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Optical frequency synthesizer with an integrated erbium tunable laser

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Light(Science & Applications) 2019年第1期8卷 22-29页

作者： Ming Xin Nanxi Li Neetesh Singh Alfonso Ruocco Zhan Su Emir Salih Magden Jelena Notaros Diedrik Vermeulen Erich P.Ippen michael R.watts Franz X.Kartner Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA John A.Paulson School of Engineering and Applied Science Harvard UniversityCambridgeMA 02138USA Center for Free-Electron Laser Science DESY and Hamburg UniversityNotkestraße 8522607 HamburgGermany Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)138634 SingaporeSingapore Analog Photonics 1 Marina Park DriveBostonMA 02210USA Department of Electrical and Electronics Engineering Koc UniversitySarıyerIstanbul 34450Turkey

Optical frequency synthesizers have widespread applications in optical spectroscopy,frequency metrology,and many other ***,their applicability is currently limited by size,cost,and power *** photonics technology,which is compatible with complementary-metal-oxide-semiconductor fabrication processes,provides a low-cost,compact size,lightweight,and low-power-consumption *** this work,we demonstrate an optical frequency synthesizer using a fully integrated silicon-based tunable *** synthesizer can be self-calibrated by tuning the repetition rate of the internal mode-locked laser.A 20 nm tuning range from 1544 to 1564 nm is achieved with~10−13 frequency instability at 10 s averaging *** flexibility and fast reconfigurability are also demonstrated by fine tuning the synthesizer and generating arbitrary specified patterns over time-frequency *** work promotes the frequency stability of silicon-based integrated tunable lasers and paves the way toward chip-scale lowcost optical frequency synthesizers.

关键词： synthesizer tunable tuning

High capacity, low power, short reach integrated silicon photonic interconnects

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Photonics Research 2024年第11期12卷 2400-2417页

作者： ANDREW NETHERTON MARIO DUMONT ZACHARY NELSON JAHYUN KOO JINESH JHONSA ALICE MO DAVID MCCARTHY SKYLAR DECKOFF-JONES YUN GAO NOAH PESTANA JORDAN GOLDSTEIN REN-JYE SHIUE CHRISTOPHER POULTON M.J.KENNEDY MARK HARRINGTON BOZHANG DONG JOCK BOVINGTON michael FRANKEL LUKE THEOGARAJAN michael watts DANIEL BLUMENTHAL JOHN E.BOWERS Department of Electrical and Computer Engineering University of CaliforniaSanta Barbara Analog Photonics Cisco Systems Ciena Corporation

The architecture and component technology of a low power, high capacity, short reach optical interconnect are detailed. Measurements from high-performance 300 mm silicon photonics components that comprise the system are shown, along with a quantum-dot mode-locked laser 20-channel comb source with free space wall plug efficiencies up to 17%, advanced packaging techniques for 3D silicon photonic-electronic integration, and schematics for integrated electronics that control the photonic integrated circuits. Techniques for operating such a system in the presence of changing ambient temperature are addressed. Experiments on a 1 Tbps design are conducted with an optical link experiment indicating sub-picojoule/bit energy consumption at scale.

关键词： Distributed feedback lasers Few mode fibers Frequency combs Laser sources Mode division multiplexing Optical transceivers

Octave-spanning coherent supercontinuum generation in silicon on insulator from 1.06μm to beyond 2.4μm

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Light(Science & Applications) 2017年第1期6卷 235-242页

作者： Neetesh Singh Ming Xin Diedrik Vermeulen Katia Shtyrkova Nanxi Li Patrick T Callahan Emir Salih Magden Alfonso Ruocco Nicholas Fahrenkopf Christopher Baiocco Bill P-P Kuo Stojan Radic Erich Ippen Franz X Kärtner michael R watts Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA John A.Paulson School of Engineering and Applied Science Harvard UniversityCambridgeMA 02138USA College of Nanoscale Science and Engineering SUNY Polytechnic InstituteAlbanyNY 12203USA Department of Electrical and Computer Engineering University of California San DiegoLa JollaCA 92039USA Centre for Free Electron Laser Science(CFEL)-DESY and University of Hamburg Hamburg 22607Germany

