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2012年环境污染与大众健康学术会议

作者： michèle bouchard John J.Spinelli Igor Burstyn Kristan J.Aronson Université de Montréal Montreal Canada BC Cancer Agency Vancouver Canada University of British Columbia Vancouver Canada Drexel University Philadelphia USA Queen's University Kingston Canada

Background:Air pollution from motor vehicle traffic is a major source of polycyclic aromatic hydrocarbon （PAH） exposure in urban areas. Certain PAHs have been classified as probable human carcinogens by the International Agency of Research on Cancer. Some research indicates that people with low socio- economic status （SES） and other vulnerabilities may be exposed to heavier air pollution and thus PAHs. However, these findings have been inconsistent. Methods:A cross-sectional study was conducted in 2011, using as the study population base a random sample of household telephone numbers within defined areas based on distance of residences to major roads and highways on the island of Montreal. 200 volunteers （107 females and 93 males） ages 20-53, without renal disease or history of cancer, were recruited throuch telephone screening. 116 participants lived within 500 feet of highways or major roads;36 participants lived between 500 and 750 feet from highways or major roads;and 48 participants lived greater than 750 feet away from highways or major roads. Each participant completed a self-administered questionnaire assessing demo-graphics that included ethnicity and socio-economic indicators. ArcMap software and DMTI electronic street files were used to create zones of distance to highways and major roads. Residential traffic density was calculated based on routinely-collected traffic volume data from municipalities on the island of Montreal and from Transport Quebec. Results:Persons in full-time employment tended to live closer to heavy traffic （OR:2.71, 95% CI:1.26-5.85 for full-time work vs. unemployed）. No association was detected between ethnicity or education and level of traffic exposure. Conclusion:We observed gradients in exposure to traffic only for the aspect of SES related to employment, in the direction that full-time employment is associated with higher traffic exposure.

关键词： Environmental inequity ethnicity socio-economic status geographic information system (GIS)

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Non-optical polyp-based resect and discard strategy:A prospective clinical study

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World Journal of Gastroenterology 2022年第19期28卷 2137-2147页

作者： Mahsa Taghiakbari Celia Hammar Mira Frenn Roupen Djinbachian Heiko Pohl Erik Deslandres Simon bouchard Mickael Bouin Daniel von Renteln Department of Gastroenterology Montreal University Hospital Research Center(CRCHUM)Montréal H2X 0A9QuebecCanada Department of Gastroenterology University of MontrealFaculty of MedicineMontreal H2X 0A9QuebceCanada Department of Internal Medicine University of Montreal Hospital Center(CHUM)Montreal H2X 0A9QuebecCanada Department of Medicine Veterans Affairs Medical CenterWhite River JunctionVT 05009United States Department of Gastroenterology Dartmouth Geisel School of Medicine and The Dartmouth InstituteHanoverNH 03755United States

BACKGROUND Post-polypectomy surveillance intervals are currently determined based on pathology *** To evaluate a polyp-based resect and discard model that assigns surveillance intervals based solely on polyp number and *** Patients undergoing elective colonoscopies at the Montreal University Medical Center were enrolled *** polyp-based strategy was used to assign the next surveillance interval using polyp size and *** intervals were also assigned using optical diagnosis for small polyps(le,933 polyps)were *** surveillance interval agreement for the polyp-based strategy was 98.0%[95%confidence interval(CI):0.97-0.99]compared with pathology-based *** diagnosis-based intervals achieved 95.8%(95%CI:0.94-0.97)agreement with *** using the polyp-based strategy and optical diagnosis,the need for pathology assessment was reduced by 87.8%and 70.6%,*** polyp-based strategy provided 93.7%of patients with immediate surveillance interval recommendations vs 76.1%for optical *** The polyp-based strategy achieved almost perfect surveillance interval agreement compared with pathology-based assignments,significantly reduced the number of required pathology evaluations,and provided most patients with immediate surveillance interval recommendations.

