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Correlations of morphology and molecular alterations in traditional serrated adenoma

World Journal of Gastrointestinal Pathophysiology 2020年第4期11卷 78-83页

作者： Hongxing Gui Michael A Husson Rifat Mannan Department of Pathology and Laboratory Medicine Pennsylvania Hospital of the University of Pennsylvania Health SystemPhiladelphiaPA 19107United States

Traditional serrated adenoma was first reported by Longacre and FenoglioPresier in 1990.Their initial study described main features of this lesion,but the consensus diagnostic criteria were not widely adopted until recently.Traditional serrated adenoma presents with grossly protuberant configuration and pineconelike appearance upon endoscopy.Histologically,it is characterized by ectopic crypt formation,slit-like serration,eosinophilic cytoplasm and pencillate nuclei.Although much is now known about the morphology and molecular changes,the mechanisms underlying the morphological alterations are still not fully understood.Furthermore,the origin of traditional serrated adenoma is not completely known.We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity.

关键词： Traditional serrated adenoma Serrated polyps KRAS BRAF Colon

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Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

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Case Reports in Clinical Medicine 2014年第12期3卷 650-659页

作者： Xinying Shen michael husson William Lipshutz Penn Gastroenterology at Pennsylvania Hospital Philadelphia USA Department of Pathology & Laboratory Medicine Pennsylvania Hospital Philadelphia USA

Cronkhite-Canada syndrome (CCS) is a rare, non-inherited polyposis syndrome, characterized by diffuse gastrointestinal (GI) hamartomatous polyposis with unique dermatologic changes including alopecia, skin hyperpigmentation, and nail dystrophy. Patients can typically present with diarrhea, weight loss, protein-losing enteropathy, and nutritional deficiency. However, it can demonstrate diverse other clinical features, usually with poor prognosis. Currently, there are no specific diagnostic criteria established yet. The etiology of CCS is still obscure, but an autoimmune process has been suggested. Here we present an 81-year-old Caucasian female who had clinical presentations, physical exam, imaging, endoscopy and pathology findings that were all consistent with the diagnosis of CCS. We also include a detailed literature review of the other gastrointestinal polyposis syndromes (hamartomatous, adenomatous, hyperplastic and inflammatory polyposis). A high index of suspicion and recognition of the characteristic clinical, endoscopic as well as histopathological findings of CCS, as well as different gastrointestinal polyposis conditions, can help clinicians with more timely and correct diagnosis.

关键词： Cronkhite-Canada Syndrome Intestinal Polyposis Adenomatous Polyposis Hamartomatous Polyposis Hyperplastic Polyposis Inflammatory Polyposis

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