检索结果-南通市图书馆

Large-scale genome-wide SnP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： natalia V.DEMEnTIEVA Yuri S.SHCHERBAKOV Olga I.STAnISHEVSKAYA Anatoly B.VAKHRAMEEV Tatiana A.LARKInA Artem P.DYSIn Olga A.nIKOLAEVA Anna E.RYABOVA Anastasiia I.AZOVTSEVA Olga V.MITROFAnOVA Grigoriy K.PEGLIVAnYAn natalia R.REInBACH Darren K.GRIFFIn michae. n.romanov Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),north America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SnP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SnP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SnP)analysis Gene pool Global ancestry Phylogeny Demographic history

Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第3期14卷 887-907页

作者： michae. n.romanov Alexandra S.Abdelmanova Vladimir I.Fisinin Elena A.Gladyr natalia A.Volkova Olga A.Koshkina Andrey n.Rodionov Anastasia n.Vetokh Igor V.Gusev Dmitry V.Anshakov Olga I.Stanishevskaya Arsen V.Dotsev Darren K.Griffin natalia A.Zinovieva L.K.Ernst Federal Research Centre for Animal Husbandry DubrovitsyPodolskMoscow RegionRussia School of Biosciences University of KentCanterburyUK Federal State Budget Scientific Institution Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Breeding and Genetic Centre“Zagorsk Experimental Breeding Farm”–Branch of the Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Russian Research Institute of Farm Animal Genetics and Breeding–Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry St.PetersburgRussia

Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture *** to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed *** Using the Chicken 50K_CobbCons SnP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White *** of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation *** regions of true selection signatures were identified by two or more methods or in two or more *** these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other *** them,SOX5,ME3,ZnF536,WWP1,RIPK2,OSGIn2,DECR1,TPO,PPARGC1A,BDnF,MSTn,and beta-keratin genes can be especially mentioned as candidates for cold *** factors may be involved in regulating some of these important genes(e.g.,TPO and BDnF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken *** include genes representing the sine qua non for adaptation to harsh *** tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.

关键词： Acclimation Adaptation Chicken breeds Cold tolerance Divergent selection Genetic diversity Genomewide scan Phenotypic traits Selective sweeps

Waxes in asphaltenes of crude oils and wax deposits

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2016年第4期13卷 737-745页

作者： Yulia M.Ganeeva Tatiana n.Yusupova Gennady V.romanov A.E. Arbuzov Institute of Organic and Physical Chemistry Kazan Scientific Center Russian Academy of Sciences Institute of Geology and Petroleum Technologies Kazan (Volga region) Federal University

Composition and molecular mass distribution of n-alkanes in asphaltenes of crude oils of different ages and in wax deposits formed in the borehole equipment were studied. In asphaltenes, n-alkanes from C12 to C60 were detected. The high molecular weight paraffins in asphaltenes would form a crystalline phase with a melting point of 80–90 ℃. The peculiarities of the redistribution of high molecular paraffin hydrocarbons between oil and the corresponding wax deposit were detected. In the oils, the high molecular weight paraffinic hydrocarbons C50–C60were found, which were not practically detected in the corresponding wax deposits.

关键词： Waxes Asphaltenes Hydrocarbon composition Crude oil Wax deposit

Coal-gas interaction： implications of changes in texture and porosity

在线全文

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2016年第1期3卷 10-19页

作者： Vyacheslav n. romanov Lauren C. Graeser Sinisha A. Jikich Yee Soong Gino A. Irdi U. S. Department of Energy National Energy TechnologyLaboratory P. O. Box 10940 Pittsburgh 15236 USA

Transient sorption and desorption of helium and carbon dioxide in Upper Freeport coal powder and lumps were analyzed. Differences in texture and porosity between the powder and lumps may affect the transport and interaction of the penetrant and coal. In this work, we address macroscopic and mesoscopic structural differences between powdered and non-powdered coals that influence the rates of the gas transport kinetics and changes in coal texture （swelling, shrinkage, and changes in the pore structure and interconnectivity） and the reciprocal free-phase pressure decay （relaxation）. Com- parison of the multi-exponential relaxation time constants as a function of pressure, for CO2 and inert gas （helium）, allows us to postulate several mechanisms responsible for observed pressure decay patterns.

关键词： Coal Gas Porosity Structure Diffusion Sorption Swelling

Calibrated dilatometer exercise to probe thermoplastic properties of coal in pressurized CO2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2017年第3期4卷 245-251页

作者： Vyacheslav n. romanov Ronald J. Lynn Robert P. Warzinski U. S. Department of Energy National Energy TechnologyLaboratory P. O. Box 10940 Pittsburgh PA 15236 USA

This research was aimed at testing a hypothesis, that at elevated CO2 pressure coal can soften at temperatures well below those obtained in the presence of other gases. That could have serious negative implications for injection of CO2 into deep coal seams. We have examined the experimental design issues and procedures used in the previously published studies, and experimentally investigated the physical behavior of a similar coal in the presence of COa as a function of pressure and temperature, using the same high-pressure micro-dilatometer refurbished and carefully calibrated for this purpose. no notable reduction in coal softening temperature was observed in this study.