关键词： Colonoscopy Colorectal pathology Colorectal adenomas Endoscopy Surveillance Optical diagnosis

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Effect of Si,Cu and Fe on mechanical properties of cast semi-solid 206 alloys

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1555-1560页

作者： A.leMIEUX J.LANGLAIS D.bouchard X.GRANT CHEN Rio Tinto Alcan Arvida Research and Development Centre Rio Tinto Alcan Laterrière Works NRC-Aluminium Technology Centre Université du Québec à Chicoutimi

The development of a modified 206 alloy whose composition was optimized to minimize hot tearing during semi-solid forming was reported. The effect of varying silicon, copper and iron contents was investigated using a design of experiment (DOE) approach. Semi-solid slurries were prepared using the SEED process and injected into a high pressure die casting press. The hot tearing sensitivity results were reported for different alloy variants. The microstructure evolution during the semi-solid preparation was presented along with actual die cast components. The effects of silicon, copper and iron on mechanical properties in the T7 condition were also analyzed. Beyond the benefit of reducing hot tearing, it is shown that the tensile and fatigue properties remain compatible with the automotive industry requirements.

关键词：半固态合金力学性能铁含量热裂敏感性硅铜铸造半固态成形

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Safety and predictors of adherence of a new rehabilitation program for older women with congestive heart failure

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Journal of Geriatric Cardiology 2012年第3期9卷 243-246页

作者： Nahid A. Azad Kathy bouchard Alain Mayhew Maureen Carter Frank J. Molnar Geriatric Assessment Unit Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada Cochrane Effective Practice and Organisation of Care Group Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada JET Programme Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada The IElisabeth-Bruybre Research Institute 43 Bruybre St. Ottawa Ontario KIN 5C8 Canada

ObjectivesTo 与充血的心失败(CHF ) 为老妇人估计一个心脏的康复节目的安全并且决定有 CHF 的超过 65 岁的某些因素影响 *** 是否出席了 physiotherapist 监督的一个锻练节目。生活的质量被纽约心协会(NYHA ) 班被明尼苏达生活与心失... 详细信息

ObjectivesTo 与充血的心失败(CHF ) 为老妇人估计一个心脏的康复节目的安全并且决定有 CHF 的超过 65 岁的某些因素影响 *** 是否出席了 physiotherapist 监督的一个锻练节目。生活的质量被纽约心协会(NYHA ) 班被明尼苏达生活与心失败问询表(MLHFQ ) 和疾病的严厉测量。题目会议被分类进出席了 90% 的那些或更多，出席了不到 90%*** 一个题目的那些被学习。八个题目没出席任何会议。43 个参加者，出席的会议的平均百分比是 87% 。在年龄， MLHFQ 或 NYHA 班的二个组之间没有重要差别。仅仅从有的 280 参加者 *** 节目有一个不利事件在这张人口的坚持的高水平。班没在会话出席上影响的年龄， MLHFQ 或 NYHA。我们的数据建议这个节目为这张人口是安全的。进一步的研究被需要决定出席的另外的预言者和安全问题和长期的坚持的考试在这张人口锻练。

关键词：充血性心力衰竭安全性心脏妇女老年康复预测生活质量

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Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations:A multicenter cross-sectional study

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World Journal of Gastroenterology 2022年第9期28卷 961-972页

作者： Laura Sirmai Anne-Laure Pelletier Nathalie Gault Camille Zallot Guillaume Bouguen Dominique bouchard Pascale Roland Nicaise Marine Peyneau Sandrine Sironneau Marcelo De Carvalho Bittencourt Antoine Petitcollin Pedro Fernandez Xavier Roblin Laurent Siproudhis Laurent Abramowitz Division of Hepato-Gastroenterology and Digestive Oncology Bichat Claude Bernard University HospitalParis 75018France Division of Hepato-Gastroenterology Hospital Croix Saint SimonParis 75020France Division of Epidemiology Biostatistics and Clinical ResearchUniversity Hospital Center BichatParis 75018France National Institute of Health and Medical Research CIC-EC1425 University Hospital Center BichatParis 75018France Division of Gastroenterology Nancy Regional and University Hospital CenterNancy 54035France Imphy CIC 1414 Group and Division of Gastroenterology and Hepatology University Hospital of RennesPontchaillouRennes 35033France Division of Proctology Hospital BagatelleTalence 33400France Division of Immunology University Hospital Center BichatParis 75018France Inflammation Microbiome and ImmunosurveillanceFaculty of PharmacyUniversitéParis-SaclayChâtenay-Malabry 92290France Division of Radiology Bagatelle Hospital CenterTalence 33400France Division of Immunology Nancy Regional and University Hospital CenterNancy 54000France University of Lorraine CNRS UMR 7365IMoPANancy 54000France Antoine Petitcol Department of Clinical and Biological Pharmacology and Pharmacovigilance Pharmacoepidemiology and Drug Information CenterRennes University HospitalRennes 35700France Division of Radiology University Hospital Center BichatParis 75018France Orangerie Center Le Perreux-sur-Marne 94170France Division of Gastroenterology CHU Saint EtienneSaint-Priest-en-Jarez 42270France Division of Gastroenterology and Hepatology and Proctology University Hospital Center BichatParis 75018France Ramsay GDS Clinique Blomet Paris 75018France

