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Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan

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World Journal of Gastroenterology 2015年第46期21卷 13113-13123页

作者： Shin Kono Takuji Gotoda Shigeaki Yoshida Ichiro Oda Hitoshi Kondo Luigi Gatta Greg Naylor michael Dixon Fuminori Moriyasu Anthony Axon Department of Gastroenterology and Hepatology Tokyo Medical University Aomori Prefectural Central Hospital Endoscopy Division National Cancer Center Hospital Center for Digestive Diseases Tonan Hospital Gastroenterology and Digestive Endoscopy Unit Versilia Hospital Chesterfield Royal Hospital Academic Unit of Pathology University of Leeds Centre for Digestive Disease Leeds General Infirmary

AIM: To assess the diagnostic concordance between endoscopic and histological atrophy in the United Kingdom and ***: Using published data,a total of 252 patients,126 in the United Kingdom and 126 in Japan,aged 20 to 80 years,were evaluated. The extent of endoscopic atrophy was classified into five subgroups according to a modified Kimura-Takemoto classification system and was compared with histological findings of atrophy at five biopsy sites according to the updated Sydney ***: The strength of agreement of the extent of atrophy between histology and visual endoscopic inspection showed good reproducibili ty,wi th a weighted kappa value of 0.76(P < 0.001). Multivariate analysis showed that three factors were associated with decreased concordance: Japanese ethnicity [odds ratio(OR) 0.22,95% confidence interval(CI) 0.11-0.43],older age(OR = 0.32,95%CI: 0.16-0.66) and endoscopic atrophy(OR = 0.10,95%CI: 0.03-0.36). The strength of agreement between endoscopic and histological atrophy,assessed by cancer risk-oriented grading,was reproducible,with a kappa value of 0.81(95%CI: 0.75-0.87). Only nine patients(3.6%) were endoscopically underdiagnosed with antral predominant rather than extensive atrophy and were considered false ***: Endoscopic grading can predict histological atrophy with few false negatives,indicating that precancerous conditions can be identified during screening endoscopy,particularly in patients in western countries.

关键词： Gastritis Atrophy Histology Endoscopy Diagnosis

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恶化型大脑半球大面积脑梗死的处理

中国神经精神疾病杂志 2003年第1期29卷 1-6页

作者： michael Diringer 齐明华华盛顿大学神经科

临床上常见到急性缺血性脑梗死后病情恶化,这可能与神经系统和全身性因素均有关.可以引起临床症状恶化的全身性因素包括:发热、感染、低血压、低氧血症和高碳酸血症.

关键词：恶化型大脑半球脑梗死处理治疗

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融合BDS/GPS/GLONASS解算卫星差分码偏差及精度分析

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测绘通报 2018年第10期 6-9,21页

作者：王健党亚民王虎刘洋洋任政兆中国测绘科学研究院北京100830 山东科技大学测绘科学与工程学院山东青岛266590

卫星差分码偏差是影响用户导航定位和授时定位精度的重要因素。本文融合BDS/GPS/GLONASS三系统数据,采用中国测绘科学研究院i GMAS分析中心自主研发的软件解算卫星差分码偏差。结果表明:GPS卫星P1P2差分码偏差与CODE产品非常吻合,精度... 详细信息

卫星差分码偏差是影响用户导航定位和授时定位精度的重要因素。本文融合BDS/GPS/GLONASS三系统数据,采用中国测绘科学研究院i GMAS分析中心自主研发的软件解算卫星差分码偏差。结果表明:GPS卫星P1P2差分码偏差与CODE产品非常吻合,精度非常高,且非常稳定; BDS卫星B1B3差分码偏差与CODE产品基本吻合,且基本稳定; GLONASS卫星P1P2差分码偏差与CODE产品相对吻合,精度较高,且比较稳定。对比三系统,GPS系统P1P2差分码偏差精度最高,且最稳定; GLONASS系统P1P2差分码偏差精度和稳定性比GPS略低; BDS系统B1B3差分码偏差精度和稳定性最低,可能是星座不完善的原因。

关键词：差分码偏差融合 BDS/GPS/GLONASS

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头颈部癌肉瘤13例临床分析

新乡医学院学报 2022年第12期39卷 1158-1162页

作者：郭晓郭相岑曹华张亚民王刘中郑州大学第一附属医院咽喉头颈外科河南郑州450052

目的探讨头颈部癌肉瘤的病理学特征、治疗及预后。方法回顾性分析2010年4月至2020年7月郑州大学第一附属医院收治的13例头颈部癌肉瘤患者的临床资料,总结其病理学特性、治疗方式及随访情况,应用Kaplan-Meier法计算其累积生存率。结果超... 详细信息

