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Rea.-Time Prediction a.gorithm for Intelligent Edge Networks with Federa.ed Lea.ning-Ba.ed Modeling

Computers, Ma.eria.s & Continua 2023年第11期77卷 1967-1983页

作者： Seungwoo Ka.g Seyha.ros.Inseok Song Prohim Ta. Sa.Ma.h Seokhoon Kim Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Telecommunica.ion a.d Electronic Engineering Royal University of Phnom PenhPhnom Penh12156Cambodia Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea

Intelligent hea.thca.e networks represent a.significa.t component in digita. a.plica.ions,where the requirements hold within qua.ity-of-service(QoS)relia.ility a.d sa.egua.ding *** pa.er a.dresses these requirements through the integra.ion of ena.ler pa.a.igms,including federa.ed lea.ning(FL),cloud/edge computing,softwa.edefined/virtua.ized networking infra.tructure,a.d converged prediction *** study focuses on a.hieving relia.ility a.d efficiency in rea.-time prediction models,which depend on the intera.tion flows a.d network *** response to these cha.lenges,we introduce a.modified version of federa.ed logistic regression(FLR)tha. ta.es into a.count convergence la.encies a.d the a.cura.y of the fina. FL model within hea.thca.e *** esta.lish the FLR fra.ework for mission-critica. hea.thca.e a.plica.ions,we provide a.comprehensive workflow in this pa.er,introducing fra.ework setup,itera.ive round communica.ions,a.d model eva.ua.ion/*** optimiza.ion process delves into the formula.ion of loss functions a.d gra.ients within the doma.n of federa.ed optimiza.ion,which concludes with the genera.ion of service experience ba.ches for model *** a.sess the pra.tica.ity of our a.proa.h,we conducted experiments using a.hypertension prediction model with da.a.sourced from the 2019 a.nua. da.a.et(Version 2.0.1)of the Korea.Medica. Pa.el *** metrics,including end-to-end execution dela.s,model drop/delivery ra.ios,a.d fina. model a.cura.ies,a.e ca.tured a.d compa.ed between the proposed FLR fra.ework a.d other ba.eline *** study offers a. FLR fra.ework setup for the enha.cement of rea.-time prediction modeling within intelligent hea.thca.e networks,a.dressing the critica. dema.ds of QoS relia.ility a.d priva.y preserva.ion.

关键词： Edge computing federa.ed logistic regression intelligent hea.thca.e networks prediction modeling priva.y-a.a.e a.d rea.-time lea.ning

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a.Ca.ionic [60] Fullerene Deriva.ive Reduces Inva.ion a.d Migra.ion of HT-29 CRC Cells in Vitro a. Dose Free of Significa.t Effects on Cell Surviva.

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Na.o-Micro Letters 2014年第2期6卷 163-168页

作者： Ma.ia.na.Luca.ò Chia.a.Pelillo Ma.co Ca.ini Ta.ia.a.Da.ros.Ma.rizio Pra.o Gia.ni Sa.a Depa.tment of Life Sciences University of Trieste Depa.tment of Chemica. a.d Pha.ma.eutica. Sciences University of Trieste

Na.oma.eria.s with unique cha.a.teristics exhibit fa.ora.le thera.eutic a.d dia.nostic properties,implying their enormous potentia. a. biomedica. ca.dida.es. C60 ha. been used in gene- a.d drug-delivery, a. ima.ing a.ents, a.d a. photosensitizers in ca.cer thera.y. In this study, the influences of a.ca.ionic functiona.ized fullerene on cellula. beha.ior of huma. colorecta. ca.cer cell line(HT-29) were investiga.ed. Results indica.ed tha. HT-29 trea.ed with the studied compound showed a.lower sensitivity but a.significa.t impa.rment in migra.ion a.d inva.ion by interfering with the a.tivities of ma.rix meta.loproteina.es(MMP-2 a.d9). The presence of fullerene a.so a.tered the ca.a.ity of a.hesion-rela.ed proteins to perform their a.tivity,thereby inducing dra.a.ica.ly a.verse effects on the cell physiologica. functions such a. cell a.hesion. Thus,our study suggests tha. this compound is a.new potentia. a.ti-meta.ta.ic effector a.d a.thera.eutic component for ma.igna.t colorecta. ca.cer.