BACKGROUND Crohn’s disease(CD)is complicated by perianal fistulas in approximately 20%of *** permanent fistula closure remains a challenge for *** association between serum anti-tumor necrosis factor-αconcentrations and clinical outcomes in patients with CD has been demonstrated;however,little information is available on serum adalimumab(ADA)concentrations and remission of perianal fistulas in such *** To study the relationship between serum ADA concentrations and clinical remission of CDassociated perianal *** This cross-sectional study of patients with CD-associated perianal fistulas treated with ADA was performed at four French hospitals between December 2013 and March *** the time of each serum ADA concentration measurement,we collected information about the patients and their *** primary study endpoint was clinical remission of fistulas defined as the absence of drainage(in accordance with Present’s criteria),with a PDAI≤4,absence of a seton and assessment of the overall evaluation as favorable by the proctologist at the relevant *** also assessed fistula healing[defined as being in clinical and radiological(magnetic resonance imaging,MRI)remission]and adverse *** The study cohort comprised 34 patients who underwent 56 evaluations(patients had between one and four evaluations).Fifteen patients had clinical remissions(44%),four of whom had healed fistulas on *** ADA concentrations were significantly higher at evaluations in which clinical remission was identified than at evaluations in which it was not[14(10-16)vs 10(2-15)μg/mL,P=0.01].Serum ADA concentrations were comparable at the times of evaluation of patients with and without healed fistulas[11(7-14)vs 10(4-16)μg/mL,P=0.69].The adverse event rate did not differ between different serum ADA *** We found a significant association between high serum ADA concentrations and clinical remission of CD-associated

关键词： Crohn’s disease Clinical pharmacology Peri-anal disorders Adalimumab

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High rate of complicated idiopathic gallstone disease in pediatric patients of a North American tertiary care center

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World Journal of Gastroenterology 2008年第10期14卷 1544-1548页

作者： Denise Herzog Guylaine bouchard Division of Gastro-enterology and Nutrition Sainte Justine Hospital University of Montreal Montreal Quebec Canada

AIM: To assess spectrum and etiology of gallstones and biliary sludge in the pediatric population of a North American tertiary care centre. METHODS: Retrospective review of abdominal ultraso- unds recorded at Saint Justine Hospital over a period of 24 mo (8/2003 to 8/2005) in patients 2 years of age idiopathic gallstone disease was found. These 48 patients represent 2.1% of the population who required ultrasound for abdominal pain. Complicated gallstone disease occurred in 28/48 with idiopathic disease, mainly adolescent girls. Patients with hemolytic disorders, cystic fibrosis, oncologic diseases or kidney transplantation and gallstones were asymptomatic and stones were detected during routine abdominal ultrasound. Twenty two patients lescent girls with abdominal pain and idiopathic gallstones require special attention for complicated disease course.

关键词：胆囊切除术溶血疾病囊性纤维变性儿童突发性胆石症

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The SPLASH Action Group—Towards standardized sampling strategies in permafrost science

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Advances in Polar Science 2020年第3期31卷 153-155页

作者： Frederic bouchard Yannick AGNAN Lisa BRODER Julien FOUCHE Catherine HIRST Ylva SJOBERG Geosciences Paris Sud(GEOPS) UniversiteParis SaclayOrsayFrance Centre d’etudes nordiques(CEN) UniversiteLavalQuebecCanada Earth and Life Institute Universitecatholique de LouvainLouvain-la-NeuveBelgium Department of Earth Sciences Swiss Federal Institute of Technology(ETH)ZurichSwitzerland Department of Earth Sciences Vrije Universiteit AmsterdamAmsterdamthe Netherlands LISAH Univ MontpellierINRAEIRDInstitut AgroMontpellierFrance Department of Geosciences and Natural Resource Management CENPERMUniversity of CopenhagenCopenhagenDenmark

The Action Group called‘Standardized methods across Permafrost Landscapes:from Arctic Soils to Hydrosystems’(SPLASH)is a community-driven effort aiming to provide a suite of standardized field strategies for sampling mineral and organic components in soils,sediments,and water across permafrost *** unified approach will allow data from different landscape interfaces,field locations and seasons to be shared and compared,thus improving our understanding of the processes occurring during lateral transport in circumpolar Arctic watersheds.