目的探讨头颈部癌肉瘤的病理学特征、治疗及预后。方法回顾性分析2010年4月至2020年7月郑州大学第一附属医院收治的13例头颈部癌肉瘤患者的临床资料,总结其病理学特性、治疗方式及随访情况,应用Kaplan-Meier法计算其累积生存率。结果超声检查结果显示,1例患者仅左侧颈部Ⅱ、Ⅲ区淋巴结直径>1 cm,形态不规则,血流丰富,与周围血管粘连;3例患者双侧颈部Ⅱ~Ⅳ区均存在直径>1 cm淋巴结,形态不规则,血流信号增强,诊断为异常肿大淋巴结,考虑颈部淋巴结转移。头颈部CT检查显示,13例患者均可见病变部位软组织低密度影,形态不规则,与周围组织边界欠清,增强为不均匀轻中度强化,考虑恶性肿瘤可能。核磁共振成像检查结果显示,平扫表现为软组织团片状稍长T1加权信号、稍长T2加权信号,弥散加权成像呈不均匀稍高或低信号,增强扫描观察到病变明显不均匀强化,考虑恶性肿瘤可能。13例患者术后常规组织病理形态学检查结果均证实为癌肉瘤,肉眼观呈菜花样或结节状,表面呈灰红色及棕红色,质地软或稍韧,部分肿瘤内部可见出血或坏死组织;在光镜下其形态学表现为上皮样癌成分与间质样肉瘤成分共存,相互之间存在移行或过渡现象。癌成分主要为鳞状细胞癌(8例)、腺癌(3例)、未分化癌(2例);肉瘤成分复杂多样,包括恶性纤维肉瘤、梭形细胞肉瘤、平滑肌肉瘤、横纹肌肉瘤及未分化肉瘤等。13例患者均完成随访,中位随访时间16个月,其中4例无瘤生存,2例复发后死亡(1例于术后6个月复发伴颈部淋巴结转移,经放化疗后病灶未见明显改变,10个月后死亡;另1例为鼻侧切右侧上颌窦根治术后9个月复发,再次行鼻侧切鼻窦肿物切除术,二次手术后1个月死亡),余7例发生远处转移(肺转移5例,骨转移1例,肠道转移1例);发生远处转移时间最短的1例为术后4个月发生骨转移,转移后2个月死亡;发生远处转移时间最长的1例为术后51个月发生肺转移,转移后11个月死亡。Kaplan-Meier法计算结果显示,13例头颈部癌肉瘤患者1、3、5 a累积生存率分别为61.5%、46.2%、30.8%。结论头颈部癌肉瘤临床特征缺乏特异性,确诊主要依据术后病理,其恶性程度高,预后差,手术是目前治疗的首选方法。

关键词：头颈部肿瘤癌肉瘤病理学特征治疗预后

Enhancing Genetic Gain through Genomic Selection: From Livestock to Plants

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Plant Communications 2020年第1期1卷 4-24页

作者： Yunbi Xu Xiaogang Liu Junjie Fu Hongwu Wang Jiankang Wang Changling Huang Boddupalli MPrasanna michael SOlsen Guoying Wang Aimin Zhang Institute of Crop Science/CIMMYT-China Chinese Academy of Agricultural SciencesBeijing 100081China CIMMYT-China Tropical Maize Research Center Foshan UniversityFoshan 528231China CIMMYT-China Specialty Maize Research Center Shanghai Academy of Agricultural SciencesShanghai 201400China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China CIMMYT(International Maize and Wheat Improvement Center) ICRAF CampusUnited Nations AvenueNairobiKenya

Although long-term genetic gain has been achieved through increasing use of modern breeding methods and technologies,the rate of genetic gain needs to be accelerated to meet humanity’s demand for agricultural *** this regard,genomic selection(GS)has been considered most promising for genetic improvement of the complex traits controlled by many genes each with minor *** scientists pioneered GS application largely due to livestock’s significantly higher individual values and the greater reduction in generation interval that can be achieved in ***-scale application of GS in plants can be achieved by refining field management to improve heritability estimation and prediction accuracy and developing optimum GS models with the consideration of genotype-by-environment interaction and non-additive effects,along with significant cost ***,it would be more effective to integrate GS with other breeding tools and platforms for accelerating the breeding process and thereby further enhancing genetic *** addition,establishing an open-source breeding network and developing transdisciplinary approaches would be essential in enhancing breeding efficiency for small-and medium-sized enterprises and agricultural research systems in developing *** strategies centered on GS for enhancing genetic gain need to be developed.

