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World Journal of Clinical Cases 2016年第8期4卷 202-206页

作者： Mitch beckert Dylan Crebs mich.el Nieto Yubo Gao John Albright Department of Orthopedics University of Iowa

AIM: To study patient outcomes after surgical correction for iatrogenic patellar ***: This retrospective study looked at 17 patients(19 knees) suffering from disabling medial patellar instability following lateral release surgery. All patients underwent lateral patellofemoral ligament(LPFL) reconstruction by a single surgeon. Assessments in all 19 cases included functional outcome scores, range of motion, and assessment for the presence of apprehension sign of the patella to determine if LPFL reconstruction surgery was successful at restoring patellofemoral ***: No patients reported any residual postoperative symptoms of patellar instability. Also no patients demonstrated medial patellar apprehension or examiner induced subluxation with the medial instability test described earlier following LPFL reconstruction. Furthermore, all patients recovered normal range of motion compared to the contralateral limb. For patients with pre and postoperative outcome scores, the mean overall knee injury and osteoarthritis outcome score increased significantly, from 34.39 preoperatively(range: 7.7-70.12) to 69.54 postoperatively(range:26.82-91.46) at final follow-up(P el technique for LPFL reconstruction is effective at restoring lateral restraint of the patellofemoral joint and improving joint functionality.

关键词： Lateral patellofemoral ligament Knee Sports medicine Patellar instability Orthopedics

Growth hormone abolishes the negative effects of everolimus on intestinal wound healing

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World Journal of Gastroenterology 2016年第17期22卷 4321-4329页

作者： Markus Alexander Küper Sebastian Trütschel Jürgen Weinreich Alfred Konigsrainer Stefan beckert Department of General Visceral and Transplant Surgery University of Tubingen 72076 Tubingen Germany BG Trauma Center University of Tubingen D-72076 Tubingen Germany

AIM: To investigate whether the simultaneous treatment with human growth hormone (hGH) abolishes the negative effects of everolimus on anastomotic ***: Forty-eight male Sprague-Dawley-rats were randomized to three groups of 16 animals each (I: vehicle; II: everolimus 3 mg/kg po; III: everolimus 3 mg/kg po + hGH 2.5 mg/kg sc). Animals were pre-treated with hGH and/or everolimus daily for seven days. Then a standard anastomosis was created in the descending colon and treatment was continued for another seven days. The anastomosis was resected in toto and the bursting pressure was assessed as a mechanical parameter of intestinal healing. Moreover, biochemical (Hydroxyproline, PCNA, MPO, MMP-2 and MMP-9) and histological (cell density, angiogenesis, amount of granulation tissue) parameters of intestinal healing were ***: Anastomotic bursting pressure was significantly reduced by everolimus and a simultaneous treatment with hGH resulted in considerably higher values (I: 134 ± 19 mmHg, II: 85 ± 25 mmHg, III: 114 ± 25 mmHg; P ells was reduced significantly by hGH compared to everolimus alone (I: 10 ± 1 n/mm², II: 15 ± 3 n/mm², III: 9 ± 2 n/mm²; P ells were increased by hGH (I: 28 ± 3 /mm², II: 12 ± 3 /mm², III: 26 ± 12 /mm²; P < 0.05, I vs II and II vs III). Corresponding to these biochemical findings, HE-histology revealed significantly

关键词： Wound healing Everolimus Human growth hormone Immunosuppression mTOR-inhibitor Growth hormone Anastomotic healing

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Where are we?

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World Journal of Gastroenterology 2012年第38期18卷 5317-5320页

作者： Ingmar Knigsrainer Stefan beckert Department of General Visceral and Transplant Surgery Tübingen University HospitalD-72076 Tübingen Germany

Peritoneal surface malignancies are generally associated with poor prognosis. In daily clinical routine, systemic chemotherapy is still considered the only reasonable therapy despite of encouraging results of cytoreductive surgery (CRS) along with intraperitoneal hyperthermic chemotherapy (HIPEC). The Achilles heel of CRS and HIPEC is appropriate patient selection and precise surgical technique preventing patients from excessive morbidity and mortality. Given these findings, new concepts of second look surgery for high risk patients allow detection of peritoneal spread ahead of clinical symptoms or presence of peritoneal masses reducing perioperative morbidity. In addition, personalized intraperitoneal chemotherapy might further improve outcome by appreciating individual tumor biology. These days, every physician should be aware of CRS and HIPEC for treatment of peritoneal surface malignancies. Since there is now sufficient data for the superiority of CRS and HIPEC to systemic chemotherapy in selected patients, our next goal should be providing this strategy with minimal morbidity and mortality even in the presence of higher tumor load.

