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Production of meta.lic iron na.opa.ticles in a.ba.fled stirred ta.k rea.tor: Optimiza.ion via.computa.iona. fluid dyna.ics simula.ion

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Pa.ticuology 2020年第5期18卷 83-96页

作者： Giorgio Vila.di Nicola.verdone Sa.ienza.University of Rome Department of Chemical Engineering Materials EnvironmentVia Eudossiana 1800184RomeItaly

The a.m of this work is to optimize iron na.opa.ticle production in stirred ta.k rea.tors equipped with two cla.sica. impellers:Rushton a.d four-pitched bla.e turbines,which a.e la.gely used in ba.ch industria. synthesis a.d efficient *** ma.n opera.ive pa.a.eters of na.opa.ticle synthesis a.e the precursor initia. concentra.ion,reducing a.ent/precursor mola. ra.io,impeller-ta.k clea.a.ce,a.d impeller rota.iona. *** pa.a.eters were va.ied during the synthesis to find the optima. opera.ing va.ues ba.ed on the Fe(0)(%)production,zeta.potentia.,pa.ticle size distribution,a.d powder X-ra. diffra.tion pa.tern *** found tha. the optima. opera.ing conditions for na.opa.ticle production were a. impeller velocity of 1500 rpm,initia. iron precursor concentra.ion of 20 mM,mola. ra.io of reducing a.ent to iron precursor of 3 mol/mol,a.d impeller clea.a.ce of 0.25 a.d 0.4 times the vessel dia.eter for Rushton a.d four-pitched bla.e impellers,*** these conditions a.hieved a.tota. conversion of 0.94-0.98 a.d yielded a.product with a.unimoda. size distribution a.d a.era.e dia.eters in the ra.ge 30-50 *** computa.iona. fluid dyna.ics results a.reed with the expecta.ions,a.d the obta.ned mixing Da.kohler numbers show tha. the process is mixed controlled.

关键词： Na.o zero-va.ent iron Computa.iona. fluid dyna.ics Turbulence Micromixing Length sca.e

Like a.G6-na.:tra.scriptiona. control of G-protein coupled receptors during oligodendroglia. development

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2001-2002页

作者： Tim a.erle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multila.ered control of myelina.ion:Quick,sa.ta.ory conduction of a.tion potentia.s a.ong nerve fibers requires the electrica. insula.ion of a.ons by myelina.ing *** the centra. nervous system,this role is ta.en up by *** a.e ma.ked by the expression of the linea.e determina.ts Sox10 a.d Olig2 a.d a.ise from oligodendrocyte precursor cells(OPCs)during embryona. *** the ma.ority of OPCs differentia.e into ma.ure oligodendrocytes when nea.by a.ona. segments require myelina.ion,a.sma.l subpopula.ion of OPCs persist a. a.progenitor ***,the timing of myelina.ion a.d ma.ntena.ce of the OPC pool both need to be precisely *** tra.scription fa.tors either positively or nega.ively a.fect oligodendrocyte differentia.ion a.d ma.ntena.ce of the OPC pool a. components of a.complex gene regula.ory network(reviewed in Sock a.d Wegner,2021).Network a.tivity is a.ditiona.ly influenced by extra.ellula. signa.ing molecules tha. bind to receptors on the oligodendroglia. cell surfa.e a.d a.tiva.e intra.ellula. signa.ing *** the receptors a.e linked to the network is poorly understood so fa.,but pivota. to understa.ding the overa.l regula.ion of centra. nervous system(CNS)myelina.ion in response to environmenta. *** insights were recently ga.ned for Gpr37(Schmidt et a..,2024),a.G-protein coupled receptor(GPCR)with known releva.ce in differentia.ing oligodendrocytes(Ya.g et a.,2016).

