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Altitude-dependent metabolite biomarkers reveal the mechanism of plateau pika adaptation to high altitudes

Integrative Zoology 2023年第6期18卷 1041-1055页

作者： Xi CHEN Zaiwei WANG Junhu su Huan LI Jinbo XIONG Keyi FU Zilong WANG Xuefeng YUAN Ziyue SHI Xiumei miao Mei YANG Yunfeng YANG Zunji SHI State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems Center for Grassland MicrobiomeCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouChina College of Grassland Science Key Laboratory of Grassland Ecosystem(Ministry of Education)Gansu Agricultural UniversityLanzhouChina School of Marine Sciences Ningbo UniversityNingboChina State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityChina

The harsh environment in the Tibetan plateau,the highest place in the world,poses thermoregulatory challenges and hypoxic stress to *** impacts of plateau environment on animal physiology and reproduction include external factors such as strong ultraviolet radiation and low temperature,and internal factors such as animal metabolites and gut ***,it remains unclear how plateau pika adapt to high altitudes through the combination of serum metabolites and gut *** this end,we captured 24 wild plateau pikas at the altitudes of 3400,3600,or 3800 m *** a Tibetan alpine *** the machine learning algorithms(random forest),we identified five biomarkers of serum metabolites indicative of the altitudes,that is,dihydrotestosterone,homo-l-arginine,alpha-ketoglutaric-acid,serotonin,and threonine,which were related to body weight,reproduction,and energy metabolism of *** metabolic biomarkers were positively correlated with Lachnospiraceae_Agathobacter,Ruminococcaceae,or Prevotellaceae_Prevotella,suggesting the close relationship between metabolites and gut *** identifying the metabolic biomarkers and gut microbiota analysis,we reveal the mechanisms of adaptation to high altitudes in plateau pika.

关键词： biomarkers gut microbiota machine learning metabolomics plateau pika

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Laparoscopic *** lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction:An exploratory,observational,prospective,IDEAL stage2b cohort study(CLASS-10 study)

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Chinese Journal of Cancer Research 2022年第4期34卷 406-414页

作者： Shuangxi Li Xiangji Ying Fei Shan Yongning Jia Zhemin Li Kan Xue Rulin miao Yinkui Wang Zhaode Bu Xiangqian su Ziyu Li Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open ***:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal *** and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall ***:The study will provide data for the guidance and development of surgical treatment strategies for *** registration number:The study has been registered in ***(***04443478).

关键词： Esophagogastric junction laparoscopy lymph node excision stomach neoplasms

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Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats

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Acta Pharmacologica Sinica 2004年第2期25卷 22-25页

作者： Ding-feng su2, Li-ping XU, Chao-yu miao, He-hui XIE, Fu-ming SHEN, Yuan-ying JIANG Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University Shanghai 200433 Chin

AIM: Computerized analysis of blood pressure in conscious freely moving rats is a sound technique for physiologi- cal and pharmacological studies. The present work, based on this technique, was designed to introduce two useful methods for the evaluation of antihypertensive drugs in conscious spontaneously hypertensive rat (SHR). They were the directly intragastric administration of drugs and modified probability sum test for evaluating the synergism of the combination of two drugs. METHODS AND REsuLTS: (1) Directly intragastric administration was used in conscious rats. A catheter was inserted into stomach immediately after arterial catheter insertion. Three days after operation, blood pressure was recorded and drug might be given intragastically via the gastric catheter. (2) Modi- fied probability sum test was used to evaluate the synergism of two drugs. The formula was: q=PA+B/(PA+PB?PA×PB). With this method, it was obtained: q=1.32 for the effects of the combination of atenolol and nitrendipine (20 mg/kg+10 mg/kg) on systolic blood pressure; q=1.41 for the effects of the combination of atenolol and amlodipine (10 mg/ kg+1 mg/kg) on systolic blood pressure. CONCLUSION: The two methods introduced by the present work will be important and useful for antihypertensive drug evaluation in conscious freely moving rats.

