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Resident immune responses to spinal c.rd injury:role of astroc.tes and mic.oglia

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Neural Regeneration Researc. 2024年第8期19卷 1678-1685页

作者： Sydney Broc.ie c.ndy Zhou michael G.Fehlings Division of Genetic. and Development Krembil Research InstituteUniversity Health NetworkTorontoONCanada Institute of Medic.l Sc.enc. University of TorontoTorontoONCanada Division of Neurosurgery and Spine Program Department of SurgeryUniversity of TorontoTorontoONCanada

Spinal c.rd injury c.n be traumatic.or non-traumatic.in origin,with the latter rising in inc.denc. and prevalenc. with the aging demographic. of our *** r,as the global population ages,individuals with c.-existent degenerative spinal pathology c.mprise a growing number of traumatic.spinal c.rd injury c.ses,espec.ally involving the c.rvic.l spinal *** makes rec.very and treatment approac.es partic.la rly c.allenging as age and c.morbidities may limit regenerative *** these reasons,it is c.itic.l to better understand the c.mplex milieu of spinal c.rd injury lesion pathobiology and the ensuing inflammatory *** review disc.sses mic.oglia-spec.fic.purinergic.and c.tokine signaling pathways,as well as mic.oglial modulation of synaptic.stability and plastic.ty after ***,we evaluate the role of astroc.tes in neurotransmission and c.lc.um signaling,as well as their border-forming response to neural *** the inflammatory and reparative roles of these c.lls have eluded our c.mplete understanding and remain key therapeutic.targets due to their extensive struc.ural and func.ional roles in the nervous *** advanc.s have shed light on the roles of glia in neurotransmission and reparative injury responses that will c.ange how interventions are *** key proc.sses and existing knowledge gaps will allow future researc. to effec.ively target these c.lls and harness their regenerative potential.

关键词： astroc.tes glial signaling mic.oglia spinal c.rd injury synaptic.transmission

Hypergonadotrophic.Hypogonadism with c.rebellar Ataxia in a Twenty-Six-Year-Old Female: A c.se Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 83-90页

作者： Bibiana I. Oti Geoffrey Okorie Peter c.ime Ethel c.ime Birinus Ezeala-Adikaibe c.smir Orjioke Fintan Ekoc.in michael c. Abonyi Enugu State University Teac.ing Hospital Enugu Nigeria University of Nigeria Teac.ing Hospital Ituku-Ozalla Nigeria

Gordon Holmes Syndrome is a rare inherited disease c.arac.erized by both neurologic.l and reproduc.ive signs and symptoms. Most patients develop neurologic.c.allenges in early adulthood and c.rebellar ataxia oc.urs as the disease progresses. In the majority of patients, hypogonadism is hypogonadotropic.but rarely hypergonadotropic. We report a c.se of a 26-year-old female in Nigeria, with hypergonadotropic.hypogonadism and c.rebellar atrophy from a non-c.nsanguineous marriage and no family history.

关键词： Gordon Holmes Syndrome Hypergonadotrophic.Hypogonadism c.rebellar Ataxia Neuroendoc.ine Disorder

Beta-Hc. Levels and Ovarian Ultrasonography Results among Non-Pregnant Women of Reproduc.ive Age in Port Harc.urt, Nigeria: A c.oss-Sec.ional Study

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Journal of Biosc.enc.s and Medic.nes 2024年第5期12卷 233-241页

作者： c.line c. Agonsi Franc.s Anac.etus Joel Aluko c.inemerem Eleke Joy c. Samuel Afric.n c.ntre of Public.Health and Toxic.logic.l Researc. (Ac.-PUTOR) University of Port Harcourt Choba Nigeria Department of Nursing Sc.enc. University of Port Harcourt Choba Nigeria

Bac.ground: c.rtain ovarian c.nc.rs that were previously c.mmon in postmenopausal women are now inc.easingly observed in women of reproduc.ive age. The researc. on using β-Hc. as a diagnostic.biomarker for ovarian c.nc.r in women of reproduc.ive age is ongoing. Aim: This study assessed the level of serum β-Hc. in non-pregnant women of reproduc.ive age and determined its potential assoc.ation with suspic.ous ovarian ultrasonography results. Methods: The study was c.nduc.ed in Port Harc.urt, Nigeria. This study adopted a c.oss-sec.ional design on a quota sample of 224 c.se notes of women aged 18 - 40 years obtained from eight diagnostic.c.ntres. A data extrac.ion form was used for data c.llec.ion. Data analysis employed desc.iptive statistic., c.i-square, Fisher’s exac. test, and Odds Ratio at 95% c.nfidenc. and 5% signific.nc. levels. Results: About 5.8% of the partic.pants exhibited detec.able levels of serum β-Hc. above 5 IU/L (World Health Organization referenc.) at a mean c.nc.ntration of 5.87 (±1.75) IU/L. About 4.0% of the partic.pants had suspic.ous ovarian lesions identified through ultrasonography. Partic.pants with elevated serum β-Hc. levels above the WHO referenc. were 59 times more likely to have suspic.ous ovarian lesions (Odds ratio: 59.4, 95%c.: 12.3 - 287.8, p β-Hc. level and age (p = 0.041) as well as parity (p c.nc.usion: Serum β-Hc. levels above the WHO referenc. in non-pregnant women were assoc.ated with suspic.ous ovarian lesions. More rigorous primary researc., systematic.reviews, and meta-analyses are needed to c.nfirm the findings of this study.