关键词： genomic selection genetic gain open-source breeding genomic prediction molecular marker livestock breeding

主位推进理论在高中英语概要写作教学中的应用

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基础外语教育 2022年第5期24卷 69-76,111,112页

作者：潘雅敏吴格奇杭州师范大学 311121

主位推进理论是功能语言学的重要概念,对语篇分析有着积极的作用。该理论将句子划分为主位和述位两部分,认为句子中主述位的关系以及篇章中主位推进的模式能够反映信息传递的方向,从而体现语篇构建的整体思路。针对当前中学生英语写作... 详细信息

主位推进理论是功能语言学的重要概念,对语篇分析有着积极的作用。该理论将句子划分为主位和述位两部分,认为句子中主述位的关系以及篇章中主位推进的模式能够反映信息传递的方向,从而体现语篇构建的整体思路。针对当前中学生英语写作缺乏连贯性和衔接性的问题,本文探讨了主位推进理论在概要写作教学的两个环节——阅读和写作中的应用。案例分析表明,主位推进理论在阅读中可以帮助学生定位语篇话题,梳理语篇结构;在写作中可以帮助学生训练主位意识,增强写作逻辑。

关键词：主位结构主位推进模式英语概要写作

粉末形貌对选区激光熔化316L不锈钢力学性能的影响

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金属热处理 2021年第2期46卷 173-177页

作者：张亚民吴姚莎杨均宝刘孝青中山火炬职业技术学院装备智造学院广东中山528436 广东正德材料表面科技有限公司广东中山528437

以气雾化316L不锈钢粉为原料,结合等离子球化和选区激光熔化技术制备了不锈钢块体,并用XRD、SEM、激光粒度仪、振实密度仪和万能力学试验机等对等离子球化粉体和选区激光不锈钢块的组织结构和性能进行了表征。结果表明:316L不锈钢粉经... 详细信息

以气雾化316L不锈钢粉为原料,结合等离子球化和选区激光熔化技术制备了不锈钢块体,并用XRD、SEM、激光粒度仪、振实密度仪和万能力学试验机等对等离子球化粉体和选区激光不锈钢块的组织结构和性能进行了表征。结果表明:316L不锈钢粉经等离子球化处理后,不规则扁平状颗粒数量减少,球形颗粒数量增加,振实密度与松装密度的比值(HR值)从1.28减少到1.08,流动性得到明显改善。等离子球化颗粒经SLM成形后的块体物相组成与前驱粉体一致,均为典型的奥氏体不锈钢组织(γ-Fe+α-Fe)。与气雾化块体相比,等离子球化块体力学性能和致密性均有一定程度提高,这主要归因于经等离子球化处理后的前驱粉体致密度提高,球形度增加且流动性良好。

关键词： 316L不锈钢等离子球化选区激光熔化组织结构力学性能

Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 249-256页

作者： Wan Suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid michael Pak-KaiWong Mohd Nizam Md Hashim Department of Pharmacology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Surgery School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To determine the anti-proliferative activity of Abrus precatorius(***)leaf extracts and their effect on cell ***:*** leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet *** extract was prepared by decoction at 50 ℃.Extracts of *** leaves were used to treat selected cancer and normal cell lines for72 ***,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell *** of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow ***:Methanolic extract of *** leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/*** cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of *** *** extract of *** leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of ***:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.

关键词： Abrus precatorius MDA-MB-231 Apoptosis Cell cycle Breast cancer

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高技术企业创业的成功因素

科研管理 2004年第z1期25卷 106-111页

作者： Prof.Dr.michael Dowling University of Regensburg

通过对美国及德国的十多年研究表明,对于创新及合作网络的投资有利于促进高技术行业企业不断进步和发展。这些高技术行业包括电信、电脑设备及生物工艺的行业。研究表明政府政策在促进竞争及支持地区合作网络发展中起到了极其重要的作用。

关键词：技术战略创业企业进步地区网络