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Quantifying spatiotemporal variability in occupant exposure to an indoor airborne contaminant with an uncertain source location

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Building Simulation 2023年第6期16卷 889-913页

作者： John e.Castellini Jr Cary A.Faulkner Wangda Zuo michael D.Sohn Department of Mechanical engineering University of Colorado BoulderUCB 427BoulderCO80309USA Department Architectural engineering The Pennsylvania State UniversityUniversity ParkPA16802USA National Renewable energy National Laboratory GoldenCO80401USA energy Analysis and environmental Impacts Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA94720USA

Well-mixed zone models are often employed to compute indoor air quality and occupant *** effective,a potential downside to assuming instantaneous,perfect mixing is underpredicting exposures to high intermittent concentrations within a *** such cases are of concern,more spatially resolved models,like computational-fluid dynamics methods,are used for some or all of the ***,these models have higher computational costs and require more input information.A preferred compromise would be to continue with a multi-zone modeling approach for all rooms,but with a better assessment of the spatial variability within a *** do so,we present a quantitative method for estimating a room’s spatiotemporal variability,based on influential room *** proposed method disaggregates variability into the variability in a room’s average concentration,and the spatial variability within the room relative to that *** enables a detailed assessment of how variability in particular room parameters impacts the uncertain occupant *** demonstrate the utility of this method,we simulate contaminant dispersion for a variety of possible source *** compute breathing-zone exposure during the releasing(source is active)and decaying(source is removed)*** CFD methods,we found after a 30 minutes release the average standard deviation in the spatial distribution of exposure was approximately 28%of the source average exposure,whereas variability in the different average exposures was lower,only 10%of the total *** also find that although uncertainty in the source location leads to variability in the average magnitude of transient exposure,it does not have a particularly large influence on the spatial distribution during the decaying period,or on the average contaminant removal *** systematically characterizing a room’s average concentration,its variability,and the spatial variability within the room important insights can be gain

关键词： uncertainty variability airborne contaminant spatiotemporal variability well-mixed heterogeneity

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Viability and hatchability of brine shrimp Artemia franciscana cysts after passing through the digestive system of eared grebes Podiceps nigricollis

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Journal of Oceanology and Limnology 2023年第4期41卷 1300-1306页

作者： michael R.CONOVeR Mark e.BeLL Leah M.DeLAHOUSSAYe Department of Wildland Resources and ecology Center LoganUT 84322-5230USA

Brine shrimp Artemia franciscana provide food for many migrating and staging birds that spend summer and fall on Great Salt Lake,Utah,*** produce live young and cysts(hard-walled eggs);these cysts are commercially harvested on Great Salt Lake and support a large industry in *** is unclear the impact that millions of hungry birds have on the Artemia population in the *** help assess that,this study evaluated cyst viability(percentage of cysts that contain an embryo)and hatchability(percent of cysts that hatch)from cysts that had passed through the digestive tract of eared grebes Podiceps nigricollis and cysts obtained directly from Great Salt Lake at the same site where each grebe was *** was significantly higher for cysts collected from the water column(19%)than from the stomach(0.3%)or intestines(3%)of eared *** also was significantly different for cysts collected from the water column(29%),stomach(0.7%),and intestines(5%).These results indicate that eared grebes nutritionally benefit from eating cysts and that they may be an important food source for grebes in late fall after the adult population of Artemia dies off due to the water becoming too ***,enough cysts survive their passage through the digestive system that grebes can vector hatchable cysts to other waterbodies.

关键词： Artemia dispersal eared grebes hatchability invasive species Great Salt Lake salty lakes viability

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn e.Taylor Julian C.Schmidt michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher e.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems engineering Colorado State UniversityFort CollinsCO 80523USA element Biosciences San DiegoCA 10055USA Department of environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low earth orbit(LeO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Ignition of nanothermites by a laser diode pulse

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Defence Technology（防务技术） 2022年第2期18卷 194-204页

