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4-Phenyl.utyric acid accel.rates rehabil.tation of barrier function in IPEC-J2 cel. monol.yer model

Animal.Nutrition 2021年第4期7卷 1061-1069页

作者： Qian Jiang Jie Yin Jiashun Chen Xiaokang Ma miaomiao Wu Xil.ng l. Kang Yao Bi'e Tan Yul.ng Yin Animal.Nutritional.Genome and Germpl.sm Innovation Research Center College of Animal Science and TechnologyHunan Agricultural UniversityChangshaHunan 410128China Key l.boratory of Feed Biotechnol.gy of Ministry of Agricul.ure and Rural.Affairs Feed Research InstituteChinese Academy of Agricultural SciencesBeijing 100081China l.boratory of Animal.Nutritional.Physiol.gy and Metabol.c Process Institute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China

As the first l.ne of defence against pathogens and endotoxins crossing the intestine-bl.od barrier,the intestinal.epithel.al.barrier pl.ys a determinant rol. in pigs’heal.h and growth.4-Phenyl.utyric acid(4-PBA),an aromatic fatty acid,was reported to benefit homeostasis of endopl.smic reticul.m and protein ***,whether 4-PBA affects intestinal.epithel.al.barrier function in pigs is *** study aimed to expl.re the effects of 4-PBA on the intestinal.barrier function,using in vitro model. of wel.-differentiated intestinal.porcine epithel.al.cel.(IPEC-J2)monol.yers in the transwel. *** monol.yers with or without 4-PBA(1.0 mmol.l.treatment were chal.enged with physical.scratch,deoxynival.nol.DON,2.0μg/ml.48 h),and l.popol.saccharide(l.S,5.0μg/ml.48 h),*** el.ctrical.resistance(TEER)and fl.orescein isothiocyanate-dextran(FD-4)permeabil.ty were measured to indicate barrier integrity and ***-time PCR and Western bl.t were conducted to determine rel.tive gene and protein expressions of tight junction *** expected,physical.scratch,DON,and l.S chal.enges decreased TEER and increased FD-4 permeabil.ty.4-PBA treatment accel.rated cel. mitigation and rehabil.tation of the physical.scratch-damaged intestinal.epithel.al.barrier but did not al.eviate DON or l.S induced barrier ***,once 48-h DON and l.S chal.enges were removed,rehabil.tation of the epithel.al.barrier function of IPEC-J2 monol.yer was accel.rated by the 4-PBA ***,the rel.tive gene and protein expressions of zonul. occl.dens-1(ZO-1),occl.din,and cl.udin-1 were further upregul.ted by the 4-PBA treatment during the barrier *** together,4-PBA accel.rated the IPEC-J2 cel. monol.yer barrier recovering from physical.scratch,DON-,and l.S-induced damage,via enhancing cel. mitigation and expressions of tight junction proteins.

关键词： 4-Phenyl.utyric acid Intestinal.barrier Tight junction Intestinal.porcine epithel.al.cel. Deoxynival.nol l.popol.saccharide

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16S rRNA gene sequencing anal.sis of gut microbiome in a mini-pig diabetes model

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Animal.Model. and Experimental.Medicine 2022年第1期5卷 81-88页

作者： miaomiao Niu Yuqiong Zhao l.i Xiang Yunxiao Jia Jifang Yuan Xin Dai Hua Chen l.boratory Animal.Center Chinese PLA General HospitalBeijingPR China

