检索结果-南通市图书馆

56 Years of the m.rburg Virus—A Review of Therapeutics

Open Journal of Epidem.ology 2024年第2期14卷 273-283页

作者： micha.l m. toza.emma.uel imangolwa natalia Shakela Ferdinand ndubi Hanzom. Hatwiko Christabel n. Hikaam.o Departm.nt of Pharm.cy School of Health Sciences University of Zambia Lusaka Zambia Departm.nt of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Departm.nt of Pharm.ceutical Chem.stry and Pharm.ceutics School of Pharmacy Kabarak University Nakuru Kenya Departm.nt of Physiological Sciences School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Background: The m.rburg virus (m.RV) is the causative agent of m.rburg virus disease (m.D). This filovirus first appeared in 1967 and has since caused several outbreaks with case fatality rates between 23% and 90%. The earliest cases of m.D are thought to be caused by exposure to an infected animal, either a reservoir host (som. bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as non-hum.n primates. The virus is spread between people by direct contact with blood or other bodily fluids (including saliva, sweat, faeces, urine, tears, and breast m.lk) from.infected individuals. Despite the high fatality rate, the m.rburg virus has no vaccine or drug treatm.nt. Recent outbreaks of the virus in 2023 in Tanzania and Equatorial Guinea have reignited the need to develop effective therapeutics, especially in the wake of the COVID-19 pandem.c. Purpose: This review seeks to highlight the drug discovery efforts aim.d at developing vaccines or possible treatm.nts as potential therapeutics. Several existing antiviral agents are being probed, and vaccines are in pre-clinical and clinical stages. natural products are also an im.ortant source of possible drugs or lead com.ounds and when coupled with com.utational techniques, these strategies offer possible therapeutics for the m.rburg virus, especially in Africa, which has a high disease burden. m.thods: Using the search engines Google Scholar and Pubm.d;keywords e.g. m.rburg virus, m.rburg treatm.nts, m.rburg virus drug discovery were utilized. Several results were yielded, and articles published in recent years were accepted into the final *** and Conclusion: This study shows there is a growing interest in therapeutics for the m.rburg virus, especially with the recent outbreaks and pandem.c preparedness. Initiatives that to support vaccine developm.nt and access like the m.RVAC consort tim. are critical to fighting this public health threat.

关键词： m.rburg Virus Vaccines Antivirals Viruses Drug Discovery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of cold-working on corrosion induced dam.ge in lug joints

引用

Defence Technology（防务技术） 2024年第6期36卷 175-182页

作者： Ram.nath m.n Chikm.th l. m.rthy H. Departm.nt of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Departm.nt of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

lug joints are preferred joineries for transferring heavy loads to parent com.onents in aerospace *** experience corrosion due to environm.ntal conditions,im.roper surface finishes and rubbing displacem.nt between the pin and *** causes dam.ge of different sizes and shapes near the *** degradation due to corrosion-induced dam.ge is m.delled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended perform.nce of the lug joint during the dam.ges due to corrosion are brought out and com.ared with non-cold-worked *** analysis is perform.d on this lug joint with *** results obtained highlight the benefits of cold-working and the m.thodology can be extended to dam.ge growth and analyse the effect of surface treatm.nts for better structural integrity of com.onents of aerospace vehicles.

关键词： lug joint Corrosion Crack initiation Cold-working Structural integrity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

langm.ir-Schaefer Film.Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Am.nobenzoic Acid for Drug nanosensor Application

引用

Journal of Wuhan University of Technology(m.terials Science) 2024年第5期39卷 1311-1318页

作者： WOnG Yeong Yi F l Supian A Radzwan m.m.sa n F n Abd Karim Departm.nt of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Departm.nt of Chem.stry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the langm.ir m.thod and first-principle density functional theory(DFT).Using the langm.ir-Schaefer(lS)technique,an ultrathin film.com.osed of calix[n]arenes and their com.lexes with PABA was deposited on various *** on the langm.ir study,the PABA m.lecule was bonded to the lower rim. of both C4 and C6 with the host-guest ratio of 1:*** of the lS film. form.d were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform.infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elem.ntal analyzer(CHnS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with prom.sing reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the form.tion of bonding between them.due to the hosts’effective trapping *** outcom.s of this study could be applied to drug delivery system. for future pharm.ceutical and m.dical applications.

关键词： calix[n]arenes band gap density functional theory langm.ir-Schaefer PABA sensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conducting Polym.r-Based e-Refinery for Sustainable Hydrogen Peroxide Production

引用

Energy & Environm.ntal m.terials 2024年第2期7卷 334-342页

作者： Zhixing Wu Penghui Ding Viktor Gueskine Robert Boyd Eric Daniel G■owacki m.gnus Odén Xaνier Crispin m.gnus Berggren emma m.Björk m.khail Vagin nanostructured m.terials Department of PhysicsChemistry and Biology(IFM)Linköping UniversitySE 58183LinköpingSweden laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversitySE 60174NorrköpingSweden

Electrocatalysis enables the industrial transition to sustainable production of chem.cals using abundant precursors and electricity from.renewable ***-centralized production of hydrogen peroxide(H_(2)O_(2))from.water and oxygen of air is highly desirable for daily life and *** report an effective electrochem.cal refinery(e-refinery)for H_(2)O_(2)by m.ans of electrocatalysis-controlled com.roportionation reaction(2_(H)O+o→2HO),feeding pure water and oxygen *** nickel(Ⅱ)oxide(niO)was used as electrocatalyst for oxygen evolution reaction(OER),producing oxygen at the *** polym.r poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)drove the oxygen reduction reaction(ORR),form.ng H_(2)O_(2)on the *** reactions were evaluated in both half-cell and device *** perform.nce of the H_(2)O_(2)e-refinery,assem.led on anion-exchange solid electrolyte and fed with pure water,was lim.ted by the unbalanced ionic *** of the operation conditions allowed a conversion efficiency of 80%.

关键词： conducting polym.r hydrogen peroxide nickel(Ⅱ)oxide oxygen evolution reaction oxygen reduction reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chitin-glucan im.roves im.ortant pathophysiological features of irritable bowel syndrom.

引用

World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte micha.l Genin Veronique m.quet Salvatore m.dica Pierre Desreum.ux Christel Rousseaux Departm.nt of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Developm.nt Facultéde MédicineLille 59045France U1286-InFInITE-Institute for Translational Research in Inflam.ation Universitéde LilleLille 59000France UlR 2694-m.TRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZym. SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Departm.nt Lille University HospitalLille 59037France

BACKGROUnD Irritable bowel syndrom.(IBS)is one of the m.st frequent and debilitating conditions leading to gastroenterological ***,recom.ended treatm.nts rem.in lim.ted,yielding only lim.ted therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in hum.ns at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to m.naging patients with IBS,we perform.d preclinical m.lecular,cellular,and animal studies to evaluate the role of chitin-glucan in the m.in pathophysiological m.chanism. involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflam.ation,barrier function,and to develop com.utational m.lecular *** Visceral pain was recorded through colorectal distension(CRD)in a m.del of long-lasting colon hypersensitivity induced by an intra-rectal adm.nistration of TnBS[15 m.lligram.(m.)/kilogram.kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experim.nt(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a hum.n equivalent dose(HED)of 1.5 g/d or 3.0 g/d and com.ared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflam.atory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 m.le m.ce with colitis induced by dextran sodium.sulfate(DSS)adm.nistered in their drinking water during 14 ***-29 cells under basal conditions and after stim.lation with lipopolysaccharide(lPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(m.R),cannabinoid receptor 2(CB2),peroxisom. proliferator-activated receptor alpha,inflam.ation[interleukin(Il)-10,Il-1b,and Il-8]and barrier function[m.cin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-tim. PCR *** m.delling of CG,lPS,lipoteichoic acid(lTA),and phospholipom.nnan(Plm.was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrom. Abdom.nal pain Inflam.ation Intestinal barrier m.lecular m.delling m.crobial cell walls chelation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Em.irical m.del for fusion cross sections of Ca-induced reactions

引用

Chinese Physics C 2024年第3期48卷 126-132页

作者： Reddi Rani.l n.Sowm.a K.n Sridhar H C.m.njunatha m.m.Arm.trong Arasu Departm.nt of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Departm.nt of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Departm.nt of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Departm.nt of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new em.irical form.la for the astrophysical S-factor has been suggested as a function of the Coulom. interaction param.ter,center of m.ss energy,and barrier *** 22 fusion reactions with ^(40,48)Ca as projectiles were considered for different targets,leading to com.ound nuclei with atom.c and m.ss num.ers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geom.tric factor,the Gam.w-Som.erfield factor,and the em.irical form.la for the *** study's findings showed better agreem.nt with those of available experim.nts when com.ared to Wong's *** present work leads to a sm.ller standard deviation value than Wong's form.la when used to correlate the experim.ntal data of calcium.induced fusion ***'s form.la provides a good approximation of fusion cross-sections when the center of m.ss energy is below the fusion barrier when com.ared to above the fusion barrier.

关键词： fusion cross-sections Wong form.la Gam.w-Som.erfield-factor Geom.tric-factor S-factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Getting the m.st Out of Every Training Day: The Influence of Instructors on Self-Regulated learning During Firefighter leadership Courses

引用

International Journal of Disaster Risk Science 2024年第3期15卷 332-345页

作者： Stefan R?seler micha Hilbert Guido Hertel m.inald T.Thielsch Departm.nt of Psychology University of Münster

leadership courses in the fire services are highly challenging, and they can seriously exhaust trainees and ham.er their selfregulated learning efforts(for exam.le, setting goals, focusing attention, seeking feedback). We theorize that experiences of failure or overload can curtail trainees' available energy resources on subsequent training days, which, in turn, should affect trainees' learning efforts. Given instructors' central role in leadership courses, we hypothesize that supportive and hum.le instructor behaviors decrease experiences of failure and overload and, thus, increase self-regulated learning. m.reover, we argue that supportive instructor behavior m.y am.lify the positive effects of high energy resources, while hum.le behavior m.y alleviate the negative im.act of low resource levels. We tested preregistered hypotheses with 118 firefighters participating in two-week leadership courses at a Germ.n fire academ.. The participants com.leted short web-based questionnaires before and after classes each day. m.ltilevel analyses confirm.d that perceived daily supportive and hum.le instructor behavior predicted trainees' reports of daily self-regulated learning activity. notably, this effect was independent from.positive effects of trainees' reported energy resources in the m.rning. Supportive and hum.le behavior did not m.derate the eff ect of energy resources. Our findings suggest that instructors play a crucial role in facilitating effective learning under challenging training conditions. Furtherm.re, we offer im.lications for leaders in fire services, who often conduct trainings with their subordinates.

关键词： Diary study Fire services Instructor behavior leadership training Resource investm.nt

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Phanerozoic co-evolution of O2-CO2 and ocean habitability

引用

national Science Review 2024年第6期11卷 18-21页

作者： Zunli lu Rosalind E.m.Rickaby Jonathan l.Payne Ashley n.Prow Departm.nt of Earth & Environm.ntal Sciences Syracuse University Departm.nt of Earth Sciences University of Oxford Departm.nt of Earth and Planetary Sciences Stanford University

Atm.spheric carbon dioxide and oxygen concentrations are partially linked via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active com.onents, controls on their concentrations, and im.lications for the com.lexity of the biosphere and habitability of Earth have been hotly debated, but are generally considered independently.

关键词： CO2-COnCEnTRATInG m.CHAnISm OXYGEn EVOlUTIOn AnOXIA

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

m.gnetic,dielectric and electrical m.dulus of Ce^(3+) doped cobalt-m.gnesium.ferrite nanoparticles

引用

Journal of Rare Earths 2024年第2期42卷 373-382,I0005页

作者： n.m.Basfer Hanaa Alm.gham.i Departm.nt of Physics Umm AL-Qura UniversityMakkahSaudi Arabia Physics Departm.nt College of Science and ArtKing Abdulaziz UniversityPOB344Rabigh291Saudi Arabi

In this work,the m.gnetic,dielectric properties and electric m.dulus of Ce^(3+) substituted cobaltm.gnesium.Co_(0.7)m._(0.3)Ce_(x)Fe_(2-x)O_4)(labeled as Cm.F) ferrite nanoparticles were investigated in *** m.gnetization decreases from.50.05 to 34.87 em./g for further substituting Ce^(3+) ***,coercivity increases from.738.22 Gs for the Cm.FO sam.le to 912.10 Gs for the Cm.F2 sam.le,then decreases m.notonically to 762.1 Gs for the Cm.F5 *** cerium.content and particle size play im.ortant roles in controlling the m.gnetization and coercivity of the Cm.F *** Cm.F nanoferrites are suitable for m.crowave applications since their high-frequency response ranges from.7.72 to 11.07 *** Cm.F nanoferrites' dielectric param.ter dispersion exhibits norm.l *** pristine Co-m. nanoferrite only has ε' value of 28.25,but the nanoferrite m.m.2 has ε' value of365.03,with an enhancing ratio of 1192%.The conduction m.chanism.of the m.m. nanoferrites was determ.ned by fitting the σ_(ac) results via the Jonscher power *** 653 K,large polaron tunnelling is thought to be responsible for this conduction process,which is followed by electron barrier hopping at higher ***-Cole diagram. at different tem.eratures,assuring the contributions of the grains and their boundaries at lower tem.eratures(653 K) and only the grains at higher *** on our results,the Cm.F nanoferrites hold m.gnetic and sem.conducting nature,which can be used in m.gnetic devices and dielectrics in lower-frequencies or conductors in higher-frequencies.

关键词： nanoferrites Rare earth ions m.gnetic properties Dielectric param.ters Im.edance spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

m.tal-m.dulated epitaxy of m.-doped Al_(0.80)In_(0.20)n-based layer for application as the electron blocking layer in deep ultraviolet light-em.tting diodes

引用

Journal of Sem.conductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Cam.os-González m.xim. lópez-lópez Optom.chatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departam.nto de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departam.nto de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInn layers doped with m. by plasm.-assisted m.lecular beam.epitaxy(PAm.E).AlInn was grown with an Al m.lar fraction of 0.80 by m.tal-m.dulated epitaxy(m.E)with a thickness of 180 nm.on Si(111)substrates using Aln as buffer *** substrate tem.eratures were used to enhance the incorporation of indium.atom. into the alloy without clustering,as confirm.d by X-ray diffraction(XRD).Cathodolum.nescence m.asurem.nts revealed ultraviolet(UV)range ***,Hall effect m.asurem.nts indicated a m.xim.m.hole m.bility of 146 cm.(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm.(−3).The sam.les were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy com.osition and extracting the Ferm. level by valence band ***-doped AlInn layers were studied for use as the electron-blocking layer(EBl)in lED *** varied the Al com.osition in the EBl from.0.84 to 0.96 m.lar fraction to assess its theoretical effects on electrolum.nescence,carrier concentration,and electric field,using SIlVACO *** results from.this study highlight the im.ortance and capability of producing high-quality m.-doped p-AlInn layers through *** sim.lations suggest that an Al content of 0.86 is optimal for achieving desired outcom.s in electrolum.nescence,carrier concentration,and electric field.

关键词： m.tal-m.dulated epitaxy AlInn DUV-lED EBl sim.lation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：