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Modeling the influence of livestock grazing pressure on grassland bird distributions

Ecological Processes 2020年第1期9卷 488-498页

作者： Rachel R.Fern michae. L.morrison William E.Grant Hsiaohsuan Wang Tyler A.Campbell Department of Wildlife and Fisheries Sciences Texas A&M UniversityWFES Building2258 TAMU534 John Kimbrough BlvdCollege StationTX 77843-2258USA East Foundation San AntonioTX 78216USA

Background:The influence of vegetative changes due to livestock grazing on grassland birds is well-recognized because these birds are heavily influenced by vegetative ***,species distribution models(SDMs)use direct variables,resources that the animal consumes or requires to persist in an area(e.g.,water)to define and project a species’niche and *** variables,which are features the animal does not consume or require for persistence but with which it may still interact,are often *** objective was to improve the traditional SDMs projecting the distribution of three summer resident South Texas grassland birds(Northern Bobwhite Colinus virginianus,Eastern Meadowlark Sturnella magna,and Cassin’s Sparrow Peucaea cassinii)by incorporating livestock grazing pressure,an indirect variable,into five SDM algorithms:BioClim,generalized linear model,MaxEnt,boosted regression tree,and random *** collected data from the Coloraditas Grazing Research and Demonstration Area(CGRDA),a 7684-ha area located on the San Antonio Viejo Ranch(SAV)in South *** used several relevant environmental characteristics to build SDMs and compared model performance(AUC and TSS)with and without grazing pressure as an indirect ***:Machine learning models(MaxEnt and random forest)had the highest predictive performance for all species,with random forest being the most consistent for each *** and generalized linear model remained constant or only marginally improved with the addition of the grazing ***:Our findings suggest that model selection for SDM should include consideration of species prevalence,and machine-learning algorithms should be preferred when the target species is of low or unknown ***,livestock grazing has measurable influence on grassland bird species’distributions and should be included in SDMs as an indirect variable in addition to associated vegetative changes.

关键词： Birds Grassland Grazing Livestock Species distribution model Texas

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Awareness and Perception of Genetic Modification among Science and Technical Vocational Teachers in Guyana： Focusing on Genetically Modified Foods

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Journal of Agricultural Science and Technology(B) 2012年第7期2卷 789-797页

作者： Donna morrison Faculty of Agriculture and Forestry University of Guyana P.O. Box 101110 Georgetown Guyana

A study was conducted to determine the awareness and perception of biotechnology focusing on genetically modified foods among public secondary school science and technical vocational teachers in Guyana. A questionnaire was administered to 228 randomly selected teachers of 42 schools in six administrative regions of Guyana, representing about 90% of the population. The results revealed that there was a low level of awareness among the teachers： those who were knowledgeable about the subject were mainly Biology, Agricultural Science and Integrated Science teachers. Most teachers （almost 90%） indicated that the public is not receiving adequate information about genetically-modified foods and opined that the television should be the main medium to provide information. The study also revealed that teachers felt that ethical, religious and social issues should be considered when applying the technology. This view did not vary based on qualifications, years in the profession or subjects taught. Genetic modification was more acceptable to plant-based than animal-based foods, although they seemed ambivalent as to whether genetically modified foods can be harmful to their health. The implications of these findings are that more teachers in various subject areas should be informed about emerging issues in sciences to enable them to better analyze the subject matter, transfer information to the students, and form attitudes and opinions based on facts.

关键词： Biotechnology curriculum education genetics genetic engineering awareness perception.

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Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4^(+) T cell activation

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Cellular & Molecular Immunology 2020年第2期17卷 133-142页

作者： Miguel Álvaro-Benito Eliot morrison Friederike Ebner Esam T.Abualrous Marie Urbicht Marek Wieczorek Christian Freund Laboratory of Protein Biochemistry Department of BiologyChemistry and PharmacyFreie Universität BerlinThielallee 6314195 BerlinGermany Institut für Immunologie Department of Veterinary MedicineFreie Universität BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany Computational Molecular Biology Group Institute for MathematicsFreie Universität BerlinBerlinGermany

Classical human leukocyte antigen(HLA)molecules of the major histocompatibility classⅡ(MHCⅡ)complex present peptides for the development,surveillance and activation of CD4^(+) T *** nonclassical MHCⅡ-like protein HLA-DM(DM)catalyzes the exchange and loading of peptides onto MHCⅡmolecules,thereby shaping MHCⅡ*** variations of DM in both chains of the protein(DMA and DMB)have been hypothesized to impact peptide presentation,but no evidence for altered function has been *** we define the presence of DM allotypes in human populations covered by the 1000 Genomes Project and probe their *** functional properties of several allotypes are investigated and show strong enhancement of peptide-induced T cell activation for a particular combination of DMA and *** evidence suggests a broader pH activity profile for the new variant relative to that of the most commonly expressed DM *** analysis indicates that the compartmental activity of the new DM heterodimer extends beyond the late endosome and suggests that the natural variation of DM has profound effects on adaptive immunity when antigens bypass the canonical processing pathway.

