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Chinese Journal of Polymer Science 2021年第8期39卷 1059-1068,I0008页

作者： Si-Ying Xiang Ying-Chun Yao miao-miao lu Ya-Jiang Huang Mi-Qiu Kong Guang-Xian Li College of polymer science and engineering State key laboratory of polymer materials engineering of ChinaSichuan UniversityChengdu 670065China

The influence of polystyrene particles with different nanoscale roughnesses on the morphology of polyisobutylene/poly-dimethylsiloxane blends was studied under shear flow by using confocal laser scanning *** was found that the surface roughness of particles strongly affected their diffusion and distribution behaviors,thereby determining the size and spatial arrangement of droplets in the *** roughness effect of particles was found to possess a strong dependence on both the blend ratio and the shear *** result suggested that the particle roughness can serve as a new parameter to control the structure-property correlation in particle-filled polymer blends,especially under slow flow.

关键词： Rough particles Immiscible polymer blends Shear flow

Antagonizing adipose tissue-derived exosome miR-103-hepatocyte phosphatase and tensin homolog pathway alleviates autophagy in non-alcoholic steatohepatitis:A trans-cellular crosstalk

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World Journal of Gastroenterology 2023年第29期29卷 4528-4541页

作者： miao-miao lu Yue Ren Yu-Wei Zhou Ling-Ling Xu Meng-Meng Zhang Lin-Ping Ding Wei-Xin Cheng Xi Jin Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Medicine Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Obesity plays a vital role in the occurrence and development of non-alcoholic steatohepatitis(NASH).However,the underlining mechanism is still unclear,where adipose tissue(AT)derived exosomes may actively ***(miRNAs)are commonly secreted from exosomes for cell *** the regulation of miR-103 on insulin sensitivity has been reported,the specific role of AT-derived exosomes miR-103 in NASH is still vague and further investigation may provide novel therapeutic *** To determine the specific role of AT-derived exosomes miR-103 in developing NASH through various *** The expression levels of miR-103 in the AT-derived exosomes and livers were detected and compared between NASH mice and *** effect of miR-103 on NASH progression was also explored by antagonizing miR-103,including steatosis and inflammation degree *** interaction between miR-103 and the autophagy-related gene phosphatase and tensin homolog(PTEN)was confirmed by dual-luciferase reporter *** role of the interaction between miR-103 and PTEN on autophagy was verified in NASH-like ***,the effects of miR-103 from adipose-derived exosomes on NASH and autophagy were analyzed through animal *** The expression of miR-103 was increased in NASH mice,compared to the control,and inhibition of miR-103 could alleviate *** results of the dual-luciferase reporter assay showed miR-103 could interact with ***-103-anta decreased p-AMPKa,p-mammalian target of rapamycin(mTOR),and p62 but increased the protein levels of PTEN and LC3-II/I and the number of autophagosomes in NASH *** results were also observed in NASH-like cells,and further experiments showed PTEN silencing inhibited the effect of *** derivedexosome miR-103 aggravated NASH and increased the expressions of p-AMPKa,p-mTOR,and p62 but decreased the protein levels of PTEN and LC3-II/I and the number of autophagosomes in ***

关键词： Non-alcoholic steatohepatitis Nonalcoholic fatty liver disease Exosomes Phosphatase and tensin homolog

High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1

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World Journal of Gastroenterology 2022年第29期28卷 3838-3853页

