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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar el Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

A potpourri of pancreatic issues

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World Journal of Gastroenterology 2007年第47期13卷 6327-6332页

作者： Iman Zandieh mich.el f.byrne Division of Gastroenterology Department of MedicineUniversity of British ColumbiaVancouverBritish ColumbiaCanada

Autoimmune pancreatitis has emerged over the last 40 years from a proposed concept to a well established and recognized entity. As an efficient mimicker of pancreatic carcinoma, its early and appropriate recognition are crucial. With mounting understanding of its pathogenesis and natural history, significant advances have been made in the diagnosis of autoimmune pancreatitis. The characteristic laboratory features and imaging seen in autoimmune pancreatitis are reviewed along with some of the proposed diagnostic criteria and treatment algorithms.

关键词： Autoimmune pancreatitis Chronic pancreatitis Idiopathic pancreatitis Sclerosing pancreatitis

Modeling of nonlinear envelope solitons in strongly coupled dusty plasmas:Instability and collision

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Chinese Physics B 2015年第3期24卷 237-247页

作者： S.K.el-Labany E.f.el-Shamy W.f.el-Taibany N.A.Zedan Department of Physics Faculty of ScienceDamietta University Department of Physics College of ScienceKing Khalid University Department of Physics College of Science for Girls in AbhaKing Khalid University

Modeling of instability and collision of nonlinear dust-acoustic（NDA） envelope solitons in strongly coupled dusty plasmas（SCDPs） is theoretically investigated. The SCDPs consists of strongly correlated negatively variable-charged dust grains and weakly correlated Boltzmann electrons and ions. Using the derivative expansion perturbation technique, a nonlinear Schr dinger-type（NLST） equation for describing the propagation of NDA envelope solitons is derived. Moreover,the extended Poincar′e–Lighthill–Kuo（EPLK） method is employed to deduce the analytical phase shifts and the trajectories after the collision of NDA envelope solitons. In detail, the results show that both modulation instability and phase shift after collision of NDA envelope solitons will modify with the increase in the effects of the viscosity, the relaxation time, and the dust charge fluctuation. Crucially, the modeling of dust-acoustic envelope solitons collision, as reported here, is helpful for understanding the propagation of NDA envelope solitons in strongly coupled dusty plasmas.

关键词： dust acoustic wave envelopes modulational instability head-on collision polarization effects

Nonlinear Propagation of Positron-Acoustic Periodic Travelling Waves in a Magnetoplasma with Superthermal electrons and Positrons

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Chinese Physics Letters 2017年第6期34卷 70-74页

作者： E.f.el-Shamy Department of Physics College of ScienceKing Khalid University Department of Physics Faculty of ScienceDamietta University

The nonlinear propagation of positron acoustic periodic （PAP） travelling waves in a magnetoplasma composed of dynamic cold positrons, superthermal kappa distributed hot positrons and electrons, and stationary positive ions is examined. The reductive perturbation technique is employed to derive a nonlinear Zakharov Kuznetsov equation that governs the essential features of nonlinear PAP travelling waves. Moreover, the bifurcation theory is used to investigate the propagation of nonlinear PAP periodic travelling wave solutions. It is found that kappa distributed hot positrons and electrons provide only the possibility of existence of nonlinear compressive PAP travelling waves. It is observed that the superthermality of hot positrons, the concentrations of superthermal electrons and positrons, the positron cyclotron frequency, the direction cosines of wave vector k along the z-axis, and the concentration of ions play pivotal roles in the nonlinear propagation of PAP travelling waves. Tile present investigation may be used to understand the formation of PAP structures in the space and laboratory plasmas with superthermal hot positrons and electrons.

关键词： Nonlinear Propagation of Positron-Acoustic Periodic Travelling Waves in a Magnetoplasma with Superthermal electrons and Positrons

Propofol use in endoscopic retrograde cholangiopancreatography and endoscopic ultrasound

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World Journal of Gastroenterology 2014年第18期20卷 5171-5176页

作者： Danny G Cheriyan mich.el f.byrne Department of Gastroenterology University of British ColumbiaVancouver General HospitalVancouverBC V5Z 1M9Canada

Compared to standard endoscopy,endoscopic retrograde cholangiopancreatography(ERCP)and endoscopic ultrasound(EUS)are often lengthier and more complex,thus requiring higher doses of sedatives for patient comfort and *** aim of this review is to provide the reader with information regarding the use,safety profile,and merits of propofol for sedation in advanced endoscopic procedures like ERCP and EUS,based on the current literature.

关键词： Propofol Endoscopy Ndoscopic retrograde cholangiopancreatography Endoscopic ultrasound Safety

Extraintestinal manifestations of Helicobacter pylori:A concise review

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World Journal of Gastroenterology 2014年第34期20卷 11950-11961页

作者： frank Wong Erin Rayner-Hartley mich.el f.byrne Division of Gastroenterology University of British ColumbiaVancouverBC V5Z 1M9Canada

Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. pylori. Different conditions associated with H. pylori infection include those from hematologic, cardiopulmonary, metabolic, neurologic, and dermatologic systems. The aim of this article is to provide a concise review of the evidence that supports or refutes the associations of H. pylori and its proposed extraintestinal manifestations. Based on data from the literature, PUD, mucosal associated lymphoid tumors lymphoma, and gastric adenocarcinoma has well-established links. Current evidence most supports extraintestinal manifestations with H. pylori in immune thrombocytopenic purpura, iron deficiency anemia, urticaria, Parkinson’s, migraines and rosacea; however, there is still plausible link with other diseases that requires further research.

