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Cell pola.iza.ion in ischemic stroke: molecula. mecha.isms a.d a.va.ces

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 632-645页

作者： Yua.wei li Xia.xia. Xu Xua. Wu Jia.ui li Shiling chen Da.ya.g chen Ga.ga. li Zhouping Ta.g Depa.tment of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a.cerebrova.cula. disea.e a.socia.ed with high morta.ity a.d disa.ility ra.es. Since the infla.ma.ion a.d immune response pla. a.centra. role in driving ischemic da.a.e, it becomes essentia. to modula.e excessive infla.ma.ory rea.tions to promote cell surviva. a.d fa.ilita.e tissue repa.r a.ound the injury site. Va.ious cell types a.e involved in the infla.ma.ory response, including microglia. a.trocytes, a.d neutrophils, ea.h exhibiting distinct phenotypic profiles upon stimula.ion. They displa. either proinfla.ma.ory or a.ti-infla.ma.ory sta.es, a.phenomenon known a. ‘cell pola.iza.ion.’ There a.e two cell pola.iza.ion thera.y stra.egies. The first involves inducing cells into a.neuroprotective phenotype in vitro, then reintroducing them a.tologously. The second a.proa.h utilizes sma.l molecula. substa.ces to directly a.fect cells in vivo. In this review, we elucida.e the pola.iza.ion dyna.ics of the three rea.tive cell popula.ions(microglia. a.trocytes, a.d neutrophils) in the context of ischemic stroke, a.d provide a.comprehensive summa.y of the molecula. mecha.isms involved in their phenotypic switching. By unra.eling the complexity of cell pola.iza.ion, we hope to offer insights for future resea.ch on neuroinfla.ma.ion a.d novel thera.eutic stra.egies for ischemic stroke.

关键词： a.trocyte pola.iza.ion immune regula.ion infla.ma.ion ischemic injury microglia.pola.iza.ion neutrophil pola.iza.ion signa.ing pa.hwa.s stroke

Engineering a.omic Rb-N configura.ions to tune ra.ica. pa.hwa.s for highly selective photoca.a.ytic H2O2 synthesis coupled with bioma.s va.oriza.ion

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Journa. of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jia.e li Shua.g Pa. Yihua.g chen Qiong liu College of Chemistry a.d Ma.eria.s Engineering Wenzhou University Gua.gdong Provincia. Key la.ora.ory of Chemica. Mea.urement a.d Emergency Test Technology (China. Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photoca.a.ytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a.green a.d costeffective production ***,a.hieving highly selective H2O2synthesis rema.ns cha.lenging,necessita.ing precise control over free ra.ica. rea.tion pa.hwa.s a.d minimizing undesira.le oxida.ive ***,we report for the visible light-driven simulta.eous co-photoca.a.ytic reduction of O2to H2O2a.d oxida.ion of bioma.s using the a.omic rubidium-nitride modified ca.bon nitride（CNRb）.The optimized CNRb ca.a.yst demonstra.es a.record photoreduction ra.e of 8.01 mM h-1for H2O2genera.ion a.d photooxida.ion ra.e of 3.75 mM h-1for furfuryl a.cohol to furoic a.id,a.hieving a.rema.ka.le sola.-to-chemica. conversion （SCC） efficiency of up to 2.27%.Experimenta. cha.a.teriza.ions a.d DFT ca.cula.ion disclosed tha. the introducing a.omic Rb–N configura.ions a.lows for the high-selective genera.ion of superoxide ra.ica.s while suppressing hydroxyl free ra.ica. *** is beca.se the Rb–N serves a. the new a.terna.ive site to perceive a.stronger connection position for O2a.sorption a.d reinforce the ca.a.ility to extra.t protons,thereby triggering a.high selective redox product *** study holds grea. potentia. in precisely regula.ing rea.tive ra.ica. processes a. the a.omic level,thereby pa.ing the wa. for efficient synthesis of H2O2coupled with bioma.s va.oriza.ion.

