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Circulating metabolites difference in type 2 diabetes patients from regions:a cross-sectional study

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Medical Data Mining 2024年第4期7卷 1-9页

作者： Jiang-Lan Long Zeng-Hui miao Ling-Wei Kong Hui-Jing cui Na-Na Zhang Dan Yan Beijing Institute of Clinical Pharmacy Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Clinical laboratory Beijing Jiaotong University Community Health CenterBeijing 100044China Department of Pharmacy Kaifeng Hospital of Traditional Chinese MedicineKaifeng 475000China

Background:Type 2 diabetes(T2D)has already become a global *** its simple,rapid,economical,and relatively non-invasive,metabolic markers have become a method for T2D ***,region,race,and diet all affect the metabolism of the *** purpose of current study is to explore the differences of metabolites in T2D patients from ***:We recruited 103 T2D patients in two clinical centers,including 52 T2D patients from Beijing(T2D_(B))and 51 T2D patients from Kaifeng(T2D_(K)).The serum samples from T2D patients were analyzed using high-resolution mass *** screened using univariate and multivariate analysis,the differential metabolites were ***,to reveal biological information,we performed pathway analysis with the differential ***:Thirty-six differential metabolites were identified,including 16 metabolites were higher concentrations while 20 metabolites were lower concentrations in the serum of T2D_(B) patients than T2D_(K) *** were higher serum concentrations of L-phenylalanine,4-methyl-2-oxovaleric acid,L-carnitine,decanoylcarnitine,9-decenoylcarnitine and sphinganine in T2D_(B) patients,in which decanoylcarnitine in T2D_(B) patients was up to 35-fold higher than T2D_(K) *** there were lower concentrations of L-valine,L-isoleucine,arachidonic acid,oleic acid,16-hydroxyhexadecanoic acid,lysophosphatidylcholine(18:0)and 1-Phenylethylamine in T2D_(B) patients,in which 1-phenylethylamine in T2D_(B) patients was decreased to 0.45-fold lower than T2D_(K) *** reason for the differences might be that phosphatidylethanolamine biosynthesis,phosphatidylcholine biosynthesis,valine,leucine and isoleucine degradation,and beta-oxidation of very long chain fatty acids were different in T2D_(B) patients and in T2D_(K) ***:Metabolites from different pathways are independently related to regions,providing valuable insight and potential for the diagnosis and treatment

关键词： type 2 diabetes metabolomics region high-resolution mass spectrometer

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酚醛树脂气凝胶复合材料热物性参数预测方法

航空学报 2024年第6期45卷 338-348页

作者：张春云陈雄斌刘健崔苗大连理工大学工业装备结构分析优化与CAE软件全国重点实验室大连116024 大连理工大学辽宁省空天飞行器前沿技术重点实验室大连116024 北京空天技术研究所北京100074

针对酚醛树脂气凝胶复合材料(IPC)碳化过程热物性参数动态变化和难以准确测量的问题,基于试验测量信息,通过求解瞬态非线性热传导反问题,提出了一种预测IPC碳化过程热物性参数的新方法。采用改进的梯度算法对瞬态非线性热传导反问题进... 详细信息

针对酚醛树脂气凝胶复合材料(IPC)碳化过程热物性参数动态变化和难以准确测量的问题,基于试验测量信息,通过求解瞬态非线性热传导反问题,提出了一种预测IPC碳化过程热物性参数的新方法。采用改进的梯度算法对瞬态非线性热传导反问题进行求解,预测随温度变化的热物性参数。引入复变量求导法准确计算灵敏度矩阵,提高预测精度。结果表明,与传统的梯度算法相比,该算法在求解瞬态非线性热传导反问题时具有很好的稳定性、精度和效率,计算时间由75 s降至35 s。测点温度计算值和试验测量值的平均相对误差为3.279%,采用该算法预测IPC碳化过程等效导热系数精度高。该工作为获取热防护材料的高温热物性参数提供了一种有效方法,为碳化型热防护材料的工程设计提供了关键参数。

关键词：热防护酚醛树脂气凝胶复合材料等效导热系数参数预测梯度算法

A review on numerical studies of airflow dynamics and particle deposition in human respiratory system Author links open overlay panel

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Particuology 2024年第8期91卷 351-377页

作者： Hao Jing Xinguang cui School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan430074China

Accurate assessment and prediction of airflow dynamics and particle deposition in the human respiratory tract are essential for human health,involving inhaled drugs for treating various diseases and toxic particles that can cause *** intricate process involves complex multiphase flow with distinct respiratory *** fluid dynamics(CFD)acts as a bridge,overcoming the limitations of in vivo and in vitro experiments and providing a means to fully comprehend and reveal the fundamental mechanisms of respiratory flow and particle behavior on a microscopic *** paper provides a comprehensive overview and concise summary of recent advancements in the numerical simulation of airflow and particle deposition in the human respiratory ***,it summarizes the transition of respiratory tract models from segmented models to emerging physiological characteristic models and whole-lung airway models,and the latest developments on the effects of key factors such as geometric variations,respiratory patterns,and particle physical/chemical properties on respiratory flow and particle deposition.A notable focus of this review is on emerging physiological characteristics models and their associated complex airflow and particle dynamics inside *** paper concludes with recommendations for future research to further advance the development of this field.