关键词： Fullerene Ca.cer a.ti-meta.ta.ic drug Na.omedicine

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Ca.bon Dioxide/Metha.e Sepa.a.ion by a.sorption on Sepiolite

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Journa. of Na.ura. Ga. Chemistry 2007年第3期16卷 235-243页

作者： José a.Delga.o Ma.ía.a.Uguina.José L.Sotelo Bea.riz Ruíz Ma.cio ros.rio Depa.tment of Chemica. Engineering Universidad Complutense de Madrid28040Madrid.Spain

In this work, the use of sepiolite for the remova. of ca.bon dioxide from a.ca.bon dioxide/metha.e mixture by a.pressure swing a.sorption （PSa. process ha. been resea.ched. a.sorption equilibrium a.d kinetics ha.e been mea.ured in a.fixed-bed, a.d the a.sorption equilibrium pa.a.eters of ca.bon dioxide a.d metha.e on sepiolite ha.e been obta.ned. a.model ba.ed on the LDF a.proxima.ion ha. been employed to simula.e the fixed-bed kinetics, using the La.gmuir equa.ion to describe the a.sorption equilibrium isotherm. The functioning of a.PSa.cycle for sepa.a.ing ca.bon dioxide/metha.e mixtures using sepiolite a. a.sorbent ha. a.so been studied. The experimenta. results were compa.ed with the ones predicted by the model a.a.ted to a.PSa.system. Metha.e with purity higher tha. 97% ca. be obta.ned from feeds conta.ning ca.bon dioxide with concentra.ions ra.ging from 34% to 56% with the proposed PSa.cycle. These results suggest tha. sepiolite is a. a.sorbent with good properties for its employment in a.PSa.cycle for ca.bon dioxide remova. from la.dfill ga.es.

关键词： ca.bon dioxide metha.e sepiolite a.sorption fixed-bed pressure swing a.sorption

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Modified mesenchyma. stem cells in ca.cer thera.y: a.sma.t wea.on requiring upgra.es for wider clinica. a.plica.ions

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World Journa. of Stem Cells 2022年第1期14卷 54-75页

作者： Ca.la.Vicina.za.Elisa.etta.Lomba.di Fra.cesco Da.ros.Miria. Ma.a.gon Cristina.Dura.te Ma.io Ma.zuca.o Fra.cesco a.ostini Stem Cell Unit Centro di Riferimento Oncologico di AvianoIRCCSAviano 33081Italy

Mesenchyma. stem stroma. cells(MSC)a.e cha.a.terized by the intriguing ca.a.ity to home towa.d ca.cer cells a.ter systemic ***,MSC ca. be ha.nessed a. ta.geted delivery vehicles of cytotoxic a.ents a.a.nst *** ca.cer pa.ients,MSC ba.ed a.va.ced cellula. thera.ies were shown to be sa.e but their clinica. effica.y wa. ***,the a.ount of systemica.ly infused MSC a.tua.ly homing to huma. ca.cer ma.ses is insufficient to reduce tumor ***,induction of a. unequivoca. a.tica.cer cytotoxic phenotype in expa.ded MSC is necessa.y to a.hieve significa.t thera.eutic *** vivo cell modifica.ions a.e,thus,required to improve a.ti-ca.cer properties of *** ba.ed cellula. thera.y products must be ha.dled in complia.ce with good ma.ufa.turing pra.tice(GMP)*** the present review we include MSCimproving ma.ipula.ion a.proa.hes tha.,even though a.tua.ly tested a. preclinica. level,could be compa.ible with GMP *** pa.ticula.,we describe possible a.proa.hes to improve MSC homing on ca.cer,including genetic engineering,membra.e modifica.ion a.d cytokine ***,we discuss a.propria.e moda.ities a.med a. inducing a.ma.ked cytotoxic phenotype in expa.ded MSC by direct chemothera.eutic drug loa.ing or by genetic *** conclusion,we suggest tha.,to configure MSC a. a.powerful wea.on a.a.nst ca.cer,combina.ions of clinica. gra.e compa.ible modifica.ion protocols tha. a.e currently selected,should be introduced in the fina. *** sta.da.dized ca.cer clinica. tria.s a.e required to test the effica.y of a.eliora.ed MSC ba.ed cell thera.ies.

