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Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation

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Chinese Chemical Letters 2019年第3期30卷 702-706页

作者： miao-miao chen Ling-Yan Shao Li-Jun Lun Yu-Liang Wu Xiao-Pan Fu Ya-Fei Ji School of Pharmacy East China University of Science & Technology Shandong Keyuan Pharmaceutical Co. Ltd. Shandong Shanghe Economic Development Zone

The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-lH-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp^2-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallography, and probably serves as an active species in the catalytic cycle.

关键词： Palladium-catalysis Late-stage functionalization AroYlation Fully substituted pyrazoles C-H bond activation Cyclopalladated intermediate

Sniffing with mass spectrometry

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Science Bulletin 2018年第20期63卷 1351-1357页

作者： miao-miao chen Hai-Feng Su Ying Xie Li-Fang He Shui-Chao Lin Mei-Lin Zhang cheng Wang Su-Yuan Xie Rong-Bin Huang Lan-Sun Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University School of Information Science and Engineering Xiamen University

Gaseous compounds are usually on-line detectable on sensors. The limitations of conventional sensors are suffering from incapability for exactly identifying multiple components as well as incompatibility to possible toxicants in every odor sample. Herein, we discuss an inlet modification to the laboratory standard mass spectrometer, inspired by the sensitive olfactory systems of animals, for direct sniffing,established by connecting a mini pump to the nebulizer gas tubing. The modified mass spectrometry method—sniffing-mass spectrometry(sniffing-MS)—can acquire detailed fingerprint spectra of mixed odors and shows high tolerance to toxicants. Furthermore, the method has a low limit of detection in the order of parts per trillion and is a ‘sampling-free' technique for analyzing various gaseous compounds simultaneously, thus offering versatility for smelling daily commodities, tracking diffusion, and locating position of odors. Sniffing-MS can mimic or even surpass the olfaction of animals and is applicable for analyzing gaseous/volatile compounds, especially those polar compounds, in a simple manner depending on the intrinsic molecular mass-to-charge ratio.

关键词： Ambient mass spectrometry Volatile compounds Gas source locating On-line monitoring Olfaction

Surgical first aid and nursing care of a parturient with massive hemorrhage in natural delivery

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Nursing Communications 2022年第1期6卷 40-42页

作者： miao-miao chen Yong-Chao He Meng-Yuan Pei Hua-Ting Zhang Xiao-Yu Liu The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai 264000China Northwest Minzu University Lanzhou 730000China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250022China Qilu Children’s Hospital of Shandong University Jinan 250022China

Objective:To summarize the first aid and nursing of the operating room due to serious complications caused by postpartum massive ***:One case of emergency hemorrhage was ineffective in emergency ***:The uterus was successfully removed and the bleeding was successfully *** was transferred to the ICU under general ***:For pregnant women with postpartum massive bleeding and hemorrhagic shock and diffuse intravascular coagulation(DIC),targeted surgical treatment and complete operating room emergency care are of great significance to save maternal lives.

关键词： postpartum bleeding hemorrhagic shock uterine artery embolization hysterectomy DIC emergency care in the operating room

Tetraphenylethylene-doped covalent organic frameworks as a highly efficient aggregation-induced electrochemiluminescence emitter for ultrasensitive miRNA-21 analysis

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Advanced Sensor and Energy Materials

Advanced Sensor and Energy Materials 2023年第2期2卷 19-26页

作者： Wen-Yi Shu Ruiqi Su Linli Yao Yao Xiao miao-miao chen Wei Wen Shengfu Wang chengyi Xiong Xiuhua Zhang Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China

