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Functiona. Morphology of the Sperma.ogenesis of Gir Bulls

a.ricultura. Sciences 2020年第11期11卷 1081-1094页

作者： Da.iel F. M. Silva.Fa.io J. C. Fa.ia.Ferna.do H. G. Furta.o Ca.los a. C. Ferna.des Julia.a.C. B. Silva.a.ria.o Ga.cia.Deiler S. Costa Federa. University of Ma.o Gros.o do Sul Campo Grande Brazil University José do ros.rio Vella.o Alfenas Brazil Embra.a.Pa.ta.a. Corumbá Brazil Bra.ilia. Zebu Breeders a.socia.ion ABCZ Campo Grande Brazil Nucleus of a.ima. Production a.d Reproduction (NUPRa. Campo Grande Brazil

The purpose of this study wa. to eva.ua.e the functiona. morphology of the sperma.ogenesis of Gir bulls, with empha.is on the testicula. biometry a.d testicula. pa.enchyma.histomorphometry. Testicula. fra.ments from eight Gir bulls were used. The fra.ments were fixed by tissue perfusion with Ka.novsck’s solution, a.d inclusion wa. subsequently performed using glycol metha.ryla.e. Histologica. sections of 4 μm were ma.e a.d sta.ned with a.1% toluidine blue-sodium bora.e solution. The mea. a.e of the bulls wa. 8.0 ± 1.3 yea.s a.d the mea. body weight wa. 467.5 ± 26.7 kg. Testicula. weight wa. 289.2 ± 30.5 g on a.era.e, a.d the a.era.e gona.osoma.ic index wa. 0.12% ± 0.02%. The seminiferous tubules, Leydig cells, stroma. a.d intertubula. tissue composed 80.9% ± 1.7%, 5.4% ± 1.3%, 13.7% ± 1.1%, a.d 19.1% ± 1.7% of the tota. testicula. weight, respectively. The mea. length of the seminiferous tubule per gra. of testicle wa. 17 ± 0.8 m. Losses during sperma.ogonia.mitosis a.era.ed 75.5% ± 3.22%, while losses were 30.6% ± 8.17% during the meiotic pha.e, which resulted in a. a.era.e tota. loss of 81.49% ± 2.58% of cells during the entire process of sperma.ogenesis. The a.era.e da.ly sperm production per gra. of pa.enchyma.wa. 28.0 × 106 cells. It wa. concluded tha. the histometric mea.urements of testicula. pa.a.eters in the Gir breed a.e within the a.era.es reported for other zebu ca.tle breeds.

关键词： Sperma.ogonia Leydig Sertoli Testicle

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沿面空气等离子体对Ha.a.细胞因子mRNa.达及分泌的影响

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中国皮肤性病学杂志 2015年第10期29卷 1004-1008页

作者：钟世玉董颖颖刘定新肖生祥孔刚玉西安交通大学医学院第二附属医院皮肤病院陕西西安710004 西安交通大学电力设备电气绝缘国家重点实验室陕西西安710054 西安交通大学电气工程学院陕西西安710049 老道明大学生物电学中心弗吉尼亚州23508

目的探讨等离子体对Ha.Ca.T细胞活性、细胞因子表达的影响及作用机制,为其在皮肤创伤愈合的应用提供理论依据。方法 CCK-8法测定不同时间等离子体处理对Ha.Ca.T细胞活性的影响,流式细胞术检测处理后细胞内活性氧水平改变,并与有Na.存在... 详细信息

目的探讨等离子体对Ha.Ca.T细胞活性、细胞因子表达的影响及作用机制,为其在皮肤创伤愈合的应用提供理论依据。方法 CCK-8法测定不同时间等离子体处理对Ha.Ca.T细胞活性的影响,流式细胞术检测处理后细胞内活性氧水平改变,并与有Na.存在条件下的改变进行比较;酶标仪检测处理介质PBS中H2O2浓度;采用ELISa.Rea.time PCR方法分析等离子体处理后Ha.Ca.T生成细胞因子在蛋白和mRNa.平的改变。结果沿面空气等离子体对Ha.Ca.T细胞具有细胞毒性,呈剂量-时间依赖性。等离子体处理可升高细胞内ros.平,Na.能够明显抑制等离子体处理引起的Ha.Ca.T细胞活性下降及细胞内ros.平的增加。与对照组相比,等离子体照射可在不同程度上引起细胞因子IL-1βmRNa.平的增加,可明显增加IL-6、IL-8、VEGF蛋白及mRNa.水平。结论空气沿面等离子可通过提高细胞内ros.平发挥细胞毒性作用,其一定程度上的促炎作用及促进生长因子的分泌作用可能在创伤愈合治疗中具有重要意义。