关键词： ga.ned insula.ion conduction

Emerging structures a.d dyna.ic mecha.isms ofγ-secreta.e for a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. michael S.Wolfe Computa.iona. Medicine Progra. a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of Medicina. Chemistry University of KansasLawrenceKSUSA

γ-Secreta.e,ca.led“the protea.ome of the membra.e,”is a.membra.e-embedded protea.e complex tha. clea.es 150+peptide substra.es with centra. roles in biology a.d medicine,including a.yloid precursor protein a.d the Notch fa.ily of cell-surfa.e *** inγ-secreta.e a.d a.yloid precursor protein lea. to ea.ly-onset fa.ilia. a.zheimer’s disea.e.γ-Secreta.e ha. thus served a. a.critica. drug ta.get for trea.ing fa.ilia. a.zheimer’s disea.e a.d the more common la.e-onset a.zheimer’s disea.e a. ***,critica. ga.s rema.n in understa.ding the mecha.isms of processive proteolysis of substra.es,the effects of fa.ilia. a.zheimer’s disea.e muta.ions,a.d a.losteric modula.ion of substra.e clea.a.e byγ-*** this review,we focus on recent studies of structura. dyna.ic mecha.isms ofγ-*** mecha.isms,including the“Fit-Sta.-Trim,”“Sliding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been proposed for substra.e proteolysis of a.yloid precursor protein byγ-secreta.e ba.ed on a.l-a.om molecula. dyna.ics *** a. incorrect registry of the Notch1 substra.e wa. identified in the cryo-electron microscopy structure of Notch1-boundγ-secreta.e,molecula. dyna.ics simula.ions on a.resolved model of Notch1-boundγ-secreta.e tha. wa. reconstructed using the a.yloid precursor protein-boundγ-secreta.e a. a.templa.e successfully ca.turedγ-secreta.e a.tiva.ion for proper clea.a.es of both wildtype a.d muta.t Notch,being consistent with biochemica. experimenta. *** a.proa.h could be potentia.ly a.plied to decipher the processing mecha.isms of va.ious substra.es byγ-*** a.dition,controversy over the effects of fa.ilia. a.zheimer’s disea.e muta.ions,pa.ticula.ly the issue of whether they sta.ilize or desta.ilizeγ-secreta.e-substra.e complexes,is ***,a. outlook is provided for future studies ofγ-secreta.e,including pa.hwa.s of substra.e binding a.d product relea.e,effects of modula.ors on fa.ilia. a.zheimer’s disea.e muta.ions

关键词： a.zheimer’s disea.e a.yloid precursor protein cryo-EM structures drug design intra.embra.e proteolysis molecula. dyna.ics Notch

NECa. fa.ily of neurona. ca.cium-binding proteins in hea.th a.d disea.e

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Scha.er Sudena.Wa.g michael J.Schmeisser a.el Methner Institute for Molecula. Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Depa.tment of a.esthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of a.a.omy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-termina. EF-ha.d ca.cium-binding proteins 1–3(NECa.1–3) constitute a.fa.ily of predomina.tly neurona. proteins cha.a.terized by the presence of a. lea.t one EF-ha.d ca.cium-binding doma.n a.d a.functiona.ly less well cha.a.terized C-termina. a.tibiotic biosynthesis monooxygena.e doma.n. a.l three fa.ily members were initia.ly discovered due to their intera.tions with other proteins. NECa.1 a.socia.es with syna.tota.min-1, a.critica. neurona. protein involved in membra.e tra.ficking a.d syna.tic vesicle exocytosis. NECa.2 intera.ts with predomina.tly stria.a. G-protein-coupled receptors, while NECa.3 pa.tners with a.yloid-β a. precursor protein-binding fa.ily a.members 2 a.d 3, key regula.ors of a.yloid-β production. This demonstra.es the ca.a.ity of the fa.ily for intera.tions with va.ious cla.ses of proteins. NECa. proteins exhibit distinct subcellula. loca.iza.ions: NECa.1 is found in the nucleus a.d cytosol, NECa.2 resides in endosomes a.d the pla.ma.membra.e, a.d NECa.3 is present in the endopla.mic reticulum a.d Golgi a.pa.a.us. The a.tibiotic biosynthesis monooxygena.e doma.n, a. evolutiona.ily a.cient component, is a.in to a.ypica. heme oxygena.es in proka.yotes but is not wellcha.a.terized in vertebra.es. Proka.yotic a.tibiotic biosynthesis monooxygena.e doma.ns typica.ly form dimers, suggesting tha. ca.cium-media.ed conforma.iona. cha.ges in NECa. proteins ma. induce a.tibiotic biosynthesis monooxygena.e doma.n dimeriza.ion, potentia.ly a.tiva.ing some enzyma.ic properties. However, the substra.e for this enzyma.ic a.tivity rema.ns uncerta.n. a.terna.ively, ca.cium-media.ed conforma.iona. cha.ges might influence protein intera.tions or the subcellula. loca.iza.ion of NECa. proteins by controlling the a.a.la.ility of protein–protein intera.tion doma.ns situa.ed between the EF ha.ds a.d the a.tibiotic biosynthesis monooxygena.e doma.n. This review summa.izes wha. is known a.out genomic orga.iza.ion, tissue expression, intra.ellula. loca.iza.ion, intera.

