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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 1027-1043页

作者： Marta Borowska-Stefańska michałkowalski Filip Turoboś Szymon Wiśniewski Institute of the Built Environment and Spatial Policy Faculty of Geographical SciencesUniversity of LodzŁódź90–137Poland Institute of Mathematics Lodz University of TechnologyŁódź90–924Poland

In the paper we discuss and compare two commonly used methods of finding the shortest paths in networks,namely Dijkstra’s and A**** compare their effectiveness in terms of traversing road network in circumstances that require swift decision making in the event of dynamically changing road conditions on the basis of studies conducted for evacuation *** build a proper model of such a network,a method of appropriate edge-weighting is introduced,based on empirical data collected by other ***,we use the basics of the theory of quasimetric spaces to introduce a heuristic to such graphs,which is easy to calculate *** heuristic we obtain is both admissible and consistent,which allows us to use it efficiently in A*search *** developed application can be used in studies into evacuation from hazardous *** this case,optimum calculative efficiency is achievable with a simultaneous reduction of calculation time(when compared to Dijkstra’s algorithm).Our application can be applied during the first stage,i.e.,prior to the occurrence of a disaster,since this is an appropriate time for preparation by planning,drilling,early warning,and designating the rescue services that are to participate in the following stages.

关键词： A*algorithm Dijkstra Heuristic methods Mathematical modelling Quasimetric spaces Planning escape routes

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Experimental study on the feasibility of alternative materials for tilting pad thrust bearings operating in transition to mixed friction

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Friction 2024年第4期12卷 812-822页

作者： michałWASILCZUK michałWODTKE Faculty of Mechanical Engineering and Ship Technology Gdańsk University of TechnologyGdańsk 80-233Poland

In hydrodynamic bearings traditional bearing alloys:Babbitts and bronzes are most frequently *** sliding layers are sometimes applied as a valuable *** diamond-like carbon(DLC)coatings,which are also considered for certain applications may show some advantages,as *** material selection is of secondary importance in a full film lubrication regime it becomes important in mixed friction conditions,which is crucial for bearings with frequent starts and *** research aimed at studying the performance of fluid film bearings in the specific operating regime,including the transition to mixed friction,is described in the *** tests were carried out on four tilting pad bearings of different material compositions:Steel/bronze,DLC/steel,steel/polyether ether ketone(PEEK),and steel/*** tests comprised stopping under load and reproduction of the Stribeck curve by decreasing rotational speed to very low values,and observing the changes of friction force during the transition to mixed friction *** of the transition conditions and other results showed clear differences between the tested bearings,illustrating the feasibility of less popular material compositions for bearings operating in specific *** specifically,the DLC/steel bearing was demonstrating superior performance,*** friction,transition to mixed friction occurring at higher load,and more stable performance at start-stop regime over the other tested bearings.

关键词： tilting pad thrust bearing experimental research start-stop regime polyether ether ketone(PEEK) diamond-like carbon(DLC)coating metallic bearing alloys

Getting the Most Out of Every Training Day: The Influence of Instructors on Self-Regulated Learning During Firefighter Leadership Courses

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International Journal of Disaster Risk Science 2024年第3期15卷 332-345页

作者： Stefan R?seler micha Hilbert Guido Hertel Meinald T.Thielsch Department of Psychology University of Münster

Leadership courses in the fire services are highly challenging, and they can seriously exhaust trainees and hamper their selfregulated learning efforts(for example, setting goals, focusing attention, seeking feedback). We theorize that experiences of failure or overload can curtail trainees' available energy resources on subsequent training days, which, in turn, should affect trainees' learning efforts. Given instructors' central role in leadership courses, we hypothesize that supportive and humble instructor behaviors decrease experiences of failure and overload and, thus, increase self-regulated learning. Moreover, we argue that supportive instructor behavior may amplify the positive effects of high energy resources, while humble behavior may alleviate the negative impact of low resource levels. We tested preregistered hypotheses with 118 firefighters participating in two-week leadership courses at a German fire academy. The participants completed short web-based questionnaires before and after classes each day. Multilevel analyses confirmed that perceived daily supportive and humble instructor behavior predicted trainees' reports of daily self-regulated learning activity. Notably, this effect was independent from positive effects of trainees' reported energy resources in the morning. Supportive and humble behavior did not moderate the eff ect of energy resources. Our findings suggest that instructors play a crucial role in facilitating effective learning under challenging training conditions. Furthermore, we offer implications for leaders in fire services, who often conduct trainings with their subordinates.

