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Science China Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （k+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （kOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing k+.Under simulated sunlight irradiation,the sample with a k+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.k+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

Phosphatase and tensin homologue:a therapeutic target for SMA

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Signal Transduction and Targeted Therapy 2017年第1期2卷 108-114页

作者： Vinay k Godena ke Ning Department of Neuroscience Sheffield Institute of Translational Neuroscience(SITraN)University of SheffieldSheffieldUK

Spinal muscular atrophy(SMA)is one of the most common juvenile neurodegenerative diseases,which can be associated with child *** is caused by a mutation of ubiquitously expressed gene,Survival Motor Neuron1(SMN1),leading to reduced SMN protein and the motor neuron *** disease is incurable and the only therapeutic strategy to follow is to improve the expression of SMN protein levels in motor *** numbers of motor neurons in SMA mice and SMA cultures are caspase positive with condensed nuclei,suggesting that these cells are prone to a process of cell death called *** for other potential molecules or signaling pathways that are neuroprotective for central nervous system(CNS)insults is essential for widening the scope of developmental ***,a Phosphatase and Tensin homologue,is a tumor suppressor,which is widely expressed in *** depletion activates anti-apoptotic factors and it is evident that the pathway plays an important protective role in many neurodegenerative *** functions as a negative regulator of PIP3/AkT pathway and thereby modulates its downstream cellular functions through lipid phosphatase ***,previous reports from our group demonstrated that,PTEN depletion using viral vector delivery system in SMN delta7 mice reduces disease pathology,with significant rescue on survival rate and the body weight of the SMA *** knockdown/depletion/mutation of PTEN and manipulation of PTEN medicated Akt/PkB signaling pathway may represent an important therapeutic strategy to promote motor neuron survival in SMA.

关键词： protective therapeutic mortality

Formation mechanism of titanium and niobium carbides in hardfacing alloy

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Rare Metals 2017年第8期36卷 640-644页

作者： ke Yang kèYang Ye-Feng Bao Yong-Feng Jiang College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China

The most effective carbide-forming elements titanium and niobium were added into hardfacing *** and composition of carbides in the hardfacing alloy were investigated by means of optical microscope（OM）,scanning electron microscope（SEM）,X-ray diffraction（XRD）and energy-dispersive spectrometer（EDS）.Hardness and impact toughness of the hardfacing alloy were *** thermodynamics and formation mechanism of carbides were also *** is found that the carbides consist of TiC and NbC which are able to form directly from welding pool during the welding *** formation mechanism of carbides involves nucleation of TiC followed by epitaxial precipitation of NbC on the surface of *** formation of titanium and niobium carbides can obviously refine the microstructure and deplete the carbon in the *** micros tructure transforms to well-distributed carbides and a tough martensite matrix,contributing to a good combination of high hardness and high toughness in the hardfacing alloy.

关键词： Titanium Niobium Hardfacing alloy Carbides Microstructure

Effect of corrosion product films on the in vitro degradation behavior of Mg-3%Al-1%Zn(in wt%) alloy in Hank's solution

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Journal of Materials Science & Technology 2018年第10期34卷 1756-1764页

作者： B.J.Wang D.k.Xu J.H.Dong W.ke School of Environmental and Chemical Engineering Shenyang Ligong University CAS key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences Environmental Corrosion Center Institute of Metal Research Chinese Academy of Sciences

Through investigating the corrosion behavior of an as-extruded Mg-3wt%gAl-lwt%Zn （AZ31） alloy in a simulated physiological fluid of Hank＇s solution, it demonstrates that the corrosion process was depen- dent on the immersion time. Further analyses revealed that the highest corrosion resistance could be obtained at 24 h due to the formation of a compact layer of corrosion products on the sample surface. With increasing the immersion time to up to 48 h, the thickness of surface films increased gradually but obvious de-bonding of such film from the substrate could take place, resulting in a certain resilience of the overall corrosion resistance.

关键词： Magnesium Surface layer Corrosion product Interface

Comparative analysis of de novo transcriptome assembly

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Science China(Life Sciences) 2013年第2期56卷 156-162页

作者： CLARke kaitlin YANG Yi MARSH Ronald XIE LingLin ZHANG ke k. Bioinformatics Core Department of PathologyUniversity of North Dakota Department of Computer Science University of North Dakota Department of Biochemistry and Molecular Biology University of North Dakota

