检索结果-南通市图书馆

A new method for evaluating the firing precision of multiple launch rocket system based on Bayesian theory

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 232-241页

作者： Yunfei miao Guoping wang wei Tian College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsuChina Institute of Launch Dynamics Nanjing University of Science and TechnologyNanjingJiangsuChina

How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this *** of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight *** Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed *** the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed ***,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.

关键词： Multiple launch rocket system Bayesian theory Simulation credibility Mixed prior distribution Firing precision

Discovery of hydrothermal venting community at the base of Cambrian barite in Guizhou Province,Western China: Implication for the Cambrian biological explosion

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2008年第1期18卷 65-70页

作者： Ruidong Yang*,Huairui wei,miao Bao,wei wang,Qiang wang, Xiaodong Zhang,Ling Liu Graduate School of Guizhou University,Guiyang 550025,China Graduate School of Guizhou University Guiyang 550025 China

The barite deposit in the Niutitang Formation of Lower Cambrian,in Tianzhu County,Guizhou Province,western China,is a super- large barite deposit with about 2·109tons of ***,petrological and geochemical studies reveal that this barite deposit belongs to a hydrothermal sedimentary *** observations indicate that a lot of algae,sponge spicules and tube-type fos- sils are well-preserved in this barite section,and moreover,those fossils share most characteristics of the deep-sea hydrothermal venting community in the modern *** suggest that the hydrothermal venting community was thriving in hydrothermal vent in early Cam- brian,and it is of great significance for elucidating the geological background of the‘‘Cambrian explosion’’.China *** rights reserved.

关键词： Hydrothermal community Barite Cambrian Guizhou

Nanofluidic memristor based on the elastic deformation of nanopores with nanoparticle adsorption

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 46-54页

作者： Xi Zhou Yuanyuan Zong Yongchang wang miao Sun Deli Shi wei wang Guanghua Du Yanbo Xie Department of Chemistry and Chemical Engineering Northwestern Polytechnical University School of Physical Science and Technology Northwestern Polytechnical University School of Aeronautics and Institute of Extreme Mechanics Northwestern Polytechnical University Institute of Modern Physics Chinese Academy of Sciences

The memristor is the building block of neuromorphic computing. We report a new type of nanofluidic memristor based on the principle of elastic strain on polymer nanopores. With nanoparticles absorbed at the wall of a single conical polymer nanopore, we find a pinched hysteresis of the current within a scanning frequency range of 0.01–0.1 Hz, switching to a diode below 0.01 Hz and a resistor above 0.1 Hz. We attribute the current hysteresis to the elastic strain at the tip side of the nanopore, caused by electrical force on the particles adsorbed at the inner wall surface. Our simulation and analytical equations match well with experimental results, with a phase diagram for predicting the system transitions. We demonstrate the plasticity of our nanofluidic memristor to be similar to a biological synapse. Our findings pave a new way for ionic neuromorphic computing using nanofluidic memristors.

关键词： nanofluidics memristor neurocomputing elastic deformation

Research Progress on the Pathogenesis and Treatment of Neoatherosclerosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第4期44卷 680-685页

作者： Yi-shan GUO Ning YANG Zhen wang Yu-miao wei Department of Cardiology Hubei Key Laboratory of Biological Targeted TherapyHubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Cardiology Binzhou Medical University HospitalBinzhou256600China Department of Gynecology Binzhou Medical University HospitalBinzhou256600China

Neoatherosclerosis(NA)within stents has become an important clinical problem after coronary artery stent ***-stent restenosis and in-stent thrombosis are the two major complications following coronary stent placement and seriously affect patient *** the common pathological basis of these two complications,NA plaques,unlike native atherosclerotic plaques,often grow around residual oxidized lipids and stent *** main components are foam cells formed by vascular smooth muscle cells(VSMCs)engulfing oxidized lipids at lipid residue *** research mainly focuses on optical coherence tomography(OCT)and intravascular ultrasound(IVUS),but the specific pathogenesis of NA is still unclear.A thorough understanding of the pathogenesis and pathological features of NA provides a theoretical basis for clinical *** article reviews the previous research of our research group and the current situation of domestic and foreign research.