关键词： Diary study Fire services Instructor behavior Leadership training Resource investment

Role of gut-liver axis and glucagon-like peptide-1 receptor agonists in the treatment of metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2024年第23期30卷 2964-2980页

作者： Jakub Rochoń Piotr Kalinowski Ksenia Szymanek-Majchrzak michałGrąt Department of General Transplant and Liver SurgeryMedical University of WarsawWarsaw 02-097Poland Department of Medical Microbiology Medical University of WarsawWarsaw 02-004Poland

Metabolic dysfunction-associated fatty liver disease(MAFLD)is a hepatic manifestation of the metabolic *** is one of the most common liver diseases worldwide and shows increasing prevalence rates in most *** is a progressive disease with the most severe cases presenting as advanced fibrosis or cirrhosis with an increased risk of hepatocellular *** microbiota play a significant role in the pathogenesis and progression of MAFLD by disrupting the gut-liver *** mechanisms involved in maintaining gut-liver axis homeostasis are *** critical aspect involves preserving an appropriate intestinal barrier permeability and levels of intestinal lumen metabolites to ensure gutliver axis *** increase in intestinal barrier permeability induces metabolic endotoxemia that leads to ***,alterations in the absorption of various metabolites can affect liver metabolism and induce liver steatosis and ***-like peptide-1 receptor agonists(GLP-1 RAs)are a class of drugs developed for the treatment of type 2 diabetes *** are also commonly used to combat obesity and have been proven to be effective in reversing hepatic *** mechanisms reported to be involved in this effect include an improved regulation of glycemia,reduced lipid synthesis,β-oxidation of free fatty acids,and induction of autophagy in hepatic ***,multiple peptide receptor agonists have been introduced and are expected to increase the effectiveness of the treatment.A modulation of gut microbiota has also been observed with the use of these drugs that may contribute to the amelioration of *** review presents the current understanding of the role of the gutliver axis in the development of MAFLD and use of members of the GLP-1 RA family as pleiotropic agents in the treatment of MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease Metabolic dysfunction-associated steatohepatitis Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Metabolic syndrome Obesity Gastrointestinal microbiota Glucagon-like peptide-1 Glucagon-like peptide-2 Bariatric surgery

Effects of small molecules on neurogenesis:Neuronal proliferation and differentiation

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Acta Pharmaceutica Sinica B 2024年第1期14卷 20-37页

作者： michałK Jastrze˛bski Piotr Wo´jcik Piotr Ste˛pnicki Agnieszka A.Kaczor Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory Medical University of LublinFaculty of PharmacyLublin PL-20093Poland School of Pharmacy University of Eastern FinlandKuopio FI-70211Finland

Neurons are believed to be non-proliferating ***,neuronal stem cells are still present in certain areas of the adult brain,although their proliferation diminishes with *** as with other cells,their proliferation and differentiation are modulated by various *** mechanisms are foundational to the strategies developed to induce neuronal proliferation and differentiation,with potential therapeutic applications for neurodegenerative *** most common among these diseases are Parkinson's disease and Alzheimer's disease,associated with the formation ofβ-amyloid(Aβ)aggregates which cause a reduction in the number of *** such as LiCl,4-aminothiazoles,Pregnenolone,ACEA,harmine,D2AAK1,methyl 3,4-dihydroxybenzoate,and shikonin may induce neuronal proliferation/differentiation through the activation of pathways:MAPK ERK,PI3K/AKT,NFκB,Wnt,BDNF,and ***,combinations of these compounds can potentially transform somatic cells into *** transformation process involves the activation of neuron-specific transcription factors such as NEUROD1,NGN2,ASCL1,and SOX2,which subsequently leads to the transcription of downstream genes,culminating in the transformation of somatic cells into *** diseases are not the only conditions where inducing neuronal proliferation could be ***,the impact of pro-proliferative compounds on neurons has also been researched in mouse models of Alzheimer's disease.

关键词： Neurogenesis Proliferation Differentiation Maturation Small-molecules Drug coctail Alzheimer’s disease Parkinson’s disease

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Microfacies and palaeoenvironments of lateCisuralian and Guadalupian(Early to MiddlePermian)alatoconchid-bearing limestone inLoei fold belt,Indochina Terrane

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Journal of Palaeogeography 2024年第3期13卷 453-474页

作者： Mongkol Udchachon Hathaithip Thassanapak Clive Burrett Seksan Chaidrusamee michał Krobicki Pradit Nulay Center of Excellence in Basin Studies and Applied Palaeontology Palaeontological Research and EducationCenterMahasarakham UniversityMaha Sarakham 44150Thailand Department of Biology Faculty of ScienceMahasarakham UniversityMaha Sarakham 44150Thailand Department of General Geology and Geotourism Faculty of GeologyGeophysics and EnvironmentalProtectionAGH University of KrakowMickiewicza 3030-059 KrakowPoland Department of Mineral Resources Ministry of Natural Resources and EnvironmentRatchathewiBangkok10400Thailand

