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Influence of matrix physical properties on flow characteristics in dual network model

Petroleum Science 2023年第4期20卷 2244-2252页

作者： Chen-Chen Wang Yong-Fei Yang Deng-Lin Han miao-miao su Rong-Rong Hu Cooperative Innovation Center of Unconventional Oil and Gas Yangtze UniversityWuhan430100HubeiChina Laboratory of Reservoir Microstructure Evolution and Digital Characterization Yangtze UniversityWuhan430100HubeiChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences Yangtze UniversityWuhan430100HubeiChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina

The tight oil formation develops with microfractures and matrix pores,it is important to study the influence of matrix physical properties on flow *** first,the representative fracture and matrix samples are selected respectively in the dual media,the fracture and matrix digital rocks are constructed with micro-CT scanning at different resolutions,and the corresponding fracture and matrix pore networks are extracted,***,the modified integration method is proposed to build the dual network model containing both fracture and matrix pore-throat elements,while the geometric-topological structure equivalent matrix pores are generated to fill in the skeleton domain of fracture network,the constructed dual network could describe the geometric-topological structure characteristics of fracture and matrix pore-throat *** last,by adjusting the matrix pore density and the matrix filling domain factor,a series of dual network models are obtained to analyze the influence of matrix physical properties on flow characteristics in *** can be seen that the matrix system contributes more to the porosity of the dual media and less to the *** the decrease in matrix pore density,the porosity/permeability contributions of matrix system to dual media keep decreasing,but the decrease is not significant,the oil-water co-flow zone decreases and the irreducible water saturation increases,and the saturation interval dominated by the fluid flow in the fracture keeps *** the decrease in matrix filling domain factor,the porosity/permeability contributions of matrix system to dual media decreases,the oil-water co-flow zone increases and the irreducible water saturation decreases,and the saturation interval dominated by the fluid flow in the fracture keeps *** results can be used to explain the dual-media flow pattern under different matrix types and different fracture control volumes during tight oil production

关键词： Network integration Dual media Flow characteristics Matrix pore density Matrix filling domain

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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回旋手法在小儿股骨骨折中的应用

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中国骨伤 2017年第7期30卷 669-671页

作者：许建国许鑫喻俊辉缪苏叶缪苏健吴静武汉市新洲区骨伤专科医院湖北武汉430400

目的 :探讨回旋手法在小儿股骨骨折中的应用。方法 :2015年3月至2016年10月收治12例股骨骨折患儿,男8例,女4例;年龄1~12岁,平均6岁;均为闭合性骨折。致伤原因:摔伤10例,交通事故2例,其中橫行骨折1例,斜行骨折4例,螺旋形骨折4例,粉碎性骨... 详细信息

目的 :探讨回旋手法在小儿股骨骨折中的应用。方法 :2015年3月至2016年10月收治12例股骨骨折患儿,男8例,女4例;年龄1~12岁,平均6岁;均为闭合性骨折。致伤原因:摔伤10例,交通事故2例,其中橫行骨折1例,斜行骨折4例,螺旋形骨折4例,粉碎性骨折2例,青枝骨折1例。所有患者在伤后1~2 d行手法复位加杉树皮小夹板固定,并行下肢皮肤牵引术。结果:12例患儿获得随访,时间1~3个月,平均2个月。12例患者均达到骨折临床愈合,愈合时间平均6周,并无明显短缩、旋转成角畸形。末次随访时Schatzker-Lambert股骨远端骨折疗效评价结果:优11例,良1例。结论:中医正骨手法中回旋手法对儿童股骨骨折整复尤为关键,配合杉树皮小夹板固定,能达到满意的治疗效果。

关键词：股骨骨折正骨手法小夹板固定

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农产品中农药残留检测及消解研究进展

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粮食与饲料工业 2016年第10期 15-19页

作者：张苗苗王素雅南京财经大学食品科学与工程学院∥江苏省现代粮食流通与安全协同创新中心江苏南京210023

随着人类对农产品需求量的不断扩大,为了保证农产品的产量和质量,农药的使用量也越来越大。长期和大量使用农药导致环境及食品安全问题越来越严重,开展农药残留分析和降解方法的相关研究具有重大的意义。就近年来农产品中农药残留检测... 详细信息