作者： Dong Chen miao-miao lu Jin-Hai Wang Yue Ren Ling-Ling Xu Wei-Xin Cheng Sai-Sai Wang Xiao-Lin Li Xiao-Fei Cheng Jian-Guo Gao Farhin Shaheed Kalyani Xi Jin Department of Colorectal Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Medicine Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Emergency The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Obesity is associated with an increased risk of developing Crohn’s disease(CD),higher disease activity,and comparatively worse clinical *** To investigate the role of mesenteric adipose tissue-derived exosomes in the pathogenesis of CD aggravation in obese *** First,we induced colitis in mice initiated on high-fat and normal diets and compared the severity of *** then extracted and identified exosomes from mesenteric adipose tissue and determined the levels of metastasis-associated lung adenocarcinoma transcript 1(MALAT1)in mesenteric adipose tissue-derived exosomes and the ***,we demonstrated an interaction between MALAT1 and the miR-15a-5p/activating transcription factor 6(ATF6)***,we explored the effects of mesenteric adipose tissue-derived exosomes extracted from mice fed a high-fat or normal diet on the severity of 2,4,6-trinitrobe-nzenesulfonic acid(TNBS)-induced colitis and ATF6-related endoplasmic reticulum stress *** High-fat diet was found to aggravate TNBS-induced colitis in *** expression of MALAT1 in mesenteric adipose tissue-derived exosomes of high-fat diet-fed mice *** increased expression of MALAT1 in colon tissue exacerbated TNBS-induced colitis and activated the ATF6 endoplasmic reticulum stress *** effect was partially reversed by the reduced expression of MALAT1 and overexpression of *** Mesenteric adipose tissue-derived exosome-encapsulated long noncoding RNAs MALAT1 targets the colon and aggravates TNBS-induced colitis in obese mice,which may potentially act on the miR-15a-5p/ATF6 axis and activate endoplasmic reticulum stress.

关键词： Metastasis-associated lung adenocarcinoma transcript Crohn’s disease miR-15a-5p Mesenteric adipose tissue Obesity Colitis Inflammatory bowel disease

Palmitoylation in Crohn’s disease:Current status and future directions

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World Journal of Gastroenterology 2021年第48期27卷 8201-8215页

作者： Wei-Xin Cheng Yue Ren miao-miao lu Ling-Ling Xu Jian-Guo Gao Dong Chen Farhin Shaheed Kalyani Zi-Yan Lv Chun-Xiao Chen Feng Ji He-Ning Lin Xi Jin Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Wenzhou Medical University Renji College Wenzhou 325035Zhejiang ProvinceChina Department of Chemistry and Chemical Biology Howard Hughes Medical InstituteCornell UniversityIthacaNY 14853United States

S-palmitoylation is one of the most common post-translational modifications in nature;however,its importance has been overlooked for ***’s disease(CD),a subtype of inflammatory bowel disease(IBD),is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal *** damage and subsequent disabilities caused by CD are a growing global health ***-acknowledged risk factors for CD include genetic susceptibility,environmental factors,such as a westernized lifestyle,and altered gut ***,the pathophysiological mechanisms of this disorder are not yet comprehensively *** the rapidly increasing global prevalence of CD and the evident role of S-palmitoylation in CD,as recently reported,there is a need to investigate the relationship between CD and *** this review,we summarize the concept,detection,and function of S-palmitoylation as well as its potential effects on CD,and provide novel insights into the pathogenesis and treatment of CD.

关键词： S-palmitoylation Crohn’s disease STING Pathogenesis Signaling pathway Drug therapy

Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data

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World Journal of Gastroenterology 2024年第1期30卷 34-49页

作者： Yu-Wei Zhou Yue Ren miao-miao lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng Peng-Lei Jiang Yi-Da Yang Peng-Xu Qian Peng-Fei Xu Xi Jin Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Women’s Hospital and Institute of Genetics Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation CenterThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Crohn’s disease(CD)is caused by immune,environmental,and genetic *** can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains *** biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known *** achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost *** this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary *** supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid *** benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic *** importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.

关键词： Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish

基于多源遥感影像的道路交通对建设用地空间格局的影响分析——以从化中心城区规划区为例

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中国土地科学 2016年第11期30卷 86-94页

作者：王红梅郑标卢阳禄胡月明王淼淼易璐华南农业大学公共管理学院广东广州510642 国土资源部建设用地再开发重点实验室广东广州510640 广东省土地利用与整治重点实验室广东广州510640 华南农业大学资源环境学院广东广州510642

研究目的:以"高分一号"遥感影像为主要数据源,探讨规划区内道路交通对建设用地空间格局的影响特征。研究方法:以从化中心城区规划区道路为例,运用道路密度指数、长度—半径分维、景观破碎度、威弗指数等模型,结合GIS空间分析方法。研究... 详细信息