关键词：低温等离子体角质形成细胞细胞内活性氧细胞因子创伤愈合等离子体医学

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Intera.tion of Diet/Lifestyle Intervention a.d TCF7L2 Genotype on Glycemic Control a.d a.iposity a.ong Overweight or Obese a.ults:Big Da.a.from Seven Ra.domized Controlled Tria.s Worldwide

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Hea.th Da.a.Science 2021年第1期2021卷 174-183页

作者： Ta. Hua.g Zhenhua.g Zhua.g Yoriko Heia.za.Dia.jia.yi Sun Wenjie Ma.Wenxiu Wa.g Meng Ga. Zhe Fa.g Emilio ros.Lia.a.C.Del Gobbo Jordi Sa.a.-Sa.va.ó Miguel a.Ma.tínez-González Ja. Pola. Ma.kku La.kso a.ne a.trup Dominique La.gin Jorg Ha.er Ga.by Hul Torben Ha.sen Oluf Pedersen Jea.-Michel Oppert Wim H.M.Sa.is Peter a.ner Montserra. Cofán Suja.ha.Ra.a.a. Ja.kko Tuomilehto Ja.na.Lindström Va.essa.D.de Mello a.ena.Sta.ca.ova.Ma.ti Uusitupa.Ma.hilde Svendstrup Thorkild I.a.Sørensen Christopher D.Ga.dner Joa. Sa.a.é Dolores Corella.J.a.fredo Ma.tinez Lu Qi Depa.tment of Epidemiology&Biosta.istics School of Public HealthPeking UniversityChina Depa.tment of Globa. Hea.th School of Public HealthPeking UniversityChina Key La.ora.ory of Molecula. Ca.diova.cula. Sciences Ministry of Educa.ion China Globa. Hea.th Institute Peking University China Depa.tment of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Depa.tment of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Depa.tment of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopa.ologia.de la.Obesida. y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Sta.ford Prevention Resea.ch Center Stanford UniversityStanford CAUSA Huma. Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Na.a.ra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Depa.tment for the Study of Obesity a.d Dia.etes Third Faculty of MedicineCharles UniversityPragueCzech Republic Depa.tment of Medicine University of Eastern FinlandKuopioFinland University of Copenha.en Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut Na.iona. de la.Sa.téet de la.Recherche Médica.e(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Hea.th Sciences LausanneSwitzerland Depa.tment of Huma. Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Meta.olic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which a.socia.ed with type 2 dia.etes(T2D)by the common va.ia.t rs7903146 is the tra.scription fa.tor 7-like 2 gene(TCF7L2).We a.med to qua.tify the intera.tion of diet/lifestyle interventions a.d the genetic effect of TCF7L2 rs7903146 on glycemic tra.ts,body weight,or wa.st circumference in overweight or obese a.ults in severa. ra.domized controlled tria.s(RCTs).*** October 2016 to Ma. 2018,a.la.ge colla.ora.ive a.a.ysis wa. performed by pooling individua.pa.ticipa.t da.a.from 7 *** RCTs reported cha.ges in glycemic control a.d a.iposity of the va.ia.t rs7903146 a.ter dieta.y/lifestyle-rela.ed interventions in overweight or obese *** trea.ment intera.tion models which used the genetic effect encoded by the a.lele dose a.d common cova.ia.es were a.plica.le to individua. pa.ticipa.t da.a.in a.l *** the joint a.a.ysis,a.tota. of 7 eligible RCTs were included(n=4,114).Importa.tly,we observed a.significa.t effect modifica.ion of diet/lifestyle-rela.ed interventions on the TCF7L2 va.ia.t rs7903146 a.d cha.ges in fa.ting *** with the control group,diet/lifestyle interventions were rela.ed to lower fa.ting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity a.d overa.l effect:I^(2)=45:1%,pa.dless of genetic risk,diet/lifestyle interventions were a.socia.ed with lower wa.st ***,there wa. no significa.t cha.ge for diet/lifestyle interventions in other glycemic control a.d a.iposity tra.ts per one copy of TCF7L2 risk *** findings suggest tha. ca.rying the TCF7L2 T risk a.lele ma. ha.e a.modestly grea.er benefit for specific diet/lifestyle interventions to improve the control of fa.ting glucose in overweight or obese a.ults.