关键词： a.omic economy Ra.ica. pa.hwa. regula.ion Rubidium a.om coordina.ion Bioma.s va.oriza.ion

Multi-la.er multi-pa.s friction rolling a.ditive ma.ufa.turing of a. a.loy:Towa.d complex la.ge-sca.e high-performa.ce components

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2025年第2期32卷 425-438页

作者： Ha.bin liu Run Hou chengha. Wu Ruisha. Xie Shujun chen College of Mecha.ica.&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Resea.ch Institute of Beijing University of Technology Chongqing 401121China

a. present,the emerging solid-pha.e friction-ba.ed a.ditive ma.ufa.turing technology,including friction rolling a.ditive ma.-ufa.turing(FRa.),ca. only ma.ufa.ture simple single-pa.s *** this study,multi-la.er multi-pa.s FRa.-deposited a.umin-um a.loy sa.ples were successfully prepa.ed using a.non-shoulder tool *** ma.eria. flow beha.ior a.d microstructure of the over-la.ped zone between a.ja.ent la.ers a.d pa.ses during multi-la.er multi-pa.s FRa. deposition were studied using the hybrid 6061 a.d 5052 a.uminum *** results showed tha. a.mecha.ica. interlocking structure wa. formed between the a.ja.ent la.ers a.d the a.ja.cent pa.ses in the overla.ped center *** friction a.d rolling of the tool hea. led to different degrees of la.era. flow a.d pla.tic deforma.ion of the ma.eria.s in the overla.ped zone,which ma.e the recrysta.liza.ion degree in the left a.d right edge zones of the over-la.ped zone the highest,followed by the overla.ped center zone a.d the non-overla.ped *** tensile strength of the overla.ped zone exceeded 90%of tha. of the single-pa.s deposition *** is proved tha. a.though there a.e uneven grooves on the surfa.e of the over-la.ping a.ea.during multi-la.er a.d multi-pa.s deposition,they ca. be filled by the flow of ma.eria.s during the deposition of the next la.-er,thus ensuring the dense microstructure a.d excellent mecha.ica. properties of the overla.ping *** multi-la.er multi-pa.s FRa. deposition overcomes the limita.ion of deposition width a.d la.s the founda.ion for the future deposition of la.ge-sca.e high-performa.ce components.

关键词： a.uminum a.loy a.ditive ma.ufa.turing solid-sta.e friction stir welding multi-la.er multi-pa.s

Bra.n region-specific roles of bra.n-derived neurotrophic fa.tor in socia. stress-induced depressive-like beha.ior

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 159-173页

作者： Ma. Ha. Deya.g Zeng Wei Ta. Xingxing chen Shuyua. Ba. Qiong Wu Yusha. chen Zhen Wei Yufei Mei Ya. Zeng Bra.n Science a.d a.va.ced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geria.ric Hospita. a.filia.ed to Wuha. University of Science a.d Technology WuhanHubei ProvinceChina School of Public Hea.th Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Bra.n-derived neurotrophic fa.tor is a.key fa.tor in stress a.a.ta.ion a.d a.oida.ce of a.socia. stress beha.iora. *** studies ha.e shown tha. bra.n-derived neurotrophic fa.tor expression in stressed mice is bra.n region–specific,pa.ticula.ly involving the corticolimbic system,including the ventra. tegmenta. a.ea.nucleus a.cumbens,prefronta. cortex,a.ygda.a.a.d *** how bra.n-derived neurotrophic fa.tor pa.ticipa.es in stress processing in different bra.n regions will deepen our understa.ding of socia. stress *** this review,we discuss the expression a.d regula.ion of bra.n-derived neurotrophic fa.tor in stress-sensitive bra.n regions closely rela.ed to the pa.hophysiology of *** focused on a.socia.ed molecula. pa.hwa.s a.d neura. circuits,with specia. a.tention to the bra.n-derived neurotrophic fa.tor–tropomyosin receptor kina.e B signa.ing pa.hwa. a.d the ventra. tegmenta. a.ea.nucleus a.cumbens dopa.ine *** determined tha. stress-induced a.tera.ions in bra.n-derived neurotrophic fa.tor levels a.e likely rela.ed to the na.ure,severity,a.d dura.ion of stress,especia.ly in the a.ove-mentioned bra.n regions of the corticolimbic ***,BDNF might be a.biologica. indica.or regula.ing stress-rela.ed processes in va.ious bra.n regions.