关键词： MHC classⅡ Limited polymorphism HLA-DM,Peptide editing Epitope selection Immunopeptidome

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Numerical Methods for Solving the Hartree-Fock Equations of Diatomic Molecules I

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Communications in Computational Physics 2009年第5期5卷 959-985页

作者： John C.morrison Scott Boyd Luis Marsano Bernard Bialecki Thomas Ericsson Jose Paulo Santos Department of Physics University of LouisvilleLouisvilleKY40292USA Department of Mathematical and Computer Sciences Colorado School of MinesGoldenCO 80401-1887USA Department of Mathematical Sciences Chalmers University of Technology and the University of GothenburgSE-41296 GothenburgSweden Department of Physics New University of LisbonLisbonPortugal

The theory of domain decomposition is described and used to divide the variable domain of a diatomic molecule into separate regions which are solved *** approach makes it possible to use fast Krylov methods in the broad interior of the region while using explicit methods such as Gaussian elimination on the *** is demonstrated by solving a number of model problems,these methods enable one to obtain solutions of the relevant partial differential equations and eigenvalue equations accurate to six significant figures with a small amount of computational *** the numerical approach described in this article decomposes the variable space into separate regions where the equations are solved independently,our approach is very well-suited to parallel computing and offers the long term possibility of studying complex molecules by dividing them into smaller fragments that are calculated separately.

关键词： Fast Krylov methods splines Hartree-Fock equations diatomic molecules eigenvalue problem

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液压五步选出正确的阀

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现代制造 2013年第4期 42-43页

作者： michae.IAdkins

控制阀种类繁多，如何才能选出最理想的控制阀一直是很多用户的困扰。本文针对这一问题，介绍了正确选择控制阀的方法，并阐述了重要控制阀类型的特点。

关键词：控制阀液压多用户

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约翰·达利自传

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世界高尔夫 2009年第7期 60-67页

作者： michae.Lewis 张君楠

我不会踏上还没个P杆宽的跑步机。还有,打死我也不会去什么健康俱乐部,他们不会让我抽烟的。

关键词：达利锦标赛自传高尔夫跑步机约翰停车场推杆房车球场

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Biological insights in non-small cell lung cancer

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Cancer Biology & Medicine 2023年第7期20卷 500-518页

作者： Rafael Rosell Anisha Jain Jordi Codony-Servat Eloisa Jantus-Lewintre Blake morrison Jordi Barretina Ginesta María González-Cao Germans Trias i Pujol Research Institute Badalona 08028Spain IOR Hospital Quiron-DexeusBarcelona 08028Spain Department of Microbiology JSS Academy of Higher Education&ResearchMysuru 570015India Pangaea Oncology Hospital Quiron-DexeusBarcelona 08028Spain Department of Biotechnology Universitat Politècnica de ValenciaMixed Unit TRIAL(General University Hospital of Valencia Research Foundation and Príncipe Felipe Research Center)CIBERONCValencia 46014Spain Sumitomo Pharma Oncology Inc.CambridgeMA and LehiUT 84043USA

Lung oncogenesis relies on intracellular cysteine to overcome oxidative *** tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexpression of the cystine transporter SLC7A11,thus sustaining intracellular cysteine levels to support glutathione *** factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated protein(KEAP1)acts as a cytoplasmic repressor of the oxidative responsive transcription factor *** in KEAP1/NRF2 and p53 induce SLC7A11 activation in *** cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative *** in cystine availability lead to iron-dependent lipid peroxidation,thus resulting in a type of cell death called *** inhibitors of xCT(either SLC7A11 or GPX4)induce ferroptosis of NSCLC cells and other tumor *** cystine uptake is impaired,the intracellular cysteine pool can be sustained by the transsulfuration pathway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8^(+)T cell function and evasion of immunotherapy,diminishing immune response and potentially reducing the effectiveness of immunotherapeutic *** is a previously unrecognized form of regulated cell *** NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce pyroptotic cell death as well as *** targeted therapy,the mitochondrial intrinsic apoptotic pathway is activated,thus leading to the cleavage and activation of ***,gasdermin E is activated,thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis(indicated by characte

关键词： Solute carrier family 7 member 11(SLC7A11) nuclear factor erythroid 2-related factor 2(NRF2) ferroptosis pyroptosis KRAS G12C allele-specific inhibitors non-small cell lung cancer(NSCLC)

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表面化学物理

表面化学物理

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作者： (美)Roy morrison 赵璧英等译

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Scotland

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疯狂英语（阅读版） 2007年第7期 66-67页

作者： Donald morrison

Where the salmon leap, the eagles soar, the still of the glen, the waterfall’s roar…There’s Aberdeen——

关键词： Scotland

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RU486 Reversal of Cortisol Repression of 1,25-Dihydroxyvitamin D<sub>3</sub>Induction of the Human Osteocalcin Promoter

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Open Journal of Endocrine and Metabolic Diseases 2013年第1期3卷 55-62页

作者： Nigel A. morrison School of Medical Science Griffith University Gold Coast Campus Gold Coast Australia

In conditions of corticosteroid excess, such as Cushing’s syndrome, a reduction in serum osteocalcin is observed and bone loss occurs. The human osteocalcin gene is induced by 1,25-dihydroxyvitamin D3 derivatives and repressed by glucocorticoids. In this paper we show that cortisol, a natural glucocorticoid, represses both basal and vitamin D induced activity of the human osteocalcin promoter. Furthermore, we address the specific question as to whether the anti-progestin anti-glucocorticoid RU486 is able to antagonize the inhibitory effect of cortisol on osteocalcin gene expression. We show that RU486 has agonist activity alone, in that it is able to repress the basal promoter activity of the osteocalcin gene and antagonist activity, reversing incompletely the cortisol mediated repression of 1,25-dihydroxyvitamin D3 induction.

关键词： RU486 Osteocalcin Vitamin D Glucocorticoid

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