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手术治疗在人造瓣膜感染性心内膜炎中的应用及效果:一项国际多中心队列研究的倾向分析

世界核心医学期刊文摘(心脏病学分册) 2006年第4期 40-41页

作者： Pappas P. Anstrom K.j. 潘闽

Background: Although surgical intervention is often used in the treatment of prosthetic valve infective endocarditis(PVIE), an understanding of its effect on survival has been limited by the biases of observational studies and lack of con trolled trials. Methods: The International Collaboration on Endocarditis Merged Database is a large, multicenter, international registry of patients with definite endocardi tis by Duke criteria, including 367 patients with PVIE. Clinical, microbiologic, and echocardiographic variables were analyzed to determine those factors associ ated with the use of surgery for PVIE. Logistic regression analysis was performe d to create a propensity model of predictors of surgery use. Patients who underw ent surgery during initial hospitalization were matched by propensity score with patients treated with medical therapy alone. Logistic regression analysis was p erformed to determine variables independently associated with inhospital mortali ty in this matched subset. Results: Surgical therapy for PVIE was performed in 1 48(42%)of 367 patients. Inhospital mortality was similar for patients treated w ith surgery compared with those treated with medical therapy alone(25.0%vs 23.4 %, P=.729). Surgical therapy was independently associated with patient age, mic roorganism, intracardiac abscess, and congestive heart failure. After adjustment for these determinants, inhospital mortality was predicted by brain embolizatio n(OR 11.12, 95%CI 4.16-29.73)and Staphylococcus aureus infection(OR 3.67, 95% CI 1.29-9.74), with a trend toward benefit for surgery(OR 0.56, 95%CI 0.23-1. 36). Conclusions: Despite the frequent use of surgery for the treatment of PVIE, this condition continues to be associated with a high inhospital mortality rate in the contemporary era. After adjustment for factors related to surgical inter vention, brain embolism and S aureus infection were independently associated wit h inhospital mortality and a trend toward a survival benefit of

关键词：手术治疗感染性心内膜炎人造瓣膜

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系统性红斑狼疮继发癫痫的诊断预测因素

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 54-55页

作者： Mikdashi j. Krumholz A. Handwerger B. 黄媛 Division of Rheumatol ogy and Clinical Immunology University of Maryland School of Medicine 10 S. Pi ne St Baltimore MD 21201 United States Dr.

Objective: To determine the factors associated with seizures in systemic lupu s erythematosus (SLE). Methods: One hundred ninety- five patients with SLE were followed at the University of Maryland Lupus Clinics from january 1992 until ju ne 2004. Neuropsychiatric (NP) manifestations were defined according to the Amer ican College of Rheumatology nomenclature and case definitions for NP- SLE synd romes, and seizures were defined using the International Classification of Epile ptic Seizures. At the end of the study period, 28 of the 195 (14% )- patients with SLE had seizures (21 generalized convulsive, 7 partial) during their course of disease. Recurrent seizures or epilepsy occurred in 12 of 28 patients (43% ). The baseline features of those patients with seizures and those without them were compared to determine their contribution to the occurrence of isolated seiz ures and epilepsy. Results: Isolated seizures in SLE are common; epilepsy is les s frequent but nonetheless important. Certain clinical features at baseline were independent predictors of seizures including disease activity, in particular ps ychosis, moderate- to high- titer serum anti- cardiolipin and anti- Smith an tibodies, and damage accrual. Higher disease activity at baseline, concurrent mu ltiple NP- SLE manifestations, prior strokes, and male gender were predictive o f epilepsy. Conclusion: The risk of seizure and epilepsy in systemic lupus eryth ematosus (SLE) is increased in those patients with higher disease activity at ba seline, prior neuropsychiatric SLE disease, and anti- cardiolipin and anti- Sm ith antibodies.

关键词：系统性红斑狼疮继发癫痫诊断预测癫痫分类部分发作癫痫发作类型疾病活动度全身发作卒中史病例定义

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General Evaluation of Biocide （Bt-ASF-1） Produced from Iraqi Isolate of Bacillus thuringiensis

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journal of Agricultural Science and Technology(B) 2011年第5期1卷 669-674页

作者： A. S. Ahmed S. Kadim F. M. Sajet j. A. juwaed A. Hamdy I. Atyia S. A. Alhamid Department of Application Sciences Division of Biotechnology University of Technology Baghdad 964 lraq