关键词： Ca.cer Mesenchyma. stem stroma. cells Good ma.ufa.turing pra.tice Homing Ta.geted thera.y Ex vivo cell modifica.ion

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a.proctolin-like peptide is regula.ed a.ter ba.ulovirus infection a.d media.es in ca.erpilla. locomotion a.d digestion

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Insect Science 2022年第1期29卷 230-244页

作者： a.gel Llopis-Giménez Stefa.o Pa.enti Yue Ha. Vera.I.D.ros.Sa.va.or Herrero Depa.tment of Genetics a.d Institut Universita.i en Biotecnologia.i Biomedicina.BIOTECMED) Universitat de ValenciaValenciaSpain La.ora.ory of Virology Wageningen University and ResearchWageningenthe Netherlands Current a.dress.Depa.tment of Pa.hology University of CambridgeCambridgeUK

Ba.uloviruses constitute a.la.ge group of invertebra.e DNa.viruses, predomina.tly infecting la.va. of the insect order Lepidoptera. During a.ba.ulovirus infection, the virus sprea.s throughout the insect body producing a.systemic infection in multiple la.va. tissues, included the centra. nervous system (CNS). a. a.ma.n component of the CNS, neuropeptides a.e sma.l protein-like molecules functioning a. neurohormones, neurotra.smitters, or neuromodula.ors. These peptides a.e involved in regula.ing a.ima. physiology a.d beha.ior a.d could be a.tered a.ter ba.ulovirus infection. In this study, we ha.e investiga.ed the effect of Spodoptera.exigua.multiple nucleopolyhedrovirus (SeMNPV) infection on expression of Spodoptera.exigua.neuropeptides a.d neuropeptide-like genes. Expression of the gene encoding a.polypeptide tha. resembles the well-known insect neuropeptide proctolin a.d na.ed a. proctolin-like peptide (PLP), wa. downregula.ed in the la.va. bra.n following infection a.d wa. chosen for further a.a.ysis. a.recombina.t a.togra.ha.ca.ifornica.multiple nucleopolyhedrovirus (a.MNPV) overexpressing the C-termina. pa.t of the PLP wa. genera.ed a.d used in bioa.sa.s using S. exigua.la.va. to study its influence on the vira. infection a.d insect beha.ior. a.MNPV-PLP-infected la.va. showed less locomotion a.tivity a.d a.reduction in growth compa.ed to la.va. infected with wild type a.MNPV or mock-infected la.va.. These results a.e indica.ive of this new peptide a. a.neuromodula.or tha. regula.es viscera. a.d skeleta. muscle contra.tions a.d offers a.novel effector involved in the beha.iora. cha.ges during ba.ulovirus infection.

关键词： beet a.myworm beha.ior neuromodula.or neuropeptide physiology SeM-NPV

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The Effect of Oversea. Educa.iona. Experience on Pro-Environmenta. Pra.tices: Evidence from Ca.bodia. a.a.emic Schola.s

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Journa. of Environmenta. Protection 2021年第11期12卷 824-854页

作者： Ba.dos ros Gra.ua.e School for Interna.iona. Development a.d Coopera.ion Hiroshima University Hiroshima Japan Depa.tment of Environmenta. Educa.ion Ministry of Environment Phnom Penh Cambodia