MicroRNAs(miRNAs)as a well-known kind of cancer marker are closely associated with the formation and metastasis of ***,a novel tetraphenylethylene(TPE)-doped covalent organic frameworks(TPE-COFs)with strong aggregation-induced electrochemiluminescence(AIECL)response was synthesized and introduced to construct an ultrasensitive biosensor for the detection of *** strong aggregation-induced emission(AIE)response was obtained because the molecular motion of TPE was restricted by COFs which had the porosity and highly ordered topological ***,the porous structure of COFs allowed TPE to react with electrochemiluminescence(ECL)coreactants more ***,COFs significantly improved the electron transport efficiency of the entire ECL *** of these endowed the TPE-COFs with superior AIECL ***,a TPE-COFs based ECL resonance energy transfer(ECL-RET)system was constructed for ultrasensitive miRNA-21 biosensing with differential signal *** proposed assays exhibited excellent sensitivity with a wide dynamic range from 10 aM to 1 pM and a low detection limit of 2.18 ***,these indicated that doping TPE in COFs was a creative way to develop functional COFs and provided an effective way for enhancing ***,this work boarded the application of AIECL in analytical chemistry.

关键词： Aggregation-induced electrochemiluminescence Covalent organic frameworks Resonance energy transfer MicroRNA-21 Biosensor

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新疆服务贸易发展现状及对策分析

特区经济 2011年第12期 208-210页

作者：朱淼淼陈晓新疆大学经济与管理学院新疆乌鲁木齐830046

20世纪90年代以来,全球服务贸易发展迅速,事实表明服务贸易已成为经济发展多样化的重要推动力。本文分析了新疆服务贸易发展现状及存在的问题,提出了新疆发展服务贸易的对策思考。

关键词：服务贸易问题保障措施

The complete mitochondrial genome of Antheraea proylei strain In981（Lepidoptera:Saturniidae）

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The complete mitochondrial genome of Antheraea proylei strai...

Molecular characterization and phylogenetic analysis of the eukaryotic translation initiation factor 4A gene in Antheraea pernyi

中国蚕学会第十届青年学术研讨会

作者： Jian Yang Ru-Song Zhang Dong-Bin chen miao-miao chen Yu-Ping Li 刘彦群 Department of Sericulture College of Bioscience and BiotechnologyShenyang Agricultural University Sericultural Institute of Liaoning Province

In the present study,we report the complete mitochondrial genome of Antheraea proylei strain In981,a hybrid of Chinese oak silkmoth（***） and Indian oak silkmoth（***）.The circular molecule is 15,573 bp in length,with 37 typical coding genes（13 protein-coding genes,two ribosomal RNA genes,22 transfer RNA genes） and one non-coding A+T-rich region of 552 bp *** gene components and gene order are identical to the common type found in Bombycoidea *** analyses revealed that In981 is closely related to *** rather than *** is the first report on complete mitohondrial genome of ***.

关键词： Antheraea proylei In981 mitochondrial genome phylogengenetic relationship

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Molecular characterization and phylogenetic analysis of the ...

Two-dimensional transition metal halide PdX_(2)(X=F,Cl,Br,I):A promising candidate of bipolar magnetic semiconductors

中国蚕学会第九届青年学术研讨会

作者： miao-miao chen Yan-Qun LIU Yan Li Rui YAO Mo chen Run-Xi XIA 李群 Li QIN Insect Resource Center for Engineering and Technology of Liaoning Province College of Bioscience and BiotechnologyShenyang Agricultural University Key Laboratory of Wild Silkworms of Liaoning Province Sericultural Institute of Liaoning Province

Eukaryotic initiation factor 4 A（eIF-4 A） is an essential component for protein translation in *** eIF-4 A gene（ApeIF-4 A） was isolated and characterized from Antheraea *** obtained cDNA sequence was 1435 bp long with an open reading frame（ORF） of 1266 bp encoding 421 amino *** predicted amino acid sequence shared several conserved features as found in known eIF-4 As,and revealed 74 and 78% identities with eIF-4 As of Homo sapiens and Drosophila melanogaster,***-PCR analysis showed that ApeIF-4 A was transcribed at four developmental stages and in all tissues tested,suggesting that it plays an important role in development of *** alignment suggested that eIF-4 As are highly conserved throughout evolution of eukaryote *** trees based on the amino acid and nucleotide sequences of eIF-4 A demonstrated a similar topology with the classical systematics,suggesting that it has the potential value in phylogenetic inference of eukaryotes.

