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辅助生育技术及其妊娠结局

世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 61-61页

作者： Shevell T. malone F.D. Vida.er J. 朱国栋 Division of Ma.erna. eta. Medicine The Whittingham Pavilion Stamford Hospital 30 Shelburne Road Stamford CT 06904 United States Dr.

Objective: To determine whether the use of a.sisted reproductive technology (a.T) is a.socia.ed with a. increa.e in chromosoma. a.norma.ities, feta. ma.forma.ions, or a.verse pregna.cy outcomes. METHODS: a.prospective da.a.a.e from a.la.ge multicenter investiga.ion of singleton pregna.cies, the First a.d Second Trimester Eva.ua.ion of Risk tria., wa. exa.ined. Subjects were divided into 3 groups: no a.T use, use of ovula.ion induction (with or without intra.terine insemina.ion), a.d use of in vitro fertiliza.ion (IVF). Multiva.ia.e logistic regression a.a.ysis wa. used to a.sess a.socia.ion between a.T a.d a.verse pregna.cy outcomes (significa.ce of differences wa. a.cepted a. P a.tota. of 36,062 pregna.cies were a.a.yzed: 34,286 (95.1%) were sponta.eously conceived, 1,222 (3.4%) used ovula.ion induction, a.d 554 (1.5%) used IVF. There wa. no a.socia.ion between a.T a.d feta. growth restriction, a.euploidy, or feta. a.oma.ies a.ter a.justment for a.e, ra.e, ma.ita. sta.us, yea.s of educa.ion, prior preterm delivery, prior feta. a.oma.y, body ma.s index, smoking history, a.d bleeding in the current pregna.cy. Ovula.ion induction wa. a.socia.ed with a.sta.istica.ly significa.t increa.e in pla.enta. a.ruption, feta. loss a.ter 24 weeks, a.d gesta.iona. dia.etes a.ter a.justment. Use of IVF wa. a.socia.ed with a.sta.istica.ly significa.t increa.e in preecla.psia. gesta.iona. hypertension, pla.enta. a.ruption, pla.enta.previa. a.d risk of cesa.ea. delivery. CONCLUSION: Pa.ients who undergo IVF a.e a. increa.ed risk for severa. a.verse pregna.cy outcomes. a.though ma.y of these risks a.e not seen in pa.ients undergoing ovula.ion induction, severa. a.verse pregna.cy outcomes a.e still increa.ed in this group. There wa. no increa.ed incidence of feta. chromosoma. or structura. a.norma.ities in the women who used a.y type of a.T compa.ed with the women who conceived sponta.eously.

关键词：辅助生育技术妊娠结局妊娠不良结局体外受精胎盘早剥人工受精单胎妊娠诱导排卵胎儿流产前

四联(Qua.)筛查法作为不良妊娠结局的预测因子

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 57-57页

作者： Dugoff L. Hobbins J.C. malone F.D. 张巧利 University of Colora.o Hea.th Sciences Center Department of Obstetrics Box B198 4200 East Ninth Avenue Denver CO 80262 United States Dr.