关键词： ca.cium EF ha.d mitochondria nervous system signa. tra.sduction

Hea.y meta.s a.sorption by ba.a.a.peels micro-powder: Equilibrium modeling by non-linea. models

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Chinese Journa. of Chemica. Engineering 2018年第3期26卷 455-464页

作者： Giorgio Vila.di Luca.Di Pa.ma.Nicola.verdone Sa.ienza.University of Rome Department of Chemical Engineering Materials Environment

In this study the copper a.d lea. a.sorption efficiency onto ba.a.a.peels powder wa. investiga.ed. The a.roindustria. wa.te recovery represents one of the Circula. Economy pilla.s. In the view of the synthesis of a. environmenta.ly friendly a.sorbent ma.eria., the powder wa. used without a.y prelimina.y chemica. or therma. a.tiva.ion, but only a.ter simple wa.hing, drying a.d grinding. The bio-a.sorbent wa. cha.a.terized by the FTIR technique a.d tested in ba.ch mode on synthetic a.ueous solutions conta.ning Pb a.d Cu in the ra.ge 10–90 mg·L^(-1). a.selection of two(La.gmuir, Freundlich) a.d three(Sips, Redlich–Peterson, Koble–Corriga.) pa.a.eter isotherm models wa. chosen to fit a.sorption equilibrium da.a.by non-linea. regression procedure. The best fit isotherm model wa. selected relying on the error function with the lowest a.era.e percenta.e error(a.E) va.ue, a.ong those cha.a.terized by the highest R^2 va.ues. a. expected, the three-pa.a.eter models a.e found to better represent both meta.s bio-a.sorption, with a.E a.d R^2 va.ues a.wa.s lower a.d higher, respectively, tha. the corresponding va.ues obta.ned for the two-pa.a.eter models.

关键词： Ba.a.a.peel Hea.y meta.s Bio-a.sorbent Non-linea. model FIIR

Sma.l extra.ellula. vesicles derived from cerebra. endothelia. cells with eleva.ed microRNa.27a.promote ischemic stroke recovery

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 224-233页

作者： Yi Zha.g Zhongwu Liu michael Chopp michael Millma. Ya.feng Li Pa.qua.e Ceppa.ulo a.y Kemper Cha. Li Li Zha.g Zheng Ga.g Zha.g Depa.tment of Neurology Henry Ford HospitalDetroitMIUSA Depa.tment of Physics Oakland UniversityRochesterMIUSA Depa.tment of Pa.hology Henry Ford HospitalDetroitMIUSA Division of Pha.ma.ology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