This study presents the first record of Early Permian alatoconchid bivalves from Thailand,theErawan section,in the north of Loei fold belt with prolific fusulines in association with gastropods,and *** taxa are dominated by Pseudofusulina *** Darvasites sp.,Staffella ***,Staffella sp.,Nankinella sp.,Neofusulinella sp.,Schubertella sp.,Pamirina darvasica,Pseudoendothyra *** others,indicating an Artinskian *** wackestone with common,well-preserved smaller foraminifers,Pseudovermiporella *** ostracods indicates a restricted lagoon environment with low to moderate water *** fossils,along with well-preserved,articulated alatoconchids in life-position,suggest the autochthonous nature of the deposits in an intertidal *** the central part of the fold belt,the Pak Chong section exhibits intervals of alatoconchid biostromes *** build-ups of the alatoconchid biostromes with gregarious bivalves,in life-positionembedded in a micritic wackestone matrix,suggest their preferred life habit and *** bivalvecoquinites containing packed bivalve shells and fragments,however,indicate a high-energy *** rockfabric along with common fusuline storm sheets suggests occasional storm events in a restricted,with moderate water circulation to open lagoon *** are predominated by staffellids and othersincluding Staffella sphaerica,Staffella sp.,Sphaerulina croatica,Pisolina subsphaerica,Nankinella sp.,Neoschwagerina simplex,Presumatrina sp.,Afghanella *** others,indicating a Wordian(Middle Permian)*** the southern portion of the fold belt along the Thai-Cambodian border,the Khao Taa Ngog sectioncontains limestone with alatoconchid shells with massive rugose corals which formed local carbonate build-upsin high-energy open platform ***-sorted bioclasts with common fusuline tests,shell fragments and coated grains suggest an open marine,lagoon,back reef

关键词： Indochina terrane Carbonate build-ups Microfacies Permian Depositional environment

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LE DEMI-SICLE, DE MOÏSE AU FISCUS IUDAICUS. HISTOIRE D’UNE TÉLÉOLOGIE

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Journal of Ancient Civilizations 2024年第1期39卷 73-98,124页

作者： michaël Girardin Universitédu Littoral-Côte d’Opale

Many sources are brought together in scholarship in order to write the linear story of a specific tax,the half shekel tax paid each year by the Jews to the Temple of Jerusalem and,then,confiscated by the fiscus Iudaicus in Roman *** do these sources refer to the same tax?In this paper,I defend the idea that the linearity of this story is a *** taxes were levied and justified by the memory of a Biblical tax,but they are all different in meaning,in administration and sometimes even in *** story is a political one:how to justify a tax in ancient Judaism?

关键词： didrachm fiscus Iudaicus half shekel Jerusalem Temple Roman Judea taxation teleology

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner michał Kowalczyk Julian Srebrny Leszek Próchniak Chrystian Droste Jan Kownacki Maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte michaël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-METRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3253-3260页

作者： Jaroslaw Cwaliński Filip Lorek Łukasz Mazurkiewicz michałMazurkiewicz Wojciech Lizurej Jacek Paszkowski Hanna Cholerzyńska Wiktoria Zasada Department of General Endocrinological Surgery and Gastroenterological OncologyPoznan University of Medical SciencesPoznan 60-355Poland

BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal *** undergoing radical surgery,a subset of patients experiences recurrent inflammation at the anasto-motic site,necessitating further medical *** To investigate the risk factors associated with anastomotic insufficiency following ileocecal resection in CD *** This study enrolled 77 patients who underwent open ileocolic resection with pri-mary stapled *** were stratified into two groups:Group I co-mprised individuals without anastomotic insufficiency,while Group II included patients exhibiting advanced anastomotic destruction observed endoscopically or those requiring additional surgery during the follow-up *** and non-surgical factors potentially influencing anastomotic failure were evaluated in both *** Anastomotic insufficiency was detected in 12 patients(15.6%),with a mean time interval of 30 months between the initial surgery and *** predomi-nant reasons for re-intervention included stenosis and excessive perianastomotic *** associated with a heightened risk of anastomotic failure encompassed prolonged postoperative obstruction,anastomotic bleeding,and clinically confirmed ***,patients in Group II exhibited preoperative malnutrition and early recurrence of symptoms related to *** Successful surgical outcomes hinge on the attainment of a fully functional anastomosis,optimal metabolic status,and clinical remission of the underlying *** endoscopic surveillance following primary resection facilitates the timely identification of anastomotic failure,thereby enabling noninvasive interventions.

关键词： Crohn’s disease Ileocolic resection Anastomotic insufficiency Endoscopic surveillance Surgery Risk factors