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Polypharmacy in Primary Care Practices among Chronic Elderly Patients in Gaza Strip

Pharmacology & Pharmacy 2014年第3期5卷 291-297页

作者： Mahmoud Taleb Abed al-Kareem Abed Abedel Rahman Dahudi Ahmed Najim Adham Ahmed Faculty of Intermediate Studies University of Palestine Gaza Palestine Faculty of Pharmacy Alazhar University Gaza Palestine Medical Services Gaza Palestine Palestinian Ministry of Health Gaza Palestine

Introduction: The increasing number of elderly, and drug use among the elderly, emphasizes the need for continuous monitoring of drug utilization. Chronic diseases are frequent among the older population;the rate of drug related problems and drug-drug interactions (DDIs) with the medical and financial consequences are enormous. Polypharmacy (PP) is defined as the concomitant use of 5 or more medications. We studied PP among chronic elderly patients in Gaza Strip and its distri- bution among primary health care clinics in different areas. Materials and Methods: This study is a descriptive analytical study, analyzing prescription data from general practices during a 3-month time period, to measure the prevalence of PP and medication errors among chronic elderly pa- tients. Data were collected directly from the prescriptions and medical records, which contain per- sonal data for patients like patient age and gender, included the current illness, drug treatment for the current illness, chronic disease/s and drug treatment for chronic disease/s. SPSS software was used to analyze the obtained data. Results: Percent of major PP was the highest among patients aged 60 - 69 years when compared with other ages categories of study population but not reached to be statisticaly significant (0.012). Major PP was higher in female patients than that in male patients but difference wasn’t statistically significant (0.5). The average number of drug per prescription was 3.4 drug;and the minimum value per prescription was 1 meanwhile maximum value was 9 (SD + 1.7). Conclusion: PP (use of five drugs or more) is more prevalent among elderly patients with multiple diseases. Female patients consume more drugs than male do. There were some regional differences in drug utilization not explained by morbidity, suggesting some varia- tions in prescribing behaviors.

关键词： Polypharmacy Elderly Gaza Strip Chronic Diseases Primary Health Care

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Confirmation of the Experimentally-Proven Therapeutic Utility of Madecassoside in an Aβ<sub>1-42</sub>Infusion Rat Model of alzheimer’s Disease by in Silico Analyses

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Advances in alzheimer's Disease 2015年第2期4卷 37-44页

作者： Abdullah al Mamun michio Hashimoto Shahdat Hossain Masanori Katakura Hiroyuki Arai Osamu Shido Department of Environmental Physiology Shimane University Faculty of Medicine Izumoshi Japan Laboratory of alternative Medicine and Behavioral Neurosciences Department of Biochemistry and Molecular Biology Jahangirnagar University Dhaka Bangladesh Department of Geriatrics and Gerontology Division of Brain Sciences Institute of Development Aging and Cancer Tohoku University Sendai Japan

The accumulation of amyloid β peptide 1 - 42 (Aβ1-42) in the brain of alzheimer’s disease (AD) patients is known to be associated with neurodegeneration and memory impairment. More recently, we reported that madecassoside, an active component of Centella asiatica, improved memory impairment in an Aβ1-42 infusion rat model of AD, ameliorated neurotoxicity in SH-SY5Y cells, and inhibited in vitro Aβ1-42 fibril formation. In the present study, we investigated the utility of in silico analyses in corroborating observed in vivo and in vitro effects of madecassoside in AD to further assess the therapeutic benefits of madecassoside. The 3D structure of Aβ1-42 was downloaded from the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). The binding of madecassoside to Aβ1-42 was assessed by molecular docking. The chemical structure of madecassoside was modeled and converted to the PDB format. Madecassoside was found to successfully dock with Aβ1-42. Computational demonstration of the binding of madecassoside to Aβ1-42 further corroborated the inhibitory effect of madecassoside on Aβ1-42 fibrillogenesis which was demonstrated in our previous study. These data showed the potential utility of madecassoside as a preventive medication in Aβ1-42-induced neurodegenerative diseases such as AD.

关键词： alzheimer’s Disease Centella asiatica Madecassoside Ayurveda in Silico Drug Designing

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Creating a Dataset to Boost Civil Engineering Deep Learning Research and Application

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Engineering(科研) 2020年第3期12卷 151-165页

作者： Murad al Qurishee Weidong Wu Babatunde Atolagbe Joseph Owino Ignatius Fomunung Mbakisya Onyango Graduate Transportation Associate Tennessee Department of TransportationNashvilleTennesseeUSA University of Tennessee at Chattanooga ChattanoogaTennesseeUSA Transportation Engineer Maryland Department of TransportationBaltimoreMarylandUSA UC Foundation Professor and Department Head Department of Civil&Chemical EngineeringThe University of Tennessee at ChattanoogaChattanoogaTennesseeUSA Department of Civil&Chemical Engineering The University of Tennessee at ChattanoogaChattanoogaTennesseeUSA.