The fast development of next-generation sequencing technology presents a major computational challenge for data processing and analysis.A fast algorithm,de Bruijn graph has been successfully used for genome DNA de novo assembly;nevertheless,its performance for transcriptome assembly is *** this study,we used both simulated and real RNA-Seq data,from either artificial RNA templates or human transcripts,to evaluate five de novo assemblers,ABySS,Mira,Trinity,Velvet and *** these assemblers,ABySS,Trinity,Velvet and Oases are all based on de Bruijn graph,and Mira uses an overlap graph *** numbers of RNA short reads were selected from the External RNA Control Consortium(ERCC) data and human chromosome 22.A number of statistics were then calculated for the resulting contigs from each *** experiment was repeated multiple times to obtain the mean statistics and standard error *** had relative good performance for both ERCC and human data,but it may not consistently generate full length *** was the fastest method but its assembly quality was *** gave a good rate for mapping its contigs onto human chromosome 22,but its computational speed is not *** results suggest that transcript assembly remains a challenge problem for bioinformatics ***,a novel assembler is in need for assembling transcriptome data generated by next generation sequencing technique.

关键词： transcriptome assembly next-generation sequencing RNA-Seq De Bruijn graph overlap graph

Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease

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World Journal of Gastroenterology 2009年第46期15卷 5784-5788页

作者： Zhan-Ju Liu Praveen k Yadav Jing-Ling Su Jun-Shan Wang ke Fei Department of Gastroenteroiogy Shanghai Tenth People'sHospital Tongji University Shanghai 200072 China Department of Thoracic Surgery Shanghai TenthPeople's Hospital Tongji University Shanghai 200072 China

The etiopathology of inflammatory bowel disease （IBD） remains elusive. Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflam- mation. IBD including Crohn＇s disease （CD） and ulcerative colitis （UC） is a chronic inflammatory disease of the gastrointestinal tract, which is implicated in an inappropriate and overactive mucosal immune response to luminal flora. Traditionally, CD is regarded as a Thl- mediated inflammatory disorder while UC is regarded as a Th2-1ike disease. Recently, Th17 cells were identified as a new subset of T helper cells unrelated to Thl or Th2 cells, and several cytokines [e.g. interleukin （IL）-21, IL-23] are involved in regulating their activation and differentiation. They not only play an important role in host defense against extracellular pathogens, but are also associated with the development of autoimmunity and inflammatory response such as IBD. The identification of Th17 cells helps us to explain some of the anomalies seen in the Thl/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD.

关键词： Crohn's disease Inflammatory bowel disease Interleukin-17 Interleukin-23 Th17 cells Ulcerative colitis

Enduring legacy of coal mining on the fungal community in a High Arctic soil after five decades

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Pedosphere 2022年第5期32卷 698-706页

作者： Dorsaf keRFAHI kevin k.NEWSHAM ke DONG Hokyung SONG Mark TIBBETT Jonathan M.ADAMS School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601(Republic of Korea) NERC British Antarctic Survey Madingley RoadCambridge CB3 OET(UK) Department of Life Science Kyonggi UniversitySuwon-si 16227(Republic of Korea) School of Earth and Environmental Sciences The University of ManchesterManchester M139PL(UK) Department of Sustainable Land Management&Soil Research Center School of AgriculturePolicy and DevelopmentUniversity of ReadingReading RG66AR(UK) School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210008(China)

Mineral extraction is known to affect soil fungi in polar environments,but it is unknown how long these effects ***,by amplifying the internal transcribed spacer regions of rRNA genes in soil fungi,we compared soil fungal community in intact natural tundra with that in a nearby former coal mining area,abandoned 52 years previously,on Svalbard in the High *** with those in intact tundra,soils in the former mining area were more acidic and had lower plant *** of similar diversity in the two areas,the fungal community was dominated by Basidiomycota in the intact tundra,but by Ascomycota in the former mining *** genera formed a major part of the tundra community,but were notably less abundant in the mining *** principal variation among samples was soil ***,network connectivity analysis indicated that the fungal community in the former mining area had greater network connectivity than that in the tundra ***,the ecosystem in the former mining area has made only limited recovery towards the natural tundra state even after more than five *** is unclear whether the recovery of the fungal community is limited more by the low primary productivity,slow migration of fungi and plants,or slow changes in soil *** findings emphasize the susceptibility of polar ecosystems to disturbance,given their particularly slow recovery back towards the natural state.

