protein kinase Glucose metabolism

Diversity, abundance, and structure of tree communities in the Uluguru forests in the Morogoro region, Tanzania

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Journal of Forestry Research 2015年第3期26卷 557-569页

作者： David Sylvester Kacholi anthony michael Whitbread Martin Worbes Crop Production Systems in the Tropics Georg-August University Goettingen Grisebachstr. 6 37077 GoettingenGermany Department of Biological Sciences Dar es Salaam University College of Education (DUCE)P. O. Box 2329 Dar es Salaam Tanzania International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324 Andhra PradeshIndia

Uluguru forests are globally recognized as important biodiversity hotspots, but anthropogenic pressure threatens their value. This study examined species diver- sity, abundance, and structure of trees in the Uluguru for- ests. All trees of diameter at breast height （DBH）〉 10 cm were inventoried in seven forests ranging from 3 to 995 ha in area. A total of 900 stems, 101 species and 34 families were inventoried. Fabaceae was the most speciose family. Ehretia amoena Klotzsch was the most abundant species with relative abundance of 9.22 %. The forests differed significantly in species richness （26-93 species ha-l）, tree density （85-390 stems ha-l）, basal area （3-24 m2 ha-1） and Shannon-Wiener diversity （2.50--4.02）. Forest area was significantly and positively correlated with species richness （r = 0.92） and species diversity （r = 0.95）. Tree density showed significant positive correlation with speciesrichness （r = 0.80） and basal area （r = 0.85）. Milawilila and Nemele forests had highest floristic similarity （0.55） followed by Kimboza and Kilengwe （0.54） while the rest had similarity coefficients of less than 0.50. Despite leg- islative protection, many forests remain at risk and there- fore the possibility to conserve highly valuable tree species via enhanced protection or cultivation must be considered.

关键词： Eastern arc Biodiversity Disturbance Hotspots Similarity

An Inchworm-inspired Robot Based on Modular Body, Electronics and Passive Friction Pads Performing the Two-anchor Crawl Gait

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Journal of Bionic Engineering 2018年第5期15卷 820-826页

作者： Flavio Moreira anthony Abundis michael Aguirre Justin Castillo Pranav A. Bhounsule Robotics and Motion Laboratory Department of Mechanical Engineering The University of Texas at San Antonio One UTSA Circle San Antonio rX78249 USA

We have created an inchworm robot capable of the two-anchor crawl gait on level ground and inclined plane. The main novelty is in the design of the inchworm：（1） three-part body that is 3D printed and actuated by two servo motors to allow a looping and lengthening action, （2） passive friction pads to anchor the feet, each of which may be disengaged using a servo motor actuated lever arm, and （3） modular body and electronics. The robot is about 2 feet （61 cm） in length, has a mass of about 4 kg, and uses an open-loop controller to achieve steady crawling gait. The inchworm robot achieved a speed of 2.54 *** on level ground as well as on an incline plane of 19~. The energy usage as measured by the Mechanical Cost of Transport （a non-dimensional number defined as the energy used per unit weight per unit distance moved） is 3.34. Our results indicate that simple robotic designs that copy the basic features of natural organisms provide a promising alternative over conventional wheeled robots.

关键词： inchworm bioinspiration two-anchor crawl gait 3D printing sliding locomotion cost of transport