研究目的:以"高分一号"遥感影像为主要数据源,探讨规划区内道路交通对建设用地空间格局的影响特征。研究方法:以从化中心城区规划区道路为例,运用道路密度指数、长度—半径分维、景观破碎度、威弗指数等模型,结合GIS空间分析方法。研究结果:从化中心城区规划区,(1)道路网络分形特征较明显但道路完善度较低,建设用地用途宏观布局呈圈层分布特征;(2)综合道路最大服务范围最大,一、二级道路影响范围次之,三、四级道路逐级缩小;(3)建设用地的主要用途类型数量与道路距离整体上成反比,综合道路周围以三种用途为主,一至四级道路两侧以不同的两种用途为主;(4)高分遥感影像利于乡道提取和建设用地用途判读。研究结论:道路交通对规划区内建设用地用途格局具有导向作用。

关键词：土地信息建设用地空间格局景观格局指数道路交通规划区

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang miao Bai Yuan Zhuang Shenghua lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

新型携载人胰岛素样生长因子-1纤维屏障膜的制备及其理化和生物性能

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合成化学 2017年第6期25卷 487-492,502页

作者：杨少华常语宸何苗苗孙睿吕晓琴余占海兰州大学口腔医学院甘肃兰州730000

通过同轴静电纺丝技术制备携载人胰岛素样生长因子-1(IGF-1)的纤维屏障膜(IGF-1/SF/PLLACL),其结构和性能经SEM,TEM和XRD表征。与非载药同轴静电纺丝纤维膜在表观形貌、理化性能、生物学性能和膜屏障功能等方面进行对比,研究了其在引导... 详细信息

通过同轴静电纺丝技术制备携载人胰岛素样生长因子-1(IGF-1)的纤维屏障膜(IGF-1/SF/PLLACL),其结构和性能经SEM,TEM和XRD表征。与非载药同轴静电纺丝纤维膜在表观形貌、理化性能、生物学性能和膜屏障功能等方面进行对比,研究了其在引导性骨组织再生中的可应用性。结果显示:纤维膜呈网状结构,IGF-1/SF/PLLACL形成芯壳双层结构;非载药纤维膜的接触角和机械强度均略高于载药组纤维,差异具有统计学意义(P<0.05);载药组与非载药组纤维膜的衍射趋势与聚左旋乳酸聚己内酯晶体相似,丝素蛋白和胰岛素样生长因子-1的加入并未改变其相组成。3 d内IGF-1突释现象严重,之后曲线逐渐平缓,呈缓释状态;载药组细胞活性和碱性磷酸酶活性较非载药组高,略低于IGF-1对照组,差异有统计学意义(P<0.05),而且两组纤维膜均具有阻挡成纤维细胞长入的屏障功能。

关键词：人胰岛素样生长因子同轴静电纺丝屏障膜引导性骨组织再生制备性能

Farmer Income Differential in Regions

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Chinese Geographical Science 2006年第3期16卷 199-202页

作者： lu Qian miao Shanshan College of Economics and Management Northwest A ＆ F University Yangling 712100 China

China＇s success in reform and opening up policy for twenty years is regarded as China＇s miracles in the world, whereas the income differential widening phenomenon has been the focus of the policymakers and researchers. This article researches 1994-2003 China＇s rural regions income differential and its decomposition. The method this paper used to measure the disparity is Gini Index. There are many ways to compute it, so the easiest way to decompose Gini Index-Matrix method is adopted. And based on it, farmer＇s income could be divided into wage income, fanning income, transfer income and property income according to its composition. The conclusion is that all of the indexes are between 0.2 and 0.3, at the comparatively average level. From the fluctuation trend, it increased from 1994 to 1995, while reduced from 1995 to 1996, fluctuated in 1997, and then diminished again. In general, farmer＇s regions income differential stays at comparatively average level, but it has the widening trend with time. Through decomposing Gini Index, wage income is the most important increasing factor, while fanning income is the reducing factor.

关键词： income differential Concentration Index structure effect farmer Gini Index