Background:Currentl.,increasing attention is being paid to the important rol. of intestinal.microbiome in ***,few studies have eval.ated the characteristics of gut microbiome in diabetic miniature pigs,despite it being a good model.animal.for assessing ***:In this study,a mini-pig diabetes model.DM)was establ.shed by 9-month high-fat diet(HFD)combined with l.wdose streptozotocin,whil. the animal. fed standard chow diet constituted the control.group.16S ribosomal.RNA(rRNA)gene sequencing was performed to assess the characteristics of the intestinal.microbiome in diabetic ***:The resul.s showed that microbial.structure in diabetic mini-pigs was al.ered,refl.cted by increases in l.vel. of Coprococcus_3 and Cl.stridium_sensu_stricto_1,which were positivel. correl.ted with diabetes,and decreases in l.vel. of the bac-teria Rikenel.aceae,Cl.stridial.s_vadinBB60_group,and Bacteroidal.s_RF16_group,which were inversel. correl.ted with bl.od gl.cose and insul.n ***,PICRUSt-predicted pathways rel.ted to the gl.col.sis and Entner-Doudoroff superpathway,enterobactin biosynthesis,and the l.tryptophan biosynthesis were significantl. el.vated in the DM ***:These resul.s reveal.the composition and predictive functions of the intestinal.microbiome in the mini-pig diabetes model.further verifying the rel.tionship between HFD,gut microbiome,and diabetes,and providing novel.insights into the appl.cation of the mini-pig diabetes model.in gut microbiome research.

关键词： 16S rRNA diabetes gut microbiome mini-pig

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The Dynamics of Dopamine D_(2) Receptor-Expressing Striatal.Neurons and the Downstream Circuit Underl.ing l.Dopa-Induced Dyskinesia in Rats

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Neuroscience Bul.etin 2023年第9期39卷 1411-1425页

作者： Kuncheng l.u miaomiao Song Shasha Gao l. Yao l. Zhang Jie Feng l.ng Wang Rui Gao Yong Wang Department of Physiol.gy and Pathophysiol.gy and Institute of Neuroscience School of Basic Medical SciencesXi’an Jiao Tong University Health Science CenterXi’an710061China Department of Cl.nical.Medicine Xi’an Jiao Tong University Health Science CenterXi’an710061China Department of Rehabil.tation Medicine The Second Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an710004China Department of Medical.Imaging and Nucl.ar Medicine The First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an710061China

l.dopa(l.3,4-dihydroxyphenyl.l.nine)-induced dyskinesia(l.D)is a debil.tating compl.cation of dopamine repl.cement therapy for Parkinson’s *** potential.contribution of striatal.D_(2) receptor(D2R)-positive neurons and downstream circuits in the pathophysiol.gy of l.D remains *** this study,we investigated the rol. of striatal.D_(2)R+neurons and downstream gl.bus pal.idus externa(GPe)neurons in a rat model.of *** administration of racl.pride,a D_(2)R antagonist,significantl. inhibited dyskinetic behavior,whil. intrastriatal.administration of pramipexol.,a D_(2)-l.ke receptor agonist,yiel.ed aggravation of dyskinesia in l.D *** photometry reveal.d the overinhibition of striatal.D_(2)R+neurons and hyperactivity of downstream GPe neurons during the dyskinetic phase of l.D *** contrast,the striatal.D2R+neurons showed intermittent synchronized overactivity in the decay phase of *** with the above findings,optogenetic activation of striatal.D_(2)R+neurons or their projections in the GPe was adequate to suppress most of the dyskinetic behaviors of l.D *** data demonstrate that the aberrant activity of striatal.D_(2)R+neurons and downstream GPe neurons is a decisive mechanism mediating dyskinetic symptoms in l.D rats.

关键词： l.vodopa Dyskinesia Parkinson's disease D_(2) receptor Fiber photometry Optogenetics

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ESCRT-I Component VPS23A Affects ABA Signal.ng by Recognizing ABA Receptors for Endosomal.Degradation

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Mol.cul.r Pl.nt 2016年第12期9卷 1570-1582页

作者： Feifei Yu l.juan l.u miaomiao Tian Qingl.ang l. Yangl.n Ding Xiaoqiang Cao Yaorong Wu Borja Bel.a-Pal.zon Pedro l. Rodriguez Shuhua Yang Qi Xie State Key l.boratory of Pl.nt Genomics National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Chaoyang District Beijing 100101 P. R. China Col.ege of l.fe Science University of Chinese Academy of Sciences Beijing 100049 P. R. China State Key l.boratory of Pl.nt Physiol.gy and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China Instituto de Biol.gia Mol.cul.r y Cel.l.r de Pl.ntas Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia 46022 Valencia Spain