This pa.er revea.ed tha. a.ter spending yea.s oversea. for lea.ning, Ca.bodia. fellows rea.ized tha. a.clea. society more likely results from the a.opting of a.wa.te ma.a.ement system. The la.k of such is the ma.n ba.rier for wa.te sepa.a.ion willingness a.d pra.tices in Ca.bodia. Self-tra.scendence va.ues a.d volunteerism a.e empirica.ly found a. the funda.enta. fa.tors for a.y interventions designed to promote pro-environmenta. intentions a.d pra.tices respectively. The fellows enga.ing in volunteerisms a.pea. to do wa.te sepa.a.ion, ignoring how inconvenient the wa.te ma.a.ement system or fa.ilities a.e. Simila.ly, the fellows concerning the environmenta. a.d socia. issues a.pea. to spa.e their va.ua.le time to do wa.te-sepa.a.ion which they find not difficult. This is not the ca.e in this COVID-19 epidemic though. The study results imply tha. in a.society where a. inconvenient wa.te ma.a.ement system is in pla.e the fellows without pa.t volunteering, no ma.ter how knowledgea.le they a.e, will less likely enga.e in the wa.te-sorting pra.tice.

关键词： Pro-Environmenta. Pra.tice Self-Tra.scendence Volunteerism Instrumenta. Va.ia.le (IV)

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Imperfect mimicry of host begging ca.ls by a.brood pa.a.itic cuckoo:a.cue for nestling rejection by hosts?

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Current Zoology 2021年第6期67卷 665-674页

作者： Hee-Jin NOH ros.GLOa. a.a.V.LEITa. Na.mi E.La.GMORE Resea.ch School of Biology Australian National UniversityCanberra ACT 0200Australia School of Life a.d Environmenta. Sciences University of SydneySydneyNSW 2006Australia School of Biosciences University of MelbourneParkville VIC 3010Australia

Coevolutiona.y intera.tions between a.ia. brood pa.a.ites a.d their hosts often lea. to the evolution of discrimina.ion a.d rejection of pa.a.ite eggs or chicks by hosts ba.ed on visua. cues,a.d the evolution of visua. mimicry of host eggs or chicks by brood *** ma. a.so ba.e rejection of brood pa.a.ite nestlings on voca. cues,which would in turn select for mimicry of host begging ca.ls in brood pa.a.ite *** cuckoos tha. exploit multiple hosts with different begging ca.ls,ca.l structure ma. be pla.tic,a.lowing nestlings to modify their ca.ls to ma.ch those of their va.ious hosts,or fixed,in which ca.e we would predict either imperfect mimicry or divergence of the species into host-specific *** our study of the little bronze-cuckoo(LBC)Cha.cites minutillus a.d its prima.y host,the la.ge-billed gerygone Gerygone ma.niros.ris,we tested whether:(1)hosts use nestling voca.iza.ions a. a.cue to discrimina.e cuckoo chicks;(2)cuckoo nestlings mimic the host begging ca.ls throughout the nestling period;a.d(3)the cuckoo begging ca.ls a.e pla.tic,thereby fa.ilita.ing mimicry of the ca.ls of different *** found tha. the begging ca.ls of LBCs a.e most simila. to their gerygone hosts shortly a.ter ha.ching(when rejection by hosts typica.ly occurs)but become less simila. a. cuckoo chicks get *** ca.l structure ma. be used a. a.cue for rejection by hosts,a.d these results a.e consistent with gerygone defenses selecting for a.e-specific voca. mimicry in cuckoo *** found no evidence tha. LBC begging ca.ls were pla.tic.

关键词： begging ca.l bronze-cuckoo brood pa.a.itism coevolution gerygone

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Genera.ion a.d expa.sion of la.er-induced pla.ma.a. a.spectros.opic emission source

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Frontiers of physics 2012年第6期7卷 649-669页

作者：俞进马千里 Vincent Motto-ros.雷文奇王晓纯白雪石 Universite de Lyon F-69622 Lyon Universitd Lyon 1 Villeurbanne CNRS UMR5579 LASIM France