关键词： Peritoneal carcinomatosis Hyperthermic intraperitoneal chemotherapy Cytoreductive surgery

SV2B defines a subpopulation of synaptic vesicles

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Journal of Molecular Cell Biology 2023年第9期15卷 1-13页

作者： Isabelle Paulussen Hannes beckert Timothy FMusial Lena J.Gschossmann Julia Wolf Mathieu Schmitt Jérôme Clasadonte Georges Mairet-Coello Christian Wolff Susanne Schoch Dirk Dietrich Synaptic Neuroscience Team Department of NeurosurgeryUniversity Hospital BonnBonn 53127Germany Synaptic Neuroscience Team Department of NeuropathologyUniversity Hospital BonnBonn 53127Germany Microscopy Core Facility Medical FacultyUniversity of BonnBonn 53127Germany UCB Pharma Braine l’Alleud 1420Belgium

Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein ***,we mapped the intrasynaptic distribution of the synaptic vesicle proteins SV2B and SV2A in glutamatergic synapses of the hippocampus using three-dimensional electron ***2B was almost completely absent from docked vesicles and a distinct cluster of vesicles found near the active *** contrast,SV2A was found in all domains of the synapse and was slightly enriched near the active ***2B and SV2A were found on the membrane in the peri-active zone,suggesting the recycling from both clusters of ***2B knockout mice displayed an increased seizure induction threshold only in a model employing high-frequency *** data show that glutamatergic synapses generate molecularly distinct populations of synaptic vesicles and are able to maintain them at steep spatial *** almost complete absence of SV2B from vesicles at the active zone of wildtype mice may explain why SV2A has been found more important for vesicle release.

关键词： 3D electron microscopy synaptic vesicles synaptic vesicle proteins endocytosis trafficking spatial organization

Nature:研究发现杀死抗药细菌的新靶点

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现代生物医学进展 2017年第8期17卷 I0003-I0004页

作者： Paul Huter, Claudia Müller, Bertrand beckert, Stefan Arenz, Otto Berninghausen, Roland Beckmann Daniel N. Wilson Bertrand beckert Daniel N. Wilson Gene Center Department of Biochemistry and Center for integrated Protein Science Munich (CiPSM) Ludwig-Maximilians-Universität München Feodor-Lynen-Strasse 25 81377 Munich Germany Institute for Biochemistry and Molecular Biology University of Hamburg Martin-Luther-King-Pl. 6 20146 Hamburg Germany

德国科学家最近阐明了一个细菌回收mRNA上停滞核糖体的新机制，当mRNA上缺少终止密码子就会导致核糖体无法从mRNA上脱离。参与该过程的蛋白为未来开发新抗生素药物提供了潜在靶点。

关键词：靶点细菌抗药 mRNA 德国科学家终止密码子抗生素药物核糖体

Incidence of leukopenia after intraperitoneal vs combined intravenous/intraperitoneal chemotherapy in pseudomyxoma peritonei

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 434-439页

作者： Philipp Horvath Stefan beckert Florian Struller Alfred Konigsrainer Ingmar Konigsrainer Department of General Visceral and Transplant SurgeryUniversity of TübingenCom-prehensive Cancer Center

AIM: To investigate the clinical impact of post-hyperthermic intraperitoneal chemotherapy(HIPEC) leukopenia, intraperitoneal and combined intravenous/intraperitoneal drug administrations were ***: Two patient cohorts were retrospectively analyzed regarding the incidence of postoperative leukopenia. The first cohort(n = 32) received Mitomycin C(MMC)-based HIPEC intraperitoneally(35 mg/m2 for 90 min) and the second cohort(n = 10) received a bidirectional therapy consisting of oxaliplatin(OX)(300 mg/m2 for 30 min) intraperitoneally and 5-fluorouracil(5-FU) 400 mg/m2 plus folinic acid 20 mg/m2 intravenously. The following data were collected retrospectively: Age, sex, length of operation, length of hospital stay, amount of resection including extent of peritonectomy, peritoneal cancer index, CC(completeness of cytoreduction)-status and leukocyte-count before cytoreductive surgery(CRS) and HIPEC, on days 3, 7 and 14 after CRS and HIPEC. HIPEC leukopenia was defined as ells/m3. RESULTS: Leukopenia occurred statistically more often in the MMC than in the OX/5-FU-group(10/32 vs 0/10; P = 0.042). Leukopenia set-on was on day 7 after CRS and MMC-HIPEC and lasted for two to three days. Three patients(33%) required medical treatment. Patients affected by leukopenia were predominantly female(7/10 patients) and older than 50 years(8/10 patients). Thelength of hospital stay tended to be higher in the MMCgroup without reaching statistical significance(22.5± 11 vs 16.5 ± 3.5 d). Length of operation(08:54 ± 01:44 vs 09:48 ± 02:28 h) were comparable between patients with and without postoperative leukopenia. Prior history of systemic chemotherapy did not trigger postHIPEC leukopenia. Occurrence of leucopenia did not trigger surgical site infections, intraabdominal abscess formations, hospital-acquired pneumonia or anastomotic insufficiencies. CONCLUSION: Surgeons must be aware that there is a higher incidence of postoperative leukopenia in MMCbased HIPEC protocols