General evaluation of isolate Bacillus thuringiensis （Bt-ASF-1） used as biocide in meddle scale application was conducted. Some morphological and confirmation tests were achieved. The sensitivity tests had been accomplished by diffusion and dilution techniques to determine the response of isolate against the antibiotics. The results of diffusion tests showed to the sensitivity of bacteria to antibiotics of cefixime, erythromycin, gentamicin and tetracycline respectively. It was resistant to trimethoprim sulfonamide （TMP）, bacitracin, penicillin and all its generations, and moderate resistance to nalidixic acid. Minimum Inhibitory Concentration （mic） for amoxicillin was ranged between 30-40 pg/mL and these results are an approximation of the universal findings. Curing experiments showed the effective role of sodium dodecyl sulfate （SDS）（1.5%） comparing with temperature. The bacterial cells became sensitive to amoxicillin and TMP. The curing by temperature did not differ significantly from control treatment in plasmid pattern or antibiotics response. Plasmid profile referring that curing by SDS has been caused disturbance in beta -lactamase genes through the sensitivity to amoxicillin and remaining resistance to ampicillin. Curing isolate by SDS also became more sensitive to nalidixic acid, erythromycin and tetracycline respectively. It was found from the curing treatments the complexity distribution of r-genes between different plasmid size and chromosome but not effect on their insecticidal ability.

关键词： Bacillus thuringiensis (Bt-ASF-1) Iraqi isolate general characteristics antibiotic susceptibility tests curing plasmid profile.

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Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar(Panthera onca) populations

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journal of Genetics and Genomics 2022年第1期49卷 77-80页

作者： Gustavo P.Lorenzana Henrique V.Figueirò jeremy johnson Elinor Karlsson Ronaldo G.Morato Dênis A.Sana Laury Cullen joares A.May jr. Edsel A.Moraes jr. Daniel L.Z.Kantek Leandro Silveira William j.Murphy Oliver A.Ryder Eduardo Eizirik Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Christopher B.Kaelin Gregory S.Barsh HudsonAlpha Institute for BiotechnologyHuntsvilleAL 35806USA Vertebrate Genome Biology Broad InstituteCambridgeMA 02142USA CENAP/ICMBio AtibaiaSP 12952Brazil PPG Biologia Animal Instituto de Bioci^enciasUFRGSPorto AlegreRS 90650Brazil Instituto de Pesquisas Ecol ogicas Teodoro SampaioSP 19280Brazil UniSul TubarãoSC 88704Brazil Instituto Prò-CarnivorosAtibaiaSP 12945Brazil Instituto Biotr opicos DiamantinaMG39100Brazil Estacão Ecologica de Taiamã ICMBioCaceresMT 78200Brazil Instituto Onca-pintada-jaguar Conservation Fund MineirosGO 75830Brazil Texas A&M University College StationTX 77843USA San Diego Zoo Institute for Conservation Research San DiegoCA 92027USA Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Instituto Pr o-Carni¬vorosAtibaiaSP 12945Brazil Centro Regional del Bajio INECOLP atzcuaroMIC61600Mexico Smithsonian Conservation Biology Institute WashingtonDC20008USA

Whole-genome sequences provide massive amounts of data that can illuminate many aspects of a species’biology and evolutionary history,as well as valuable information for conservation *** is particularly important for large carnivores,whose large area requirements and typical low densities make them prone to undergo rapid genetic erosion(*** of runs of homozygosity,Diez del Molino et al.,2018;Leroy et al.,2018)in the face of habitat loss and human *** such species is the jaguar(Pan-thera onca),the largest extant felid in the Americas,whose range has already declined by>50%and some of whose remaining popu-lations have been severely impacted by human-induced habitat frag-mentation(De La Torre et al.,2018).

关键词： Whole habitat erosion

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废纸的水解

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世界环境 1989年第3期 51-53页

作者： j.I.Walpot H.Visscher 朱耀强 Organization for Applied Scientific Research TNO

水解植物纤维素并发酵制造其它产物的方法有几种。本文只对酸水解法和酶水解法的经济优点进行比较。所使用的原料是生活垃圾中的废纸。现已得出结论:酶水解法的费用仍然大大高于酸水解法,其重要原因是酶的价格较高。

关键词：酸水解法酶水解法植物纤维素酶法水解荷兰盾纤维素纤维最佳温度水解物链锁反应活塞式流动

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氧代赖氨酸抗真菌作用机制的初步研究

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微生物学报 1993年第6期33卷 411-417页

作者：张鸿龙顾秀玉王蕖 j.M.Pecker 中国科学院上海药物研究所上海200031 美国田纳西大学微生物系

氧代赖氨酸对致病真菌类秃发念珠菌的ＭＩＣ为０．８－３．１μｇ／ｍｌ，而两性霉素Ｂ为１．６－３．１μｇ／ｍｌ．氧代赖氨酸高于赖氨酸１０倍浓度，无明显抑制白含珠菌对Ｌｙｓｉｎｅ的吸收。Ｏｘａｌｙｓｉｎｅ０．４ｍｍｏｌ／Ｌ... 详细信息