关键词： TCF7L2 weight finding

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刺五加叶纯化物对2型糖尿病大鼠降血糖、降血脂作用的实验研究

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中国医学创新 2016年第5期13卷 22-26页

作者：翟春梅孟永海王欣慰王知斌依古拉斯a.凯恩田振坤黑龙江中医药大学北药基础与应用研究省部共建教育部重点实验室黑龙江哈尔滨150040 黑龙江省中药及天然药物药效物质基础研究重点实验室美国密西西比大学天然产物中心

目的:探索刺五加叶纯化物对2型糖尿病大鼠血糖、血脂的作用及其治病机理。方法:通过高脂饮食联合STZ诱导的方法建立2型糖尿病大鼠动物模型,给予模型大鼠不同药物及剂量,观察刺五加叶纯化物对模型大鼠血糖、血脂及抗氧化机制的影响。结果... 详细信息

目的:探索刺五加叶纯化物对2型糖尿病大鼠血糖、血脂的作用及其治病机理。方法:通过高脂饮食联合STZ诱导的方法建立2型糖尿病大鼠动物模型,给予模型大鼠不同药物及剂量,观察刺五加叶纯化物对模型大鼠血糖、血脂及抗氧化机制的影响。结果:刺五加乙醇提取物组,刺五加叶纯化物高、中剂量组及阳性药物组FBG均低于模型对照组,比较差异均有统计学意义(Pa.量明显高于正常对照组,比较差异有统计学意义(Pa.量均低于模型对照组,比较差异均有统计学意义(Pros.产生,起到抗氧化应激、防止氧化损伤的效果,最终达到抗糖尿病、改善胰岛素抵抗的作用。刺五加叶纯化物比乙醇提取物和参芪降糖胶囊具有更加优越的治疗2型糖尿病的作用,并呈现剂量正相关。有望开发成为新一代的降血糖药物。

关键词：刺五加叶纯化物 2型糖尿病血糖血脂

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Molecula. links between non-a.coholic fa.ty liver disea.e a.d hepa.ocellula. ca.cinoma

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Hepa.oma.Resea.ch 2019年第12期5卷 1-11页

作者： Sa.a.Ra.a.Sa.ga. Ra.a. Ba.y a.jum Rohit a.Sinha Depa.tment of Bioscience Integral UniversityLucknow 226026India Depa.tment of Endocrinology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

Non-a.coholic fa.ty liver disea.e(Na.LD)a.d its a.va.ced complica.ion,non-a.coholic stea.ohepa.itis(Na.H),ha.e become lea.ing ca.ses of hepa.ocellula. ca.cinoma.HCC)*** this review,we discuss the role of meta.olic,gut microbia.,immune a.d endocrine media.ors which promote the progression of Na.LD to *** pa.ticula.,this progression involves multiple hits resulting from lipotoxicity,oxida.ive stress,inhibition of hepa.ic a.topha.y a.d ***,dysbiosis in the gut a.socia.ed with obesity a.so promotes HCC via.induction of proinfla.ma.ory cytokines a.d Toll like receptor signa.ling a. well a. a.tered bile ***,compromised T-cell function a.d impa.red hepa.ic hormona. a.tion promote the development of Na.H-a.socia.ed ***,we discuss the current cha.lenges involved in the dia.nosis a.d trea.ment of Na.LD/Na.H-a.socia.ed HCC.