a.ona. remodeling is a.critica. a.pect of ischemic bra.n repa.r processes a.d contributes to sponta.eous functiona. *** previous in vitro study demonstra.ed tha. exosomes/sma.l extra.ellula. vesicles(sEVs)isola.ed from cerebra. endothelia. cells(CEC-sEVs)of ischemic bra.n promote a.ona. growth of embryonic cortica. neurons a.d tha. microRNa.27a.miR-27a.is a. eleva.ed miRNa.in ischemic *** the present study,we investiga.ed whether norma. CEC-sEVs engineered to enrich their levels of miR-27a.27a.sEVs)further enha.ce a.ona. growth a.d improve neurologica. outcomes a.ter ischemic stroke when compa.ed with trea.ment with non-engineered CEC-sEVs.27a.sEVs were isola.ed from the conditioned medium of hea.thy mouse CECs tra.sfected with a.lentivira. miR-27a.expression *** EVs isola.ed from CECs tra.sfected with a.scra.ble vector(Scra.sEVs)were used a. a.*** ma.e mice were subjected to perma.ent middle cerebra. a.tery occlusion a.d then were ra.domly trea.ed with 27a.sEVs or *** a.ra. of beha.ior a.sa.s wa. used to mea.ure neurologica. *** with trea.ment of ischemic stroke with Scra.sEVs,trea.ment with 27a.sEVs significa.tly a.gmented a.ons a.d spines in the peri-infa.ct zone a.d in the corticospina. tra.t of the spina. grey ma.ter of the denerva.ed side,a.d significa.tly improved neurologica. *** vitro studies demonstra.ed tha. CEC-sEVs ca.rying reduced miR-27a.a.olished 27a.sEV-a.gmented a.ona. *** a.a.ysis revea.ed tha. 27a.sEVs systemica.ly a.ministered preferentia.ly loca.ized to the pre-syna.tic a.tive zone,while qua.tita.ive reverse tra.scription-polymera.e cha.n rea.tion a.d Western Blot a.a.ysis showed eleva.ed miR-27a.a.d reduced a.ona. inhibitory proteins Sema.horin 6a.a.d Ra. Homolog Fa.ily Member a.in the peri-infa.ct *** of the Cla.hrin-dependent endocytosis pa.hwa. substa.tia.ly reduced neurona. interna.iza.ion of *** da.a.provide evidence tha. 27a.sEVs ha.e

关键词： a.ona. remodeling cerebra. endothelia. cells exosomes miR-27a mitochondria Sema.horin 6A sma.l extra.ellula. vesicles stroke

a.ute a.d chronic excitotoxicity in ischemic stroke a.d la.e-onset a.zheimer's disea.e

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1981-1988页

作者： Sha. Ping Yu Emily Choi michael QJia.g Ling Wei Depa.tment of a.esthesiology Emory University School of MedicineAtlantaGAUSA Center for Visua. a.d Neurocognitive Reha.ilita.ion Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke a.d a.zheimer's disea.e a.e common neurologica. disorders a.d often occur in the sa.e *** comorbidity of the two neurologica. disorders represents a.gra.e hea.th threa. to older *** review presents a.brief ba.kground of the development of novel concepts a.d their clinica. *** a.tivity of gluta.a.ergic N-methyl-D-a.pa.ta.e receptors a.d N-methyl-D-a.pa.ta.e receptor-media.ed Ca.(2+)influx is critica. for neurona. *** ischemic insult induces prompt a.d excessive gluta.a.e relea.e a.d dra.tic increa.es of intra.ellula. Ca.(2+)ma.nly via.N-methyl-D-a.pa.ta.e receptors,pa.ticula.ly of those a. the extra.yna.tic *** Ca.(2+)-evoked neurona. cell dea.h in the ischemic core is domina.ed by necrosis within a.few hours a.d da.s known a. a.ute ***,mild but susta.ned Ca.(2+)increa.es under neurodegenera.ive conditions such a. in the dista.t penumbra.of the ischemic bra.n a.d ea.ly sta.es of a.zheimer's disea.e a.e not immedia.ely toxic,but gra.ua.ly set off deteriora.ing Ca.(2+)-dependent signa.s a.d neurona. cell loss mostly beca.se of a.tiva.ion of progra.med cell dea.h *** on the Ca.(2+)hypothesis of a.zheimer's disea.e a.d recent a.va.ces,this Ca.(2+)-a.tiva.ed“silent”degenera.ive excitotoxicity evolves from yea.s to deca.es a.d is recognized a. a.unique slow a.d chronic *** N-methyl-D-a.pa.ta.e receptor subunit GluN3a.prima.ily a. the extra.yna.tic site,serves a. a.ga.ekeeper for the N-methyl-D-a.pa.ta.e receptor a.tivity a.d is neuroprotective a.a.nst both a.ute a.d chronic *** stroke a.d a.zheimer's disea.e,therefore,sha.e a. N-methyl-D-a.pa.ta.e receptor-a.d Ca.(2+)-media.ed mecha.ism,a.though with much different time *** is thus proposed tha. ea.ly interventions to control Ca.(2+)homeosta.is a. the preclinica. sta.e a.e pivota. for individua.s who a.e susceptible to spora.ic la.e-onset a.zheimer's disea.e a.d a.zheimer's disea.e-rela.ed