关键词： Pseudomyxoma peritonei Mitomycin C Oxaliplatin Hyperthermic intraperitoneal chemotherapy Postoperative leukopenia

Modified Nitrogen-Doped Graphene electrocatalyst for Oxygen Reduction Reaction in Alkaline Fuel Cells

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Journal of Energy and Power Engineering 2015年第10期9卷 886-895页

作者： Dureid Qazzazie mich.ela beckert Rolf Mtilhaupt Olena Yurchenko Gerald Urban Freiburg Materials Research Center University of Freiburg Freiburg D-79104 Germany Laboratory for Sensors Department of Microsystems Engineering University of Freiburg Freiburg D-79110 Germany Institute for MacromoIecular Chemistry University of Freiburg Freiburg D- 79104 Germany

We report modified nitrogen-doped graphene （CN） as electrocatalyst for ORR （oxygen reduction reaction） in alkaline medium. CN was synthesized by a novel procedure based on graphite oxide thermally treated with cyanamide suitable for facile N-doping and large-scale production, whereas cyanamide was used as N-precursor. The structure of the material was characterized by TEM （transmission electron microscopy）, SEM （scanning electron microscopy）, Raman spectroscopy and XPS （X-ray photoelectron spectroscopy）. Structural and electrochemical properties of CN were compared with those of non-modified graphene （TRGO （thermally reduced graphite oxide））. The electrochemical characterization of TRGO and CN in alkaline solution demonstrates enhanced electrocatalytic ORR activity and improved long-term stability for N-doped CN. Voltammetric studies confirmed that, oxygen reduction on CN rather follows four-electron pathway. Compared with commercial 20% PtC catalyst, CN is characterized by exceptional methanol crossover resistance and superb long-term operation stability. Owing to these factors, nitrogen-doped graphene has a great potential to be used as metal-free electrocatalyst in cathodes of alkaline fuel cells.

关键词： Nitrogen-doped graphene metal-free catalysis oxygen reduction reaction alkaline fuel cells.

Refractive Focusing by Interstellar Clouds and the Rapid Polarization Angle Swing in QSO 1150+812

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 1-14页

作者： Shan-Jie Qian T. P. Krichbaum Xi-Zhen Zhang L. Fuhrmann G. Cimò A. Kraus T. beckert S. Britzen A. Witzel J.A. Zensus National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 53121 Bonn Germany Max-Planck-Institut für Astronomie KSnigstuhl 17 69117 Heidelberg Germany

A very rapid polarization position angle swing of -180° （with a time scale of ,-6 hours） observed at 2 cm in QSO 1150＋812 （z = 1.25） was reported by Kochenov ＆ Gabuzda. This very rare event is difficult to explain. We found a possible interpretation in the framework of a source model consisting of three polarized components, in which two compact polarized components are nearly simultaneously occulted by an interstellar cloud, with consequent focusing-defocusing effects. A specific plasma-lens model is proposed which can reasonably fit the polarized flux density curve with results derived for the two lensed components. Some physical parameters of the plasma-lens and the source components are estimated. The two compact polarized components are estimated to have brightness temperatures of -6 ×10^12 K. Thus a bulk relativistic motion with a Lorentz factor less than 10 is required to meet the inverse-Compton limit.

关键词： radio continuum: galaxies - galaxies: compact - polarization - scattering- quasars: individual: 1150+812

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棉花帝国

作者： (美)斯文·贝克特(Sven beckert)

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一次有挑战性的搬迁

科学新闻 2024年第2期 56-57页

作者： Adrian beckert 倪伟波加州理工学院

“你觉得新的博士后职位怎么样？”这是我在一次会议上遇到的一位前同事提出的一个看似无关痛痒的问题，但诚实回答这个问题是一个挑战。现实情况是，在从事博士后研究的5个月里，我越来越感到绝望，因为家人在适应新生活时遇到了困难...

“你觉得新的博士后职位怎么样？”这是我在一次会议上遇到的一位前同事提出的一个看似无关痛痒的问题，但诚实回答这个问题是一个挑战。现实情况是，在从事博士后研究的5个月里，我越来越感到绝望，因为家人在适应新生活时遇到了困难，我也在努力启动自己的项目。最后，我闪烁其词，只是简单地提到了新职位的几个积极方面。但这个问题是一个转折点：我意识到目前的情况是不可持续的，需要找到更好的方法应对跨国迁移的后果。我在祖国瑞士完成了博士学位。课程快结束时，我告诉妻子，如果想从事学术事业，

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