关键词： Non-a.coholic fa.ty liver disea.e non-a.coholic stea.ohepa.itis hepa.ocellula. ca.cinoma Gut microbiome dysbiosis a.topha.y ER-stress ros TNFα TLR-9 TLR-4 hyperinsulinemia

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酒渣鼻患者血清活性氧簇的活性和抗氧化能力:与幽门螺杆菌血清阳性的相关性

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 30-30页

作者： Ba. K. Cimen M.Y.B. Kokturk a. 田中伟 Mersin Univ.Tip Fa.ultesi Ha.ta.esi Dermatoloji Anabilim Dali 33079 Zeytinlibahce Mersin Turkey Dr.

*** studies ha.e suggested tha. there might be a. etiologic role for Helicoba.ter pylori (HP) in *** is a.Gra.-nega.ive ba.terium tha. colonizes the ga.tric mucosa. increa.es the genera.ion of rea.tive oxygen species (ros., a.d decrea.es pla.ma.a.tioxida.ts such a. a.corbic *** investiga.e pla.ma.ros.a.tivities a.d a.tioxida.t sta.us, a.d their rela.ionship with HP infection, in ros.cea.***-nine ros.cea.pa.ients a.d 20 a.e-a.d sex-ma.ched hea.thy controls were exa.ined for specific immunoglobulinG (IgG) a.d IgM a.a.nst HP, pla.ma.ma.ondia.dehyde (MDa., a.d a.tioxida.t potentia. (a.P) *** with controls, the seropositivity of HP for IgM wa. signifi-ca.tly higher (P = 0.03) a.d the seropositivity of HP for IgG wa. significa.tly lower (P = 0.0001) in pa.ients with *** MDa.levels were higher (P = 0.0001) a.d a.P levels were lower (P = 0.019) in pa.ients tha. in controls, rega.dless of the severity of the *** MDa.a.d a.P levels were not a.fected by the seropositivity of HP for IgM a.d/or IgG in either *** results suggest tha. ros.cea.is a. oxida.ive stress condition, a. reflected by the increa.ed ros.a.tivity a.d decrea.eda.P, rega.dless of HP infection.

关键词：活性氧簇血清阳性 IgG 氧化应激状态革兰阴性菌特异性可由

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In vitro effect of copper chloride exposure on rea.tive oxygen species genera.ion a.d respira.ory cha.n complexes a.tivities of mitochondria.isola.ed from broiler liver

In vitro effect of copper chloride exposure on reactive oxyg...

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中国畜牧兽医学会家畜内科学分会第七届代表大会暨学术研讨会

作者： Rongsheng Su~(a.).Rongmei Wa.g~(b1).Shining Guo~(a.).Hua.in Ca.~(c1).Jia.ia.g Pa.~a. Chengmei Li~a.Da.ou Shi~a.Zha.xin Ta.g~(a.) (a.College of Veterina.y Medicine,South China.a.ricultura. University,Gua.gzhou 510642,China.b College of Ying Dong bio-engineering,Sha.gua. University,Sha.gua. 510042,China.c College of a.ima. Science a.d Technology Jia.gxi a.ricultura. University Na.cha.g 330045,China.

This study is to exa.ine if Cu ca. a.t directly on mitochondria.or indirectly by producing rea.tive oxygen species(ros.,isola.ed broiler hepa.ic mitochondria.were exposed to different concentra.ion of Cu(10,30,50μM). Respira.ory cha.n complexes a.tivities,ros.genera.ion,respira.ory control ra.io(RCR) a.d mitochondria. membra.e potentia.(MMP) were ***-dependent inhibition of respira.ory cha.n complexes a.d induction of ros.were observed,which coincided with decrea.ing of respira.ory control ra.io(RCR) both with gluta.a.e+ma.a.e or succina.e. Further investiga.ion indica.ed tha. the membra.e potentia. determined by Rhoda.ine 123 relea.e decrea.ed a.ter CuCl exposure a. 30 a.d 50μ*** a.ditioa.effects of the a.tioxida.ts Na.(200μM) a.d GSH(200μM) were studied a. 50μM *** results indica.e Cu ca. induce mitochondria. dysfunction in excessive dose a.d the effect of Cu exposure on respira.ory cha.n is not site-specific,a.d a.tioxida.ts ca. protect the mitochondria. function by reducing the forma.ion of free ra.ica.s.

关键词： copper chloride(CuCl2) Rea.tive oxygen species Respira.ory cha.n complexes Free ra.ica.s Membra.e potentia.

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