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Application of Rayleigh Light Scattering Spectroscopy to the Determination of Proteins Using Bromo-Pyrogallol Red

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Chinese Chemical Letters 1997年第1期8卷 57-58页

作者： ma, CQ Li, ka Tong, SY BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

The binding of bromo-pyrogallol red (BPR) to proteins is accompanied by the enhancement of Rayleigh light scattering at 332nm. and based on this a new quantitative protein assay method is put forward.

关键词： Application of Rayleigh Light Scattering Spectroscopy to the Determination of Proteins Using Bromo-Pyrogallol Red

Immunomodulation by mesenchymal stem cells:Interplay between mesenchymal stem cells and regulatory lymphocytes

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World Journal of Stem Cells 2016年第9期8卷 268-278页

作者： Oscar ka-Fai ma Koon Ho Chan Department of Medicine Li Ka Shing Faculty of Medicine the University of Hong Kong

Mesenchymal stem cells(MSCs) possess immunomodulatory properties, which confer enormous potential for clinical application. Considerable evidence revealed their efficacy on various animal models of autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus and uveitis. MSCs elicit their immunomodulatory effects by inhibiting lymphocyte activation and proliferation, forbidding the secretion of proinflammatory cytokines, limiting the function of antigen presenting cells, and inducing regulatory T(Treg) and B(Breg) cells. The induction of Treg and Breg cells is of particular interest since Treg and Breg cells have significant roles in maintaining immune tolerance. Several mechanisms have been proposed regarding to the MSCs-mediated induction of Treg and Breg cells. Accordingly, MSCs induce regulatory lymphocytes through secretion of multiple pleiotropic cytokines, cell-to-cell contact with target cells and modulation of antigen-presenting cells. Here, we summarized how MSCs induce Treg and Breg cells to provoke immunosuppression.

关键词： Mesenchymal stem cells Regulatory T cells Regulatory B cells Immunomodulation Autoimmunity

Acute-on-chronic liver failure：recent update

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The Journal of Biomedical Research 2017年第4期31卷 283-300页

作者： Azeem Alam ka Chun Suen Daqing ma Anaesthetics Pain Medicine and Intensive Care Department of Surgery and Cancer Faculty of Medicine Imperial College London Chelsea & Westminster Hospital London SW7 2AZ UK

Acute on chronic liver failure（ACLF） was first described in 1995 as a clinical syndrome distinct to classic acute *** by complications of decompensation,ACLF occurs on a background of chronic liver dysfunction and is associated with high rates of organ failure and significant short-term mortality estimated between45%and 90%.Despite the clinical relevance of the condition,it still remains largely undefined with continued disagreement regarding its precise etiological factors,clinical course,prognostic criteria and management *** is concerning that,despite our relative lack of understanding of the condition,the burden of ACLF among cirrhotic patients remains significant with an estimated prevalence of 30.9%.This paper highlights our current understanding of ACLF,including its etiology,diagnostic and prognostic criteria and *** is evident that further refinement of the ACLF classification system is required in order to detect high-risk patients and improve short-term mortality *** field of metabolomics certainly warrants investigation to enhance diagnostic and prognostic parameters,while the use of granulocyte-colony stimulating factor is a promising future therapeutic intervention for patients with ACLF.

关键词： acute liver failure acute decompensation of cirrhosis hepatorenal syndrome chronic hepatic encephalopathy systemic inflammation

Perioperative"remote"acute lung injury:recent update

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The Journal of Biomedical Research 2017年第3期31卷 197-212页

作者： Zhaosheng Jin ka Chun Suen Daqing ma Anaesthetics Pain Medicine and intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea&Westminster HospitalLondon SW10 9NHUK

Perioperative acute lung injury（ALI） is a syndrome characterised by hypoxia and chest radiograph *** is a serious post-operative complication,associated with considerable mortality and *** addition to mechanical ventilation,remote organ insult could also trigger systemic responses which induce ***,there are limited treatment options available beyond conservative respiratory ***,increasing understanding of the pathophysiology of ALI and the biochemical pathways involved will aid the development of novel treatments and help to improve patient outcome as well as to reduce cost to the health *** this review we will discuss the epidemiology of peri-operative ALI;the cellular and molecular mechanisms involved on the pathological process;the clinical considerations in preventing and managing perioperative ALI and the potential future treatment options.

关键词： acute lung injury intraoperative care/adverse effects postoperative complications inflammation,anesthetics general fluid therapy

Simultaneous portohepatic vein embolization a radiological:a short cut to associating liver partition and portal vein ligation for staged hepatectomy?

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 373-375页

作者： ka Wing ma Albert Chi Yan Chan Department of Surgery Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Insufficient future liver remnant(FLR)represented one of the most common contraindications for major hepatectomy as post-hepatectomy liver failure(PHLF)was associated with high mortality with no effective *** the description of portal vein embolization(PVE)by makucchi in 1984(1),FLR volumetric modulation was made *** of PVE before major hepatectomy for patients with insufficient FLR(i.e.,mated standard liver volume)had greatly improved resectability.