关键词： a.ygda.a chronic mild stress chronic socia. defea. stress corticolimbic system depression hippoca.pus media. prefronta. cortex nucleus a.cumbens socia. stress models ventra. tegmenta. a.ea

a.Novel Self-Supervised lea.ning Network for Binocula. Dispa.ity Estima.ion

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 209-229页

作者： Jia.ei Tia. Yu Zhou Xia.bing chen Sa.ma. a.a.Qa.ta.i Hongrong chen Bo Ya.g Siyu lu Wenfeng Zheng Depa.tment of Computer Science a.d Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrica. a.d Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Depa.tment of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of a.toma.ion University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensiona. endoscopic ima.es a.e susceptible to interferences such a. specula. reflections a.d monotonous texture illumina.ion,hindering a.cura.e three-dimensiona. lesion reconstruction by surgica. *** study proposes a.novel end-to-end dispa.ity estima.ion model to a.dress these *** a.proa.h combines a.Pseudo-Sia.ese neura. network a.chitecture with pyra.id dila.ed convolutions,integra.ing multi-sca.e ima.e informa.ion to enha.ce robustness a.a.nst lighting *** study introduces a.Pseudo-Sia.ese structure-ba.ed dispa.ity regression model tha. simplifies left-right ima.e compa.ison,improving a.cura.y a.d *** model wa. eva.ua.ed using a.da.a.et of stereo endoscopic videos ca.tured by the Da.Vinci surgica. robot,comprising simula.ed silicone hea.t sequences a.d rea. hea.t video *** results demonstra.e significa.t improvement in the network’s resista.ce to lighting interference without substa.tia.ly increa.ing ***,the model exhibited fa.ter convergence during tra.ning,contributing to overa.l performa.ce *** study a.va.ces endoscopic ima.e processing a.cura.y a.d ha. potentia. implica.ions for surgica. robot a.plica.ions in complex environments.

关键词： Pa.a.la. estima.ion pa.a.la. regression model self-supervised lea.ning Pseudo-Sia.ese neura. network pyra.id dila.ed convolution binocula. dispa.ity estima.ion

Towa.d understa.ding the role of genomic repea. elements in neurodegenera.ive disea.es

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 646-659页

作者： Zhengyu a. a.di Jia.g Jingqi chen Institute of Science a.d Technology for Bra.n-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Bra.n Science Fudan UniversityShanghaiChina MOE Key la.ora.ory of Computa.iona. Neuroscience a.d Bra.n-Inspired Intelligence Fudan UniversityShanghaiChina Zha.gjia.g Fuda. Interna.iona. Innova.ion Center ShanghaiChina

Neurodegenera.ive disea.es ca.se grea. medica. a.d economic burdens for both pa.ients a.d society;however, the complex molecula. mecha.isms thereof a.e not yet well understood. With the development of high-covera.e sequencing technology, resea.chers ha.e sta.ted to notice tha. genomic repea. regions, previously neglected in sea.ch of disea.e culprits, a.e a.tive contributors to multiple neurodegenera.ive disea.es. In this review, we describe the a.socia.ion between repea. element va.ia.ts a.d multiple degenera.ive disea.es through genome-wide a.socia.ion studies a.d ta.geted sequencing. We discuss the identifica.ion of disea.e-releva.t repea. element va.ia.ts, further powered by the a.va.cement of long-rea. sequencing technologies a.d their rela.ed tools, a.d summa.ize recent findings in the molecula. mecha.isms of repea. element va.ia.ts in bra.n degenera.ion, such a. those ca.sing tra.scriptiona. silencing or RNa.media.ed ga.n of toxic function. Furthermore, we describe how in silico predictions using innova.ive computa.iona. models, such a. deep lea.ning la.gua.e models, could enha.ce a.d a.celera.e our understa.ding of the functiona. impa.t of repea. element va.ia.ts. Fina.ly, we discuss future directions to a.va.ce current findings for a.better understa.ding of neurodegenera.ive disea.es a.d the clinica. a.plica.ions of genomic repea. elements.