作者： Alexander Yu.Dolgoborodov Vladimir G.Kirilenko michael A.Brazhnikov Leonid I.Grishin michael L.Kuskov Georgii e.Valyano Joint Institute for High Temperatures Russian Academy of SciencesRussia N.Semenov Federal Research Center for Chemical Physics Russian Academy of SciencesRussia National Research Nuclear University MePhI Moscow Russia

experimental investigation has been carried out for laser ignition and combustion of nanothermites based on aluminum and oxides of copper,bismuth and *** mixing of nanosized powders was used to produce *** thermite ignition,initiating laser pulse with a maximum intensity of 770 W/cm2 was generated by a laser diode with a wavelength of 808 *** ignition delay times,the minimum initiation energy density,and the average burning rate at various thermite densities and mass fractions of components were determined by recording the emission of radiation of the reaction products using a multichannel pyrometer jointly with a high-speed video *** effect of adding carbon black on the threshold parameters of a laser pulse was also *** on the obtained results,certain assumptions were put forward with regard to the mechanism of nanothermites’ignition by laser radiation and their *** particular,the assumptions were made on the two-stage process of the reaction initiation and jet burning mechanism of porous nanothermites.

关键词： Nanothermites Laser ignition Burning rate Ignition delay

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Mainstreaming the Full eNSO:Linking Present Weather and Future Climate

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International Journal of Disaster Risk Science 2022年第6期13卷 829-841页

作者： michael H.Glantz Lino Naranjo-Diaz Qian Ye Gregory e.Pierce Consortium for Capacity Building(CCB) University of Colorado BoulderBoulderCO 80301USA Integrated Risk Governance Program Beijing Normal UniversityBeijing 100875China

In this article we propose that all countries that are striving to become a Weather-Ready Nation(WRN)would beneft greatly from including el Niño-Southern Oscillation(eNSO)-related research findings into their decision-making processes,not only when an el Niño or a La Niña forecast has been issued *** an aspiring WRN,to beneft from eNSO information,such as disruptive or benefcial changes that could be foreseeably expected to occur in seasonal fow and in sub-seasonal hydrometeorological anomalies,requires its continuous mainstreaming about the status of the eNSO process into a WRN’s decision-making *** eNSO process provides a bridge between sub-seasonal weather anomalies and a sub-decadal climate phenomenon as well as a bridge between coping with weather extremes today and preparing for climate change-related hydrometeorological hazards in the *** extremes every few years provide a chance to evaluate a nation’s strategic and tactical responses to hydrometeorological hazard forecasts and *** successive eNSO extreme and its Neutral phase tests previously designed best *** of today’s youth and young professionals on climate,water,and weather issues has been increasing and will do so in coming *** awareness and attention to eNSO and away from eNSO extremes is *** heightened urgency for understanding the full eNSO“cycle”especially by youth and young professionals today is because they will soon be in professional positions that enable them to advise decision makers about climate policy *** understanding of the eNSO cycle is critically needed,as global warming is expected to continue to increase for the rest of the twentyfrst century.

关键词： eNSO WRN Hydromet Climate change Young professionals

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College Algebra with Trigonometry Raymond A. Barnett, michael R. Ziegler, Karl e. Byleen 7th ed.

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丛书名： Barnett, Ziegler & Byleen's precalculus series

2001年

作者： Raymond A. Barnett michael R. Ziegler Karl e. Byleen

Includes indexes.

ISBN: (纸本)0072368691

Includes indexes.

关键词： Algebra.

来源：畅想之星图书光盘版（南... 评论

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Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.eichacker Linda e.Franken Davide e.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel e.Rivas Max Rose Amit K.Samanta Philipp Schmidt egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches electronen-Synchrotron DeSY Notkestrasse 8522607 HamburgGermany european XFeL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden eLI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoeM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-eppendorf(UKe) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden european Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of escherichia coli GroeL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

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Minimally invasive keyhole techniques for resection of giant intracranial tumors

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Chinese Neurosurgical Journal 2022年第4期8卷 230-238页

作者： Qing Lan michael e.Sughrue Robert G.Briggs Department of Neurosurgery 2nd Affiliated HospitalSoochow UniversitySuzhouChina Center for Minimally Invasive Neurosurgery Prince of Wales Private HospitalSydneyAustralia Department of Neurosurgery University of Oklahoma Health Science CenterOklahoma CityOklahomaUSA

Background:While keyhole neurosurgery is increasingly utilized in the operating room,there are few reports regarding the use of keyhole techniques to resect giant intracranial *** feasibility and technique of that were discussed in this ***:We retrospectively reviewed 95 consecutive patients who were admitted to our service between February 2012 and September 2017 with a maximum intracranial tumor diameter>5 *** approaches were used to resect these tumors in each case,including supraorbital,subtemporal,suboccipital,retromastoid,frontal,temporal,occipital,parietal,pterional,a combined temporo-parietal keyhole approach,and an approach via the longitudinal ***:We achieved gross total resection in 68/95 cases(71.6%)and subtotal resection in 27/95 cases(28.4%).No surgical death or severe disabilities such as coma and limb dyskinesia occurred following *** the time of discharge,8 patients had complications related to impaired cranial nerve *** addition,2 patients developed hydrocephalus requiring ventriculo-peritoneal shunt placement,and 4 patients developed a postoperative CSF leak requiring surgical ***:With meticulous design and reasonable selection,resection of giant intracranial tumors utilizing minimally invasive keyhole approaches can be done safely with satisfactory surgical outcomes.

关键词： Giant tumor Keyhole approach Meningioma Pituitary adenoma Schwannoma Glioma

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Anopheles gambiae strain(Ag55)cultured cells originated from Anopheles coluzzii and are phagocytic with hemocyte-like gene expression

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Insect Science 2022年第5期29卷 1346-1360页

作者： Ruchir Mishra Gang Hua Ujwal R.Bagal Donald e.Champagne michael J.Adang Department of entomology College of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGeorgiaUSA Department of entomology and Nematology University of FloridaGainesvilleFloridaUSA Institute of Bioinformatics University of GeorgiaAthensGeorgiaUSA Department of Biochemistry and Molecular Biology University of GeorgiaAthensGeorgiaUSA

Anopheles gambiae and Anopheles coluzzii are closely related species that are predominant vectors of malaria in ***,*** form M was renamed *** and we now conclude on the basis of a diagnostic PCR-restriction fragment length polymorphism assay that Ag55 cells were derived from *** established an Ag55 cell transcriptome,and KeGG pathway analysis showed that Ag55 cells are enriched in phagosome pathway *** Ag55 transcriptome has an abundance of specific transcripts characteristic of mosquito *** *** bioparticle uptake experiments visualized by fluorescence microscopy and confocal microscopy and quantified by flow cytometry establish the phagocytic competence of Ag55 *** from this investigation of Ag55 cell properties will guide researchers in the use and engineering of the Ag55 cell line to better enable investigations of Plasmodium,other microbes,and insecticidal toxins.

关键词： Anopheles coluzzii transcriptome Anopheles gambiae confocal microscopy flow-cytometry FPKM hemocyte-like phagocytosis

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Transcatheter Device Closure of a Perimembranous Ventricular Septal Defect in Congenitally Corrected Transposition of the Great Arteries

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Congenital Heart Disease 2022年第2期17卷 193-199页

作者： Catherine e.Tomasulo Lindsay S.Rogers Lauren Andrade michael LO’Byrne Division of Cardiology The Children’s Hospital of PhiladelphiaPhiladelphiaUSA Division of Cardiology Hospital of the University of PennsylvaniaPhiladelphiaUSA Center for Pediatric Clinical effectiveness The Children’s Hospital of PhiladelphiaPhiladelphiaUSA Leonard Davis Institute and Center for Cardiovascular Outcomes Qualityand Evaluative ResearchUniversity of PennsylvaniaPhiladelphiaUSA

The majority of patients with congenitally corrected transposition of the great arteries,also known as transposition of the great arteries{S,L,L}have ventricular septal defects(VSD),most commonly perimembranous VSD(pmVSD).Transcatheter device closure of pmVSD in these patients has not been widely *** present a case of device closure of pmVSD in L-TGA with an Amplatzer Duct Occluder II(ADOII)device using a deployment starting in the subpulmonary left *** case demonstrates some of the technical advantages of the ADOII device for VSD closure,specifically its low profile,symmetric shape,and soft *** characteristics are advantageous in closing conventional pmVSD but are especially useful in patients with challenging anatomic substrates.

关键词： Percutaneous catheterization congenital heart disease thromboembolism

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