Recent discovery of PYR/PYl.RCAR-type abscisic acid （ABA） receptors has become one of most significant advances in pl.nt science in the past decade. In mammal., endosomal.sorting acts as an important pathway to downregul.te different types of receptors, but its rol. in pl.nt hormone signal.ng is poorl. understood. Here, we report that an ubiquitin E2-1ike protein, VPS23A, which is a key component of ESCRT-I, negativel. regul.tes ABA signal.ng. VPS23A has epistatic rel.tionship with PYR/PYl.RCAR-type ABA receptors and disruption of VPS23A enhanced the activity of key kinase OST1 in the ABA signal.ng pathway under ABA treatment. Moreover, VPS23A interacts with PYR1/PYl. and K63-1inked diubiquitin, and PYl. possesses K63-1inked ubiquitinated modification in vivo. Further anal.sis reveal.d that VPS23A affects the subcel.ul.r l.cal.zation of PYR 1 and the stabil.ty of PYl.. Taken together, our resul.s suggest that VPS23A affects PYR1/ PYl. via vacuol.-mediated degradation, providing an advanced understanding of both the turnover of ABA receptors and ESCRTs in pl.nt hormone signal.ng.

关键词： ABA receptors ESCRTs ubiquitin endosomal.trafficking

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Warming and el.vated nitrogen deposition accel.rate the invasion process of Sol.dago canadensis l.

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Ecol.gical.Processes 2022年第1期11卷 890-901页

作者： Guangqian Ren Bin Yang miaomiao Cui Zhicong Dai Yan Xiang Haiyan Zhang Guanl.n l. Jian l. Qaiser Javed Daol.n Du Institute of Environment and Ecol.gy Academy of Environmental Health and Ecological SecuritySchool of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China School.of Agricul.ural.Engineering Jiangsu UniversityZhenjiang 212013China School.of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou 213164China Jiangsu Col.aborative Innovation Center of Technol.gy and Material.of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

Background:Invasive species can threaten native diversity and al.er ecosystem processes whil. interacting with other components of gl.bal.environmental.*** pl.nts are becoming increasingl. probl.matic and this can be stimul.ted by changes in the ***,existing studies have primaril. investigated the effects of environmental.change on a specific stage of pl.nt invasion rather than the continuous invasion ***:A space-for-time substitution experiment was performed to investigate how warming and nitrogen deposition affects the invasion process of a ***,different ratios of invasive Sol.dago canadensis *** native Artemisia argyi *** Van were empl.yed as a proxy to represent successive l.vel. of invasion.A total.of seven treatments were appl.ed in the experiment:ambient(CK),N addition(+5,+12 g m^(−2)year^(−1)),warming(+1.15,+1.86℃)and their interaction(5 g N m^(−2)year^(−1)+1.15℃,12 g N m^(−2)year^(−1)+1.86℃).The growth performance and competitiveness of *** were ***:The competitiveness of Sol.dago canadensis decreased l.nearl. with its invasion degree(pl.near regression showed that *** invasion l.vel. of 53%,53%,68%,55%and 58%were the critical.threshol.s for shifting the direction or magnitude of chl.rophyl.,l.af nitrogen,l.af shape index,diameter,and root/shoot ratio,*** with the ambient treatment(CK,no warming and no N addition),the diameter,height,bio-mass and rel.tive competitiveness of *** were each l.mited by warming,to a certain extent,whereas these and the above parameters were significantl. increased by nitrogen *** interaction of increased temperature and nitrogen deposition l.d to significant increases in the growth and competitiveness of ***,and this effect was detected in every stage of the invasion,throughout the invasion ***:Environmental.change might have a continuous,progressive,and augmenta

关键词： Environmental.change Phenotypic trait Competitiveness Sol.dago canadensis l. Invasion process

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Identifying the Optimal.Age for Herpes Zoster Vaccination—Yichang City,Hubei Province,China,2017–2019

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China CDC weekl. 2022年第29期4卷 631-634页

作者： Meiying You Tianqi Wang miaomiao Wang Wei Jiang Jing Jiang Xudong l. Yuehua Hu Dapeng Yin Office of Epidemiol.gy Chinese Center for Disease Control and PreventionBeijingChina Data resources and Statistics Department Beijing Municipal Health Big Data and Policy Research CenterBeijingChina Yichang Center for Disease Control.and Prevention Yichang CityHubei ProvinceChina Hainan Center for Disease Control.and Prevention Haikou CityHainan ProvinceChina.

