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Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

World Journal of Gastroenterology 2024年第24期30卷 3086-3105页

作者： miao-miao lin Shan-Shan Yang Qiu-Yue Huang Guang-Hui Cui Xiao-Fen Jia Yao Yang Zong-Ming Shi Hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100034China

BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric *** infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to *** has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in *** In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected *** vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,*** most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm *** assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm *** violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP *** effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain ***-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD *** HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the *** had str

关键词： Qingre Huashi decoction Helicobacter pylori Drug resistance Biofilm Metabolomics

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Real-time Fluorescence PCR Method for Detection of Burkholderia glumae from Rice

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Rice science 2009年第2期16卷 157-160页

作者： FANG Yuan XU Li-hui TIAN Wen-xiao HUAI Yan YU Shan-hong LOU miao-miao XIE Guan-lin State Key Laboratory of Rice Biology/Institute of Biotechnology Zhejiang University Hangzhou 310029 China

Burkholderia glumae causing seedling rot and grain rot of rice was listed as a plant quarantine disease of China in 2007. It＇s quite necessary to set up effective detection methods for the pathogen to manage further dispersal of this disease. The present study combined the real-time PCR method with classical PCR to increase the detecting efficiency, and to develop an accurate, rapid and sensitive method to detect the pathogen in the seed quarantine for effective management of the disease. The results showed that all the tested strains of B. glumae produced about 139 bp specific fragments by the real-time PCR and the general PCR methods, while others showed negative PCR result. The bacteria could be detected at the concentrations of 1×10^4 CFU/mL by general PCR method and at the concentrations below 100 CFU/mL by real-time fluorescence PCR method. B. glumae could be detected when the inoculated and healthy seeds were mixed with a proportion of 1：100.

关键词： Burkholderia glumae bacterial grain rot detection real-time fluorescence polymerase chain reaction dce

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Analysis of herbs use law and mechanism of traditional Chinese medicine in preventing and treating postoperative complications of breast cancer

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Drug Combination Therapy 2019年第2期1卷 40-55页

作者： Yao Yang Li-Hui Zhang Mei-Ting Liu miao-miao lin Guo-Wei Zhang College of Traditional Chinese Medicine Hebei UniversityBaodingHebei province071000China

Objective:Excavate the compatibility rules of traditional Chinese medicine for preventing and treating postoperative complications of breast cancer,study the potential mechanism of prevention and treatment with traditional Chinese ***:Collate and analyze the relevant prescriptions collected from CNKI and the core drug combination and the new formula are obtained by adopting the traditional Chinese medicine inheritance auxiliary system(TCMISSV2.5).Use BATMAN-TCM online analysis tool to analyze KEGG pathways of high frequency drugs and predict the potential signal ***:Data mining has selected 10 pairs of core herb combinations and 5 new recipes of 133 *** the network pharmacology analysis of bai zhu,huang qi,fu ling,the potential signaling pathways of its action are the neuroactive ligand-receptor interaction pathway and calcium signaling ***:Herbs for invigorating spleen and qi and herbs for nourishing blood and activating blood are commonly used to prevent and treat postoperative complications of breast *** herbs may play their role by interfering with the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.

关键词： Postoperative breast cancer Complications Data mining Path analysis Medication law Mechanism of action

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The inheritance path research of the processing of Chinese materia medica in Anguo herbs market

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TMR Theory and Hypothesis 2019年第1期2卷 128-134页

作者： Ying Chen Li-Na Zhang Yu-Hui Ma miao-miao lin Xing Zhang Yu Wang Guo-Wei Zhang College of Traditional Chinese Medicine Hebei UniversityBaodingChina

Anguo,known as Qizhou in ancient time,its herbs industry began in Song Dynasty,boomed in Ming,and flourished in *** the development of Qizhou herbs industry,a number of special processing techniques of Chinese Materia Medicine were produced."Qizhou's Four Uniqueness",of which,the most representative medicine includes"Hundred pieces areca","Cicada feather of Qingxia","Yunpian deer antler"and"Pound Rhinoceros unicornis L".To investigate the present inheritance situation of the traditional processing technology of Chinese Materia Medicine in Anguo herbs market,we will consult literature including the ancient books and records,Anguo local chronicles and visit the inheritors of the traditional processing technology in Anguo,and research the processing technology historical *** study aims to create the Anguo herbs cultural card,and enrich the cultural heritage of Chinese medicine industry of Anguo country even Hebei province.

关键词： Qizhou's Four Uniqueness Processing of Chinese Materia Medicine Anguo Herbs Market Inheritance Path

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Analysis of pharmacological action and clinical application of DaXueTeng based on its anti-inflammatory action

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TMR Modern Herbal Medicine 2018年第4期1卷 233-240页

作者： Li-hui Zhang miao-miao lin Ying Chen Xue-song Wu Li-jing Cai Mei-shan Li Guo-wei Zhang College of Chinese Medicine Hebei University Baoding Hebei province China. Laiyuan hospital of Chinese Medicine Laiyuan Hebei province China.

As one of the representative drugs for clearing heat-toxicity, Chinese medicine DaXueTeng （Caulis Sargentodoxae） contains various chemical substances such as tannins, glycosides, cyclic polyphenols, triterpenoids, lignins, flavonoids, terpenoids and organic acids. It has a wide range of pharmacological effects. Meanwhile, it is valued by the doctor. Modern research suggests that DaXueTeng has antibacterial, antiviral, anti-inflammatory, anti-tumor, and immunosuppressive effects. It has been experimentally and clinically proven that the active constituents of DaXueTeng have a good therapeutic effect on inflammatory diseases. It is widely used in the treatment of pelvic inflammatory disease, annexitis, prostatitis, appendicitis, periappendiceal abscess, inflammatory intestinal obstruction, UC, endometriosis, inflammatory secondary infertility, gouty arthritis, pharyngitis, and stomatitis. Here we review the anti-inflammatory pharmacological effects and clinical applications of.