With cutting edge deep learning breakthrough,numerous innovations in many fields including civil engineering are ***,a fundamental issue that civil engineering research community currently facing is lack of a publicly available,free,quality-controlled and human-annotated large dataset that supports and drives civil engineering deep learning research and applications on such as intelligent transportation including connected vehicle,structural health monitoring,and bridge *** paper is a general discussion about demanding needs and construction of a long-anticipated dataset for researchers and engineers in civil engineering and beyond for providing critical training,testing and benchmarking *** establishment of such a free dataset will remove a major hurdle and boost deep learning research in civil engineering and we hope this work will urge researchers,engineers,government agencies and even computer scientists to work together to start building such datasets.A framework has been developed for the proposed ***,some pilot study databases were developed for concrete crack detection,pavement crack detection using normal and infrared thermography,as well as pedestrian and bicyclist detection.A convolution neural network model called Faster RCNN was deployed to check the detection accuracy and a 98%detection accuracy of the proposed datasets was obtained.

关键词： Dataset Deep Learning AI Civil Engineering ITS Transportation

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The Inhibition and Significance of Pigment Epithelium-Derived Factor in Prostate Cancer Development and Metastasis

The Inhibition and Significance of Pigment Epithelium-Derive...

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第十五届全国泌尿外科学术会议

作者： Huang Hai, Lin Tianxin, Huang Jian, et al. 中山大学附属第二医院

Objective: To research the inhibition and significance of pigment epithelium-derived factor( PEDF) in prostate cancer development and metastasis. Methods: Test the expression of PEDF in the normal prostate tissue, benign prostatic hyperplasia, prostate cancer tissue and prostate cancer cell lines, PC-3 and Lncap by immunohistochemical SP method and the Western Blot.

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赣西地区肉牛胃肠道寄生虫病调查及防治

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中国兽医杂志 2019年第12期55卷 56-58页

作者：康劲文郑文亚彭瑞妮 Hamad al i hamad Kassim al i bakar Habiba mkomre pandu 刘犇宜春学院生命科学与资源环境学院江西宜春336000 江西绿科农牧科技有限公司江西宜春336000

为了调查清楚赣西地区肉牛胃肠道寄生虫的感染情况,结合饱和蔗糖溶液漂浮、甲醛-乙酸乙酯-改良耐酸染色、卢戈氏碘液染色、离心沉淀以及显微镜观察等多种方法对赣西地区肉牛的粪便进行处理与观察。从168份样本的结果来看,总体感染率为18... 详细信息

为了调查清楚赣西地区肉牛胃肠道寄生虫的感染情况,结合饱和蔗糖溶液漂浮、甲醛-乙酸乙酯-改良耐酸染色、卢戈氏碘液染色、离心沉淀以及显微镜观察等多种方法对赣西地区肉牛的粪便进行处理与观察。从168份样本的结果来看,总体感染率为18.45%,大多数是单一感染,其中,艾美耳球虫感染率最高(8.93%),其次是类圆线虫(5.36%),其他虫种包括莫尼茨绦虫、肝片吸虫和隐孢子虫。调查结果表明,赣西地区肉牛胃肠道寄生虫对阿苯达唑伊维菌素预混剂敏感,该药对寄生虫具有良好的杀虫效果,但该药对球虫的驱杀效果不佳,球虫可以通过抗寄生虫药物如盐酸氨丙啉、莫能霉素、磺胺二甲嘧啶来控制。

关键词：肉牛胃肠道寄生虫感染率

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Morphological Patterns of Elastic and Reticulum Fibers in Breast Lesions

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Health 2018年第12期10卷 1625-1633页

作者： Abdelbaset Mohamed Elasbali Ziad al-Onzi alneil Hamza Ezeldine Khalafalla Hussain Gadelkarim Ahmed Department of Clinical Laboratory Sciences College of Applied Medical Sciences Jouf University Qurayyat KSA Department of Clinical Laboratory Sciences College of Applied Medical Sciences Jouf University Skaka KSA Department of Pathology College of Medicine University of Hail Hail KSA