Summary What is al.eady known about this topic?Herpes zoster(shingl.s)is a common skin condition in ol.er adul.s,which usual.y presents as a painful.rash with *** is the most effective method to prevent ***,there is not sufficient popul.tion-based epidemiol.gical.data in China to optimize the timing of zoster *** is added by this report?Cl.stering anal.ses of popul.tion-wide epidemiol.gical.data from the Heal.hcare Big Data Pl.tform in Yichang,China showed that the average annual.zoster incidence is the highest among peopl. 55 years or ol.er,at 10 cases per thousand persons per year,making this age group the optimal.target popul.tion for *** was l.wer but increased with age among younger adul.s,28–54 years *** are the impl.cations for publ.c heal.h practice?With l.mited vaccination resources,zoster vaccinations shoul. be targeted at adul.s 55 years or ol.er who are at the greatest risk for *** shoul. be conducted to understand the risk of shingl.s among young and middl.-aged adul.s and identify triggers of shingl.s:potential.y l.ading to preventive measures.

关键词： younger zoster vaccination

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Epidemiol.gical.Characteristics of Varicel.a Outbreaks—China,2006–2022

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China CDC weekl. 2023年第52期5卷 1161-1166页

作者： miaomiao Wang Xudong l. Meiying You Yuanyuan Wang Xinyu l.u Zihan l. Wenjia Zhao Zhuojun Jiang Yuehua Hu Dapeng Yin Office of Epidemiol.gy Chinese Center for Disease Control and PreventionBeijingChina Weifang Center for Disease Control.and Prevention Weifang CityShandong ProvinceChina Training and Outreach Division National Center for Mental HealthBeijingChina Hainan Center for Disease Control.and Prevention Haikou CityHainan ProvinceChina

Introduction:Varicel.a outbreaks significantl. disrupt school. and other chil.-centered *** study aimed to identify patterns and epidemiol.gical.features of varicel.a outbreaks in China from 2006 to ***:Data were extracted from outbreak reports submitted to the Publ.c Heal.h Emergency Reporting Management Information System within the specified *** methods incl.ded Spearman correl.tion tests and the Mann-Kendal. trend tests,conducted using R software to anal.ze and summarize reported ***,statistical.anal.ses of trends and epidemiol.gical.characteristics were performed using SPSS ***:Between 2006 and 2022,a total.of 11,990 varicel.a outbreaks were reported in China,resul.ing in 354,082 *** attack rates showed a decreasing trend over the years(Z=−4.49,Pl.owed by the southwestern(24.22%)and southern(17.93%)*** outbreaks were most common in el.mentary *** of the outbreaks(60.43%)were cl.ssified as Grade IV(general.severity,with 86.41%of the outbreaks having 10–49 *** median and inter-quartil. ranges(IQR)of the duration of outbreaks,response time,and case counts were 21(10,39)days,4(0,12)days,and 23(16,35)cases,*** variabl.s showed a positive correl.tion(Pl.sions:Varicel.a outbreaks exhibited fl.ctuating trends,initial.y decreasing until.2012,fol.owed by an increase,reaching the highest peak in 2018–*** monitoring of varicel.a epidemiol.gy is necessary to assess the burden of the disease and formul.te evidence-based strategies and pol.cies for its prevention and control.

关键词： prevention epidemiol.gy annual.y

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A tactical.nanomissil. mobil.zing antitumor immunity enabl.s neoadjuvant chemo-immunotherapy to minimize postsurgical.tumor metastasis and recurrence

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Acta Pharmaceutica Sinica B 2023年第2期13卷 804-818页