氧代赖氨酸对致病真菌类秃发念珠菌的ＭＩＣ为０．８－３．１μｇ／ｍｌ，而两性霉素Ｂ为１．６－３．１μｇ／ｍｌ．氧代赖氨酸高于赖氨酸１０倍浓度，无明显抑制白含珠菌对Ｌｙｓｉｎｅ的吸收。Ｏｘａｌｙｓｉｎｅ０．４ｍｍｏｌ／Ｌ对白色念珠菌细胞膜透性，如胞内物于ＵＶ２６０ｎｍ下的吸收物质外泄无明显影响。放射性前体物渗入试验结果指出，Ｏｘａｌｙｓｉｎｅ０．４ｍｍｏｌ／Ｌ弱抑制（＾１４Ｃ）－Ｍｅｔｈｉｏｎｉｎ和（

关键词：氧代赖氨酸白色念珠菌真菌药物

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结核病患者氧氟沙星的群体药代动力学

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国际结核病与肺部疾病杂志 2002年第4期 152-157页

作者： M.Zhu j.j.Stambaugh S.E.Berning A.E.Bulpitt E.S.Hollender M.Narita D.Ashkin C.A.Peloquin 马玙 Department of Medicine National Jewish Medical and Research Center Denver Colorado Drug Metabolism and Pharmacokinetics Schering-Plough Research Institute Kenilworth New Jersey AG Holley State Hospital Lantana Florida Department of Medicine National Jewish Medical and Research Center Denver Colorado School of Pharmacy University of Colorado Denver Colorado Department of Medicine National Jewish Medical and Research Center Denver Colorado AG Holley State Hospital Lantana Florida School of Pharmacy University of Colorado Denver Colorado Division of Pulmonary and Critical Care Medicine University of Miami School of Medicine Miami Bureau of Tuberculosis and Refugee Health Florida Department of Health Miami Florida Department of Medicine National Jewish Medical and Research Center Denver Colorado School of Pharmacy University of Colorado Denver Colorado School of Medicine University of Colorado Denver Colorado USA

背景:美国两所结核病医院。目的:测定口服多种剂量氧氟沙星后的群体药代动力学(PK)。设计:共73例结核病患者参加本研究,其中一部分患者接受多种剂量的氧氟沙星。根据药敏结果,同时服用其它药物。收集10小时以上的血清样本经高压液相... 详细信息

背景:美国两所结核病医院。目的:测定口服多种剂量氧氟沙星后的群体药代动力学(PK)。设计:共73例结核病患者参加本研究,其中一部分患者接受多种剂量的氧氟沙星。根据药敏结果,同时服用其它药物。收集10小时以上的血清样本经高压液相色谱仪测定,采用群体方法分析浓度-时间数据。结果:氧氟沙星浓度随增加的口服剂量呈线形上升。29％患者至少有一次吸收延缓。氧氟沙星清除随肾功能下降和年龄增加而降低。患者对较高剂量耐受良好,且可最大限度提高血药峰值浓度与最低抑菌浓度之比值(Cmax:mic)。结论:氧氟沙星群体药代动力学参数与以往报告结果相似。较高剂量可具有良好的药代动力学,有利于结核病的治疗。

关键词：氧氟沙星结核病药代动力学

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Single Step microwave Assisted Synthesis and Antimicrobial Activity of Silver, Copper and Silver-Copper Nanoparticles

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journal of Materials Science and Chemical Engineering 2020年第8期8卷 13-29页

作者： Myrna Reyes-Blas Nadja M. Maldonado-Luna Carla M. Rivera-Quiñones Ana L. Vega-Avila Felix R. Roman-Velázquez Oscar j. Perales-Perez Department of Chemistry University of Puerto Rico at Mayagüez Mayaguez USA Department of Mechanical Engineering University of Puerto Rico at Mayagüez Mayaguez USA Department of Chemical Engineering University of Puerto Rico at Mayagüez Mayaguez USA Department of Engineering Science & Materials University of Puerto Rico at Mayagüez Mayaguez USA

Copper and silver nanoparticles were synthesized and characterized in two minutes at 175°C in a one-step synthesis using a modified polyol (ethylene glycol) method and a microwave heating process. We successfully synthesized spherical Silver (Ag) and Copper nanoparticles (CuNP) with a crystallite size of less than 10 nm, as well as irregular silver-copper nanoparticles (AgCuNP) with a crystallite size of less than 15 nm, as confirmed by X-Ray Diffraction (XRD) and High-Resolution Transmission Electron microscopy (HRTEM). The successful synthesis of AgCuNP with 1:1 molar ratio and constituted by 51.74% of copper and 48.26% of silver was corroborated using the Energy Dispersive X-ray (EDX) mapping technique. The AgNP and AgCuNP exhibited more stability in suspension, in comparison to CuNP, as observed by continuously monitoring the absorbance with UV-Vis spectroscopy for 12 days. Furthermore, the minimum inhibitory concentration (mic) and minimum bactericidal concentration (MBC) of AgNP, CuNP, and AgCuNP were determined, against Gram-negative and Gram-positive bacteria, and yeast. The obtained mic and MBC values indicate that AgCu nanoparticles exhibited bactericidal properties greater than its constituents. On the contrary, antifungal activity of AgCuNP against yeast was not observed.