Objective: To estima.e the effect of second-trimester levels of ma.erna. serum a.pha.fetoprotein (a.P), huma. chorionic gona.otrophin (hCG), unconjuga.ed estriol (uE3), a.d inhibin a.(the qua. screen) on obstetric complica.ions by using a.la.ge, prospectively collected da.a.a.e (the Fa.TER da.a.a.e). Methods: The Fa.TER tria. wa. a.multicenter study tha. eva.ua.ed first-a.d second-trimester screening progra.s for a.euploidy in women with singleton pregna.cies. a. pa.t of this tria., pa.ients ha. a.qua. screen dra.n a. 15-18 6/7 weeks. We a.a.yzed the da.a.to identify a.socia.ions between the qua. screen ma.kers a.d preterm birth, intra.terine growth restriction, preecla.psia. a.d feta. loss. Our a.a.ysis wa. performed by eva.ua.ing the performa.ce cha.a.teristics of qua. screen ma.kers individua.ly a.d in combina.ion. Crude a.d a.justed effects were estima.ed by multiva.ia.le logistic regression a.a.ysis. Pa.ients with feta. a.oma.ies were excluded from the a.a.ysis. Results: We a.a.yzed da.a.from 33,145 pregna.cies. We identified numerous a.socia.ions between the ma.kers a.d the a.verse outcomes. There wa. a.rela.ively low, but often significa.t, risk of ha.ing a. a.verse pregna.cy complica.ion if a.pa.ient ha. a.single a.norma. ma.ker. However, the risk of ha.ing a. a.verse outcome increa.ed significa.tly if a.pa.ient ha. 2 or more a.norma. ma.kers. The sensitivity a.d positive predictive va.ues using combina.ions of ma.kers is rela.ively low, a.though superior to using individua. ma.kers. Conclusion: These da.a.suggest tha. components of the qua. screen ma. prove useful in predicting a.verse obstetric outcomes. We a.so showed tha. the tota. number a.d specific combina.ions of a.norma. ma.kers a.e most useful in predicting the risk of a.verse perina.a. outcome.

关键词：不良妊娠结局 Qua. 筛查法宫内发育迟缓非整倍体单胎妊娠胎儿畸形妊娠中期围生期绒促性素

急性发作性疼痛性肢端环状肉芽肿:4例报道及临床和组织学谱的讨论

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 30-30页

作者： Brey N. V. malone J. Ca.len J. P. 潘敏(译) 不详 Division of Derma.ology Department of Medicine University of Louisville School of Medicine 310E Broadway Louisville KY 40202 United States

Ba.kground: Gra.uloma.a.nula.e is a.benign cuta.eous infla.ma.ory disea.e of unknown etiology most commonly presenting on the ha.ds a.d feet a.d consisting of a.ymptoma.ic to mildly pruritic, flesh-colored to erythema.ous a.nula. pla.ues. To our knowledge, a. a.ute-onset, pa.nful a.ra. eruption ha. not been previously recognized. Observa.ions: We report 4 pa.ients who presented with a.ute onset, pa.nful a.ra. gra.uloma.a.nula.e. Conclusions: It is possible for gra.uloma.a.nula.e to present a. a.pa.nful eruption with a. a.ute onset a.d a. a.ra. distribution. Biopsy results a.e a.crucia. fa.tor when esta.lishing the dia.nosis of this a.ypica. clinica. presenta.ion of gra.uloma.a.nula.e.

关键词：临床表现不典型环状肉芽肿疼痛性发作性肢端急性组织学皮肤炎症性疾病病因不明手足部位

Predictors of hospita.iza.ion a.d institutiona.iza.ion in Medica.d pa.ient popula.ions with a.zheimer’s Disea.e

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加州兰德斯7.3级地震远距离触发的地震活动

a.va.ces in a.zheimer's Disea.e（阿尔茨海默氏病研究进展） 2013年第3期

作者： a.rienne M.Gilliga. Da.iel C.malone Terri L.Wa.hola. Edwa.d P.a.mstrong

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世界地震译丛 1994年第4期25卷 15-23页

作者： D.P.Hill P.a.Rea.enberg a.Micha.l W.Ja.a.a. G.Beroza.D.Brumba.gh J.N.Drune R.Ca.tro S.Da.is D.dePolo W.L.Rllsworth J.Gombers S.Ha.msen L.House S.M.Ja.kon M.J.S.Johnston R.Keller S.malone L.Mungula.S.na.a.J.C.Pechma.n a.Sa.ford R.W.Simpson R.B.Smith M.Stickney a.Vuda. S.Wa.ter V.Wong J.Zollweg 张嘉延河北省地震局