关键词： abandoned mining site ectomycorrhizal fungi intact tundra mine tailings mineral extraction polar ecosystem recovery

基于Alt-Geohash编码的k-匿名位置隐私保护方案

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计算机应用研究 2025年第1期42卷 276-281页

作者：李晶刘苛张磊佳木斯大学信息电子技术学院黑龙江佳木斯154007 佳木斯大学黑龙江省自主智能与信息处理重点实验室黑龙江佳木斯154007 佳木斯大学佳木斯市卫星导航技术与装备工程技术重点实验室黑龙江佳木斯154007

在对享受基于位置服务(LBS)用户进行位置隐私保护时,传统k-匿名技术在执行匿名操作时没有全面考虑时间开销和位置背景信息。针对上述问题,提出了一种基于Alt-Geohash编码的k-匿名位置隐私保护方案(k-anonymous location privacy protect... 详细信息

在对享受基于位置服务(LBS)用户进行位置隐私保护时,传统k-匿名技术在执行匿名操作时没有全面考虑时间开销和位置背景信息。针对上述问题,提出了一种基于Alt-Geohash编码的k-匿名位置隐私保护方案(k-anonymous location privacy protection scheme based on Alt-Geohash coding,kLPPS-AGC)。首先,通过位置泛化和Alt-Geohash编码技术实现对历史数据的快速检索;其次,根据历史查询概率筛选出能与用户构建高位置熵的位置;再次,利用海伦公式改善匿名集的位置分散度;最后,构建安全匿名集实现对用户的位置隐私保护。实验证明,该方案拥有较低的时间开销和较高的隐私性。

关键词：基于位置服务隐私保护位置隐私 k-匿名 Geohash

Molecular genetics of Brugada syndrome

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Frontiers in Biology 2010年第4期5卷 339-347页

作者： Tie ke Xin TU Shuoyan ZHANG Yuhua LIAO Qing k.WANG key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology and Center for Human Genome ResearchHuazhong University of Science and TechnologyWuhan 430074China Cardio-X Institute Huazhong University of Science and TechnologyWuhan 430074China Institute of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Center for Cardiovascular Genetics Cleveland ClinicClevelandOH 44195USA

Brugada syndrome(BrS)is a life-threatening cardiac rhythm disorder characterized by persistent STsegment elevation in leads V1–V3 and right bundle branch block on electrocardiograms(ECG),and by syncope and sudden death from ventricular tachycardia(VT)and ventricular fibrillation(VF).BrS is responsible for nearly 4%of sudden cardiac deaths and considered to be the most common cause of natural death in males younger than 50 years in some Asian *** the first diseasecausing gene for BrS(the cardiac sodium channel gene SCN5A)was identified in 1998,extensive investigations on both clinical and basic aspects of BrS have occurred ***5A mutations remain the most common cause of BrS;nearly 300 SCN5A mutations have been identified and are responsible for 20%–30%of BrS *** genetic testing is available for ***,seven other disease-causing genes for BrS have been identified and include GPD1L(BrS2),CACNA1C(Cav1.2,BrS3),CACNB2(Cavβ2,BrS4),SCN1B(Navβ1,BrS5),kCNE3(MiRP2,BrS6),SCN3B(Navβ3,BrS7),and HCN4(BrS8).This article will briefly review the progress made over the past decade in our understanding of the clinical,genetic and molecular aspects of BrS.

关键词： Brugada syndrome molecular genetics arrhythmia sudden death SCN5A ion channel

Experimental and modeling study of de novo formation of PCDD/PCDF on MSW fly ash

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Journal of Environmental Sciences 2007年第1期19卷 117-122页

作者： LI Xiao-dong ZHANG Ji YAN Jian-hua CEN ke-fa RYAN Shawn P GULLETT Brian k LEE Chunwai State key Laboratory of Clean Energy Utilization Institute for Thermal Power Engineering Zhefiang University Hangzhou 310027 China U.S. Environmental Protection Agency Office of Research and Development National Risk Management Research Laboratory E305-01 Research Triangle Park North Carolina 27711 USA

The effect of sulfur dioxide （SO2） on the formation of polychlorinated dibenzo-p-dioxins （PCDDs） and polychlorinated dibenzofurans （PCDFs） has been studied in an entrained-flow reactor （EFR） under simulated waste combustion conditions. A chlorination model based on conditional probability was employed to evaluate the homologue patterns of PCDDs and PCDFs. Results revealed that the presence of SO2 did not alter the formation pathway although SO2 suppressed PCDD/F formation. The prediction model of PCDF showed good agreement with the experimental data （R--0.95）, whereas the prediction for PCDDs did not correlate well with the experimental data. This may be explained because potential chlorination pathways play a significant role in PCDF formation, whereas PCDDs are mainly formed through condensation reactions. Furthermore, the result indicated that the steric hindrance during formation has more effects on PCDD than on PCDF due to the symmetric molecular structures of PCDDs.

关键词： PCDDs PCDFs de novo synthesis formation chlorination model sulfur dioxide air pollution waste combustion