关键词： Migraine Iron deficiency Urticaria Rosacea Immune thrombocytopenic purpura

Effect of substitution group on dielectric properties of 4H-pyrano [3,2-c] quinoline derivatives thin films

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Chinese Physics B 2016年第7期25卷 440-449页

作者： H M Zeyada f M el-Taweel M M el-Nahass M M el-Shabaan Department of Physics Faculty of Science Damietta University Department of Chemistry Faculty of Science Damietta University Department of Physics Faculty of Education Ain Shams University

The AC electrical conductivity and dielectrical properties of 2-amino-6-ethyl-5-oxo-4-（3-phenoxyphenyl）-5,6-dihydro-4H-pyrano[3, 2-c]quinoline-3-carbonitrile（Ph-HPQ） and 2-amino-4-（2-chlorophenyl）-6-ethyl-5-oxo-5,6-dihydro-4H-pyrano [3, 2-c] quinoline-3-carbonitrile（Ch-HPQ） thin films were determined in the frequency range of 0.5 k Hz–5 MHz and the temperature range of 290–443 K. The AC electrical conduction of both compounds in thin film form is governed by the correlated barrier hopping（CBH） mechanism. Some parameters such as the barrier height, the maximum barrier height, the density of charges, and the hopping distance were determined as functions of temperature and frequency. The phenoxyphenyl group has a greater influence on those parameters than the chlorophenyl group. The AC activation energies were determined at different frequencies and temperatures. The dielectric behaviors of Ph-HPQ and Ch-HPQ were investigated using the impedance spectroscopy technique. The impedance data are presented in Nyquist diagrams for different temperatures. The Ch-HPQ films have higher impedance than the Ph-HPQ films. The real dielectric constant and dielectric loss show a remarkable dependence on the frequency and temperature. The Ph-HPQ has higher dielectric constants than the Ch-HPQ.

关键词： thin films quinoline derivatives dielectrical properties correlated barrier hopping

Implementing Effective Learning with Ubiquitous Learning Technology During Coronavirus Pandemic

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Computer Systems Science & Engineering 2022年第1期40卷 389-404页

作者： Hosam f.el-Sofany Samir A.el-Seoud King Khalid University AbhaKingdom of Saudi Arabia Cairo Higher Institute for Engineering Computer Science and ManagementCairoEgypt British University in Egypt—BUE Faculty of Informatics and Computer ScienceCairoEgypt

Ubiquitous computing supports U-learning to develop and implement a new educational environment that provides effective and interactive learning to students wherever they *** study aims to present a qualitative evaluation for using U-learning instead of traditional education to avoid the spread of the Coronavirus *** authors introduce a UTAUT(Unified Theory of Acceptance and Use of Technology)model to assess the capability of the given factors that are expected to affect the learners’intention and behavior for accepting the U-learning technology for full *** research study shows a promising impact on the use of U-learning apps for implementing their learning activities in both the present and coming *** study also presents the descriptive statistics that affect the students’answers by using U-learning while implementing learning assignments including exams,projects,forums,essays,presentations,and *** research experiments demonstrate both the composite reliability(CR)and the average variance extracted(AVE)of the presented *** experimental results have shown that(1)the factor loadings≥0.75,CR≥0.9,and AVE≥0.75,which present appropriate proof for the validity and reliability of the proposed model,and(2)the total average of students that accept the U-learning is 82.99%,and who disagree is 8.13%,while who neither agree nor disagree is 6.44%.

关键词： Ubiquitous learning U-learning E-learning M-learning COVID-19 pandemic coronavirus UTAUT model

formation of Alfvénic supernonlinear waves in a plasma containing double spectral distributed electrons

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Communications in Theoretical Physics 2024年第12期76卷 140-149页

作者： A A el-Tantawy W f el-Taibany S K el-Labany A M Abdelghany Department of Physics Faculty of Science Damietta University Center of Space Research and Its Application Damietta University

The characteristics of nonlinear and supernonlinear Alfvén waves propagating in a multicomponent plasma composed of a double spectral electron distribution and positive and negative ions were investigated. The Sagdeev technique was employed, and an energy equation was derived. Our findings show that the proposed system reveals the existence of a double-layer solution, periodic, supersoliton, and superperiodic waves. The phase portrait and potential analysis related to these waves were investigated to study the main features of existing waves. It was also found that decreasing the electron temperature helps the superperiodic structure to be excited in our plasma model. Our results help interpret the nonlinear and supernonlinear features of the recorded Alfvén waves propagating in the ionosphere D-region.

关键词： Alfvén waves double spectral distribution nonlinear waves Sagdeev method supernonlinear waves