关键词： neoatherosclerosis vascular smooth muscle cells

The genome-wide meiotic recombination landscape in ciliates and its implications for crossover regulation and genome evolution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第3期51卷 302-312页

作者： Lu Fu Chen Gu Kazufumi Mochizuki Jie Xiong wei miao Guangying wang Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China University of Chinese Academy of Sciences Beijing 100049China Institute of Human Genetics(IGH) CNRSUniversity of Montpellier34396 MontpellierFrance Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Chinese Academy of SciencesWuhanHubei 430072China Key Laboratory of Lake and Watershed Science for Water Security Chinese Academy of SciencesNanjingJiangsu 210008China

Meiotic recombination is essential for sexual reproduction and its regulation has been extensively studied in many ***,genome-wide recombination landscape has not been reported in ciliates and it remains unknown how it is affected by the unique features of ciliates:the synaptonemal complex(SC)-independent meiosis and the nuclear ***,we show the recombination landscape in the model ciliate Tetrahymena thermophila by analyzing single-nucleotide polymorphism datasets from 38 hybrid *** detect 1021 crossover(CO)events(35.8 per meiosis),corresponding to an overall CO rate of 9.9 cM/***,gene conversion by non-crossover is rare(1.03 per meiosis)and not biased towards G or C *** with the reported roles of SC in CO interference,we find no obvious sign of CO *** tends to occur within germ-soma common genomic regions and many of the 44 identified CO hotspots localize at the centromeric or subtelomeric *** ontology analyses show that CO hotspots are strongly associated with genes responding to environmental *** discuss these results with respect to how nuclear dimorphism has potentially driven the formation of the observed recombination landscape to facilitate environmental adaptation and the sharing of machinery among meiotic and somatic recombination.

关键词： Meiotic recombination Hotspot Crossover interference Adaptive evolution

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第4期44卷 726-734页

作者： Liang wang Ping wang Bing LIU Hui ZHANG Cheng-cheng wei Ming XIONG Gang LUO miao wang Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014.China

Objective This study aimed to investigate the role of the long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)in the epithelial-mesenchymal transition(EMT)of bladder cancer cells and the potential *** Cell invasion,migration,and wound healing assays were conducted to assess the effects of MEG3 on the invasive and migratory capabilities of bladder cancer *** expression levels of E-cadherin were measured using Western blotting,RT-qPCR,and dual luciferase reporter *** immunoprecipitation and pull-down assays were performed to investigate the interactions between MEG3 and its downstream *** MEG3 suppressed the invasion and migration of bladder cancer cells and modulated the transcription of *** binding of MEG3 to the zinc finger region of the transcription factor Snail prevented its ability to transcriptionally repress ***,MEG3 suppressed the phosphorylation of extracellular regulated protein kinase(ERK),c-Jun N-terminal kinase(JNK),and P38,thereby decreasing the expression of Snail and stimulating the expression of *** MEG3 plays a vital role in suppressing the EMT in bladder cancer cells,indicating its potential as a promising therapeutic target for the treatment of bladder cancer.

关键词： long noncoding RNA bladder cancer maternally expressed gene 3 epithelial-mesenchymal transition Snail

Pig pangenome graph reveals functional features of non‑reference sequences

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第3期15卷 956-970页

作者： Jian miao Xingyu wei Caiyun Cao Jiabao Sun Yuejin Xu Zhe Zhang Qishan wang Yuchun Pan Zhen wang College of Animal Sciences Zhejiang UniversityHangzhou 310058ZhejiangChina Yazhou Bay Science and Technology City Hainan Institute of Zhejiang UniversityYazhou DistrictBuilding 11Yongyou Industrial ParkSanya 572025HainanChina

Background The reliance on a solitary linear reference genome has imposed a significant constraint on our compre-hensive understanding of genetic variation in *** constraint is particularly pronounced for non-reference sequences(NRSs),which have not been extensively *** In this study,we constructed a pig pangenome graph using 21 pig assemblies and identified 23,831 NRSs with a total length of 105 *** findings revealed that NRSs were more prevalent in breeds exhibiting greater genetic divergence from the reference ***,we observed that NRSs were rarely found within coding sequences,while NRS insertions were enriched in immune-related Gene Ontology ***,our investigation also unveiled a close association between novel genes and the immune capacity of *** observed substantial differences in terms of frequencies of NRSs between Eastern and Western pigs,and the heat-resistant pigs exhibited a substantial number of NRS insertions in an 11.6 Mb interval on chromosome ***,we discovered a 665 bp insertion in the fourth intron of the TNFRSF19 gene that may be associated with the ability of heat tolerance in South-ern Chinese *** Our findings demonstrate the potential of a graph genome approach to reveal important functional features of NRSs in pig populations.