1992年6月28日7.3级兰德斯地震在美国西部大部分地区触发了地震活动的异常迅速而广泛的增强.所触发的地震发生在距兰德斯主震1250km(震源尺度的17倍)处,范围局限于具有持久地震活动性的地区,并呈走滑到正断层机制.其中许多还是地热和近... 详细信息

1992年6月28日7.3级兰德斯地震在美国西部大部分地区触发了地震活动的异常迅速而广泛的增强.所触发的地震发生在距兰德斯主震1250km(震源尺度的17倍)处,范围局限于具有持久地震活动性的地区,并呈走滑到正断层机制.其中许多还是地热和近代火山活动场所.根据计算的地震弹性模型的静应力交化似乎很小,并不足以导致触发。最有可能的解释是,伴随主震地震波的大的动应交和地壳流体(或许还包括地壳岩浆)之间的非线性相互作用。

关键词：地震地震活动性远距离触发加州

术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除（英文）

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中华神经外科疾病研究杂志 2016年第5期15卷 465-465页

作者： Neira.Ja.Ung TH Sims J malone HR Chow DS Sa.a.a.ud JL Za.a.zi GJ Guo X Bowden SG Zha. B Sheth Sa.McKha.n GM 2nd Sisti MB Ca.oll P D'a.ico RS Bruce JN Depa.tment of Neurologica. Surgery Columbia University Medical Center Depa.tment of Neurora.iology Columbia University Medical Center Depa.tment of Pa.hology a.d Cell Biology Columbia University Medical Center Depa.tment of Ra.iology Columbia University Medical Center

Objective Extent of resection is a. importa.t prognostic fa.tor in pa.ients undergoing surgery for gliobla.toma. GBM).Recent evidence suggests tha. intra.enously a.ministered fluorescein sodium a.socia.es with tumor tissue,fa.ilita.ing sa.e ma.ima. resection of GBM. In this study,the a.thors eva.ua.e the sa.ety a.d utility of intra.pera.ive fluorescein guida.ce for the prediction of histopa.hologica. a.tera.ion both in the contra.t-enha.cing( CE) regions,where this rela.ionship ha. been esta.lished,a.d into the nonCE( NCE),diffusely infiltra.ed ma.gins. Methods Thirty-two pa.ients received fluorescein sodium( 3 mg/kg) intra.enously prior to resection. Fluorescence wa. intra.pera.ively visua.ized using a.Zeiss Pentero surgica. microscope equipped with a.YELLOW 560 *** loca.ized biopsy specimens were a.quired from CE a.d NCE regions ba.ed on preopera.ive MRI in conjunction with neurona.iga.ion. The fluorescence intensity of these specimens wa. subjectively cla.sified in rea. time with subsequent qua.tita.ive ima.e a.a.ysis,histopa.hologica. eva.ua.ion of loca.ized biopsy specimens,a.d ra.iologica. volumetric a.sessment of the extent of *** Bright fluorescence wa. observed in a.l GBMs a.d loca.ized to the CE regions a.d portions of the NCE ma.gins of the tumors,thus serving a. a.visua. guide during resection. Gross-tota. resection( GTR) wa. a.hieved in 84% of the pa.ients with a. a.era.e resected volume of 95%,a.d this ra.e wa. higher a.ong pa.ients for whom GTR wa. the surgica. goa.( GTR a.hieved in 93. 1% of pa.ients,a.era.e resected volume of 99. 7%). Intra.pera.ive fluorescein sta.ning correla.ed with histopa.hologica. a.tera.ion in both CE a.d NCE regions,with positive predictive va.ues by subjective fluorescence eva.ua.ion grea.er tha. 96% in NCE regions. Conclusions Intra.pera.ive a.ministra.ion of fluorescein provides a. ea.ily visua.ized ma.ker for glioma.pa.hology in both CE a.d NCE regions of GBM. These findingssupport the u

关键词：神经外科学疾病研究医学研究临床分析