关键词： amlodipine atenolol blood pressure nifedipine nitrendipine spontaneously hypertensive rat

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试论广谱哲学的研究对象及其建构思想

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自然辩证法研究 2018年第9期34卷 118-121页

作者：苏淼华北水利水电大学马克思主义学院郑州450045

广谱哲学所提出的研究对象——哲学命题的普遍性与精确性的矛盾、哲学方法的非程序化与程序化的矛盾,在哲学史上具有独创性和全新性。为了解决这两对矛盾,广谱哲学提出了辩证结构主义的建构思想,正是贯彻这一思想,使广谱哲学成功地解决... 详细信息

广谱哲学所提出的研究对象——哲学命题的普遍性与精确性的矛盾、哲学方法的非程序化与程序化的矛盾,在哲学史上具有独创性和全新性。为了解决这两对矛盾,广谱哲学提出了辩证结构主义的建构思想,正是贯彻这一思想,使广谱哲学成功地解决了传统哲学及相关学科的诸多难题,取得了一批又一批崭新的成果。

关键词：广谱哲学研究对象建构思想

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哲学话语体系:从思辨哲学、实证哲学到广谱哲学

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自然辩证法研究 2019年第9期35卷 124-128页

作者：苏淼华北水利水电大学马克思主义学院

哲学话语体系是哲学思想和相应知识体系的表现形式。在哲学史上,思辨哲学和实证主义哲学是两种截然不同的、相反的哲学话语体系。广谱哲学在哲学思想、知识体系、表现形式等方面吸取和提升了思辨哲学与实证主义哲学的合理内核,同时抛弃... 详细信息

哲学话语体系是哲学思想和相应知识体系的表现形式。在哲学史上,思辨哲学和实证主义哲学是两种截然不同的、相反的哲学话语体系。广谱哲学在哲学思想、知识体系、表现形式等方面吸取和提升了思辨哲学与实证主义哲学的合理内核,同时抛弃或置换了它们错误的或不合理的成分,形成了有自己独立特色的话语体系。

关键词：哲学话语体系思辨哲学实证哲学广谱哲学

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关于老庄哲学若干观点的广谱分析

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自然辩证法研究 2020年第7期36卷 123-127页

作者：苏淼华北水利水电大学马克思主义学院郑州450045

道家哲学的代表人物是老子和庄子,他们的哲学观点在中国哲学史上有深远的影响。但老庄哲学除了达到了"形而上"的层次外,又有脱离现实、逃避现实、异想天开的成分。从广谱哲学的视角分析其合理内核与缺陷,对其合理内核给出其符合现代科... 详细信息

道家哲学的代表人物是老子和庄子,他们的哲学观点在中国哲学史上有深远的影响。但老庄哲学除了达到了"形而上"的层次外,又有脱离现实、逃避现实、异想天开的成分。从广谱哲学的视角分析其合理内核与缺陷,对其合理内核给出其符合现代科学的解释,对其缺陷指出其不足的根源,对于批判地继承和发展道家哲学具有重要的意义。

关键词：老庄哲学合理内核广谱分析

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Comorbid presentation of severe novel influenza A （H1N1） and Evans syndrome： a case report

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Chinese Medical Journal 2011年第11期124卷 1743-1746页

作者： CHEN Hui JIA Xin-lei GAO Heng-miao QIAN su-yun National Key Discipline of Pediatrics (Capital MedicalUniversity) Ministry of Education Emergency Center BeijingChildren's Hospital Beijing 100045 China

One 22-month-old boy who was admitted for a fever lasting 6 days as well as a cough and wheezing lasting 2 days was reported. He was diagnosed with influenza A （H1N1, severe type）, severe pneumonia, acute respiratory distress syndrome （ARDS）, Evans syndrome and multiple organ failure. This is the first case of novel influenza A （HIN1） and Evans syndrome. The pathogenesis is still unknown.