关键词： Ca.(2+)hypothesis cognitive deficits hypera.tivity la.e-onset a.zheimer's disea.e neurodegenera.ion N-methyl-D-a.pa.ta.e receptors N-methyl-D-a.pa.ta.e receptor subunits pa.hogenesis preventive trea.ment

Best opera.ing conditions to produce hydroxya.a.ite na.opa.ticles by mea.s of a.spinning disc rea.tor

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Frontiers of Chemica. Science a.d Engineering 2014年第2期8卷 156-160页

作者： a. F. D' Intino B. de Ca.ra.iis M.L. Sa.ta.elli N. verdone a. Chia.ese Depa.tment of Chemica. Engineering Sapienza University via Eudossiana 00184 Rome Italy

In this work, Mg2＋ doped hydroxya.a.ite （Mg-Ha.） na.opa.ticles were produced by a.rea.tionprecipita.ion process by using a.spinning disc rea.tor （SDR） a. high rota.iona. speed. The production process of these na.opa.ticles consisted of the neutra.iza.ion rea.tion between two a.ueous solutions of ca.cium chloride a.d a.monia.orthophospha.e a. room tempera.ure. By opera.ing a. pH = 10, a.high purity Mg-Ha. na.opa.ticles were obta.ned. In pa.ticula., they were 51 nm in a.era.e size when the two rea.ents were fed over the disc symmetrica.ly a. 3 cm from the disc center a.d a.rota.iona. speed of the disc rea.tor equa. to 1400 r/min wa. a.opted.

关键词： hydroxya.a.ite na.opa.ticles spinning discrea.tor

Ca.l it sleep-wha. a.ima.s without ba.kbones ca. tell us a.out the phylogeny of intrinsica.ly genera.ed neuromotor rhythms during ea.ly development

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Neuroscience Bulletin 2013年第3期29卷 373-380页

作者： michael a. Corner Netherla.ds Institute for Bra.n Resea.ch Amsterdam The Netherlands Université de Ba.se Norma.die Caen France Ha.moniehof 16/i 1071TC Amsterdam The Netherlands

a.comprehensive overview is presented of the litera.ure dea.ing with the development of sleep-like motility a.d neurona. a.tivity pa.terns in non-vertebra.e a.ima.s. It ha. been esta.lished tha. sponta.eous, periodica.ly modula.ed, neurogenic bursts of movement a.pea. to be a.universa. fea.ure of prena.a. beha.ior. New empirica. da.a.a.e presented showing tha. such ＇seismic sleep＇ or ＇ra.id-body-movement＇ bursts in cuttlefish persist for some time a.ter birth. Extensive ontogenetic resea.ch in both vertebra.es a.d non-vertebra.es is thus essentia. before current hypotheses a.out the phylogeny of motorica.ly a.tive sleep-like sta.es ca. be ta.en seriously.

关键词： sleep phylogeny beha.ior development sponta.eous motility neurona. networks cuttlefish