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A Minireview of Marine Algal Virus-Coccolithoviruses

Journal of Ocean University of China 2015年第2期14卷 293-300页

作者： LIU Jingwen xu miaomiao ZHENG Tianling College of Food and Bioengineering Jimei University Research Center of Food Microbiology and Enzyme Engineering Technology of Fujian Province State Key Laboratory for Marine Environmental Sciences and Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem School of Life Sciences Xiamen University

Coccolithophorid is unicellular marine microalgae with a global distribution in temperate and sub-temperate oceanic regions and has the ability to produce ＇the coccoliths＇. It is considered to be the second most productive calcifying organism on earth and becoming an important factor in the global carbonate cycle. Emiliania huxleyi is one of the only two bloom-forming coccolithophores and becomes a species crucial to the study of global biogeochemical cycles and climate modeling. Coccolithoviruse is a recently discovered group of viruses infecting the marine coceolithophorid E. huxleyi. They are a major cause of coceolithophore bloom termination, and DMSP concentration is increasing in the process of viral lysis. Phylogenetic evidences support that some genes are functional both in E. huxleyi and its virus （EhV）. Horizontal gene transfer （HGT） of multiple functionally coupled enzymes occurs in E. huxleyi and its DNA virus EhV has been confirmed, which contributes to the diversification and adaptation of plankton in the oceans and also critically regulates virus-host infection by allowing viruses to control host metabolic pathways for their repli- cation. Therefore, it is of particular interest to understand this host-virus interaction. On this issue, we have made a minireview of coeeolithoviruses focusing on the basic characteristics, phylogenesis, horizontal gene transfer and the interaction between the host and its viruses, as well as its important role in global biogeochemical cycling.

关键词： eoccolithoviruses phylogenetic characteristics virus-host interaction horizontal gene transfer (HGT) global climatechange

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Self-Assembly of Switchable Protein Nanocages via Allosteric Effect

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CCS Chemistry 2021年第8期3卷 2226-2235页

作者： miaomiao xu Rongjin Zeng Jun Xiang Qiang Yan Department of Macromolecular Science Fudan UniversityShanghai 200433 Department of Biomass Science and Engineering Sichuan UniversityChengdu 610065

Protein cages have promising applications in highly efficient gene *** methods of engineering protein–interface interactions have been developed to build such viral *** in current approaches is how to turn off the interactions and unpack the protein shell for controlled cargo ***,we present a concise protein allosteric strategy to create protein nanocages with dismountable coats.

关键词： supramolecular cage allosteric effect protein–ligand interactions protein self-assembly virus mimics

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A convenient immunochromatographic test strip for rapid detection of Scylla serrata reovirus

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Virologica Sinica 2017年第4期32卷 335-337页

作者： Dongyang Fan Jingwen Liu miaomiao xu Yangyang Yuan Jifang Yang Jigang Chen College ofFood and Bioengineering Jimei UniversityXiamen 361021China

Scylla serrata reovirus （SsRV）, first discovered in Chinain 2004, is now known to be widespread in the mud crab（Scylla serrata） farming pond of China. （Chen et al.,2008）. Since there are no effective treatments ... 详细信息

关键词：中国病毒学英文版

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Regional Differences in the Income of Farmers and Herdsmen in Inner Mongolia

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Asian Agricultural Research 2014年第2期6卷 21-26页

作者： miaomiao xu College of Economics and Management Southwest University

This paper analyzes the key indicators which reflect farmer and herdsman's income in Inner Mongolia region,and then carries out regression analysis,factor analysis and cluster analysis of their income status in this region with SPSS software. Through the analysis,it can be seen that the net income of per farmer and herdsman in Inner Mongolia,has not reached the national level,and the differences in the influencing factors of the income are very obvious. According to present specific situation of farmers and herdsman in Inner Mongolia,this paper gives suggestions like proposing an agricultural prices security system,speeding up the strategic investment,improving the investment environment to promote the reasonable layout of the whole area,so as to improve the incomes of famers and herdsmen in Inner Mongolia region.

关键词： Inner Mongolia Economic development Influencing fa

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Michel Hockx, Internet Literature in China

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2019年第1期13卷 150-157页

作者： xu miaomiao Beijing Academy of Social Sciences

Internet Literature in China, written by Michel Hockx is the first comprehensive work about this issue published in English. Before that, Jin Feng from Grinnell College had published Romancing the Internet: Producing and Consuming Chinese Web Romance (Leiden: Brill, 2013), which focused on online romance fictions and their social influence among fans.

关键词： China influence fans.

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New Policy Calls for Ships Flying Convenience Flag to “Go Home”

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中国船检 2016年第10期 110-111页

作者： xu miaomiao

On August 31,2016,a new notice on import tax policy for Chinese-capital ships flying convenience flag returning to China for registration was jointly issued by the Ministry of Finance and the General Administration of... 详细信息

关键词： registration issued jointly Flying Go Home Customs import convenience notice simplify

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Window to China

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中国船检 2006年第1期 20-21页

作者： xu miaomiao

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127 high quality domestic ships are awarded“CSAD”class

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中国船检 2005年第12期 15-17页

作者： Reporter xu miaomiao

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β-amyloid plaque deposition in the brain of Alzheimer’s disease mouse model by ^(18)F-FINH-Me imaging

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China Medical Abstracts(Internal Medicine) 2021年第2期38卷 65-66页

作者： xu miaomiao Dept Nucl Med Xinhua HospShanghai Jiaotong Univ Med SchShanghai 200092

Objective To synthesize a newβ-amyloid(Aβ)radioactive tracer(2-((2-6-[^(18)F]fluoro-5-(methylamino)pyridin-2-yl)benzothiazol-6-yl)thio)ethanol(^(18)F-FINH-Me),and evaluate its biological distribution and affinity to Aβ ***^(18)F-FINH-Me was synthesized by GE FN automated module,and the quality control and stability of ^(18)F-FINH-Me were determined with high performance liquid chromatography(HPLC).

关键词： (1 FIN 8)

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Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes

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Science China(Life Sciences) 2024年第2期67卷 301-319页

作者： Xiaoli Tang Hong Liu Rongjia Rao Yafei Huang Mengqi Dong miaomiao xu Shanshan Feng xun Shi Li Wang Zengwu Wang Bingying Zhou State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China Department of Epidemiology Cardiovascular Institute and Fuwai HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100037China Shenzhen Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical SciencesShenzhenShenzhen 518020China

Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’***,mitochondrial toxicity testing is not incorporated into routine cardiac safety screening *** accurately model native human cardiomyocytes,we comprehensively evaluated mitochondrial responses of adult human primary cardiomyocytes(h PCMs)to a nucleoside analog,remdesivir(RDV).Comparison of their response to human pluripotent stem cell-derived cardiomyocytes revealed that the latter utilized a mitophagy-based mitochondrial recovery response that was absent in h ***,action potential duration was elongated in h PCMs,reflecting clinical incidences of RDV-induced QT *** a screen for mitochondrial protectants,we identified mitochondrial ROS as a primary mediator of RDV-induced *** study demonstrates the utility of h PCMs in the detection of clinically relevant cardiac toxicities,and offers a framework for h PCM-based high-throughput screening of cardioprotective agents.

关键词： remdesivir mitochondrial toxicity cardiotoxicity human primary cardiomyocytes high-throughput screening

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