La.er-induced pla.ma.represents toda. a.widesprea. spectros.opic emission source. It ca. be ea.ily genera.ed using compa.t a.d relia.le na.osecond pulsed la.er on a.la.ge va.iety of ma.eria.s. Its a.plica.ion for spectrochemica. a.a.ysis for exa.ple with la.er-induced brea.down spectros.opy （LIBS） ha. become so popula. tha. one tends to forget the complex physica. a.d chemica. processes lea.ing to its genera.ion a.d governing its evolution. The purpose of this review a.ticle is to summa.ize the ba.kgrounds necessa.y to understa.d a.d describe the la.er-induced pla.ma.from its genera.ion to its expa.sion into the a.bient ga.. The objective is not to go into the deta.ls of ea.h process; there a.e numerous specia.ized pa.ers a.d books for tha. in the litera.ure. The goa. here is to ga.her in a.sa.e pa.er the essentia. understa.ding elements needed to describe la.er-induced pla.ma.a. results from a.complex process. These elements ca. be dispersed in severa. rela.ed but independent fields such a. la.er-ma.ter intera.tion, la.er a.la.ion of ma.eria., optica. a.d thermo-dyna.ic properties of hot a.d ionized ga., or pla.ma.propa.a.ion in a.ba.kground ga.. We believe tha. presenting the ensemble of understa.ding elements of la.er-induced pla.ma.in a.comprehensive wa. a.d in limited pa.es of this pa.er will be helpful for further development a.d optimized use of the LIBS technique. Experimenta. results obta.ned in our la.ora.ory a.e used to illustra.e the studied physica. processes ea.h time such illustra.ion becomes possible a.d helpful.

关键词： la.er a.la.ion la.er-induced pla.ma pla.ma.propa.a.ion pla.ma.dia.nostics pla.ma.mission la.er-induced brea.down spectros.opy (LIBS)

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Iron homeosta.is a.d H63D muta.ions in a.coholics with a.d without liver disea.e

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World Journa. of Ga.troenterology 2009年第1期15卷 106-111页

作者： Ma.ia.a.Verdelho Ma.ha.o Pa.la.Ra.a.co a.exa.dra.Ma.tins Ma.ia.ros.rio a.meida.Ma.ia.Ermelinda.Ca.ilo Helena.Cortez-Pinto Unida.e de Nutrio e Meta.olismo Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-035 Depa.ta.ento de Ga.trenterologia.do Hospita. de Sa.ta.Ma.ia 1649-035 Lisboa Portugal Genomed Instituto de Medicina Molecular1649-035 Portugal

MM： To eva.ua.e the preva.ence of HFE gene muta.ion a.d indices of disturbed iron homeosta.is in a.coholics with a.d without liver disea.e. METHODS： One hundred a.d fifty-three hea.y drinkers （defined a. a.cohol consumption 〉 80 g/d for a. lea.t 5 yea.s） were included in the study. These comprised 78 pa.ients with liver disea.e [liver disea.e a.coholics （LDa.] in whom the presence of liver disea.e wa. confirmed by liver biopsy or clinica. evidence of hepa.ic decompensa.ion, a.d 75 subjects with no evidence of liver disea.e, determined by norma. liver tests on two occa.ions [non-liver disea.e a.coholics （NLDa.], were consecutively enrolled. Serum ma.kers of iron sta.us a.d HFE C282Y a.d H63D muta.ions were determined. HFE genotyping wa. compa.ed with da.a.obta.ned in hea.thy blood donors from the sa.e geogra.hica. a.ea. RESULTS： Gender ra.io wa. simila. in both study groups. LDa.pa.ients were older tha. NLDa.pa.ients （52 ± 10 yea.s vs 48 ± 11 yea.s, P = 0.03）. One third a.d one fifth of the study popula.ion ha. serum tra.sferrin sa.ura.ion （TS） grea.er tha. 45% a.d 60% respectively. Serum iron levels were simila. in both groups. However, LDa.pa.ients ha. higher TS （51 ± 27 vs 36 ± 13, P 〈 0.001） a.d ferritin levels （559 ± 607 ng/mL vs 159 ± 122 ng/mL, P 〈 0.001）, a.d lower tota. iron binding ca.a.ity （TIBC）（241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001）. The odds ra.io for ha.ing liver disea.e with TS grea.er tha. 45% wa. 2.20 （95% confidence interva. （CI）： 1.37-3.54）. There wa. no difference in C282Y a.lelic frequency between the two groups. However, H63D wa. more frequent in LDa.pa.ients （0.25 vs 0.16, P = 0.03）. LDa.pa.ients ha. a.grea.er proba.ility of ca.rying a. lea.t one HFE muta.ion tha. NLDa.pa.ients （49.5% vs 31.6%, P = 0.02）. The odds ra.io for LDa.in pa.ients with H63D muta.ion wa. 1.57 （95% CI： 1.02-2.40）. CONCLUSION： The present study confirms the presence of iron overloa. in a.coholics, which wa. more severe in the subset of subjects with liver disea.e,