关键词： Airflow dynamics Particle deposition Human respiratory system Numerical modeling

Multi-Sensor Fusion Adaptive Estimation for Nonlinear Under-observed System with Multiplicative Noise

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Chinese Journal of Electronics 2024年第1期33卷 282-292页

作者： Yongpeng cui Xiaojun SUN School of Electronic Engineering Heilongjiang University Key Laboratory of Information Fusion Estimation and Detection

The adaptive fusion estimation problem was studied for the multi-sensor nonlinear under-observed systems with multiplicative noise. A one-step predictor with state update equations was designed for the virtual state with virtual noise first of all. An extended incremental Kalman filter(EIKF) was then proposed for the nonlinear under-observed systems. Furthermore, an adaptive filtering method was given for optimization. The fusion adaptive incremental Kalman filter weighted by scalar was finally proposed. The comparison analysis was made to verify the optimization of the state estimation using adaptive filtering method in the filtering process.

关键词： Adaptive systems Information filters Matrices Adaptive estimation Kalman filters State estimation Nonlinear systems

Number of Solitons Emerged in the Initial Profile of Shallow Water Using Convolutional Neural Networks

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Journal of Systems Science & Complexity 2024年第2期37卷 463-479页

作者： WANG Zhen cui Shikun School of Mathematical Sciences Dalian University of TechnologyDalian 116024China School of Mathematical Sciences Beihang UniversityBeijing 100191China

The soliton resolution conjecture proposes that the initial value problem can evolve into a dispersion part and a soliton ***,the problem of determining the number of solitons that form in a given initial profile remains unsolved,except for a few specific *** this paper,the authors use the deep learning method to predict the number of solitons in a given initial value of the Korteweg-de Vries(KdV)*** leveraging the analytical relationship between Asech^(2)(x)initial values and the number of solitons,the authors train a Convolutional Neural Network(CNN)that can accurately identify the soliton count from spatio-temporal *** trained neural network is capable of predicting the number of solitons with other given initial values without any additional *** extensive calculations,the authors demonstrate the effectiveness and high performance of the proposed method.

关键词： Convolutional neural network deep learning method KdV equation soliton

菠菜中毒死蜱能力验证样品的制备及实验室检测能力评价

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质量安全与检验检测 2024年第4期34卷 30-35页

作者：崔淼山西省检验检测中心(山西省标准计量技术研究院) 山西太原030012

能力验证的目的在于对参加实验室的检测能力进行评价。本次能力验证样品制备采用单一水平,并通过实施能力验证计划完成对样品的考核。采用稳健法对山西省10个地区的56家和省外1家共57家实验室的检测结果进行统计,验证结果数据符合正态分... 详细信息

能力验证的目的在于对参加实验室的检测能力进行评价。本次能力验证样品制备采用单一水平,并通过实施能力验证计划完成对样品的考核。采用稳健法对山西省10个地区的56家和省外1家共57家实验室的检测结果进行统计,验证结果数据符合正态分布,利用稳健Z比分数对实验室检测能力进行评价。结果显示,满意结果数为54家,满意率94.7%;有问题结果数为2家,有问题率3.5%;不满意结果数为1家,不满意率为1.8%。结果表明,各实验室检测菠菜中毒死蜱的技术水平总体良好。通过对离群结果的原因进行技术分析,可以帮助实验室查找并纠正问题,以提高检测能力。

关键词：毒死蜱能力验证稳健统计

持续用户生成内容的实现机制:可供性—实现视角下Bilibili案例研究

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南开管理评论 2024年第1期27卷 40-50,I0007,I0008页

作者：崔淼钱金芳王之澜大连理工大学经济管理学院

持续的用户生成内容是平台获取竞争优势和实现长期发展的基础。现有文献多采用因素视角探究用户生成内容的影响因素“是什么”,而对多重因素“如何”系统地发挥作用、实现持续用户生成内容这一过程性问题尚不清晰。本文基于可供性—实... 详细信息