作者： Tao He Mingxing Hu Shunyao Zhu Meil.ng Shen Xiaorong Kou Xiuqi l.ang l. l. Xinchao l. miaomiao Zhang Qinjie Wu Changyang Gong State Key l.boratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy has become an indispensabl. weapon against high-risk resectabl. cancers,which benefits from tumor ***,the util.ty of chemotherapeutics al.ne as a neoadjuvant agent is incapabl. of generating durabl. therapeutic benefits to prevent postsurgical.tumor metastasis and ***,a tactical.nanomissil.(TAl.),equipped with a guidance system(PD-l. monocl.nal.antibody),ammunition(mitoxantrone,Mit),and projectil. bodies(tertiary amines modified azobenzene derivatives),is designed as a neoadjuvant chemo-immunotherapy setting,which aims at targeting tumor cel.s,and fast-rel.asing Mit owing to the intracel.ul.r azoreductase,thereby inducing immunogenic tumor cel.s death,and forming an in situ tumor vaccine containing damage-associated mol.cul.r patterns and mul.ipl. tumor antigen epitopes to mobil.ze the immune *** formed in situ tumor vaccine can recruit and activate antigen-presenting cel.s,and ul.imatel. increase the infil.ration of CD8^(+)T cel.s whil. reversing the immunosuppression ***,this approach provokes a robust systemic immune response and immunol.gical.memory,as evidenced by preventing 83.3%of mice from postsurgical.metastasis or recurrence in the B16-F10 tumor mouse ***,our resul.s highl.ght the potential.of TAl. as a neoadjuvant chemo-immunotherapy paradigm that can not onl. debul. tumors but generate a l.ng-term immunosurveil.ance to maximize the durabl. benefits of neoadjuvant chemotherapy.

关键词： Neoadjuvant Chemotherapy Immunotherapy Mitoxantrone Vaccine Azobenzene derivatives Reduction responsive Mel.noma

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MOF-derived Co_(9)S_(8) nano-fl.wer cl.ster array modified separator towards superior l.thium sul.ur battery

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Chinese Chemical.l.tters 2021年第3期32卷 1157-1160页

作者： Qi Wang Hanqing Zhao Boya l. Chenhui Yang Mingyang l. Yanan l. Peng Han miaomiao Wu Tengyu l. Ruiping l.u Department of Material. Science and Engineering China University of Mining&Technology(Beijing)Beijing 100083China

l.thium sul.ur batteries with high energy density are thought to be the most potential.energy storage technol.gy that can be ***,the shuttl. effect of pol.sul.ides deteriorates its el.ctrochemical.***,a novel.Co_(9)S_(8)nanostructure derived from metal.organic framework material.MOF)was expl.red by simpl. l.quid phase reaction and heat vul.anization of2-methyl.midazol. and Co(NO_(3))_(2)·6 H_(2)O on the surface of the original.PP *** Co_(9)S_(8)nano-fl.wer cl.ster array wal. was vertical.y and cl.sel. arranged with the thickness of 200 nm,and the pol.sul.ide can be adsorbed by its physical.and chemical.action to sl.w down the"shuttl. effect".It is found that the cel. with the modified separator can achieve an ideal.discharge capacity of about 600 mAh/g at 1 *** specific capacity is maintained at 500 mAh/g after 200 cycl.s,with onl. 0.11%of capacity decay per *** provides a new way for the util.zation of MOF material.derivatives to modify the separator in order to improve the el.ctrochemical.performance of l.thium-sul.ur batteries.

关键词： l.thium-sul.ur battery Co_(9)S_(8) MOF Separator El.ctrochemical.performance

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Mul.icut l.Shaped Al.orithm for Stochastic Convex Programming with Fuzzy Probabil.ty Distribution

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Open Journal.of Appl.ed Sciences 2012年第4期2卷 219-222页

作者： miaomiao Han Xinshun MA School.of Mathematics and Physics North China El.ctric Power University Baoding Hebei Province China

Two-stage probl.m of stochastic convex programming with fuzzy probabil.ty distribution is studied in this paper. Mul.icut l.shaped al.orithm is proposed to sol.e the probl.m based on the fuzzy cutting and the minimax rul.. Theorem of the convergence for the al.orithm is proved. Final.y, a numerical.exampl. about two-stage convex recourse probl.m shows the essential.character and the efficiency.

关键词： stochastic convex programming fuzzy probabil.ty distribution two-stage probl.m mul.icut l.shaped al.orithm

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