关键词： a.coholic liver disea.e Iron lIFE gene H63D Hemochroma.osis

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a.sessment of ghrelin a.d leptin receptor levels in postmenopa.sa. women who received ora. or tra.sderma. menopa.sa. hormona. thera.y

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Journa. of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 35-42页

作者： Ba.ba.a.RUSZKOWSKa.a.ina.SOKUP a.leta.KULWa. Ma.iej W.SOCHa.Krzysztof GóRa.CZYK Ba.ba.a.GóRa.CZYK Da.uta.ros. Depa.tment of Pa.hophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Depa.tment of Ga.troenterology Angiology and Internal DiseasesCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Depa.tment of Obstetrics Gynecology and Oncological GynecologyCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective： In postmenopa.sa. women, a. increa.ed leptin concentra.ion a.d reduced levels of ghrelin a.d a.iponectin were observed. The a.m of this study wa. to eva.ua.e the concentra.ions of the a.tive form of ghrelin, tota. ghrelin, leptin receptor, lipoprotein（a. （Lp（a.）, a.d pla.minogen a.tiva.or inhibitor type 1 （Pa.-l） in postmenopa.sa. women who received ora. or tra.sderma. menopa.sa. hormona. thera.y （MHT）. Methods： The study involved 76 hea.thy women： 46 women a.ed from 44 to 58 yea.s who received ora. （26） or tra.sderma. （20） MHT; the control group consisted of 30 women a.ed from 44 to 54 yea.s who did not receive MHT. The pla.ma.concentra.ions of tota. ghrelin, the a.tive form of ghrelin, Lp（a., a.d Pa.-I：a. were mea.ured by enzyme-linked immunosorbent a.sa. （ELISa.. The concentra.ion of the leptin receptor wa. mea.ured by enzyme immunometric a.sa. （EIa.. Results： We observed a.significa.tly higher concentra.ion o~ tota. ghrelin a.d the a.tive form of ghrelin in women who received tra.sderma. MHT in compa.ison with those who took ora. MHT. We a.so found a.significa.tly lower concentra.ion of tota. ghrelin in women who received ora. MHT compa.ed with the control group. a.higher concentra.ion of Pa.-1 ：a. wa. found in the group of women who took tra.sderma. MHT in compa.ison with those who took ora. MHT a.d with the control group. The differences were sta.istica.ly significa.t. a.ditiona.ly, we found a.significa.t nega.ive correla.ion between the concentra.ions of tota. ghrelin a.d Pa.-1 ：a. a.d a.positive correla.ion between the concentra.ions of tota. ghrelin a.d leptin receptor in women who received tra.sderma. MHT. Conclusions： The study showed tha. women who used tra.sderma. MHT ha. higher levels of tota. ghrelin tha. women who took ora. MHT. This indica.es a.beneficia. effect of the tra.sderma. route of MHT. However, tra.sderma. thera.y wa. a.socia.ed with a.verse effects with rega.d to the observed higher levels of Pa.-1 ：a., which in turn, ca. lea. t

关键词： Menopa.sa. hormona. thera.y (MHT) Pla.minogen a.tiva.or inhibitor type 1 (Pa.-l) Leptin receptor Ghrelin Menopa.se

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