关键词： Heat tolerance Immune ability Non-reference sequences Pig pangenome

Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第1期44卷 212-219页

作者： REN Ping wang Quanwu BAI wei SUN miao LIU Zheling GAO Ming wang Liang PENG Bo XU Liguang Department of Health Management the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchun 130117China Department of Dirty Tuina the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Acupuncture the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Rehabilitation Medicine the 924th Hospital of the PLA Joint Logistic Support ForceFoshan 528226China Department of College of Acupuncture and Massage Changchun University of Chinese MedicineChangchun 130117China

Worldwide,as the population age,osteoporosis is becoming increasingly common,and osteoporotic fractures have a significant economic *** women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal *** this regard,we hypothesize rational combination of acupuncture and Traditional Chinese Medicine(TCM)in the form of herbal extract could prevent osteoporosis in *** deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts,the boneresorbing cells,and simultaneously inhibits the viability and function of osteoblasts,the bone-forming *** most potent inflammatory cytokine in skeletal homeostasis is the receptor activator of nuclear factor kappa B ligand(RANKL)that stimulates osteoclast ***,the canonical Wnt pathway is essential for osteoblastogenesis and bone formation,and estrogen deficiency leads to diminished functioning of this *** and acupuncture could target the RANKL and the Wnt pathway in favorable ways to prevent the accelerated bone loss experienced during the early menopausal stage and promote the gain in bone mass in postmenopausal *** this review,we propose a rational combination of specific TCM and acupuncture targeting those signaling molecules/pathways by the drugs that are in clinical use for the treatment of postmenopausal *** rational approach revealed that Danshen(Radix Salviae Miltiorrhizae)could exert a synergistic effect with *** then propose a translational path for developing the putative combination in women with postmenopausal osteoporosis to curtail the risk of osteoporotic fractures.

关键词： medicine traditional osteogenic anti-resorptive review

Dual modification of LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2) cathode materials by K^(+) doping and Li_(3)PO_(4) coating for lithium ions batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3007-3018页

作者： wei Xiao Jia-Le wang Zhi-Cheng Yi Cheng-Jin Liu Chang miao Yu Xin Shu-Qing Nie College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China

Li_(3)PO_(4)@Li_(0.99)K_(0.01)Ni_(0.83)Co_(0.11)Mn_(O.06)O_(2)(NCM-KP) cathode powders are synthesized via K^(+)doping in calcination processes and H_3PO_4 coating in sol-gel processes.K^(+) precisely enters into the lattice to widen the(003) plane to 0.4746 nm with a lower cationic disordered degree of 1.87%.Moreover,the surface residual lithium salts are treated by H_3PO_4 to generate a uniform Li_(3)PO_(4) coating layer of approximately 11.41 nm,which completely covers on the surface of secondary spherical particles to improve the interfacial *** 25℃,the NCM-KP electrode delivers a discharge specific capacity of 148.9 mAh·g^(-1) with a remarkable capacity retention ratio of 84.1% after 200 cycles at 1.0C and retains a high reversible specific capacity of 154.4 mAh·g^(-1) at *** at 1.0C and 60℃,it can maintain a reversible discharge specific capacity of 114.6 mAh·g^(-1) with 0.21% of capacity decay per cycle after 200 cycles,which is significantly lower than 0.40% for the pristine NCM ***,the charge transfer resistance of 238.89 Ω for the NCM-KP electrode is significantly lower than 947.41 Ω for the pristine NCM one by restricting the interfacial side ***,combining K+doping and Li_(3)PO_(4) coating is an effective strategy to enable the significant improvement of the electrochemical property of high-nickel cathode materials,which may be mainly attributed to the widened diffusion pathway and the formed Li_(3)PO_(4) protective layer,thus promoting Li~+diffusion rate and preventing the erosion of HF.

关键词： High-nickel cathode material Residual lithium K^(+)doping Li_(3)PO_(4)coating Lithium ions battery