关键词： Ag Nanoparticles Cu Nanoparticles microwave Synthesis Modified Polyol Method Antimicrobial Properties AgCu Nanoparticles

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重组人瘦素在下丘脑性闭经妇女中的应用

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 4-5页

作者： Welt C.K. Bullen j. C.S.Mantzoros 兰玲 Div.of Endocrinol. Dia bet./Metab.Beth Is-rael Deaconess Medical Center330B rookline Ave.BostonMA 02215United States Dr.

BACKGROUND:Disruptions in hypothalamic -gonadal and other endocrine axes due to energ y deficits are associ-ated with low levels of the adipocyte-secreted hormone leptin and may result in hypothalami c *** hypothesized that exogenous recomb inant leptin replace-ment would improve reproductive and neuroendocrine function in women with hypothalamic ***:Eight women with hypothala mic amenorrhea due to strenuous exercise or low weig ht were studied for one month before receiving recombinant human leptin and then while receiving treatment for up to t hree *** con-trol subjects with hypothalamic ame norrhea received no treatment and were studied for a mean(±SD)of 8.5±***:Luteinizing hormone(LH)-pulsatility,body weight,ovarian v ariables,and hormone levels did not change significantly over time in the controls and during a one -month control perio d before recombinant leptin therapy in the treated subjec *** contrast,recom-binant leptin treatment increased mean LH levels and LH pulse frequency after two weeks and i ncreased maximal follicular diameter,the number of d ominant follicles,ovarian volume,and estradiol levels over a period of three *** patients had an ovulatory menstrual cycle(Pmic amenorrhea appears to improve repro ductive,thyroid,and growth hormone axes and markers of bone formation,sug-gesting that leptin,a peripheral signal reflecting the ade-quacy of energy st

关键词：下丘脑性闭经神经内分泌功能卵巢体积瘦素水平促黄体生成素性腺轴卵泡发育排卵前能量储备三碘甲腺原氨酸

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替加色罗重复疗法对肠易激综合征女性患者合并便秘的疗效和安全性:一项随机、对照试验评估

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 40-41页

作者： Tack j Müller-Lissner S Bytzer P. 王志宇 Department of Internal Medicine Division of Gastroenterology University Hospital Gasthuisberg Herestraat 49 B-3000 Leuven BelgiumDr.

Background: It has been proposed that treatments for irritable bowel syndrome with constipation (IBS-C) should provide rapid symptomatic relief, be intermittent, and effective upon repeated use. Aims: To evaluate the efficacy and safety of tegaserod on IBS symptoms, and its impact on quality of life and health econo mic measures. Patients: Women (≥18 years of age) with IBS-C according to the R ome II criteria. Methods: Prospective, double blind, placebo controlled, randomi sed trial. Women with IBS-C either received tegaserod 6 mg twice daily or place bo for one month. Patients with at least a partial response entered a treatment free interval. Upon symptom recurrence, tegaserod treated patients were re-rand omised to tegaserod or placebo for an additional month. Primary efficacy variabl es were response (overall IBS symptoms and abdominal discomfort/pain) to first a nd repeated treatment. Analysis was by intention to treat. Results: 2660 patient s and 1191 patients were randomised for first and repeated treatment respectively. Tegaserod was superior to placebo for each primary efficacy vari able (first treatment: 33.7%v 24.2%responders respectively for relief of IBS s ymptoms and 31.3%v 22.1%for relief of abdominal discomfort/ pain; repeated tre atment: 44.9%v 28.7%, and 42.4%v 27.1%, all p < 0.0001). Tegaserod was super ior to placebo for every secondary efficacy variable (relief of abdominal discom fort/pain, bloating and constipation; stool frequency and consistency). A respon se to tegaserod was observed within the first treatment week. Tegaserod produced greater satisfaction, work productivity, and improved quality of life than plac ebo (p < 0.05). Conclusion: Tegaserod provides rapid and sustained relief of IBS -C symptoms both during first and repeated treatment.

关键词：替加色罗肠易激综合征对照试验安慰剂对照症状缓解率生活质量意度间隔期随机分配随机试验

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