关键词： DaXueTeng Anti-inflammatory effect review

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Immunoregulation and anti-tumor effects of Polyporusus Bellatus： a review of recent research

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TMR Modern Herbal Medicine 2018年第3期1卷 181-188页

作者： miao-miao lin Mei-Yu Cui Hai-Yan Cao Xue-Song Wu Li-Jing Cai Li-Hui Zhang Guo-Wei Zhang College of Chinese Medicine Hebei University Baoding Hebei province China Laiyuan hospital of Chinese Medicine Laiyuan Hebei province China

Background： We summarized the Polyporusus Bellatus （PPS） efficacy of immunomodulation, liver protection and anti-tumor, then provide scientific basis for further research and clinical application. This dissertation first overview relevant literatures of PPS recent years and describe comprehensively the research progress of the immunoregulation, liver protection and anti-tumor effects and mechanism of PPS. The review shows that the PPS play anti-tumor effects through antioxidation, scavenging free radicals, inhibiting tumor cell proliferation, inducing apoptosis, affecting tumor gene expressions and enhancing immune functions. PPS can exert immunoregulatory, hepatoprotective and anti-tumor effects through multiple pathways and multiple targets, which provides a good application prospect in clinic.

关键词： Polyporusus Bellatus Immunoregulation Anti-tumor review

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Erahertz spectral analysis of Xiling Zhimu with different geological conditions and plant age

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TMR Modern Herbal Medicine 2019年第3期2卷 158-166页

作者： Li-Na Zhang Yu-Hui Ma Ze-Jia Zhang Kai-Xuan Hou miao-miao lin Guo-Wei Zhang Cun-Guang Lou College of Chinese Medicine Hebei UniversityBaodingHebeiChina School of Electronics and Information Engineering Hebei UniversityBaodingHebeiChina

Objective: In order to identify the quality of different geological conditions and plant ages of Xiling Zhimu. Methods: This article uses the terahertz spectroscopy to detect and analyze different geological conditions and ages of Zhimu (Anemarrhenae Rhizoma) from the same origin. Results: The terahertz time-domain spectroscopy of different geological conditions and ages has a decrease relative to the reference amplitude and has a delay. The refractive index has obvious differences, and the refractive index can be used as a way to identify the tablets. The absorption coefficients of different ages Zhimu samples has significant differences in the range of 1.0-2.0 THz. The absorption coefficients of different geological conditions Zhimu samples has significant differences in the range of 1.1-2.0 THz. Conclusions: The differences caused by different production methods should be considered in the identification of genuine regional drug. When the Zhimu is grown due to different geological conditions and plant ages, its efficacy will also change. we can detect this change by terahertz spectroscopy.

关键词： terahertz spectrum Xiling Zhimu index of refraction absorption coefficients

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柴油机选择性催化还原后处理系统建模

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船海工程 2009年第3期38卷 68-71页

作者：温苗苗吕林武汉理工大学能源与动力工程学院武汉430063

采用计算流体动力学(CFD)与化学反应动力学结合的方法,建立了柴油机尿素选择性催化还原排气后处理系统的三维数值模型,包括尿素水溶液蒸发及热解、催化还原化学反应等过程。在该模型基础上计算研究了1600r/min不同负荷(33%,49%,72%,100%... 详细信息

采用计算流体动力学(CFD)与化学反应动力学结合的方法,建立了柴油机尿素选择性催化还原排气后处理系统的三维数值模型,包括尿素水溶液蒸发及热解、催化还原化学反应等过程。在该模型基础上计算研究了1600r/min不同负荷(33%,49%,72%,100%)条件下SCR后处理系统的特性。结果表明模拟与试验结果吻合较好。通过不同结构形式的对比计算,提出了该系统的改进方案。

关键词：选择性催化还原氮氧化物计算流体动力学模拟尿素水溶液

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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Estimating the Baseline Error of Wide-Swath Altimeters Using Nadir Altimeters via Numerical Simulation

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Journal of Ocean University of China 2022年第3期21卷 681-693页

作者： miao Xiangying JIA Yongjun lin Mingsen miao Hongli College of Information Science and Engineering Ocean University of ChinaQingdao266100China National Satellite Ocean Application Service(NSOAS) Beijing100081China

The baseline roll and length errors for wide-swath altimeters are major error sources in sea surface measurements that exhibit strong spatial characteristics in the cross-track *** errors can be identified and estimated in accordance with height differences at crossover points generated with nadir altimeters after excluding the interference from other error *** of the wide-swath altimeter baseline estimation methods considered only the roll error in previous studies.A numerical simulation was conducted in this study using nadir altimeters to estimate the roll and length errors simultaneously to provide a selectable scheme for baseline error estimation and correction for future wide-swath *** based on the parameters of the surface water and ocean topography mission and Sentinel-3A show that the correlation coefficient of the roll error between the estimated and simulated values is 0.89,while the correlation coefficient of the length error is *** sea surface height root mean square error(RMSE)can be reduced from 12.18 cm to 6.45 cm based on the two estimated *** estimation effect can be increased by using multiple nadir altimeters to form an observation *** numerical simulation of the five nadir altimeter constellation shows that the correlation coefficients of the roll and length errors would increase to 0.97,which reduces the sea surface height RMSE to 2.88 *** addition,the stability of this method is indicated in simulation experiments,which introduce different degrees of sea state errors.

关键词： baseline error wide-swath altimeter roll angle baseline length nadir altimeter crossover point height difference

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