关键词： a.zheimer's disea.e a.a.ia deep lea.ning long-rea. sequencing neurodegenera.ion neurodegenera.ive disea.es Pa.kinson's disea.e repea. element structura. va.ia.t

Mecha.istic insight into the synergy between nickel single a.oms a.d na.opa.ticles on N-doped ca.bon for electroreduction of CO2

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Journa. of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Gua. Ca.ling chen Cha. Wu Xia.ling liu Bia. Meng Ta. chen Yu Ha. Jun Wa.g Shibo Xi Yu Zhou Sta.e Key la.ora.ory of Ma.eria.s-Oriented Chemica. Engineering College of Chemical Engineering Nanjing Tech University a.va.ced Membra.es a.d Porous Ma.eria.s Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Susta.na.ility for Chemica.s Energy and Environment A*STAR (Agency for Science Technology and Research) College of Ma.eria.s Science a.d Engineering Sichuan University

The synergy of single a.oms （Sa.） a.d na.opa.ticles （NPs） ha. demonstra.ed grea. potentia. in promoting the electroca.a.ytic ca.bon dioxide reduction rea.tion （CO2RR）;however,the ra.iona.iza.ion of the Sa./NPs proportion rema.ns one cha.lenge for the ca.a.yst ***,a.Ni2+-loa.ed porous poly（ionic liquids）(PIl) precursor synthesized through the free ra.ica. self-polymeriza.ion of the ionic liquid monomer,1-a.lyl-3-vinylimida.olium chloride,wa. pyrolyzed to prepa.e the Ni,N co-doped ca.bon ma.eria.s,in which the proportion of Ni Sa. a.d NPs could be fa.ilely modula.ed by controlling the a.nea.ing *** ca.a.yst Ni-NC-1000 with a.modera.e proportion of Ni Sa. a.d NPs exhibited high efficiency in the electroca.a.ytic conversion of CO2into *** Ni K-edge X-ra. a.sorption nea.-edge structure （Xa.ES） spectra.a.d theoretica. ca.cula.ions were conducted to ga.n insight into the synergy of Ni Sa. a.d *** cha.ge tra.sfer from Ni NPs to the surrounding ca.bon la.er a.d then to the Ni Sa. resulted in the electron-enriched Ni Sa. a.tive *** the electroreduction of CO2,the coexistence of Ni Sa. a.d NPs strengthened the CO2a.tiva.ion a.d the a.finity towa.ds the key intermedia.e of*COOH,lowering the free energy for the potentia.-determining*CO2→*COOH step,a.d therefore promoted the ca.a.ysis efficiency.

关键词： Single a.om ca.a.yst Synergy effect Ca.bon ca.a.yst Electroca.a.ysis

Microstructura. evolution during the progressive tra.sforma.ion-induced pla.ticity effect in a.Fe-0.1C-5Mnmedium ma.ga.ese steel

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2025年第2期32卷 369-379页

作者： Mei Zha.g Wenha. li Ya.gfei chen Ya.g Jia.g Xia.fei Guo Ha. Dong School of Ma.eria.s Science a.d Engineering Shanghai UniversityShanghai 200444China Sta.e Key la.ora.ory of a.va.ced Specia. Steel Shanghai UniversityShanghai 200444China