关键词： biogeochemistry soils organic matter minerals lateral transport aquatic systems

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自动化硼酸盐熔融与X-射线荧光光谱分析组合技术在铁合金工业中的应用

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冶金分析 2012年第5期32卷 29-35页

作者： BRUB Luc1 RIVARD Sébastien bouchard Mathieu Corporation Scientifique Claisse QuébecCanada Corporation Scientifique Claisse-Division Europe ParisFrance

铁合金是高附加值的金属,在用作钢铁行业的原材料时,铁合金可以调节钢的最终成分并赋予其物理和化学性质。在炼钢过程中,精确控制铁合金加入量可以降低成本,另外,铁合金中的杂质又可能影响钢的性能。铁合金正确的表征是必要的,因为这对... 详细信息

铁合金是高附加值的金属,在用作钢铁行业的原材料时,铁合金可以调节钢的最终成分并赋予其物理和化学性质。在炼钢过程中,精确控制铁合金加入量可以降低成本,另外,铁合金中的杂质又可能影响钢的性能。铁合金正确的表征是必要的,因为这对钢的生产质量以及钢铁生产企业的经济效益有重大影响。在种类繁多的铁合金中,采用硼酸盐熔融制备样品并用X-射线荧光光谱测定主次及一些微量元素是非常有效、广为人知的方法,有着很好的准确度和精度。多种高性能的熔融仪器可被集成rFUSION自动熔融系统,该系统的熔融片制备可实现独立操作而不用人工介入。对于生产来说,rFUSION自动熔融系统可以提高并且稳定分析速度,确保分析结果的质量不会因生产率而降低。另外,因为采用有效的标准化设计、rFUSION熔融系统还可以确保熔融过程的标准化,使结果有很好的一致性和均匀性。

关键词：自动化硼酸盐熔融 X-射线荧光光谱法铁合金

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Video capsule endoscopy:Perspectives of a revolutionary technique

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World Journal of Gastroenterology 2014年第46期20卷 17330-17344页

作者： Simon bouchard Mostafa Ibrahim Andre Van Gossum Department of Gastroenterology Hepatopancreatology and Digestive OncologyErasme HospitalULB1070 BrusselsBelgium Gastroenterology Department Theodor Bilahrz Research InstituteCairo 12411Egypt

Video capsule endoscopy(VCE)was launched in 2000and has revolutionized direct endoscopic imaging of the *** is now a first-line procedure for exploring the small bowel in cases of obscure digestive bleeding and is also indicated in some patients with Crohn’s disease,celiac disease,and polyposis syndrome.A video capsule has also been designed for visualizing the esophagus in order to detect Barrett’s esophagus or esophageal *** capsules are now available and differ with regard to dimensions,image acquisition rate,battery life,field of view,and possible optical *** recently,the use of VCE has been extended to exploring the *** the last 5 years,tremendous developments have been made toward increasing the capabilities of the colon *** colon capsule cannot be proposed as a first-line colorectal cancer screening procedure,colon capsule may be used in patients with incomplete colonoscopy or in patients who are unwilling to undergo *** the near future,new technological developments will improve the diagnostic yield of VCE and broaden its therapeutic capabilities.

关键词： Video capsule endoscopy Esophagus Small bowel Colo

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O-RADS超声风险分层和管理系统的外部验证

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国际医学放射学杂志 2022年第5期 601-602页

作者： K.Hack N.Gandhi G.bouchard-Fortier T.P.Chawla S.E.Ferguson S.Li 郭虹

摘要卵巢-附件报告和数据系统（O-RADS）超声（US）风险分层和管理系统（O-RADS US）旨在提高卵巢和附件病变的风险评估和管理。作为手术和非手术治疗参考标准的验

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