持续的用户生成内容是平台获取竞争优势和实现长期发展的基础。现有文献多采用因素视角探究用户生成内容的影响因素“是什么”,而对多重因素“如何”系统地发挥作用、实现持续用户生成内容这一过程性问题尚不清晰。本文基于可供性—实现理论视角,通过对Bilibili的探索性案例研究,构建内容平台实现持续用户生成内容的AIGA模型,揭示了内容平台实现持续用户生成内容的过程。研究发现:内容平台为内容生成提供信息可供性和社交可供性(A),内容生产者和消费者分别在两种可供性的基础上进行人机互动与人际互动(I),平台企业设计包括用户筛选、内容生产者激励、内容生产者教育、内容消费者自监管及活动组织等治理机制(G),它们被用来促进互动过程,最终内容生产者获取经济资源、机会资源、社会声誉、情感依恋,两类可供性实现结果协同作用,共同促进内容平台实现持续用户生成内容(A)。这一研究有助于完善用户生成内容理论体系,并推动持续用户生成内容理论研究从因素观向过程观发展,对内容平台打造核心竞争优势、实现持续用户生成内容具有重要的理论参考价值;同时,本文将可供性实现过程研究从单一的技术使用者视角,拓展至技术使用者和技术提供者双重视角,对可供性实现理论形成有益补充。

关键词：内容平台持续用户生成内容可供性实现案例研究

基于经验模态分解的船舶辐射噪声特征提取研究

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舰船科学技术 2024年第18期46卷 150-153页

作者：崔建忠姜淼青岛大学计算机科学技术学院山东青岛266071

船舶辐射噪声中的线谱分量具有较高的强度和稳定度,通过测定并跟踪线谱,可以精确地估计目标的运动参数。为此,研究基于经验模态分解的船舶辐射噪声特征提取方法。首先,构建船舶辐射噪声数学模型,用于获取船舶辐射噪声信号;然后,运用经... 详细信息

船舶辐射噪声中的线谱分量具有较高的强度和稳定度,通过测定并跟踪线谱,可以精确地估计目标的运动参数。为此,研究基于经验模态分解的船舶辐射噪声特征提取方法。首先,构建船舶辐射噪声数学模型,用于获取船舶辐射噪声信号;然后,运用经验模态分解方法提取船舶辐射噪声的7个经验模态分量和1个余项,并计算船舶辐射噪声经验模态分量的样本熵;最后,选择样本熵最大的船舶辐射噪声检验模态分量作为船舶辐射噪声的特征。实验结果表明,该方法可以准确获得船舶运行设备的辐射噪声,且具备较强的舰船辐射噪声分帧能力。该方法还可以有效地将舰船辐射噪声分解成不同经验模态分量,大大降低了船舶辐射噪声余项接近零。

关键词：经验模态分解船舶辐射噪声特征提取样本熵

基于L型铁钴的三维力触觉传感器设计及输出特性

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电工技术学报 2024年第16期39卷 4944-4954页

作者：崔淼李明明黄文美翁玲河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300130 河北工业大学河北省电磁场与电器可靠性重点实验室天津300130

该文提出了一种基于L型铁钴丝的三维力触觉传感器,利用磁致伸缩材料铁钴合金设计制作了三维力触觉传感单元,并测试了该结构的输出特性。基于电磁原理、逆磁致伸缩效应和欧拉伯努利动力学原理,推导了输出电压方程。搭建触觉传感单元实验... 详细信息

该文提出了一种基于L型铁钴丝的三维力触觉传感器,利用磁致伸缩材料铁钴合金设计制作了三维力触觉传感单元,并测试了该结构的输出特性。基于电磁原理、逆磁致伸缩效应和欧拉伯努利动力学原理,推导了输出电压方程。搭建触觉传感单元实验平台,对传感器进行法向和切向标定,设计的传感器法向测力范围为0~13 N,切向测力范围为0~6 N,输出特性具有良好的线性关系。其中,0~8 N法向力范围内灵敏度约为23.997 mV/N,9~13 N法向力范围内灵敏度约为17.537 mV/N;0~4 N切向力范围内灵敏度约为11.599 mV/N,5~6 N切向力范围内灵敏度约为6.281mV/N。在4Hz频率、2N法向力条件下,该传感器动态响应的输出电压幅值变化范围为46.5~49.8mV,与静态力输出电压幅值的相对误差低于5%,响应时间和恢复时间分别为25 ms和29ms,表明该传感器具有良好的动态特性。分别采用广义逆矩阵和BP神经网络对传感器测得的三维力进行解耦,其中,BP神经网络解耦方法平均误差仅有2.90%,可有效提高测量精度。该传感器体积小、输出线性度好,可同时实现静态力和动态力的测量,在智能机器人等领域具有良好的应用前景。

关键词：逆磁致伸缩效应 BP神经网络 L型铁钴丝动态力测量静态力测量