关键词： novel influenza A (H1N1) Evans syndrome acute respiratory distress syndrome

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Indoor Radon survey in 31 Provincial Capital Cities and Estimation of Lung Cancer Risk in Urban Areas of China

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Biomedical and Environmental Sciences 2024年第11期37卷 1294-1302页

作者： Xiaoxiang miao Yinping su Changsong Hou Yanchao Song Bowei Ding Hongxing Cui Yunyun Wu Quanfu sun Key Laboratory of Radiological Protection and Nuclear Emergency China CDCNational Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing 100088China

Objective We aimed to analyze the current indoor radon level and estimate the population risk of radon-induced lung cancer in urban areas of *** Using the passive monitoring method,a new survey on indoor radon concentrations was conducted in 2,875 dwellings across 31 provincial capital cities in Chinese mainland from 2018 to *** attributable risk of lung cancer induced by indoor radon exposure was estimated based on the risk assessment *** The arithmetic mean(AM)and geometric mean(GM)of indoor radon concentrations were 65 Bq/m^(3)and 55 Bq/m^(3),respectively,with 13.6%of measured dwellings exceeding 100 Bq/m^(3)and 0.6%exceeding 300 Bq/m^(3).The estimated number of lung cancer deaths induced by indoor radon exposure was 150,795,accounting for 20.30%(95%CI:20.21%-20.49%)of the lung cancer death *** This study provided the most recent data on national indoor radon levels in urban areas and the attributable risk of lung *** results served as an important foundation for further research on the disease burden of indoor radon exposure and radon mitigation efforts.

关键词： Indoor radon Urban Attributable risk Lung cancer

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Influence of polarization of laser beam on emission intensity of femtosecond laser-induced breakdown spectroscopy

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Chinese Physics B 2020年第6期29卷 314-320页

作者： Lan Yang miao Liu Yi-Tong Liu Qing-Xue Li su-Yu Li Yuan-Fei Jiang An-Min Chen Ming-Xing Jin Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China College of Physics Jilin UniversityChangchun 130012China

Laser-induced breakdown spectroscopy(LIBS)is an important technique which is widely used to analyze element *** order to improve the sensitivity of LIBS,much effort has been made to enhance the spectral intensity of LIBS by proposing a number of *** addition,we find that laser polarization has great influence on the emission intensity of femtosecond *** comparing the emission intensity of femtosecond LIBS in the circular polarization with that in the linear polarization,the spectral intensity in the case of circular polarization is stronger than that in the case of linear ***,this phenomenon is more obvious as laser energy *** polarization plays an important role in LIBS signal *** on the observation,the enhanced mechanism of the laser polarization for the spectral intensity is discussed in this paper,which will be helpful in spectral analysis and component analysis.

关键词： LIBS femtosecond laser laser polarization spectral enhancement

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一维钡铁氧体纳米线的制备及操控

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航空材料学报 2012年第2期32卷 87-92页

作者：苗璐黄英苏武西北工业大学理学院应用化学系西安710129

采用Sol-gel法,以自制的AAO模板制备了直径40～60nm,长度为150～200nm的一维BaFe12O19纳米线。利用X射线衍射(XRD),场发射扫描电镜(FESEM),振动样品磁强计(VSM)对BaFe12O19纳米线的组成、形貌与磁性能进行了研究。在外磁场的驱动下,对一... 详细信息

采用Sol-gel法,以自制的AAO模板制备了直径40～60nm,长度为150～200nm的一维BaFe12O19纳米线。利用X射线衍射(XRD),场发射扫描电镜(FESEM),振动样品磁强计(VSM)对BaFe12O19纳米线的组成、形貌与磁性能进行了研究。在外磁场的驱动下,对一维BaFe12O19纳米线进行操控。研究发现:BaFe12O19纳米线的易磁化方向平行其轴线方向,且操控后,BaFe12O19纳米线定向连接成"链",当磁场与BaFe12O19纳米链阵列平行(∥)时,纳米链的剩余磁化强度(Mr)、饱和磁化强度(Ms)和最大磁能积(BH)m都得到增强。矫顽力(Hc)由3.98×105A/m增大至5.01×105A/m,矩形比为0.9,可成为优异的高密度垂直磁记录材料。

关键词： BaFe12O19 纳米线磁场磁操控

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