随着人类对农产品需求量的不断扩大,为了保证农产品的产量和质量,农药的使用量也越来越大。长期和大量使用农药导致环境及食品安全问题越来越严重,开展农药残留分析和降解方法的相关研究具有重大的意义。就近年来农产品中农药残留检测及降解技术的研究进展进行了综述,对样品前处理技术,农药残留检测技术及降解技术做了详细的介绍,以期为相关问题的研究提供参考。

关键词：农产品农药残留消解检测

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线粒体介导产生的活性氧在血管紧张素Ⅱ诱导的肾脏损害中的作用

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中国现代医学杂志 2017年第2期27卷 13-18页

作者：冯苗苗刘素晓王小晓崔琳谢世阳沈思朱明军王幼平河南中医学院中西医结合临床学科河南郑州450008 河南中医学院第一附属医院河南郑州450000

目的利用特异性的线粒体活性氧清除剂mito TEMPO,探讨线粒体介导产生的活性氧(ROS)在血管紧张素Ⅱ(AngⅡ)诱发的肾脏损害中的作用。方法通过miniosmotic pump对小鼠皮下灌注AngⅡ复制AngⅡ依赖型高血压模型,而对照组小鼠仅皮下灌注生理... 详细信息

目的利用特异性的线粒体活性氧清除剂mito TEMPO,探讨线粒体介导产生的活性氧(ROS)在血管紧张素Ⅱ(AngⅡ)诱发的肾脏损害中的作用。方法通过miniosmotic pump对小鼠皮下灌注AngⅡ复制AngⅡ依赖型高血压模型,而对照组小鼠仅皮下灌注生理盐水。AngⅡ依赖型高血压小鼠分为AngⅡ组和AngⅡ+mito TEMPO组,分别于皮下注射溶媒和mito TEMPO。实验处理4周后,分别检测小鼠尾动脉收缩压、尿8-异构前列腺素及24 h白蛋白排泄量、肌酐清除率和肾脏中线粒体所产生ROS含量的变化,并同时对肾脏组织病理学的改变进行分析。结果与对照组比较,AngⅡ组小鼠血压升高、尿8-异构前列腺素和白蛋白排泄量增加、肌酐清除率下降,肾脏中肾小球硬化指数、肾小管间质损害程度均增加,并伴有线粒体介导产生ROS水平的升高(P<0.05)。除血压外,mito TEMPO能抑制上述病理性变化,从而减轻AngⅡ所诱发的肾脏损害(P<0.05)。结论在AngⅡ诱发的高血压过程中,特异性的线粒体活性氧清除剂mito TEMPO抑制该过程诱发的肾脏损害,并同时伴有肾脏线粒体ROS产生的下降。因此,上述研究结果提示线粒体介导产生的ROS能够促进AngⅡ诱发的肾脏损害。

关键词：血管紧张素Ⅱ 高血压肾脏损害线粒体活性氧

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Transition of electrical conductivity in carbon nanotube/silver particle composite buckypapers

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Particuology 2014年第6期12卷 15-21页

作者： Fenghua su Menghe miao School of Mechanical and Automotive Engineering South China University of Technology CSIRO Materials Science and Engineering P.O.Box 21BelmontVictoria 3216Australia

The electrical conductivity of carbon nanotube buckypapers can be dramatically increased by incorporation of silver particles contained in a commercial silver *** methods,co-dispersion during the production of buckypaper and surface coating on a preformed buckypaper,were used to prepare composite *** two types of composite buckypapers exhibited very different electrical conductivity *** composite buckypapers prepared by the surface coating method showed a distinct step transition in electrical conductivity at 3 vol%silver content,leading to a 15-fold improvement at 6%silver *** composite buckypapers prepared by the co-dispersion method showed a gradual change in electrical conductivity with increasing silver particle content,resulting in a five-fold improvement at12%silver *** and sectional morphologies of the two types of composite buckypapers were examined and related to their electrical conductivity profiles.