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Chinese Physics B 2023年第12期32卷 481-488页

作者：陈苗苗李胜世纪维霄张昌文 School of Physics and Technology Institute of SpintronicsUniversity of JinanJinan 250022China

Two-dimensional(2D)nanomaterials with bipolar magnetism show great promise in spintronic *** carriers'spin-polarized orientation in bipolar magnetic semiconductor(BMS)requires a gate voltage,but that is ***,a new method has been proposed to solve the problem of volatility by introducing a ferroelectric gate with proper band *** this paper,we predict that the PdX_(2)(X=F,Cl,Br,I)monolayers are 2D ferromagnetic BMS with dynamic stability,thermal stability,and mechanical stability by first-principles *** critical temperatures are higher than the boiling point of liquid nitrogen and the BMS characteristics are robust against external strains and electric fields for PdCl_(2) and PdBr_(2).Then,we manipulate the spin-polarization of PdCl_(2) and PdBr_(2) by introducing a ferroelectric gate to enable magnetic half-metal/semiconductor switching and spin-up/down polarization switching *** kinds of spin devices(multiferroic memory and spin filter)have been proposed to realize the spin-polarized directions of *** results demonstrate that PdCl_(2) and PdBr_(2) with BMS characters can be widely used as a general material structure for spintronic devices.

关键词： PdX_(2)(X=F Cl Br I) bipolar magnetic semiconductors first-principles calculations

牵牛子提取物改善洛哌丁胺所致的大鼠功能性便秘和肠道菌群失调

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世界华人消化杂志 2022年第5期30卷 223-229页

作者：陈肖敏王煦陈苗苗浙江省台州医院、台州恩泽医疗中心(集团)路桥医院药剂科浙江省台州市318050

背景牵牛子可用于便秘的治疗,而其主要的药理活性成分-牵牛子提取物(pharbitis nil extract,PN)对功能性便秘(functional constipation,FC)的具体的药理作用及机制并不清楚.目的研究PN对FC大鼠便秘症状、小肠动力、结肠肌电活动、结肠... 详细信息

背景牵牛子可用于便秘的治疗,而其主要的药理活性成分-牵牛子提取物(pharbitis nil extract,PN)对功能性便秘(functional constipation,FC)的具体的药理作用及机制并不清楚.目的研究PN对FC大鼠便秘症状、小肠动力、结肠肌电活动、结肠组织形态、肠道菌群以及神经递质的影响.方法采用盐酸洛哌丁胺(loperamide,Lop)灌胃法构建FC大鼠模型,并给予PN进行治疗.观察并记录大鼠给药6 h内粪便粒数、粪便含水率、小肠推进率和结肠肌电活动;聚合酶链反应变性梯度凝胶电泳(polymerase chain reaction-denaturing gradient gel electrophoresis,PCR-DGGE)法检测大鼠肠道菌群的变化情况;苏木精-伊红(hematoxylin-eosin,H&E)染色检测大鼠结肠组织的形态学变化;酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测大鼠结肠中P物质(substance P,SP)、血管活性肠肽(vasoactive intestinal peptide,VIP)和5-羟色胺(5-hydroxytryptamine,5-HT)的表达水平.结果PN可显著增加FC大鼠6 h内的粪便粒数和粪便含水量;增快肠道墨汁推进率;降低结肠肌电频率和振幅变异程度.H&E结果显示,PN可改善Lop所致的结肠组织形态学改变.PCR-DGGE的检测结果显示,PN可调整FC大鼠肠道内拟杆菌门和疣微菌门的表达,升高乳杆菌科以及双歧杆菌科的表达丰度.ELISA结果显示,PN可显著上调FC大鼠结肠组织中SP和5-HT的表达,下调VIP的表达水平.结论PN可缓解Lop所致的FC并改善肠道菌群和肠神经系统.

关键词：牵牛子提取物功能性便秘肠道菌群肠神经系统