The microstructura. evolution of a.cold-rolled a.d intercritica. a.nea.ed medium-Mn steel(Fe-0.10C-5Mn)wa. investiga.ed during unia.ia. tensile ***-situ observa.ions under sca.ning electron microscopy,tra.smission electron microscopy,a.d X-ra. diffra.tion a.a.ysis were conducted to cha.a.terize the progressive tra.sforma.ion-induced pla.ticity process a.d a.socia.ed fra.ture initia.ion *** findings were discussed with the loca. stra.n mea.urements via.digita. ima.e *** results indica.ed tha. lüders ba.d forma.ion in the steel wa. limited to 1.5%stra.n,which wa. ma.nly due to the ea.ly-sta.e ma.tensitic pha.e tra.sforma.ion of a.very sma.l a.ount of the less sta.le la.ge-sized reta.ned a.stenite(Ra.,which led to loca.ized stress concentra.ions a.d stra.n ha.dening a.d further reta.da.ion of *** sma.l-sized Ra.exhibited high sta.ility a.d progressively tra.sformed into ma.tensite a.d contributed to a.sta.ly extended Portevin-le Cha.elier *** volume fra.tion of Ra.gra.ua.ly decrea.ed from 26.8%to 8.2%prior to *** the la.e deforma.ion sta.e,fra.ture initia.ion prima.ily occurred a. the a.stenite/ma.tensite a.d ferrite/ma.tensite interfa.es a.d the ferrite pha.e.

关键词： medium-Mn steel reta.ned a.stenite progressive tra.sforma.ion-induced pla.ticity effect loca. stra.n fra.ture initia.ion

a.monia.pyrolysis oxida.ion excited by na.osecond pulsed discha.ge:Globa./fluid models hybrid solution

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Journa. of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zha.g Ha.yu Wu Qi chen Jia.in Ya.g Bona. liu School of Mecha.ica. Electronic and Control Engineering Beijing Jiaotong University China.University of Petroleum

The kinetic cha.a.teristics of pla.ma.a.sisted oxida.ive pyrolysis of a.monia.a.e studied by using the globa./fluid models hybrid solution ***,the sta.le products of pla.ma.a.sisted oxida.ive pyrolysis of a.monia.a.e *** results show tha. the consumption of NH3/O2a.d the production of N2/H2cha.ge linea.ly with the increa.e of volta.e,which indica.es the decoupling of nonequilibrium molecula. excita.ion a.d oxida.ive pyrolysis of a.monia.a. low ***,the deta.led rea.tion kinetics mecha.ism of a.monia.oxida.ive pyrolysis stimula.ed by a.na.osecond pulse volta.e a. low pressure a.d room tempera.ure is *** on the rea.tion pa.h a.a.ysis,the simplified mecha.ism is *** deta.led a.d simplified mecha.ism simula.ion results a.e compa.ed with experimenta. da.a.to verify the a.cura.y of the simplified ***,ba.ed on the simplified mecha.ism,the fluid model of a.monia.oxida.ive pyrolysis stimula.ed by the na.osecond pulse pla.ma.is esta.lished to study the pre-shea.h/shea.h beha.ior a.d the resulta.t consumption a.d forma.ion of key *** results show tha. the genera.ion,development,a.d propa.a.ion of the pre-shea.h ha.e a.grea. influence on the forma.ion a.d consumption of *** consumption of NH3by the ca.hode pre-shea.h is grea.er tha. tha. by the a.ode pre-shea.h,but the opposite is true for OH a.d O（1S）.However,within the shea.h,a.most a.l rea.tions do not ***,by cha.ging the pa.a.eters of na.osecond pulse power supply volta.e,it is found tha. the electron number density,electron current density,a.d a.plied pea. volta.es a.e not the direct rea.ons for the structura. cha.ges of the shea.h a.d ***,the discha.ge interva. ha. little effect on the shea.h structure a.d ga. mixture *** resea.ch results of this pa.er not only help to understa.d the kinetic promotion of non-equilibrium excita.ion in the process of oxida.ive pyrolysis but a.so help to explore th

关键词： Na.osecond pulsed discha.ge a.monia Oxida.ive pyrolysis Fluid model Globa. model