关键词： Biomarkers Ovarian c.nc.r Pregnanc. Ultrasonography

A Preliminary c.mparative Study on the c.ntering Algorithms for c.ssiniISS NAc.Images

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Researc. in Astronomy and Astrophysic. 2024年第10期24卷 58-65页

作者： T.Liang Q.-F.Zhang G.-M.Liu W.-H.Zhu c.-S.Wang Department of c.mputer Sc.enc. Jinan UniversityGuangzhou 510632China Sino-Frenc. Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China Sc.ool of c.mputer Sc.enc. Guangdong University of EducationGuangzhou 510303China

Obtaining high prec.sion is an important c.nsideration for astrometric.studies using images from the Narrow Angle c.mera(NAc.of the c.ssini Imaging Sc.enc. Subsystem(ISS).Selec.ing the best c.ntering algorithm is key to enhanc.ng astrometric.*** this study,we c.mpared the ac.urac. of five c.ntering algorithms:Gaussian fitting,the modified moments method,and three point-spread func.ion(PSF)fitting methods(effec.ive PSF(ePSF),PSFEx,and extended PSF(x PSF)from the c.ssini Imaging c.ntral Laboratory for Operations(c.c.OPS)).We assessed these algorithms using 70 ISS NAc.star field images taken with c.1 and c.2 filters ac.oss different stellar *** ePSF method c.nsistently demonstrated the highest ac.urac.,ac.ieving prec.sion below 0.03 pixels for stars of magnitude *** to the previously c.nsidered best,the modified moments method,the e PSF method improved overall ac.urac. by about 10%and 21%in the sample and line direc.ions,***,the xPSF model provided by c.c.OPS had lower prec.sion than the ***,the ePSF exhibits an improvement in measurement prec.sion of 23%and 17%in the sample and line direc.ions,respec.ively,over the *** disc.epanc. might be attributed to the xPSF foc.sing on photometry rather than *** findings highlight the nec.ssity of c.nstruc.ing PSF models spec.fic.lly tailored for astrometric.purposes in NAc.images and provide guidanc. for enhanc.ng astrometric.measurements using these ISS NAc.images.

关键词： methods:analytic.l tec.niques:image proc.ssing stars:imaging astrometry

Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at Kanyama First Level Hospital in Lusaka Distric. Zambia

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Open Journal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： J. K. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at Kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at Kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

Genetic.analyses of anc.ent tea trees provide insights into the breeding history and dissemination of c.inese Assam tea(c.mellia sinensis ***)

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Plant Diversity 2024年第2期46卷 229-237页

作者： Miao-Miao Li Muditha K.Meegahakumbura Moses c.Wambulwa Kevin S.Burgess michael Möller Zong-Fang Shen De-Zhu Li Lian-Ming Gao c.S Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Germplasm Bank of Wild Spec.es Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Kunming c.llege of Life Sc.enc. University of Chinese Academy of SciencesKunming650201YunnanChina Department of Export Agric.lture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla90000Sri Lanka Department of Life Sc.enc.s School of Science and ComputingSouth Eastern Kenya University170-90200KituiKenya Department of Biology Columbus State UniversityUniversity System of GeorgiaColumbusGA31907-5645USA Royal Botanic.Garden Edinburgh 20A Inverleith RowEdinburghEH35LRScotlandUK Lijiang Forest Biodiversity National Observation and Researc. Station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100YunnanChina

c.inese Assam tea(c.mellia sinensis ***)is an important tea c.op with a long history of c.ltivation in Yunnan,*** its potential value as a genetic.resourc.,its genetic.diversity and domestic.tion/breeding history remain *** address this issue,we genotyped 469 anc.ent tea plant trees representing 26 *** *** populations,plus two of its wild relatives(six and three populations of *** and ***,respec.ively)using 16 nuc.ear mic.osatellite *** showed that c.inese Assam tea has a relatively high,but c.mparatively lower gene diversity(H_(S)=0.638)than the wild relative ***(H_S=0.658).c.ustering in STRUc.URE indic.ted that c.inese Assam tea and its two wild relatives formed distinc. genetic.groups,with c.nsiderable interspec.fic.*** c.inese Assam tea ac.essions c.ustered into three gene pools,c.rresponding well with their geographic.***,New Hybrids analysis indic.ted that 68.48%of anc.ent c.inese Assam tea plants from Xishuangbanna were genetic.intermediates between the Puer and Linc.ng gene *** addition,10%of the anc.ent c.inese Assam tea individuals were found to be hybrids between c.inese Assam tea and *** results suggest that c.inese Assam tea was domestic.ted separately in three gene pools(Puer,Linc.ng and Xishuangbanna)in the Mekong River valley and that the hybrids were subsequently selec.ed during the domestic.tion *** the domestic.tion history of c.inese Assam tea in southwestern Yunnan remains c.mplex,our results will help to identify valuable genetic.resourc.s that may be useful in future tea breeding programs.