Efficient complementary metal-oxide semiconductor-based nonlinear optical devices in the near-infrared are in strong *** to two-photon absorption in silicon,however,much nonlinear research is shifting towards unconventional photonics *** this work,we demonstrate the generation of an octave-spanning coherent supercontinuum in a silicon waveguide covering the spectral region from the near-to *** input pulses of 18 pJ in energy,the generated signal spans the wavelength range from the edge of the silicon transmission window,approximately 1.06 to beyond 2.4μm,with a−20 dB bandwidth covering 1.124–2.4μ*** octave-spanning supercontinuum was also observed at the energy levels as low as 4 pJ(−35 dB bandwidth).We also measured the coherence over an octave,obtaining|g_()12^(1)(λ)>90%,in good agreement with the *** addition,we demonstrate optimization of the third-order dispersion of the waveguide to strengthen the dispersive wave and discuss the advantage of having a soliton at the long wavelength edge of an octave-spanning signal for nonlinear *** research paves the way for applications,such as chip-scale precision spectroscopy,optical coherence tomography,optical frequency metrology,frequency synthesis and wide-band wavelength division multiplexing in the telecom window.

关键词： coherence integrated photonics silicon supercontinuum

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1个胜利者42个失败者2.5亿车迷

汽车测试报告 2009年第5期 44-49页

作者： michael Harvey Anton watts（图）

也许有人会说这是另外一种场景．但我坚信自己正处在沙漠中央。现在还不到早上8点，甚至可能还不到7点半，可场地里已经有位穿着一身蓝色工装的老兄在忙乎了。他戴着顶牛仔帽，长得很像凯文·贝肯，但肯定不是电影明星。他正兴奋地唱着... 详细信息

也许有人会说这是另外一种场景．但我坚信自己正处在沙漠中央。现在还不到早上8点，甚至可能还不到7点半，可场地里已经有位穿着一身蓝色工装的老兄在忙乎了。他戴着顶牛仔帽，长得很像凯文·贝肯，但肯定不是电影明星。他正兴奋地唱着乡村歌曲，突然大喊了声“伙计，我让你感受到NASCAR了吗？”显然他是冲我喊的，因为旁边没有别人。我还没吃早点，不过抽支烟也能让我心满意足。

关键词：车迷电影明星汽车运动赛车

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星条旗

汽车测试报告 2009年第8期 118-124页

作者： michael Harvey Anton watts（图）

过去与未来在棕榈泉相会,Camaro、Challenger、野马，几位美式强力轿车杰出代表的最新传人即将一较高下。

关键词：雪佛兰 Camaro 轿车外观设计发动机

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激光雷达芯片进入发展快车道

科技纵览 2023年第9期 38-43,4页

作者： michael R.watts Christopher Poulton Matthew Byrd Greg Smolka Greg Mably(图) 不详

世界卫生组织的数据显示,名相当于每年失去一个布拉格城市的人口。采用由各种电子传感器和复杂计算机控制的自动驾驶汽车和卡车或许可以挽救无数的生命。尽管有大量的研究投入、长足的技术进步,但要将这项具有发展前景的技术交到人们手... 详细信息

世界卫生组织的数据显示,名相当于每年失去一个布拉格城市的人口。采用由各种电子传感器和复杂计算机控制的自动驾驶汽车和卡车或许可以挽救无数的生命。尽管有大量的研究投入、长足的技术进步,但要将这项具有发展前景的技术交到人们手上却很困难。那么,自动驾驶汽车何时才能真正出现在我们身边的车道上呢?答案部分取决于这种汽车是否要有一种被称为激光雷达的传感器。大多数开发自动驾驶汽车的团队都将激光雷达视为实现安全操作所需的传感器套件的关键部分,因为它构建的车辆周围环境3D地图的保真度比摄像头更高。

关键词：激光雷达电子传感器计算机控制自动驾驶汽车周围环境安全操作数据显示摄像头

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： Tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao michael S.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Schafer Sudena Wang michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

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