关键词： hepatectomy mortality liver

A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 193-209页

作者： Tan To Cheung ka Wing ma Wong Hoi She Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

Importance:Hepatocellular carcinoma(HCC)is usually accompanied by liver cirrhosis,which makes treatment of this disease *** transplantation theoretically provides an ultimate solution to the disease,but the maximal surgical stress and the scarcity of liver graft make this treatment option impossible for some *** an ideal situation,a treatment that is safe and effective should provide a better outcome for patients with the ***:This article aims to give a comprehensive review of various types of loco-ablative treatment for *** Review:Loco-ablative treatment bridges the gap between surgical resection and transarterial *** types of ablative therapy have their unique ability,and evidence-based outcome analysis is the most important key to assisting clinicians to choose the most suitable treatment modality for their ***:Radiofrequency ablation(RFA)has a relatively longer history and more evidence to support its *** ablation(MWA)is gaining momentum because of its shorter ablation time and consistent ablation ***-intensity focused ultrasound(HIFU)ablation is a relatively new technology that provides non-invasive treatment for patients with *** has been carried out at centers of excellence and it is a safe and effective treatment option for selected patients with HCC and liver *** and Relevance:Selective use of different loco-ablative therapies will enhance clinicians’treatment options for treatment of HCC.

关键词： High-intensity focused ultrasound(HIFU) hepatocellular carcinoma(HCC) liver cancer radiofrequency ablation(RFA) microwave ablation(MWA) survival non-invasive treatment ablation cirrhosis complication

Importance of surgical margin in the outcomes of hepatocholangiocarcinoma

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World Journal of Hepatology 2017年第13期9卷 635-641页

作者： ka Wing ma Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Department of Surgery and State Key Laboratory for Liver Research the University of Hong Kong

AIM To evaluate the significance of resection margin width in the management of hepatocholangiocarcinoma(HCC-CC).METHODS Data of consecutive patients who underwent hepatectomy for hepatic malignancies in the period from1995 to 2014 were *** with pathologically confirmed HCC-CC were included for ***,biochemical,operative and pathological data were analyzed against survival outcomes. RESULTSForty-two patients were included for *** median age was 53.5 *** were 29 *** B virus was identified in 73.8%of the *** patients had preserved liver *** median preoperative indocyanine green retention rate at 15 min was 10.2%.The median tumor size was 6.5 *** hepatectomy was required in over 70%of the *** was performed in 6 *** hospital death *** median hospital stay was 13 *** median follow-up period was 32 *** 5-year disease-free survival and overall survival were 23.6%and 35.4%*** was the only independent factor associated with diseasefree survival[Pmargin of≥1 cm was associated with improved 1-year disease-free survival(40%vs 0%;log-rank,P=0.012).CONCLUSIONHCC-CC is a rare disease with poor *** margin of 1 cm or above was associated with improved survival outcome in patients with multifocal HCC-CC.

关键词： Hepatocholangiocarcinoma Hepatocellular cholangiocarcinoma Survival Hepatectomy Resection margin

Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level

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National Science Review 2020年第5期7卷 881-896页

作者： Dongxu He Aiqin mao Chang-Bo Zheng Hao kan ka Zhang Zhiming Zhang Lei Feng Xin ma Wuxi School of Medicine and School of Food Science and Technology Jiangnan University School of Biotechnology Jiangnan University School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University

The aorta, with ascending, arch, thoracic and abdominal segments, responds to the heartbeat, senses metabolites and distributes blood to all parts of the body. However, the heterogeneity across aortic segments and how metabolic pathologies change it are not known. Here, a total of 216 612 individual cells from the ascending aorta, aortic arch, and thoracic and abdominal segments of mouse aortas under normal conditions or with high blood glucose levels, high dietary salt, or high fat intake were profiled using single-cell RNA sequencing. We generated a compendium of 10 distinct cell types, mainly endothelial(EC), smooth muscle (SMC), stromal and immune cells. The distributions of the different cells and their intercommunication were influenced by the hemodynamic microenvironment across anatomical segments,and the spatial heterogeneity of ECs and SMCs may contribute to differential vascular dilation and constriction that were measured by wire myography. Importantly, the composition of aortic cells, their gene expression profiles and their regulatory intercellular networks broadly changed in response to high fat/salt/glucose conditions. Notably, the abdominal aorta showed the most dramatic changes in cellular composition, particularly involving ECs, fibroblasts and myeloid cells with cardiovascular risk factor-related regulons and gene expression networks. Our study elucidates the nature and range of aortic cell diversity,with implications for the treatment of metabolic pathologies.

关键词： aorta single-cell RNA sequencing cardiovascular disease

Theoretical and experimental study on frequency pushing effect of magnetron

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Chinese Physics B 2019年第11期28卷 377-381页

作者： kang Li Yi Zhang Hua-Cheng Zhu ka.ma.Huang Yang Yang School of Electronics and Information Engineering Sichuan UniversityChengdu 610064China Key Laboratory of Wireless Power Transmission of Ministry of Education Chengdu 610064China

The applications of magnetrons are greatly limited because of the poor output spectrum of the free-running ***, one of the best ways to solve this problem is injection locking. However, the injection locking theory which is widely used nowadays is based on the simplified oscillator, which does not include the frequency pushing effect of the magnetron. In this paper, the theory of injection locking magnetrons with frequency pushing effect is systematically *** analysis shows that the locking bandwidth turns larger with the consideration of the pushing parameter(α), and the increase of locking bandwidth is expanded with α increasing. Experimental results show that the locking bandwidth is expanded by 0.3 MHz, 1 MHz, and 1.6 MHz compared with the locking bandwidth from the conventional locking theory under an injection ratio(ρ) of 0.05, 0.075, and 0.1, respectively. This research provides a more accurate prediction of the properties of the injection-locked magnetron.

关键词： magnetron injection locking pushing effect