关键词： Dilatometry · Carbon dioxide· Coal· Plasticization

Fusion Material Studies Relating to Safety in Russia in 2002

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2004年第5期6卷 2496-2502页

作者： B.n.Kolbasov M.I.Guseva B.I.Khripunov Y.V.Martvnenkc P.V.romanov S.A.Lelekhov S.A.Bartenev Russian Research Centre "Kurchatov Institute" Kurchatov Sq. 1 123182 Moscow Russia RF Federal Agency for Atomic Energy Staromonetnyj pereulok 26 109180 Moscow Russia V. G. Khlopin Radium Institute 2nd Murinsky avenue 28 194021 St.-Petersburg Russia

The paper is a summary of Russian material studies performed in frames of activi-ties aiming at substantiation of safety of the International Thermonuclear Experimental Reactor(ITER)after *** sputtering of tungsten by 5 eV deuterons was revealed at temper-atures above 1150℃.Mechanism of globular films formation was further *** of tritium permeation into vacuum vessel coolant confirmed the acceptability of vacuum vessel cooling system for removal of the decay *** most dangerous accident with high-current are in toroidal superconducting magnets able to burn out a bore up to 0.6 m in diameter in the cryostat vessel was *** reprocessing of V-Cr-Ti alloy and its purification from activation products down to a contact dose rate of~10μSv/h was developed.

关键词： fusion reactor materials plasma-materials interaction vanadium and vanadium alloys

nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病

在线全文

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第17期17卷 I0003-I0004页

作者： Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A romanov, Christian Pifl Tibor Harkany Roman A romanov, Giada Spigolon, Débora Masini, michae. Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han ng Marius Wernig Laboratory of Molecular neurobiology Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden Department of Molecular neurosciences Center for Brain Research Medical University of Vienna Vienna Austria Department of neuroscience Karolinska Institutet Stockholm Sweden Department of Pharmacology Faculty of Medicine Biomedical Research Institute of Malaga (IBIMA) Malaga University Malaga Spain Institute for Stem Cell Biology and Regenerative Medicine Stanford University Stanford California USA.

帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元（dopaminergic neuron）渐进性丧失。尽管当前的疗法旨在补充多巴胺水平，但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中，... 详细信息

帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元（dopaminergic neuron）渐进性丧失。尽管当前的疗法旨在补充多巴胺水平，但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中，来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法：将神经胶质细胞（glialcell）转化为活性的多巴胺能神经元，并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。

关键词：多巴胺能神经元星形胶质细胞帕金森病治疗神经退行性疾病 nat 重编程神经胶质细胞

人和环境的剂量负担——对一起超设计基准事故造成的放射性污染地区的长期管理

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辐射防护通讯 1990年第4期10卷 39-45页

作者： C.n.romanov 马吉增

本文中的一些建议是基于下述问题提出的: 1.在事故后最初七十年内,保证生活在污染区居民的辐射安全; 2.对污染工地的使用进行安排,使之能保证居民的辐射安全及供应市场的产品符合辐射和卫生标准。上述两个问题是有机联系的。考虑到居民... 详细信息

本文中的一些建议是基于下述问题提出的: 1.在事故后最初七十年内,保证生活在污染区居民的辐射安全; 2.对污染工地的使用进行安排,使之能保证居民的辐射安全及供应市场的产品符合辐射和卫生标准。上述两个问题是有机联系的。考虑到居民居住和污染土地利用的可能性,有必要按放射性污染密度把污染区划分为几个小区域,同时也有必要对按污染密度划分的几个小区域内利用土地及方法的前景做出评价。

关键词：放射性污染地区管理剂量

Effects of Agrobacterial<i>rol</i>-Genes on the Thermodynamic and Structural Features of Starches Extracted from Potato Microtubers

在线全文

学校读者我要写书评

暂无评论

Food and nutrition Sciences 2014年第3期5卷 250-257页

作者： Luybov A. Wasserman nina P. Aksenova Tatiyana n. Konstantinova Lidiya I. Sergeeva Svetlana A. Golyanovskaya Alexey V. Krivandin Georgy A. romanov Emmanuel Institute of Biochemical Physics Russian Academy of Sciences Moscow Russia imiryazev Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Timiryazev Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Timiryazev Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Laboratory of Plant Physiology Wageningen University Wageningen The Netherlands.

Wild-type potato (Solanum tuberosum L.) plants and their transformants harboring agrobacterial rolB or rolC genes under control of the patatin class I promoter were cultured in vitro. These plants were used as a source of single-node stem cuttings. The structure of native starch in tubers formed on cuttings was determined using methods of X-ray scattering and differential scanning microcalorimetry (DSC). It was found that in starch from tubers of rolB plants the melting temperature of crystalline lamella was lower and their thickness was less than that in wild-type potato. In tubers of rolC plants starch differed from starch in wild-type plants by a higher melting temperature, reduced melting enthalpy, and a greater thickness of crystalline lamellae. The melting of starch from tubers of rolC plants proceeded as the melting of two independent crystalline structures with melting temperatures of 338.0°K and 342.8°K. Overall data show that starches of different structure can be obtained by using transgenic approach.

关键词： Solanum tuberosum Transgenic Potato Starch rol Genes Tubers Crystalline Lamellae Melting Temperature