检索结果-南通市图书馆

Comparative analysis of breast and lung cancer survival rates and clinical trial enrollments among rural and urban patients in Georgia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第9期32卷 1401-1406页

作者： TATIANA KURIlO REBECCA d.PENTZ Winship Cancer Institute Emory University School of MedicineEmory UniversityAtlanta30322USA

Objectives:Rural patients have poor cancer outcomes and clinical trial(CT)enrollment compared to urban patients due to attitudinal,awareness,and healthcare access *** of cancer survival disparities and CT enrollment is important for designing interventions and innovative approaches to address the stated *** study explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung cancer *** hypotheses are that for both cancer types,urban cancer patients will have longer 5-year survival rates and higher enrollment rates in clinical trials than those in rural ***:We compared breast and lung cancer patients’survival rates and enrollment ratios in clinical trials between rural(RUCC 4-9)and urban counties in Georgia at a Comprehensive Cancer Center(CCC).To assess these differences,we carried out a series of independent samples t-tests and Chi-Square ***:The outcomes indicate comparable 5-year survival rates across rural and urban counties for breast and lung cancer patients,failing to substantiate our *** clinical trial enrollment rates demonstrated a significant difference between breast and lung cancer patients at CCC,no significant variation was observed based on rural or urban ***:These findings underscore the need for further research into the representation of rural patients with diverse cancer types at CCC and other cancer ***,the findings have considerable implications for the initiation of positive social change to improve CT participation and reduce cancer survival disparities.

关键词： Cancer Cancer survival rates Clinical trial enrollment Rural patients Health disparities Barriers to clinical trial participation Geographic disparities

Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian J Rajkovic Matthew l Merckling Alyssa W lee Galadu Subah Aryan Malhotra Zachary d Thomas Sabrina l Zeller John V Wainwright Merritt d Kinon department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUNd Chronic inflammatory pain is associated with increased expression of interleukin(Il)-1,an inflammatory cytokine,and activity on its receptor(Il-1R).In response,the body produces Il-1R antagonist(Il-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous Il-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(ddd)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(Sd)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

Biomaterials and emerging technologies for tissue engineering and in vitro models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel Oliveira Rui l.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal

The latest advances in the field of biomaterials have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatly contributed for the successful translation of tissue engineering products into the market/***-materials are easily processed to become similar to natural extracellular matrix,making them ideal temporary supports for mimicking the three-dimensional(3d)microenvironment required for maintaining the adequate cell/tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterials engineer

Novel medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 669-678页

作者： Kaixin li Juntao Gao Xu Han Qi Shao Zhe lü School of Physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Heilongjiang Provincial Key laboratory of Advanced Quantum Functional Materials and Sensor Components Harbin 150001HeilongjiangChina

It is widely recognized that the development of ZABs is impeded by the kinetic bottleneck of oxygen evolution reaction(OER)and oxygen reduction reaction(ORR).The application of conformational entropy strategy to oxides often involves introducing multiple elements with different properties,thereby providing outstanding bifunctional catalytic activity for OER/***,the possible underlying catalytic pathways and potential interactions between various components are still poorly *** paper presents an excellent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(lower overpotential of 301 mV at 10 mA cm^(−2)).Zinc-air batteries employing it as a cathode catalyst demonstrate excellent round-trip efficiency(62%).By combining theoretical calculation with experiments,we aim to establish the link between the electronic structure of perovskite oxides with different elemental compositions and their OER *** reveals that the conformational entropy strategy can simultaneously shift the O 2p-band center and metal d-band center of perovskite oxide towards the vicinity of the Fermi energy level,thereby triggering a more favorable lattice oxygen-participated mechanism(lOM)during the OER *** outcomes of this work provide crucial insights into the role of conformational entropy strategies in oxygen catalysis and offer potential avenues for constructing efficient and stable electrocatalysts.

关键词： Sr(FeCoNiMo)_(1/4)O_(3−δ) Bifunctional catalyst Medium entropy lOM Rechargeable zinc-air batteries

Spark Plasma Sintering of Mg-based Alloys:Microstructure,Mechanical Properties,Corrosion Behavior,and Tribological Performance

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第2期12卷 405-442页

作者： Alessandro M.Ralls Mohammadreza daroonparvar Pradeep l.Menezes department of Mechanical Engineering University of Nevada RenoRenoNV89557United States

Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for Mg *** the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule *** to traditional and additive manufacturing(AM)techniques,SPS gives unique control of the structural and microstructural features of Mg *** doing so,their mechanical,tribological,and corrosion properties can be *** great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single *** motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SPS manufacturing for *** do so,the existing body of SPS Mg literature was first surveyed,with a focus on their structural formation and degradation *** was found that successful Mg SPS fabrication highly depended on the processing temperature,particle size,and particle *** addition of metal and ceramic composites also affected their microstructural features due to the Zener pinning *** degradative environments,their performance depends on their structural features and whether they have secondary phased *** industrial applications,SPS'd Mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling *** prospects to advance the field include using Mg as a doping agent for crystallite size refinement and using bulk metallic Mg-based glass powders for amorphous SPS *** these findings,the interactions of multi-composites on the processing-structure-property relationships of SPS Mg is not well *** total,this work will provide a useful direction in the SPS field and serve as a milestone for future Mg-based SPS manufacturing.

关键词： Spark plasma sintering Magnesium alloys Nanocrystalline Tribology Mechanical properties Corrosion

Error-based adaptive optimal tracking control of nonlinear discrete-time systems

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第1期67卷 154-167页

作者： Chun lI Jinliang dING Frank l.lEWIS Tianyou CHAI State Key laboratory of Synthetical Automation for Process Industries Northeastern University UTA Research Institute The University of Texas at Arlington

In this paper,for the output tracking problem of nonlinear discrete-time systems,a performance index is newly defined using the adaptive dynamic programming(AdP) technique to completely eliminate tracking errors in *** contrast to traditional definitions of performance indices in other AdP-based methods,the proposed performance index is not only designed from the perspective of output tracking errors but also introduced errors of system states and control inputs at adjacent stages,which is suitable for practical situations in many industrial applications,such as the alumina production,the flotation process,and the mineral grinding *** proved that the obtained controller can make the system output fully track the given reference trajectory by applying the iterative criteria of the AdP *** addition,the proposed algorithm was implemented using a data-driven technique and neural networks to avoid analyzing and deducing the complicated dynamics of actual industrial ***,using historical data for a forced-circulation evaporation system in the alumina production process,the effect of the proposed approach was verified through a numerical simulation and compared with that of the proportional-integral controller.

关键词： adaptive dynamic programming iterative criteria performance index tracking errors tracking problem

MART(Splitting-Merging Assisted Reliable)Independent Component Analysis for Extracting Accurate Brain Functional Networks

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第7期40卷 905-920页

作者： Xingyu He Vince d.Calhoun Yuhui du School of Computer and Information Technology Shanxi UniversityTaiyuan 030006China Tri-Institutional Center for Translational Research in Neuroimaging and data Science Georgia State UniversityGeorgia Institute of TechnologyEmory UniversityAtlanta 30303USA

Functional networks(FNs)hold significant promise in understanding brain *** component analysis(ICA)has been applied in estimating FNs from functional magnetic resonance imaging(fMRI).However,determining an optimal model order for ICA remains challenging,leading to criticism about the reliability of FN ***,we propose a SMART(splitting-merging assisted reliable)ICA method that automatically extracts reliable FNs by clustering independent components(ICs)obtained from multi-model-order ICA using a simplified graph while providing linkages among FNs deduced from different-model *** extend SMART ICA to multi-subject fMRI analysis,validating its effectiveness using simulated and real fMRI *** on simulated data,the method accurately estimates both group-common and group-unique components and demonstrates robustness to *** two age-matched cohorts of resting fMRI data comprising 1,950 healthy subjects,the resulting reliable group-level FNs are greatly similar between the two cohorts,and interestingly the subject-specific FNs show progressive changes while age ***,both small-scale and large-scale brain FN templates are provided as benchmarks for future *** together,SMART ICA can automatically obtain reliable FNs in analyzing multi-subject fMRI data,while also providing linkages between different FNs.

关键词： Independent component analysis Functional magnetic resonance imaging-Brain functional networks Clustering Multi-model-order

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.l-Hashem Salah O.Bashir Amal F.dawood Moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni Mohamed d.Morsy department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia department of Basic Medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

Are population cycles recovering?

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily d.YAKUSHOV Boris I.SHEFTEl A.N.Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was *** studies were carried out at the Yenisei ecological station“Mirnoye”of the *** Institute of Ecology and Evolution,Russian Academy of *** time series analysis was performed by the wavelet transform using the statistical data processing language *** the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;***;***;***;***;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;***)were characterized by a 4-year *** type of dynamics changed to noncyclic by the nineties,but by 2022,four species(***,***,***,and ***)and the community as a whole showed a tendency toward recovery of population *** remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform