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Phase ib study of anti-EGFR antibody(SCT200)in combination with anti-PD-1 antibody(SCT-i10A)for patients with RAS/BRAF wild-type metastatic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming bai Yao lu Chunmei Shi Jianwei Yang Wei li Xianli Yin Chenghui Huang lin Shen liangzhi Xie Yi ba Department of Gi Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical University Union Hospital Fuzhou 350001China Fujian Provincial Cancer Hospital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Medical Oncology Gastroenterology and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Department of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This study evaluated the safety and efficacy of an anti-epidermal growth factor receptor(EGFR)antibody(SCT200)and an anti-programmed cell death 1(PD-1)antibody(SCT-i10A)as third-line or subsequent therapies in patients with rat sarcoma viral oncogene(RAS)/v-raf murine sarcoma viral oncogene homolog B(BRAF)wild-type(wt)metastatic colorectal cancer(mCRC).Methods:We conducted a multicenter,open-label,phase ib clinical *** with histologically confirmed RAS/BRAF wt m CRC with more than two lines of treatment were enrolled and treated with SCT-i10A and *** primary endpoints were the objective response rate(ORR)and *** secondary endpoints included disease control rate(DCR),progression-free survival(PFS),and overall survival(OS).Results:Twenty-one patients were enrolled in the study through January 28,*** ORR was 28.57%and the DCR was 85.71%(18/21).The median PFS and OS were 4.14 and 12.84 months,*** treatment-related adverse events(TRAEs)were ***,compared with the monotherapy cohort from our previous phase i study evaluating SCT200 for RAS/BRAF wt m CRC in a third-line setting,no significant improvements in PFS and OS were observed in the combination ***:SCT200 combined with SCT-i10A demonstrated promising efficacy in previously treated RAS/BRAF wt m CRC patients with an acceptable safety *** head-to-head studies with larger sample sizes are needed to validate whether the efficacy and safety of combined anti-EGFR and anti-PD-1 therapy are superior to anti-EGFR monotherapy in the third-line setting.(Registration ***04229537).

关键词： Colorectal cancer SCT-i10A SCT200 epidermal growth factor receptor programmed cell death 1

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Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao liu lu liu Peng-Yu Guo Run-Ze Wang Zhi-Chang ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

baCKGROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRl)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRl or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/l verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

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Cathodic corrosion as a facile and universal method for scalable preparation of powdery single atom electrocatalysts

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Nano Research 2024年第6期17卷 4943-4950页

作者： Rui li Xiayan Yan Meng liu Qingkai Zhao Jie Du Xinxin Tan Jingwen ba Rongguang Zeng Wenhua luo Jingsong Xu institute of Materials China Academy of Engineering PhysicsJiangyou 621907China Science and Technology on Surface Physics and Chemistry laboratory Jiangyou 621908China

Top-down strategy has been widely applied for synthesis of metal single atom catalysts(SACs)via converting metal nanoparticles or bulk metals into atomically dispersed ***,we report a simple electrochemical atomic migration strategy for top-down synthesis of SACs via a facile cathodic corrosion process without involving high temperature or harsh *** of metal nanoparticles on cathode are firstly disbanded under high negative voltage,and emitted into the electrolyte in the form of atomic metal anions in Zintl *** escaped atomically dispersed metal species are then oxidized by water molecules and captured by the defects on the pre-added nitrogen doped carbon carriers in the *** cathodic corrosion strategy is confirmed to be suitable for scalable synthesis of kinds of metal SACs(e.g.,Pt,Pd,and ir)on doped carbon ***,the as-prepared nitrogen doped carbon powder supported Pt SACs exhibit superior catalytic activity toward hydrogen evolution reaction(HER)with a low overpotential of 0.024 V at 10 mA·cm^(−2)and a low Tafel slope of 29.7 mV·dec^(−1)as well as a long-term durability.

关键词： cathodic corrosion top-down strategy powdery single atom catalysts hydrogen evolution reaction scalable synthesis

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The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai li-Yue Zhang Shuai-Peng Wang Jing-Kai liu Yong-Gang Wu Xin-Wu ba Xiao-Qing liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

it is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(iPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate Pi3K/AKT-mTOR and MAPK pathways

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Journal of integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia liu Zhongshi Zhu Min Zhou Gui ba langda Suo Yuxuan Song lei Zhang Division of laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. in this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the Pi3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. in addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins Pi3K, AKT, mTOR, JNK, and P38 in the Pi3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

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immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against leishmania infantum infection

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat bağırova Murat ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey V.Akhundov National Scientific Research Medical Prophylactic institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Objective:To prepare and characterize polycaprolactone(PCl)nanoparticles loaded with sonicator fragmented(SlA)and freeze-thaw leishmania antigens(FTlA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCl *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in J774 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and EliSA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with leishmania ***:Compared to the control group,SlA PCl and FTlA PCl nanoparticles with calcium phosphate adjuvant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of iFN-γand *** PCl and FTlA PCl nanoparticles combined with calcium phosphate adjuvant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCl nanoparticles and the formulations with calcium phosphate adjuvant show strong in vitro immune stimulating ***,PCl-based antigen delivery systems and calcium phosphate adjuvant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adjuvant Vaccine design

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“一带一路”沿线国家数字经济合作的基础、挑战与路径

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河南社会科学 2024年第1期32卷 43-51页

作者：巴殿君吕博尧吉林大学东北亚研究中心吉林长春130012

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,... 详细信息

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,推动产业数字化转型,共建国家对数字经济的政策支持不断完善,数字基础设施得到加强,数字环境持续改善,我国数字经济蓬勃发展,为进一步的合作奠定了坚实基础。然而,共建国家在数字经济合作方面仍存在数字经济发展不平衡、网络安全威胁、数字规则机制建设滞后等问题。为应对这些挑战,需因地制宜地推动数字经济协调发展,构建全面的数字安全保障体系,妥善处理中美关系和数字领域的竞争,多层次地构建数字治理体系,加强话语权建设并构建战略互信,加大金融支持人才培育、鼓励创新力度,实现共建“一带一路”国家数字经济的共同发展和互利共赢。

关键词： “一带一路” 数字经济 “数字丝绸之路” 国际合作

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舞蹈高等教育面向未来发展的八个引擎

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北京舞蹈学院学报 2024年第1期 1-7页

作者：巴图北京舞蹈学院北京100081

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育... 详细信息

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育的数字化赋能、舞蹈课堂中的革命风暴。

关键词：舞蹈高等教育未来发展引擎

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新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学

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根茎克隆植物芦苇应对风沙活动过程的生长和生殖的权衡关系

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Journal of Plant Ecology 2024年第1期17卷 68-77页

作者： Chaoqun ba Shanshan Zhai Jianqiang Qian Bo liu Jinlei Zhu Zhimin liu institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China College of Forestry Henan Agricultural UniversityZhengzhou 450002China College of life Science Qufu Normal UniversityQufu 273165China institute of Ecological Conservation and Restoration Chinese Academy of ForestryBeijing 100093China

生长和繁殖之间的权衡是克隆植物适应性策略的重要组成部分。根茎型沙生植物通过权衡策略应对风沙过程(埋沙和风蚀)对它们在流动沙丘上的定居尤为重要。尽管根茎型物种对风沙过程的响应已经有了部分研究,但这些克隆物种如何通过生长和... 详细信息

生长和繁殖之间的权衡是克隆植物适应性策略的重要组成部分。根茎型沙生植物通过权衡策略应对风沙过程(埋沙和风蚀)对它们在流动沙丘上的定居尤为重要。尽管根茎型物种对风沙过程的响应已经有了部分研究,但这些克隆物种如何通过生长和繁殖中的潜在权衡关系来应对风沙过程仍不清楚。在本研究中,我们采用了野外调查和生物量建模的手段,评估了芦苇(Phragmites communis)在沙埋和风蚀条件下,营养生长和生殖生长以及分株数量和大小之间的权衡关系。研究结果表明,沙埋促进了种子生物量和生殖努力(RE)的增加;风蚀减少了RE,但对种子生物量没有显著影响。沙埋增加了分株的生物量,而风蚀增加了分株种群密度并加速了分株的成熟。这些研究表明,根茎型沙地植物通过调整其生长策略来应对风沙过程,即在沙埋条件下,增加生殖生长和分株大小,而在风蚀条件下,增加营养生长和分株数量。

关键词：适应策略沙埋风蚀芦苇(Phragmites communis) 有性生长无性生长根茎

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