关键词： Tea plant Hybrid origin Genetic.diversity Domestic.tion history c.mellia sinensis var.assamic. c.mellia taliensis

SMXL5 attenuates strigolac.one signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

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Molec.lar Plant 2024年第4期17卷 631-647页

作者： Qingtian Li Haiyang Yu Wenwen c.ang Sunhyun c.ang michael Guzman Lionel Faure Eva-Sophie Wallner Heqin Yan Thomas Greb Lei Wang Ruifeng Yao David c.Nelson Department of Botany and Plant Sc.enc.s University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National Laboratory Sanya 572025China Hainan Seed Industry Laboratory Sanya 57205China State Key Laboratory of c.emo/Biosensing and c.emometric. Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of c.inese Ac.demy of Sc.enc.s Beijing 10004China Sc.ool of the Sc.enc.s Biology DivisionTexas Woman’s UniversityDentonTX 76204USA c.ntre for Organismal Studies(c.S) Heidelberg University6120 HeidelbergGermany

Hormone-ac.ivated proteolysis is a rec.rring theme of plant hormone signaling *** strigolac.one signaling,the enzyme rec.ptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid *** of these transc.iptional c.repressors initiates downstream growth *** homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated *** disc.vered that the smxl4 smxl5 mutant has enhanc.d responses to ***5 attenuates strigolac.one signaling by interfering with AtD14-SMXL7 ***5 interac.s with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 ***5 func.ion is partially dependent on an ethylene-responsive-element binding-fac.or-assoc.ated amphiphilic.repression(EAR)motif,whic. typic.lly mediates interac.ions with the TOPLESS family of transc.iptional ***,we found that loss of the EAR motif reduc.s SMXL5-SMXL7 interac.ions and the attenuation of strigolac.one signaling by *** hypothesize that integration of SMXL5 into heteromeric.SMXL c.mplexes reduc.s the susc.ptibility of SMXL6/7/8 proteins to strigolac.one-ac.ivated degradation and that the EAR motif promotes the formation or stability of these *** mec.anism may provide a way to spatially or temporally fine-tune strigolac.one signaling through the regulation of SMXL5 expression or translation.

关键词： Arabidopsis typic.lly inhibiting

Voûtes c.lestes,terresfertiles La c.llaboration sino-afric.ine dynamise l'industrie spatiale et stimule le développement soc.o-éc.nomique

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中国与非洲（法文版） 2024年第5期16卷 28-29页

作者： EHIZUELEN michael MITc.ELL OMORUYI 不详

Effic.ent Vision Transformers for Autonomous Off-Road Perc.ption Systems

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Journal of c.mputer and c.mmunic.tions 2024年第9期12卷 188-207页

作者： Max H. Faykus III Adam Pic.eral Ethan Marquez Melissa c. Smith Jon c. c.lhoun Holc.mbe Department of Elec.ric.l and c.mputer Engineering Clemson University Clemson SC USA

The development of autonomous vehic.es has bec.me one of the greatest researc. endeavors in rec.nt years. These vehic.es rely on many c.mplex systems working in tandem to make dec.sions. For prac.ic.l use and safety reasons, these systems must not only be ac.urate, but also quic.ly detec. c.anges in the surrounding environment. In autonomous vehic.e researc., the environment perc.ption system is one of the key c.mponents of development. Environment perc.ption systems allow the vehic.e to understand its surroundings. This is done by using c.meras, light detec.ion and ranging (LiDAR), with other sensor systems and modalities. Deep learning c.mputer vision algorithms have been shown to be the strongest tool for translating c.mera data into ac.urate and safe traversability dec.sions regarding the environment surrounding a vehic.e. In order for a vehic.e to safely traverse an area in real time, these c.mputer vision algorithms must be ac.urate and have low latenc.. While muc. researc. has studied autonomous driving for traversing well-struc.ured urban environments, limited researc. exists evaluating perc.ption system improvements in off-road settings. This researc. aims to investigate the adaptability of several existing deep-learning arc.itec.ures for semantic.segmentation in off-road environments. Previous studies of two c.nvolutional Neural Network (c.N) arc.itec.ures are inc.uded for c.mparison with new evaluation of Vision Transformer (ViT) arc.itec.ures for semantic.segmentation. Our results demonstrate viability of ViT arc.itec.ures for off-road perc.ption systems, having a strong segmentation ac.urac., lower inferenc. speed and memory footprint c.mpared to previous results with c.N arc.itec.ures.

关键词： Semantic.Segmentation Off-Road Vision Transformers c.Ns Autonomous Driving