关键词： Carbon nanotubes Buckypaper Electrical conductivity

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Chemical Versus Thermal Folding of Graphene Edges

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Nano Research 2011年第12期4卷 1242-1247页

作者： Ninghai su miao Liu Feng Liu Department of Materials Science and Engineering University of Utahi Salt Lake City UT 84112 USA

Using molecular dynamics （MD） simulations, we have investigated the kinetics of the graphene edge folding process. The lower limit of the energy barrier is found to be -380 meV/A （or about 800 meV per edge atom） and -50 meV/A （or about 120 meV per edge atom） for folding the edges of intrinsic clean single-layer graphene （SLG） and double-layer graphene （DLG）, respectively. However, the edge folding barriers can be substantially reduced by imbalanced chemical adsorption, such as of H atoms, on the two sides of graphene along the edges. Our studies indicate that thermal folding is not feasible at room temperature （RT） for clean SLG and DLG edges and is feasible at high temperature only for DLG edges, whereas chemical folding （with adsorbates） of both SLG and DLG edges can be spontaneous at RT. These findings suggest that the folded edge structures of suspended graphene observed in some experiments are possibly due to the presence of adsorbates at the edges.

关键词： Adsorption graphene kinetics molecular dynamics

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A Two-Stage Genetic Algorithm for the Truck-Door Assignment Problem with Limited Capacity Vehicles and Storage Area

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Journal of Systems Science and Systems Engineering 2019年第3期28卷 285-298页

作者： Zhaowei miao Jie Zhang Yongquan Lan Ruize su School of Management Xiamen UniversityXiamen 361005China School of Business Administration Guangdong University of Finance and EconomicsGuangzhou 510320China

In this paper,we investigate a kind of truck-door assignment problem in a *** related realistic constraints such as the capacity of trucks,the capacity of temporary storage area,the time windows of trucks as well as the operational time inside the crossdock are considered and therefore,make the assignment problem strongly NP-hard and very challenging.A two-stage genetic algorithm is proposed to solve this problem and the experimental results show the superiority of this approach in comparison to CPLEX solver in terms of effectiveness and efficiency especially for the large-scale *** is,the decision making process can speed up and a near optimal truck-door assignment scheme can be obtained within a relatively short time by applying this two-stage approach in practice.

关键词： Truck-door assignment genetic algorithm two-stage approach crossdock

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Incomplete data management： a survey

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Frontiers of Computer Science 2018年第1期12卷 4-25页

作者： Xiaoye miao Yunjun GAO su GUO Wanqi LIU College of Computer Science Zhejiang University Hangzhou 310027 China The Key Lab of Big Data Intelligent Computing of Zhejiang Province Zhejiang University Hangzhou 310027 China

Incomplete data accompanies our life processes and covers almost all fields of scientific studies, as a result of delivery failure, no power of battery, accidental loss, etc. However, how to model, index, and query incomplete data in- curs big challenges. For example, the queries struggling with incomplete data usually have dissatisfying query results due to the improper incompleteness handling methods. In this pa- per, we systematically review the management of incomplete data, including modelling, indexing, querying, and handling methods in terms of incomplete data. We also overview sev- eral application scenarios of incomplete data, and summa- rize the existing systems related to incomplete data. It is our hope that this survey could provide insights to the database community on how incomplete data is managed, and inspire database researchers to develop more advanced processing techniques and tools to cope with the issues resulting from incomplete data in the real world.

关键词： incomplete data query processing indexing,application system

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A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain

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Chinese Chemical Letters 2011年第7期22卷 863-866页

作者： Ning Zhang Yi su miao Yu Department of Chemistry and Chemical Engineering Huanghuai University Zhumadian 463000 China Department of Chemistry Zhengzhou University Zhengzhou 450001 China

A novel cell-impermeable zinc sensor was synthesized by incorporating poly（ethylene glycol）（PEG） to N-（8-quinolyl）-p- aminobenzenesulfonamide （HQAS） group. The polymeric zinc sensor combines both valuable features of HQAS and PEG. The HQAS of the sensor has the similar functions to TSQ, and exhibits a good fluorescence response to Zn^2＋ but poor fluorescence responses to other metal ions. The PEG chain can prevent the sensor to permeate healthy cell membrane. The stained experirnents with the yeast cells as model showed that the sensor cannot stain the healthy yeast cells, but only the damaged or died yeast cells. These results indicated the novel zinc probe was a typical cell-impermeable zinc sensor.

关键词： Zinc ion Sensor Yeast Poly(ethylene glycol) Fluorescence

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