Background: The difficulty with histopathology diagnosis is the presence of numerous benign reactive breast lesions with morphological features mimic malignant lesions. Thus, the objective of this study was to assess the merit of morphological patterns of elastic and reticular fibers in differential diagnosis of benign and malignant breast lesions. Methodology: Fifty biopsies were obtained from females with breast Lesions (25 breast carcinoma and 25 benign lesions), their ages ranging from 17 to 85 years with mean age of 39 years old. Morphologic demonstrations of elastic and reticular fibers were performed using conventional histochemical procedures. Results: Intense grades of elastic fiber staining were achieved with carcinoma tissues. Dwindled grades of elastic fiber staining were detected with fibrocystic changes. Elastic fibers in breast carcinoma are significantly increased compared to benign breast lesions P Conclusion: Histochemical quantifications of elastic and reticular fibers can assist in routine diagnosis of breast lesions. Elastic fibers significantly increase in breast carcinoma compared to benign breast lesions.

关键词： Breast Cancer Benign Breast Lesions Reticular Fibers Elastic Fibers

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Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-<i>d</i>]pyrimidines

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International Journal of Organic Chemistry 2013年第2期3卷 110-118页

作者： Hend Nagah Hafez Omar Khalid al-Duaij Abdel-Rhman Barakat A. El-Gazzar Chemistry Department Faculty of Science Al-Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh KSA Photochemistry Department National Research Centre Cairo Egypt

During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.

关键词： Spirobenzothienopyrimidine Triazolopyrimidine Pyrazolopyrimidine Analgesic Anti-inflammatory Ulcerogenic Effect

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思维总动员(七十五)

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琴童 2021年第6期 37-37页

作者： mic文婷不详

这幅画表现的是一个和音乐有关的成语,快来猜猜吧!答:__图中画面表现的是一首中国民歌,你能猜出歌曲名吗?

关键词：中国民歌画面表现总动员

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Older Adults Had Similar Survival Rates Compared to Their Younger Counterparts Following Cardiopulmonary Resuscitation

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Advances in Aging Research 2017年第5期6卷 73-82页

作者： ali al Ahmar Jamal El Eid Zouheir El Imad Husam F. Ghusn Ain Wazein Medical Village Chouf Lebanon American University of Beirut Beirut Lebanon Lebanese University Beirut Lebanon Geriatrics and Extended Care Department Ain Wazein Medical Village Chouf Lebanon

Background: Several factors affect the outcome of cardiopulmonary resuscitation (CPR) following in hospital cardiac arrests, including presence of comorbidities, arrest characteristics, and resuscitation efforts. We sought to determine the outcome of CPR provided to elders suffering from in-hospital cardiopulmonary arrest and to compare it to the survival of their younger counterparts in a tertiary care center in Lebanon. Methods: Retrospective chart review of all patients suffering from cardiac arrests who received CPR during a one year period in a tertiary care center located in a rural area. Results: A total of 98 cardiac arrests were identified who received CPR according to advance cardiac life support protocols (ACLS). Initial return of spontaneous circulation was higher among younger subjects but the difference was not statistically significant (52.6% vs 34.2%, p = 0.136). Survival to discharge was low but slightly higher in the younger subgroup, yet the difference was not statistically significant (5% vs 3%, p = 0.535). Conclusions: Physicians need to be aware of the outcome of CPR in the hospitals they practice in. They can educate their patients about CPR outcome. Such education may help patients and their next of kin make informed decisions jointly with their physician regarding resuscitation.

关键词： Cardiopulmonary Resuscitation Elderly Inpatient

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Innovative Renewable Energy-Load Management Technology via Controlled Weight Motion

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Journal of Energy and Power Engineering 2012年第1期6卷 110-116页

作者： Mohammed A. El-Kady Mamdooh Saud Thinyyan al-Saud Majeed A.S. alkanhal SEC Chair in Power System Reliability and Security College of Engineering King Saud University Riyadh 11421 Saudi Arabia

The paper presents an innovative renewable energy-load management technology, which is currently being developed as a prototype, in preparation for potential large-scale implementation in power systems. The new technology employs controlled motion of large weights, which are being maneuvered （up and down） through the system peak/off-peak demand pattern. The load management scheme is similar to the pumping storage systems, but uses large weights instead of water and, therefore, is more suited to the operating environment in Saudi Arabia, in which water is relatively scarce. A portion of the off-peak valley-filling energy is supplied from wind-driven generators, which adds to the green energy component of the scheme. The controlled motion aspect of the new technology is based on partial implementation of previously published ideas by the authors as well as a registered patent. The paper describes the theoretical and analytical features of the introduced renewable energy-load management technology, and dwells on its practical implementation features.

关键词： Power systems renewable energy load management demand-supply balance.

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